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ambient temperature; animal models; body weight; calcium-calmodulin-dependent protein kinase; cardiovascular diseases; endothelium; mitochondria; protein synthesis; rats; therapeutics; vasodilation
Abstract:
... Cardiovascular disease (CVD) is a global health concern. Vascular dysfunction is an aspect of CVD, and novel treatments targeting vascular physiology are necessary. In the endothelium, eNOS regulates vasodilation and mitochondrial function; both are disrupted in CVD. (–)-Epicatechin, a botanical compound known for its vasodilatory, eNOS, and mitochondrial-stimulating properties, is a potential the ...
... Low-grade inflammation is a major player in obesity and the metabolic syndrome predicting development of type 2 diabetes (T2DM). The interleukin-1 receptor antagonist (IL-1Ra) is a vital and natural anti-inflammatory factor and mediator in glucose homeostasis disturbances. The predictive role is independent of multiple confounders, and elevated levels appear few years before T2DM. The role of IL-1 ...
... Low-grade inflammation is a factor that predisposes to many obesity-related comorbidities. The immune mechanisms controlling the inflammatory response related to the secretory activity of adipocytes and its consequences for the organism are still under investigation. Methods: 84 obese adult volunteers (BMI ≥ 30 kg/m²) were tested by BIA. Serum samples were collected to analyze the concentrations o ...
... Health and longevity populations have distinct metabolic and nutrient intake profiles. However, the relationship between biomarkers of longevity-related metabolites and dietary nutrient intake profiles, as well as metabolic markers associated with longevity features, have not been fully elucidated. Therefore, ¹H nuclear magnetic resonance (¹H NMR)-based plasma metabolomics profiling was conducted ...
flavorings; men; neoplasms; nutrients; pain; patients; screening; seasons; vitamin D; vitamin D deficiency; vitamin supplements; women
Abstract:
... The purpose of this study is to explore 25-hydroxyvitamin D (25-OHD) levels in patients with cancer in the palliative phase in relation to season, sex, age, tumor type, colectomy, and survival. To this end, we performed a post-hoc analysis of ‘Palliative-D’, a randomized placebo-controlled, double-blind trial investigating the effect of daily supplementation with 4000 IU of vitamin D for 12 weeks ...
... Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previous ...
body mass index; childhood obesity; children; cities; education; factor analysis; longitudinal studies; models; questionnaires; risk; waist-to-height ratio; China
Abstract:
... This study examined the longitudinal associations between parental feeding practices and child weight status, and their potential modification effects by child sex, age, and maternal and paternal educations among children. Data were collected from 2015 to 2017 of 2139 children aged 6–17 years and their parents in five Chinese mega-cities. Parental feeding practices were assessed using 11-items fro ...
alcohols; energy intake; food frequency questionnaires; food intake; food records; nutrient intake; regression analysis
Abstract:
... The food frequency questionnaires (FFQs) are the most common tools used in dietary research. Each newly developed, modified, or adapted FFQ should be validated in the target population. The aim of this study was to assess the reproducibility and relative validity of the 72-item semi-quantitative food frequency questionnaire (72-item SQ-FFQ) for Polish adults. The 72-item SQ-FFQ was developed based ...
National Health and Nutrition Examination Survey; ascorbic acid; copper; databases; dose response; periodontitis; regression analysis; riboflavin; risk; thiamin; vitamin A; vitamin E
Abstract:
... The association between micronutrient intake and the risk of periodontitis has received much attention in recent years. However, most studies focused on the linear relationship between them. This study aimed to explore the dose–response association between micronutrient intake and periodontitis. A total of 8959 participants who underwent a periodontal examination, and reported their micronutrient ...
Cecilia Veraar; Arabella Fischer; Martin H. Bernardi; Isabella Sulz; Mohamed Mouhieddine; Martin Dworschak; Edda Tschernko; Andrea Lassnigg; Michael Hiesmayr
catheters; energy expenditure; mitochondria; mortality; multivariate analysis; oxygen; pulmonary artery; surgery
Abstract:
... After major surgery, longitudinal changes in resting energy expenditure (REE) as well as imbalances in oxygen delivery (DO₂) and distribution and processing (VO₂) may occur due to dynamic metabolic requirements, an impaired macro- and microcirculatory flow and mitochondrial dysfunction. However, the longitudinal pattern of these parameters in critically ill patients who die during hospitalization ...
... Food fortification and folic acid supplementation during pregnancy have been implemented as strategies to prevent fetal malformations during pregnancy. However, with the emergence of conditions where folate metabolism and transport are disrupted, such as folate receptor alpha autoantibody (FRαAb)-induced folate deficiency, it is critical to find a folate form that is effective and safe for pharmac ...
Hailah M. Almohaimeed; Maryam Hassan Al-Zahrani; Mohammed Saad Almuhayawi; Sami Awda Algaidi; Ashwaq H. Batawi; Hasan Ahmed Baz; Zuhair M. Mohammedsaleh; Nhal Ahmed Baz; Fayez M. Saleh; Nasra Ayuob
... Background: Chronic stress can hinder wound healing as it suppresses both the cellular and innate immune responses. Objectives: The study aims to assess the effectiveness of the administration of topical and oral Cucurbita pepo L. (CP) ethanolic extract in prompting excisional wound healing in rats exposed to chronic stress, and to explain how it works. Materials and methods: Fifty albino rats ass ...
... The purpose of this study was to explore the perspective of renal dietitians regarding plant-based diets for chronic kidney disease (CKD) management and evaluate the acceptability of a hypothetical plant-based dietary prescription aiming for the consumption of 30 unique plant foods per week. This study used an exploratory mixed methods design. Forty-six renal dietitians participated in either an o ...
cross-sectional studies; gestational diabetes; health services; nutritional status; pre-eclampsia; pregnancy; risk; statistical analysis; weight gain
Abstract:
... Optimum nutrition and weight before and during pregnancy are associated with a lower risk of conditions such as pre-eclampsia and gestational diabetes. There is a lack of user-friendly tools in most clinical settings to support healthcare practitioners (HCPs) in implementing them. This study aimed to evaluate the acceptability of (1) using a nutrition checklist designed by the International Federa ...
Ana Cecilia Fernández-Gaxiola; Carlos Cruz-Casarrubias; Selene Pacheco-Miranda; Joaquín Alejandro Marrón-Ponce; Amado David Quezada; Armando García-Guerra; Jason Donovan
corn; food quality; obesity; prices; wheat; Latin America; Mexico
Abstract:
... The contributions of processed foods to the overweight and obesity problem in Latin America are well known. Engagement with the private and public sectors on possible solutions requires deeper insights into where and how these products are sold and the related implications for diet quality. This article characterizes the diversity of wheat and maize processed foods (WMPFs) available to consumers i ...
Tracey L. Livingstone; Shikha Saha; Federico Bernuzzi; George M. Savva; Perla Troncoso-Rey; Maria H. Traka; Robert D. Mills; Richard Y. Ball; Richard F. Mithen
... Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containin ...
coagulation; diabetes mellitus; electron transport chain; inflammasomes; inflammation; kidney diseases; mitochondria; morbidity; mortality; obesity; pandemic; proteinases; reactive oxygen species; risk
Abstract:
... Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage renal disease and is associated with an excessive risk of cardiovascular morbidity and mortality. DKD is a consequence of systemic endothelial dysfunction. The endothelial-dependent cytoprotective coagulation protease activated ...
... Effective treatments for age-related macular degeneration (AMD), the most prevalent neurodegenerative form of blindness in older adults, are lacking. Genome-wide association studies have identified lipid metabolism and inflammation as AMD-associated pathogenic changes. Liver X receptors (LXRs) play a critical role in intracellular homeostases, such as lipid metabolism, glucose homeostasis, inflamm ...
... Inflammation plays an important role in the pathogenesis of many diseases, including cardiovascular diseases, atherosclerosis, diabetes, asthma, and cancer. An appropriate diet and the active compounds contained in it can affect various stages of the inflammatory process and significantly affect the course of inflammatory diseases. Recent reports indicate that polyphenolic acids, vitamins, mineral ...
beverages; breast milk; caregivers; cross-sectional studies; data collection; food intake; food records; questionnaires
Abstract:
... The ability to comprehensively assess the diet of infants is essential for monitoring adequate growth; however, it is challenging to assess dietary intake with a high level of accuracy. Infants rely on surrogate reporting by caregivers. This study aimed to determine if surrogate reporters (e.g., caregivers) could use an image-based mobile food record adapted (baby mFR) to record infants’ eating oc ...