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1. Activated Paper Surfaces for the Rapid Hybridization of DNA through Capillary Transport

Author:
Araújo Ana Catarina; Song Yajing; Lundeberg Joakim; Ståhl Patrik L.; Brumer Harry
Source:
Analytical chemistry 2012 v.84 no.7 pp. 3311-3317
ISSN:
1520-6882
Subject:
cellulose; diagnostic techniques; dogs; filters; forensic sciences; glass; humans; mitochondria; nucleic acid hybridization; paper; single-stranded DNA
Abstract:
... The development of low-cost, accurate, and equipment-free diagnostic tests is crucial to many clinical, laboratory, and field applications, including forensics and medical diagnostics. Cellulose fiber-based paper is an inexpensive, biodegradable, and renewable resource, the use of which as a biomolecule detection matrix and support confers several advantages compared to traditional materials such ...
DOI:
10.1021/ac300025v

2. Advances in Surface Plasmon Resonance Imaging Enable Quantitative Tracking of Nanoscale Changes in Thickness and Roughness

Author:
Raegen Adam N.; Reiter Kyle; Dion Alexander; Clarke Anthony J.; Lipkowski Jacek; Dutcher John R.
Source:
Analytical chemistry 2014 v.86 no.7 pp. 3346-3354
ISSN:
1520-6882
Subject:
atomic force microscopy; bioenergy industry; cellulose; coatings; data collection; enzymes; films (materials); image analysis; polymers; quantitative analysis; roughness; surface plasmon resonance; surface roughness
Abstract:
... To date, detailed studies of the thickness of coatings using surface plasmon resonance have been limited to samples that are very uniform in thickness, and this technique has not been applied quantitatively to samples that are inherently rough or undergo instabilities with time. Our manuscript describes a significant improvement to surface plasmon resonance imaging (SPRi) that allows this sensitiv ...
DOI:
10.1021/ac4034664

3. Analysis of Technetium Species and Fractions in Natural Seaweed Using Biochemical Separation and ICP-MS Measurement

Author:
Shi Keliang; Hou Xiaolin; Qiao Jixin; Sun Xuejie; Roos Per; Wu Wangsuo
Source:
Analytical chemistry 2016 v.88 no.23 pp. 11931-11937
ISSN:
1520-6882
Subject:
Phaeophyceae; alginates; atomic absorption spectrometry; cellulose; macroalgae; technetium
Abstract:
... An extremely high accumulation and retention of technetium in marine plants, especially brown seaweed, makes it a unique bioindicator of technetium. In the present work, a novel approach was developed for the speciation analysis of technetium in seaweed, wherein a series of biochemical separations was exploited to isolate different species of technetium. Inductively coupled plasma mass spectrometr ...
DOI:
10.1021/acs.analchem.6b03837

4. Application of Time-of-Flight-Secondary Ion Mass Spectrometry for the Detection of Enzyme Activity on Solid Wood Substrates

Author:
Goacher Robyn E.; Edwards Elizabeth A.; Yakunin Alexander F.; Mims Charles A.; Master Emma R.
Source:
Analytical chemistry 2012 v.84 no.10 pp. 4443-4451
ISSN:
1520-6882
Subject:
X-ray photoelectron spectroscopy; adsorption; cellulose; decayed wood; endo-1,4-beta-glucanase; enzyme activity; high performance liquid chromatography; laccase; lignin; lignocellulose; mass spectrometry; principal component analysis; screening; sugars
Abstract:
... Time-of-flight-secondary ion mass spectrometry (TOF-SIMS) is a surface analysis technique that is herein demonstrated to be a viable tool for the detection of enzyme activity on solid substrates. Proof-of-principle experiments are presented that utilize commercial cellulase and laccase enzymes, which are known to modify major polymeric components of wood (i.e., cellulose and lignin, respectively). ...
DOI:
10.1021/ac3005346

5. Automated Electric-Field-Driven Membrane Extraction System Coupled to Liquid Chromatography–Mass Spectrometry

Author:
See Hong Heng; Hauser Peter C.
Source:
Analytical chemistry 2014 v.86 no.17 pp. 8665-8670
ISSN:
1520-6882
Subject:
cellulose; detection limit; herbicides; liquid chromatography; mass spectrometry; phosphates; plasticizers; polymers; river water
Abstract:
... An automated analyte electroextraction and preconcentration system, which was used as the front end for a liquid chromatography–electrospray mass spectrometry instrument, is described. The extraction was based on driving the anionic analytes across a polymer inclusion membrane by application of a potential of 200 V to the cell. Five milliliters (5 mL) of sample were passed through a flow-through c ...
DOI:
10.1021/ac5015589

6. BC@DNA-Mn₃(PO₄)₂ Nanozyme for Real-Time Detection of Superoxide from Living Cells

Author:
Ying Wang; Deng Wang; Li-Hong Sun; Long-Cheng Zhang; Zhi-Song Lu; Peng Xue; Feng Wang; Qing-You Xia; Shu-Juan Bao
Source:
Analytical chemistry 2020 v.92 no.24 pp. 15927-15935
ISSN:
1520-6882
Subject:
adsorption; analytical chemistry; biocompatibility; catalytic activity; cellulose; cost effectiveness; drugs; early diagnosis; electrochemistry
Abstract:
... Electrochemical in situ sensing of small signal molecules released from living cells has an increasing significance in early diagnosis, pathological analyses, and drug discovery. Here, a living cell-fixed sensing platform was built using the BC@DNA-Mn₃(PO₄)₂ nanozyme, in which a highly biocompatible bacterial cellulose riveted with very tiny Mn₃(PO₄)₂; it not only delivers high catalytic activity ...
DOI:
10.1021/acs.analchem.0c03322

7. Biosample Concentration Using Microscale Forward Osmosis with Electrochemical Monitoring

Author:
Martin K. Kimani; Rachel Loo; Edgar D. Goluch
Source:
Analytical chemistry 2019 v.91 no.11 pp. 7487-7494
ISSN:
1520-6882
Subject:
Pseudomonas aeruginosa; biomarkers; carbon; cellulose; centrifugation; copper; detection limit; diagnostic techniques; dialysis; electrochemistry; electrodes; microfluidic technology; monitoring; osmosis; pH; pathogens; point-of-care systems; pyocyanin; saliva; sucrose; temperature; ultrafiltration; urine
Abstract:
... We report the design and operation of an integrated microfluidics system that uses cellulose ester dialysis membranes coupled with disposable carbon and copper electrodes for monitoring and concentration of microliter scale biofluid samples. Dialysis membranes are typically used for buffer exchange, but in this work, membranes with 100–500 Da MWCO were evaluated for feasibility in concentrating sm ...
DOI:
10.1021/acs.analchem.9b02163

8. Capture and Detection of DNA Hybrids on Paper via the Anchoring of Antibodies with Fusions of Carbohydrate Binding Modules and ZZ-Domains

Author:
Rosa Ana M. M.; Louro A. Filipa; Martins Sofia A. M.; Inácio João; Azevedo Ana M.; Prazeres D. Miguel F.
Source:
Analytical chemistry 2014 v.86 no.9 pp. 4340-4347
ISSN:
1520-6882
Subject:
Clostridium thermocellum; DNA; DNA probes; adsorption; ambient temperature; antibodies; bioassays; biotin; carbohydrate binding; cellulose; diagnostic techniques; fluorescein; fluorescence; immunoglobulin G; paper
Abstract:
... Microfluidic paper-based analytical devices (μPADs) fabricated by wax-printing are suitable platforms for the development of simple and affordable molecular diagnostic assays for infectious diseases, especially in resource-limited settings. Paper devices can be modified for biological assays by adding appropriate reagents to the test areas. For this purpose, the use of affinity immobilization stra ...
DOI:
10.1021/ac5001288

9. Cellulose Paper Sensors Modified with Zwitterionic Poly(carboxybetaine) for Sensing and Detection in Complex Media

Author:
Zhu Yongheng; Xu Xuewei; Brault Norman D.; Keefe Andrew J.; Han Xia; Deng Yan; Xu Jiaqiang; Yu Qiuming; Jiang Shaoyi
Source:
Analytical chemistry 2014 v.86 no.6 pp. 2871-2875
ISSN:
1520-6882
Subject:
antibodies; antigen detection; blood serum; cellulose; glucose; humans; paper; zwitterions
Abstract:
... Poly(carboxybetaine) (PCB) functionalized cellulose paper was used as a paper-based microfluidic device. The results showed that the PCB modified paper sensor was able to achieve (a) more rapid and sensitive glucose detection from undiluted human serum compared to bare cellulose and (b) specific antigen detection via covalently immobilized antibodies. ...
DOI:
10.1021/ac500467c

10. Cellulose-Based Biosensors for Esterase Detection

Author:
Derikvand Fatemeh; Yin DeLu Tyler; Barrett Ryan; Brumer Harry
Source:
Analytical chemistry 2016 v.88 no.6 pp. 2989-2993
ISSN:
1520-6882
Subject:
biocompatibility; biosensors; cellulose; cellulosic fibers; esterases; fluorescent dyes; hydrocolloids; methodology
Abstract:
... Cellulose has emerged as an attractive substrate for the production of economical, disposable, point-of-care (POC) analytical devices. Development of novel methods of (bio)activation is central to broadening the application space of cellulosic materials. Ironically, such efforts are stymied by the inherent biocompatibility and recalcitrance of cellulose fibers. Here, we have elaborated a versatile ...
DOI:
10.1021/acs.analchem.5b04661

11. Cellulose-Based Strips Designed Based on a Sensitive Enzyme Colorimetric Assay for the Low Concentration of Glucose Detection

Author:
Xiaogang Luo; Jian Xia; Xiangyang Jiang; Mengru Yang; Shilin Liu
Source:
Analytical chemistry 2019 v.91 no.24 pp. 15461-15468
ISSN:
1520-6882
Subject:
Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; cameras; cellulose; color; colorimetry; detection limit; energy-dispersive X-ray analysis; enzymatic reactions; glucose; glucose oxidase; immobilized enzymes; oxidation; peroxidase; scanning electron microscopy; schiff bases; sodium; sodium hydroxide; urea; urine
Abstract:
... High-purity cellulose membranes prepared via a green pathway were used to attempt to enhance their performance of glucose detection compared with that of traditional filter paper. In this work, cellulose-based strips (CBS) for the low concentration of glucose detection have been designed based on a fast, sensitive, and easy enzyme colorimetric assay from porous and high-purity cellulose membranes ...
DOI:
10.1021/acs.analchem.9b03180

12. Characterization of Oligocellulose Synthesized by Reverse Phosphorolysis Using Different Cellodextrin Phosphorylases

Author:
Petrović Dejan M.; Kok Inge; Woortman Albert J. J.; Ćirić Jelena; Loos Katja
Source:
Analytical chemistry 2015 v.87 no.19 pp. 9639-9646
ISSN:
1520-6882
Subject:
Clostridium stercorarium; Clostridium thermocellum; catalysts; cellobiose; cellulose; gel chromatography; mass spectrometry; molecular weight; nuclear magnetic resonance spectroscopy; phosphorylase; polymerization; solvents
Abstract:
... Much progress was made in the straightforward and eco-friendly enzymatic synthesis of shorter cellulose chains (oligocellulose). Here, we report the determination of a molar mass distribution of the oligocellulose synthesized from cellobiose (CB) and α-glucose 1-phosphate by reverse phosphorolysis, using enzymes cellodextrin phosphorylase from Clostridium stercorarium or Clostridium thermocellum a ...
DOI:
10.1021/acs.analchem.5b01098

13. Characterizing the Range of Extracellular Protein Post-Translational Modifications in a Cellulose-Degrading Bacteria Using a Multiple Proteolyic Digestion/Peptide Fragmentation Approach

Author:
Dykstra Andrew B.; Rodriguez Miguel; Raman Babu; Cook Kelsey D.; Hettich Robert L.
Source:
Analytical chemistry 2013 v.85 no.6 pp. 3144-3151
ISSN:
1520-6882
Subject:
Clostridium thermocellum; acetylation; bacteria; cellulose; cellulosome; decision support systems; dissociation; electron transfer; methylation; oxidation; peptides; phosphorylation; post-translational modification; proteins; proteolysis; signal peptide; solubilization; trypsin
Abstract:
... Post-translational modifications (PTMs) are known to play a significant role in many biological functions. The focus of this study is to optimize an integrated experimental/informatics approach to more confidently characterize the range of post-translational modifications of the cellulosome protein complex used by the bacterium Clostridium thermocellum to better understand how this protein machine ...
DOI:
10.1021/ac3032838

14. Chip-Based High-Performance Liquid Chromatography for High-Speed Enantioseparations

Author:
Thurmann Sebastian; Lotter Carsten; Heiland Josef J.; Chankvetadze Bezhan; Belder Detlev
Source:
Analytical chemistry 2015 v.87 no.11 pp. 5568-5576
ISSN:
1520-6882
Subject:
cellulose; drugs; enantiomers; glass; high performance liquid chromatography; mass transfer; silica; solutes
Abstract:
... In this work, the first high-performance chiral liquid chromatography in packed microfluidic chips is presented. The chromatographic separation was performed on a column integrated into the microfluidic glass chip and packed with the particulate chiral stationary phase. Cellulose tris(3,5-dimethylphenylcarbamate) coated on 5-μm fully porous silica was used as chiral stationary phase material. Seve ...
DOI:
10.1021/acs.analchem.5b00210

15. Combining Fibrinogen-Conjugated Gold Nanoparticles with a Cellulose Membrane for the Mass Spectrometry-Based Detection of Fibrinolytic-Related Proteins

Author:
Chiu Wei-Chane; Huang Chih-Ching
Source:
Analytical chemistry 2013 v.85 no.14 pp. 6922-6929
ISSN:
1520-6882
Subject:
blood serum; cellulose; desorption; detection limit; gold; humans; ionization; irradiation; mass spectrometry; mechanism of action; nanogold; plasmin; plasminogen; proteins; u-plasminogen activator
Abstract:
... In this paper, we describe a pulsed-laser desorption/ionization mass spectrometry (LDI-MS) approach for the detection of plasmin with subnanomolar sensitivity through the analysis of gold (Au) clusters desorbed from fibrinogen-modified gold nanoparticles (Fib–Au NPs) on a mixed cellulose ester membrane (MCEM). The mechanism of action of this probe is based on the plasmin-mediated cleavage of the F ...
DOI:
10.1021/ac4013418

16. Comparison of Influenza Virus Particle Purification Using Magnetic Sulfated Cellulose Particles with an Established Centrifugation Method for Analytics

Author:
Serve Anja; Pieler Michael Martin; Benndorf Dirk; Rapp Erdmann; Wolff Michael Werner; Reichl Udo
Source:
Analytical chemistry 2015 v.87 no.21 pp. 10708-10711
ISSN:
1520-6882
Subject:
Influenza A virus; cellulose; centrifugation; mass spectrometry; purification methods; viral nonstructural proteins; virion
Abstract:
... A method for the purification of influenza virus particles using novel magnetic sulfated cellulose particles is presented and compared to an established centrifugation method for analytics. Therefore, purified influenza A virus particles from adherent and suspension MDCK host cell lines were characterized on the protein level with mass spectrometry to compare the viral and residual host cell prote ...
DOI:
10.1021/acs.analchem.5b02681

17. Comparison of the Determination of a Low-Concentration Active Ingredient in Pharmaceutical Tablets by Backscatter and Transmission Raman Spectrometry

Author:
Townshend Nichola; Nordon Alison; Littlejohn David; Myrick Michael; Andrews John; Dallin Paul
Source:
Analytical chemistry 2012 v.84 no.11 pp. 4671-4676
ISSN:
1520-6882
Subject:
Raman spectroscopy; active ingredients; cellulose; high performance liquid chromatography; maleates; models; particle size; photons; prediction
Abstract:
... A total of 383 tablets of a pharmaceutical product were analyzed by backscatter and transmission Raman spectrometry to determine the concentration of an active pharmaceutical ingredient (API), chlorpheniramine maleate, at the 2% m/m (4 mg) level. As the exact composition of the tablets was unknown, external calibration samples were prepared from chlorpheniramine maleate and microcrystalline cellul ...
DOI:
10.1021/ac203447k

18. Comprehensive Signal Assignment of 13C-Labeled Lignocellulose Using Multidimensional Solution NMR and 13C Chemical Shift Comparison with Solid-State NMR

Author:
Komatsu Takanori; Kikuchi Jun
Source:
Analytical chemistry 2013 v.85 no.18 pp. 8857-8865
ISSN:
1520-6882
Subject:
Cichorium intybus; Solanum tuberosum; Zea mays; cellulose; chicory; corn; isotope labeling; lignin; lignocellulose; nuclear magnetic resonance spectroscopy; potatoes; stable isotopes; xylan; xyloglucans
Abstract:
... A multidimensional solution NMR method has been developed using various pulse programs including HCCH-COSY and ¹³C-HSQC-NOESY for the structural characterization of commercially available ¹³C labeled lignocellulose from potatoes (Solanum tuberosum L.), chicory (Cichorium intybus), and corn (Zea mays). This new method allowed for 119 of the signals in the ¹³C-HSQC spectrum of lignocelluloses to be ...
DOI:
10.1021/ac402197h

19. Confronting the Challenge of Cellulose Molecular Weight Measurement: An Accurate, Rapid, and Universal Method with Ionic Liquid as an Additive

Author:
Yan Zhou; Yaohui Cheng; Qinyong Mi; Xiaocheng Zhang; Jinming Zhang; Jun Zhang
Source:
Analytical chemistry 2022 v.94 no.13 pp. 5432-5440
ISSN:
1520-6882
Subject:
acetates; ambient temperature; analytical chemistry; cellulose; gel chromatography; hydrogen; industrial applications; ionic liquids; molecular weight; polymers; viscosity
Abstract:
... Molecular weight parameters are the key fundamental information of polymer materials, but the accurate characterization of the molecular weight of cellulose is extremely difficult due to its strong hydrogen bonding network. Herein, we demonstrated two new methods to accurately and rapidly measure the molecular weight parameters of cellulose by using 1-butyl-3-methylimidazolium acetate (BmimAc) ion ...
DOI:
10.1021/acs.analchem.2c00558

20. Constituting Fully Integrated Visual Analysis System for Cu(II) on TiO2/Cellulose Paper

Author:
Li Shun-Xing; Lin Xiaofeng; Zheng Feng-Ying; Liang Wenjie; Zhong Yanxue; Cai Jiabai
Source:
Analytical chemistry 2014 v.86 no.14 pp. 7079-7083
ISSN:
1520-6882
Subject:
adsorbents; adsorption; cellulose; color; colorimetry; computer software; copper; detection limit; drinking water; humic substances; hydroxylamine; image analysis; pH; paper; photocatalysts; photolysis; seawater
Abstract:
... As a cheap and abundant porous material, cellulose filter paper was used to immobilize nano-TiO₂ and denoted as TiO₂/cellulose paper (TCP). With high adsorption capacity for Cu(II) (more than 1.65 mg), TCP was used as an adsorbent, photocatalyst, and colorimetric sensor at the same time. Under the optimum adsorption conditions, i.e., pH 6.5 and 25 °C, the adsorption ratio of Cu(II) was higher than ...
DOI:
10.1021/ac501513k

21. DNAzyme-Triggered Visual and Ratiometric Electrochemiluminescence Dual-Readout Assay for Pb(II) Based on an Assembled Paper Device

Author:
Yan Zhang; Jinmeng Xu; Shuang Zhou; Lin Zhu; Xue Lv; Jing Zhang; Lina Zhang; Peihua Zhu; Jinghua Yu
Source:
Analytical chemistry 2020 v.92 no.5 pp. 3874-3881
ISSN:
1520-6882
Subject:
cadmium sulfide; cellulose; color; electrochemiluminescence; energy transfer; gold; hydrogen peroxide; information processing; lead; monitoring; nanogold; oligonucleotides; oxidation; paper; peroxidase; point-of-care testing; prediction; quantum dots
Abstract:
... Currently, portable, low-cost, and easy to operate on-chip analytical units are urgently demanded to meet the requirement for point-of-care testing in resource-limited regions. Herein, a dual-mode lab-on-paper platform is presented, which integrates distance-based visualized readout with ratiometric electrochemiluminescence (ECL) assay in one device. The distance-based measurement is based on a br ...
DOI:
10.1021/acs.analchem.9b05343

22. Design Principles for Enhancing Sensitivity in Paper-Based Diagnostics via Large-Volume Processing

Author:
Eric A. Miller; Yara Jabbour Al Maalouf; Hadley D. Sikes
Source:
Analytical chemistry 2018 v.90 no.15 pp. 9472-9479
ISSN:
1520-6882
Subject:
binding proteins; cellulose; detection limit; diagnostic techniques; immunoassays; models
Abstract:
... In this work, we characterize the impact of large-volume processing upon the analytical sensitivity of flow-through paper-based immunoassays. Larger sample volumes feature greater molar quantities of available analyte, but the assay design principles which would enable the rapid collection of this dilute target are ill-defined. We developed a finite-element model to explore the operating condition ...
DOI:
10.1021/acs.analchem.8b02113

23. Detection and Quantification of Silver Nanoparticles at Environmentally Relevant Concentrations Using Asymmetric Flow Field–Flow Fractionation Online with Single Particle Inductively Coupled Plasma Mass Spectrometry

Author:
Huynh Khanh An; Siska Emily; Heithmar Edward; Tadjiki Soheyl; Pergantis Spiros A.
Source:
Analytical chemistry 2016 v.88 no.9 pp. 4909-4916
ISSN:
1520-6882
Subject:
aquatic environment; atomic absorption spectrometry; cellulose; environmental fate; environmental impact; fractionation; human health; hydrodynamics; nanoparticles; nanosilver; silica; silver; surfactants
Abstract:
... The presence of silver nanoparticles (AgNPs) in aquatic environments could potentially cause adverse impacts on ecosystems and human health. However, current understanding of the environmental fate and transport of AgNPs is still limited because their properties in complex environmental samples cannot be accurately determined. In this study, the feasibility of using asymmetric flow field-flow frac ...
DOI:
10.1021/acs.analchem.6b00764

24. Detection of Arsenic(III) through Pulsed Laser-Induced Desorption/Ionization of Gold Nanoparticles on Cellulose Membranes

Author:
Weng Cheng-I; Cang Jin-Shun; Chang Jia-Yaw; Hsiung Tung-Ming; Unnikrishnan Binesh; Hung Yu-Lun; Tseng Yu-Ting; Li Yu-Jia; Shen Yu-Wei; Huang Chih-Ching
Source:
Analytical chemistry 2014 v.86 no.6 pp. 3167-3173
ISSN:
1520-6882
Subject:
United States Environmental Protection Agency; anions; aqueous solutions; arsenic; arsenites; cellulose; detection limit; gold; groundwater; lakes; lead; mass spectrometry; metal ions; mineral water; nanogold; pH; tap water
Abstract:
... We have developed an assay based on gold nanoparticle-modified mixed cellulose ester membrane (Au NPs-MCEM) coupled with laser-induced desorption/ionization mass spectrometry (LDI-MS)-for the detection of arsenic(III) ions (arsenite, AsO₂–) in aqueous solution. When the Au NPs reacted with lead ions (Pb²⁺) in alkaline solution (5 mM glycine–NaOH, pH 12), Au–Pb complexes, PbO, and Pb(OH) were forme ...
DOI:
10.1021/ac500053e

25. Determination of Cellulose Crystallinity by Terahertz-Time Domain Spectroscopy

Author:
Vieira Francisco Senna; Pasquini Celio
Source:
Analytical chemistry 2014 v.86 no.8 pp. 3780-3786
ISSN:
1520-6882
Subject:
X-ray diffraction; absorption; cellulose; crystal structure; least squares; optics; prediction; spectral analysis; spectroscopy
Abstract:
... Terahertz-time domain spectroscopy (THz-TDS) has the ability to probe the crystallinity of several materials, due to the interaction of THz radiation with optical phonons in crystal lattices. In this work, THz-TDS has been used to quantify the degree of crystallinity of microcrystalline cellulose (MCC) samples. The THz spectra of cellulose present absorption features which could be directly correl ...
DOI:
10.1021/ac4035746

26. Development and Application of Zirconia Coated Paper Substrate for High Sensitivity Analysis of Therapeutic Drugs in Dried Blood Spots

Author:
Zheng Yajun; Wang Qian; Wang Xiaoting; Chen Ying; Wang Xuan; Zhang Xiaoling; Bai Zongquan; Han Xiaoxiao; Zhang Zhiping
Source:
Analytical chemistry 2016 v.88 no.14 pp. 7005-7013
ISSN:
1520-6882
Subject:
blood; cellulose; coatings; drugs; filtration; hydrogen bonding; mass spectrometry; paper; silica; starch; zirconium
Abstract:
... Paper spray mass spectrometry has been demonstrated to be promising for direct analysis of therapeutic drugs in dried blood spots (DBS); however, the strong hydrogen bond and van de Waals interactions between paper substrate and analytes containing polar functional groups (e.g., therapeutic drugs) affect greatly the elution behavior and analysis sensitivity of compounds of interest during paper sp ...
DOI:
10.1021/acs.analchem.5b04732

27. Diketo-Pyrrolo-Pyrrole Dyes as New Colorimetric and Fluorescent pH Indicators for Optical Carbon Dioxide Sensors

Author:
Schutting Susanne; Borisov Sergey M.; Klimant Ingo
Source:
Analytical chemistry 2013 v.85 no.6 pp. 3271-3279
ISSN:
1520-6882
Subject:
absorption; carbon dioxide; cellulose; colorimetry; dyes; fluorescence; pH; photostability; pigments; polymers; solvents
Abstract:
... New indicators for optical CO₂ sensors are synthesized in two steps from the commercially available diketo-pyrrolo-pyrrole (DPP) pigments Irgazin Ruby and Irgazin Scarlet. After introduction of bis(2-ethylhexyl) sulfonamide groups via a simple two-step synthesis, the pigments are rendered highly soluble in organic solvents and in polymers and show pH-dependent absorption and emission spectra. The ...
DOI:
10.1021/ac303595v

28. Does It Bind? A Method to Determine the Affinity of Calcium and Magnesium Ions for Polymers Using ¹H NMR Spectroscopy

Author:
Matthew Wallace; Joshua Holroyd; Agne Kuraite; Haider Hussain
Source:
Analytical chemistry 2022 v.94 no.31 pp. 10976-10983
ISSN:
1520-6882
Subject:
acetates; alginates; aqueous solutions; calcium; calorimetry; cellulose; equipment; magnesium; maleates; nuclear magnetic resonance spectroscopy; polyacrylic acid; polyethyleneimine; polystyrenes; sodium; sulfonates; titration
Abstract:
... The binding of calcium and magnesium ions (M²⁺) by polymers and other macromolecules in aqueous solution is ubiquitous across chemistry and biology. At present, it is difficult to assess the binding affinity of macromolecules for M²⁺ without recourse to potentiometric titrations and/or isothermal titration calorimetry. Both of these techniques require specialized equipment, and the measurements ca ...
DOI:
10.1021/acs.analchem.2c01166

29. Effect of Particle Properties of Powders on the Generation and Transmission of Raman Scattering

Author:
Townshend Nichola; Nordon Alison; Littlejohn David; Andrews John; Dallin Paul
Source:
Analytical chemistry 2012 v.84 no.11 pp. 4665-4670
ISSN:
1520-6882
Subject:
Raman spectroscopy; aspirin; cellulose; particle size; photons; powders; sulfur
Abstract:
... Transmission Raman measurements of a 1 mm thick sulfur-containing disk were made at different positions as it was moved through 4 mm of aspirin (150–212 μm) or microcrystalline cellulose (Avicel) of different size ranges (<38, 53–106, and 150–212 μm). The transmission Raman intensity of the sulfur interlayer at 218 cm–¹ was lower when the disk was placed at the top or bottom of the powder bed, com ...
DOI:
10.1021/ac203446g

30. Forensic Fiber Analysis by Thermal Desorption/Pyrolysis-Direct Analysis in Real Time-Mass Spectrometry

Author:
Jian Liang; Jared Frazier; Virginia Benefield; Ngee Sing Chong; Mengliang Zhang
Source:
Analytical chemistry 2019 v.92 no.2 pp. 1925-1933
ISSN:
1520-6882
Subject:
caprolactam; cellulose; cotton; desorption; dyes; fabrics; forensic sciences; mass spectrometry; melting point; polyacrylonitrile; polyethylene terephthalates; polypropylenes; principal component analysis; pyrolysis; spectral analysis; temperature
Abstract:
... The thermal desorption/pyrolysis-direct analysis in real time-mass spectrometry (TD/Py-DART-MS) method was developed for the analysis of fibers in this study. The fiber samples were pyrolyzed with a temperature gradient and the pyrolysis products were determined by DART-MS. The pyrogram from the TD/Py-DART-MS fiber analysis was found to be associated with the physical properties such as the meltin ...
DOI:
10.1021/acs.analchem.9b04167

31. Graphene Quantum Dots Sensor for the Determination of Graphene Oxide in Environmental Water Samples

Author:
Benítez-Martínez Sandra; López-Lorente Ángela Inmaculada; Valcárcel Miguel
Source:
Analytical chemistry 2014 v.86 no.24 pp. 12279-12284
ISSN:
1520-6882
Subject:
cellulose; detection limit; fluorescence; graphene; graphene oxide; hydrophobic bonding; quantum dots; river water
Abstract:
... The paper proposes a simple and sensitive approach for the preconcentration and determination of graphene oxide (GO) in environmental samples by using fluorescent graphene quantum dots (GQDs). The method is based on the preconcentration of GO on a cellulose membrane and their subsequent elution prior to fluorescence analysis of the quenching effect produced on the GQD solution due to the hydrophob ...
DOI:
10.1021/ac5035083

32. High-Performance Liquid Chromatography/High-Resolution Multiple Stage Tandem Mass Spectrometry Using Negative-Ion-Mode Hydroxide-Doped Electrospray Ionization for the Characterization of Lignin Degradation Products

Author:
Owen Benjamin C.; Haupert Laura J.; Jarrell Tiffany M.; Marcum Christopher L.; Parsell Trenton H.; Abu-Omar Mahdi M.; Bozell Joseph J.; Black Stuart K.; Kenttämaa Hilkka I.
Source:
Analytical chemistry 2012 v.84 no.14 pp. 6000-6007
ISSN:
1520-6882
Subject:
DNA; biomass; biopolymers; cellulose; chemical structure; elemental composition; hemicellulose; high performance liquid chromatography; ionization; lignin; lignocellulose; oligosaccharides; petroleum; proteins; sodium hydroxide; spectrometers; tandem mass spectrometry
Abstract:
... In the search for a replacement for fossil fuel and the valuable chemicals currently obtained from crude oil, lignocellulosic biomass has become a promising candidate as an alternative biorenewable source for crude oil. Hence, many research efforts focus on the extraction, degradation, and catalytic transformation of lignin, hemicellulose, and cellulose. Unfortunately, these processes result in th ...
DOI:
10.1021/ac300762y

33. Hollow-Channel Paper Analytical Devices

Author:
Renault Christophe; Li Xiang; Fosdick Stephen E.; Crooks Richard M.
Source:
Analytical chemistry 2013 v.85 no.16 pp. 7976-7979
ISSN:
1520-6882
Subject:
cellulose; colorimetry; diagnostic techniques; glucose; paper
Abstract:
... We present a microfluidic paper analytical device (μPAD) that relies on flow in hollow channels, rather than through a cellulose network, to transport fluids. The flow rate in hollow channels is 7 times higher than in regular paper channels and can be conveniently controlled from 0 to several mm/s by balancing capillary and pressure forces. More importantly, the pressure of a single drop of liquid ...
DOI:
10.1021/ac401786h

34. Immobilization and Function of nIR-Fluorescent Carbon Nanotube Sensors on Paper Substrates for Fluidic Manipulation

Author:
Daniel P. Salem; Xun Gong; Albert Tianxiang Liu; Kayla Akombi; Michael S. Strano
Source:
Analytical chemistry 2019 v.92 no.1 pp. 916-923
ISSN:
1520-6882
Subject:
beta-carotene; cadmium; canola oil; carbon nanotubes; cellulose; chemical interactions; chemical species; copper; dissociation; fat soluble vitamins; fluorescence; hydrophobicity; in vitro studies; lead; mercury; nanoparticles; nylon; paper; screening; single-stranded DNA; solvents; thermoplastics
Abstract:
... Nanoparticle-based optical sensors are capable of highly sensitive and selective chemical interactions and can form the basis of molecular recognition for various classes of analytes. However, their incorporation into standardized in vitro assays has been limited by their incompatibility with packaging or form factors necessary for specific applications. Here, we have developed a technique for imm ...
DOI:
10.1021/acs.analchem.9b03756

35. Improving Sample Distribution Homogeneity in Three-Dimensional Microfluidic Paper-Based Analytical Devices by Rational Device Design

Author:
Morbioli Giorgio Gianini; Mazzu-Nascimento Thiago; Milan Luis Aparecido; Stockton Amanda M.; Carrilho Emanuel
Source:
Analytical chemistry 2017 v.89 no.9 pp. 4786-4792
ISSN:
1520-6882
Subject:
cellulose; glucose oxidase; peroxidase
Abstract:
... Paper-based devices are a portable, user-friendly, and affordable technology that is one of the best analytical tools for inexpensive diagnostic devices. Three-dimensional microfluidic paper-based analytical devices (3D-μPADs) are an evolution of single layer devices and they permit effective sample dispersion, individual layer treatment, and multiplex analytical assays. Here, we present the ratio ...
DOI:
10.1021/acs.analchem.6b04953

36. In Situ Microscopy for In-line Monitoring of the Enzymatic Hydrolysis of Cellulose

Author:
Opitz Britta; Prediger Andreas; Lüder Christian; Eckstein Marrit; Hilterhaus Lutz; Lindner Patrick; Beutel Sascha; Scheper Thomas; Liese Andreas
Source:
Analytical chemistry 2013 v.85 no.17 pp. 8121-8126
ISSN:
1520-6882
Subject:
algorithms; cellulose; endo-1,4-beta-glucanase; enzymatic hydrolysis; gel chromatography; hydrolysis; microscopy; monitoring; particle size; particle size distribution; spectroscopy
Abstract:
... A new in-line method for the monitoring of enzymatic hydrolysis of cellulose is described. Using a new in situ microscope prototype, the noninvasive determination of particle size distributions was possible. For the automated analysis of the acquired images, a new processing algorithm called CelluloseAnalyzer was developed. It enabled tracking of the number of particles and moreover allowed monito ...
DOI:
10.1021/ac4008495

37. Inkjet Printing of Nanoporous Gold Electrode Arrays on Cellulose Membranes for High-Sensitive Paper-Like Electrochemical Oxygen Sensors Using Ionic Liquid Electrolytes

Author:
Hu Chengguo; Bai Xiaoyun; Wang Yingkai; Jin Wei; Zhang Xuan; Hu Shengshui
Source:
Analytical chemistry 2012 v.84 no.8 pp. 3745-3750
ISSN:
1520-6882
Subject:
cellulose; cost effectiveness; detection limit; electrochemistry; electrodes; electrolytes; gold; ionic liquids; nanogold; oxygen; paper
Abstract:
... A simple approach to the mass production of nanoporous gold electrode arrays on cellulose membranes for electrochemical sensing of oxygen using ionic liquid (IL) electrolytes was established. The approach, combining the inkjet printing of gold nanoparticle (GNP) patterns with the self-catalytic growth of these patterns into conducting layers, can fabricate hundreds of self-designed gold arrays on ...
DOI:
10.1021/ac3003243

38. Inkjet-Printed Paper-Based Colorimetric Polyion Sensor Using a Smartphone as a Detector

Author:
Wang Xuewei; Mahoney Mollie; Meyerhoff Mark E.
Source:
Analytical chemistry 2017 v.89 no.22 pp. 12334-12341
ISSN:
1520-6882
Subject:
cellulose acetate; trypsin; colorimetry; plasticizers; urine; cameras; proteolysis; cellulose; paper; anions; heparin; ammonium; color; hydrophobicity; pH; sulfonic acids; enzyme activity
Abstract:
... The first paper-based polyion-sensitive optodes are reported. Dinonylnaphthalene sulfonic acid (a cation exchanger) and chromoionophore I (a lipophilic optical pH indicator) are printed on filter paper in the absence of any plasticizer and/or additional hydrophobic polymeric phase. The resulting optodes exhibit sensitive colorimetric response to polycations such as protamine but not to small inorg ...
DOI:
10.1021/acs.analchem.7b03352

39. Inkjet-Printed Silver Nanoparticle Paper Detects Airborne Species from Crystalline Explosives and Their Ultratrace Residues in Open Environment

Author:
Wang Jianping; Yang Liang; Liu Bianhua; Jiang Haihe; Liu Renyong; Yang Jingwei; Han Guangmei; Mei Qingsong; Zhang Zhongping
Source:
Analytical chemistry 2014 v.86 no.7 pp. 3338-3345
ISSN:
1520-6882
Subject:
Raman spectroscopy; cellulose; clothing; crystals; dogs; drugs; electronic nose; explosives; foods; leather; nanosilver; odors; paper; soil; spectral analysis; trinitrotoluene; vapor pressure; volatile compounds
Abstract:
... An electronic nose can detect highly volatile chemicals in foods, drugs, and environments, but it is still very much a challenge to detect the odors from crystalline compounds (e.g., solid explosives) with a low vapor pressure using the present chemosensing techniques in such way as a dog’s olfactory system can do. Here, we inkjet printed silver nanoparticles (AgNPs) on cellulose paper and establi ...
DOI:
10.1021/ac403409q

40. Ion-Exchange Based Immobilization of Chromogenic Reagents on Microfluidic Paper Analytical Devices

Author:
Mohammad Rahbar; Aaron R. Wheeler; Brett Paull; Mirek Macka
Source:
Analytical chemistry 2019 v.91 no.14 pp. 8756-8761
ISSN:
1520-6882
Subject:
acidity; anion exchange; blood serum; calcium; cellulose; chlorides; color; ionic strength; moieties; pH; paper; water solubility; wines
Abstract:
... Distance-based detection methods, as used in development of microfluidic paper analytical devices (μPADs), rely on the dynamic formation of a colored band along the length of the paper microfluidic channels. The color change is driven by the reaction of chromogenic reagents (typically water-insoluble) that are bound to the paper, thus not subject to being washed away by the sample flow along the d ...
DOI:
10.1021/acs.analchem.9b01288

41. Low-Cost Label-Free Biosensing Bimetallic Cellulose Strip with SILAR-Synthesized Silver Core–Gold Shell Nanoparticle Structures

Author:
Kim Wansun; Lee Jae-Chul; Lee Gi-Ja; Park Hun-Kuk; Lee Anbok; Choi Samjin
Source:
Analytical chemistry 2017 v.89 no.12 pp. 6448-6454
ISSN:
1520-6882
Subject:
Raman spectroscopy; X-radiation; absorption; aniline; breast neoplasms; cellulose; disease course; drugs; early diagnosis; finite element analysis; human diseases; malachite green; models; monitoring; nanogold; nanoparticles; nanosilver; oxidation; screening; silver; sodium azide; surface plasmon resonance; urine
Abstract:
... We introduce a label-free biosensing cellulose strip sensor with surface-enhanced Raman spectroscopy (SERS)-encoded bimetallic core@shell nanoparticles. Bimetallic nanoparticles consisting of a synthesis of core Ag nanoparticles (AgNP) and a synthesis of shell gold nanoparticles (AuNPs) were fabricated on a cellulose substrate by two-stage successive ionic layer absorption and reaction (SILAR) tec ...
DOI:
10.1021/acs.analchem.7b00300

42. Luminescence Resonance Energy Transfer-Based Nucleic Acid Hybridization Assay on Cellulose Paper with Upconverting Phosphor as Donors

Author:
Zhou Feng; Noor M. Omair; Krull Ulrich J.
Source:
Analytical chemistry 2014 v.86 no.5 pp. 2719-2726
ISSN:
1520-6882
Subject:
DNA; adsorption; bioassays; cellulose; detection limit; energy transfer; fluorescence; genes; horizontal resistance; nucleic acid hybridization; oligonucleotide probes; paper; quantum dots; streptavidin
Abstract:
... A bioassay based on DNA hybridization on cellulose paper is a promising format for gene fragment detection that may be suited for in-field and rapid diagnostic applications. We demonstrate for the first time that luminescence resonance energy transfer (LRET) associated with upconverting phosphors (UCPs) can be used to develop a paper-based DNA hybridization assay with high sensitivity, selectivity ...
DOI:
10.1021/ac404129t

43. Mass Spectrometry Imaging: An Expeditious and Powerful Technique for Fast in Situ Lignin Assessment in Eucalyptus

Author:
Araújo Pedro; Ferreira Mônica Siqueira; de Oliveira Diogo Noin; Pereira Luciano; Sawaya Alexandra Christine Helena Frankland; Catharino Rodrigo Ramos; Mazzafera Paulo
Source:
Analytical chemistry 2014 v.86 no.7 pp. 3415-3419
ISSN:
1520-6882
Subject:
Eucalyptus; bioethanol; cellulose; computer software; fermentation; image analysis; ionization; lignin; mass spectrometry; phytomass; silica; solvents; stems; thin layer chromatography
Abstract:
... Plant biomass has been suggested as an alternative to produce bioethanol. The recalcitrance of plant biomass to convert cellulose into simpler carbohydrates used in the fermentation process is partially due to lignin, but the standard methods used to analyze lignin composition frequently use toxic solvents and are laborious and time-consuming. MS imaging was used to study lignin in Eucalyptus, sin ...
DOI:
10.1021/ac500220r

44. Method for Automatically Identifying Spectra of Different Wood Cell Wall Layers in Raman Imaging Data Set

Author:
Zhang Xun; Ji Zhe; Zhou Xia; Ma Jian-Feng; Hu Ya-Hong; Xu Feng
Source:
Analytical chemistry 2015 v.87 no.2 pp. 1344-1350
ISSN:
1520-6882
Subject:
Raman spectroscopy; cell walls; cellulose; cluster analysis; data collection; image analysis; lignin; principal component analysis; tension wood; wood
Abstract:
... The technique of Raman spectroscopic imaging is finding ever-increasing applications in the field of wood science for its ability to provide spatial and spectral information about the sample. On the basis of the acquired Raman imaging data set, it is possible to determine the distribution of chemical components in various wood cell wall layers. However, the Raman imaging data set often contains th ...
DOI:
10.1021/ac504144s

45. Miniature Flow-Through Low-Temperature Plasma Ionization Source for Ambient Ionization of Gases and Aerosols

Author:
Spencer Sandra E.; Santiago Brandon G.; Glish Gary L.
Source:
Analytical chemistry 2015 v.87 no.23 pp. 11887-11892
ISSN:
1520-6882
Subject:
aerosols; caffeine; cellulose; gases; ionization; ions; pyrolysis
Abstract:
... The design and operation of an inexpensive, miniature low-temperature plasma ion source is detailed. The miniature low-temperature plasma ion source is operated in a “flow-through” configuration, wherein the gaseous or aerosolized analyte, caffeine or pyrolyzed ethyl cellulose, in a carrier gas is used as the plasma gas. In this flow-through configuration, the sensitivity for the caffeine standard ...
DOI:
10.1021/acs.analchem.5b03447

46. Multifunctional Analytical Platform on a Paper Strip: Separation, Preconcentration, and Subattomolar Detection

Author:
Abbas Abdennour; Brimer Andrew; Slocik Joseph M.; Tian Limei; Naik Rajesh R.; Singamaneni Srikanth
Source:
Analytical chemistry 2013 v.85 no.8 pp. 3977-3983
ISSN:
1520-6882
Subject:
Raman spectroscopy; cellulose; coatings; detection limit; electrolytes; gold; nanorods
Abstract:
... We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10–¹⁸ M) detection limit using surface-enhanced Raman scattering as a transduction method. The microfluidic paper-based analytical device (μPAD) is made with a lithography-free process by a simple cut and drop method. Complex samples are separated by a surface chemical gradient created by different ...
DOI:
10.1021/ac303567g

47. Multitechnique Determination of Halogens in Soil after Selective Volatilization Using Microwave-Induced Combustion

Author:
Pereira L. S. F.; Pedrotti M. F.; Enders M. S. P.; Albers C. N.; Pereira J. S. F.; Flores E. M. M.
Source:
Analytical chemistry 2017 v.89 no.1 pp. 980-987
ISSN:
1520-6882
Subject:
absorption; ammonium hydroxide; atomic absorption spectrometry; bromine; cellulose; combustion; iodine; ion exchange chromatography; soil; soil sampling; statistical analysis; volatilization
Abstract:
... A method for digestion of soils with high inorganic matter content (ranging from 50 to 92%) by microwave-induced combustion (MIC) is proposed for the first time for further halogens (F, Cl, Br, and I) determination by ion chromatography (IC) and also by inductively coupled plasma mass spectrometry (ICP-MS). Microcrystalline cellulose (100–500 mg), used as a combustion aid, was mixed with sample an ...
DOI:
10.1021/acs.analchem.6b04300

48. Myco-DES: Enabling Remote Extraction of Mycotoxins for Robust and Reliable Quantification by Stable Isotope Dilution LC–MS/MS

Author:
Katharina M. Schlegel; Paul W. Elsinghorst
Source:
Analytical chemistry 2020 v.92 no.7 pp. 5387-5395
ISSN:
1520-6882
Subject:
aflatoxin B1; animal and human health; blood; cellulose; climatic factors; deoxynivalenol; foods; glass fibers; human resources; instrumentation; isotope dilution technique; liquid chromatography; ochratoxin A; polyethylene terephthalates; relative humidity; stable isotopes; storage conditions; tandem mass spectrometry; temperature; tropics
Abstract:
... Mycotoxins remain a global threat to human and animal health, especially in countries lacking effective measures to detect and control contaminated commodities. As the quantification of mycotoxins usually relies on complex and expensive techniques, the availability of suitable instrumentation is often a bottleneck in reliable mycotoxin detection. As part of our research toward strategies offering ...
DOI:
10.1021/acs.analchem.0c00087

49. Novel Inorganic Mesoporous Material with Chiral Nematic Structure Derived from Nanocrystalline Cellulose for High-Resolution Gas Chromatographic Separations

Author:
Zhang Jun-Hui; Xie Sheng-Ming; Zhang Mei; Zi Min; He Pin-Gang; Yuan Li-Ming
Source:
Analytical chemistry 2014 v.86 no.19 pp. 9595-9602
ISSN:
1520-6882
Subject:
alkanes; capillary gas chromatography; cellulose; enantiomers; nanocrystals; polycyclic aromatic hydrocarbons; porosity; porous media; silica; stereoisomerism; temperature
Abstract:
... Chiral nematic mesoporous silica (CNMS) has attracted widespread attention due to some unique features, such as its nematic structure, chirality, large pore size, high temperature resistance, low cost, and ease of preparation. We first reported the use of CNMS as a stationary phase for capillary gas chromatography (GC). The CNMS-coated capillary column not only gives good selectivity for the separ ...
DOI:
10.1021/ac502073g

50. One-Step Biotinylation of Cellulose Paper by Polymer Coating to Prepare a Paper-Based Analytical Device

Author:
Kazuki Kaneko; Manami Hara; Takashi Nishino; Tatsuo Maruyama
Source:
Analytical chemistry 2019 v.92 no.2 pp. 1978-1987
ISSN:
1520-6882
Subject:
DNA; absorbance; adsorption; avidin; biotin; biotinylation; blood serum; cellulose; coatings; hydrophilicity; models; moieties; oligonucleotides; paper; polyethylene glycol; surfactants; thrombin
Abstract:
... Cellulose paper has strong potential as an analytical platform owing to its unique characteristics. In the present study, we investigated a procedure for functionalizing the surface of cellulose paper by dip-coating a mixture of a functional polymer and a perfluoroalkylated surfactant (surfactant 1). The functional polymer comprised a mixture of methyl methacrylate and poly(ethylene glycol) methac ...
DOI:
10.1021/acs.analchem.9b04373