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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2020 Remove constraint Publication Year: 2020 Subject exosomes Remove constraint Subject: exosomes Subject bone marrow Remove constraint Subject: bone marrow Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

Author:
Bao-cheng Yang; Ming-jie Kuang; Jia-yu Kang; Jie Zhao; Jian-xiong Ma; Xin-long Ma
Source:
Biochemical and biophysical research communications 2020 v. no. pp. -
ISSN:
0006-291X
Subject:
apoptosis; bone marrow; exosomes; hindlimbs; humans; luciferase; mesenchymal stromal cells; micro-computed tomography; microRNA; osteoporosis; rats; research; umbilical cord
Abstract:
... Disuse osteoporosis (DOP) is a common complication resulting from the lack of or disuse of mechanical loading and has been unsatisfactorily treated. We hypothesized that exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) could reduce bone marrow mesenchymal stem cell (BMSC) apoptosis in rat DOP via the miR-1263/Mob1/Hippo signaling pathway.To evaluate the function of exoso ...
DOI:
10.1016/j.bbrc.2020.02.001

2. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Author:
Yu-Huan Jiang; Jing Liu; Jin Lin; Shu-Qi Li; Yan-Mei Xu; Qing-Hua Min; Qiong-Hui Zhong; Fan Sun; Jing Li; Xia-Hong You; Kai-Li Liao; Ting-Yu Qin; Cui Zhao; Bo Huang; Xiao-Zhong Wang
Source:
Biochemical and biophysical research communications 2020 v.521 no.3 pp. 584-589
ISSN:
0006-291X
Subject:
adhesion; bone marrow; coculture; exosomes; leukemia; microRNA; research
Abstract:
... A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have indicated that microRNAs (miRNAs) are contained in leukemia-derived exosomes and ar ...
DOI:
10.1016/j.bbrc.2019.10.096