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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Subject animal injuries Remove constraint Subject: animal injuries
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1. 2-BFI attenuates experimental autoimmune encephalomyelitis-induced spinal cord injury with enhanced B-CK, CaATPase, but reduced calpain activity

Author:
Pei Wang; Zhao-Wei Wang; Fu-Hong Lin; Zhao Han; Sheng-Tao Hou; Rong-Yuan Zheng
Source:
Biochemical and biophysical research communications 2011 v.406 no.1 pp. 152-157
ISSN:
0006-291X
Subject:
animal injuries; animal models; calcium; calpain; drugs; encephalitis; energy; enzyme activity; homeostasis; mice; myelin sheath; receptors; sclerosis; spinal cord
Abstract:
... The lack of disease-modifying pharmacological agents for effective treatment of multiple sclerosis (MS) still represents a large and urgent unmet medical need. Our previous studies showed that ligands to type 2 imidazoline receptors (I₂R) were effective in protecting spinal cord injury caused by experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. In this study, we further examine ...
DOI:
10.1016/j.bbrc.2011.02.018

2. Activating transcription factor 3 promotes spinal cord regeneration of adult zebrafish

Author:
Lin-Fang Wang; Shu-Bing Huang; Hou-De Zhao; Chun-Jie Liu; Li Yao; Yan-Qin Shen
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Danio rerio; adults; animal injuries; fluorescent antibody technique; in situ hybridization; inflammation; interleukin-1beta; messenger RNA; models; motor neurons; nerve tissue; neurites; quantitative polymerase chain reaction; regrowth; spinal cord; transcription factors; tumor necrosis factor-alpha
Abstract:
... Zebrafish is an excellent model to study the mechanisms underlying successful central nervous system (CNS) regeneration. Previous study shows that activating transcription factor 3 (ATF3) promotes neurite outgrowth and is involved in optic nerve regeneration in zebrafish. Here, we used zebrafish model to investigate the role of ATF3 in regeneration following spinal cord injury (SCI). Quantitative ...
DOI:
10.1016/j.bbrc.2017.05.079

3. Astrocytes directly clear myelin debris through endocytosis pathways and followed by excessive gliosis after spinal cord injury

Author:
Song Wang; Junhao Deng; Haitao Fu; Zhongkui Guo; Licheng Zhang; Peifu Tang
Source:
Biochemical and biophysical research communications 2020 v.525 no.1 pp. 20-26
ISSN:
0006-291X
Subject:
animal injuries; astrocytes; axons; endocytosis; lysosomes; macrophages; myelin sheath; research; tissue repair
Abstract:
... Persisted myelin debris inhibit axon regeneration and contribute to further tissue damage after spinal cord injury (SCI). The traditional view is that myelin debris is mainly cleared by microglia and macrophages, while astrocytes cannot directly engulf myelin debris because they are absent from lesion core. Here, we definitely showed that astrocytes could directly uptake myelin debris both in vitr ...
DOI:
10.1016/j.bbrc.2020.02.069

4. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

5. Calcium's role as nuanced modulator of cellular physiology in the brain

Author:
Hilaree N. Frazier; Shaniya Maimaiti; Katie L. Anderson; Lawrence D. Brewer; John C. Gant; Nada M. Porter; Olivier Thibault
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 981-987
ISSN:
0006-291X
Subject:
Alzheimer disease; animal injuries; brain; calcium; cell death; cell growth; death; image analysis; neurodegenerative diseases; neurons; physiology; spinal cord
Abstract:
... Neuroscientists studying normal brain aging, spinal cord injury, Alzheimer's disease (AD) and other neurodegenerative diseases have focused considerable effort on carefully characterizing intracellular perturbations in calcium dynamics or levels. At the cellular level, calcium is known for controlling life and death and orchestrating most events in between. For many years, intracellular calcium ha ...
DOI:
10.1016/j.bbrc.2016.08.105
PubMed:
27553276
PubMed Central:
PMC5303675

6. Cell-seeded porous silk fibroin scaffolds promotes axonal regeneration and myelination in spinal cord injury rats

Author:
Kemin You; Hongze Chang; Feng Zhang; Yixin Shen; Yan Zhang; Feng Cai; Liang Liu; Xiaodong Liu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 273-279
ISSN:
0006-291X
Subject:
animal injuries; animal models; axons; fibroins; flow cytometry; mesenchymal stromal cells; myelin basic protein; myelin sheath; myelination; nerve regeneration; nerve tissue; rats; spinal cord
Abstract:
... Accumulating evidence indicates that a suitable scaffold designed for the spinal cord injury (SCI) was needed to enhance the survival of transplanted Bone mesenchymal stem cells (BMSCs) and to promote nerve regeneration. The current study was aimed to evaluate the effect of the porous silk fibroin scaffold (PSFSs) seeded with BMSCS on nerve regeneration, myelination and functional recovery after S ...
DOI:
10.1016/j.bbrc.2019.04.137

7. Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis

Author:
Yu Liu; Shuang Ao; Hao Zhang; Yapeng Zhang; Yu Wang; Xiaotian Yang; Hui Leng
Source:
Biochemical and biophysical research communications 2021 v.553 pp. 126-133
ISSN:
0006-291X
Subject:
animal injuries; apoptosis; cell cycle checkpoints; cell proliferation; circular RNA; genes; neurons; protein kinases; research
Abstract:
... Circular RNA (circRNA) homeodomain-interacting protein kinase 3 (circ_HIPK3) has recently reported as regulator in spinal cord injury (SCI). The regulatory mechanism of circ_HIPK3 in SCI was further researched in this study. Circ_HIPK3 expression was inhibited by CoCl₂ in AGE1.HN cells. The CoCl₂-induced cell cycle arrest, cell proliferation inhibition and apoptosis promotion were mitigated by ove ...
DOI:
10.1016/j.bbrc.2021.03.070

8. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice

Author:
Johannes Schmitt; Martin Roderfeld; Karim Sabrane; Pan Zhang; Yinghua Tian; Joachim C. Mertens; Pascal Frei; Bruno Stieger; Achim Weber; Beat Müllhaupt; Elke Roeb; Andreas Geier
Source:
Biochemical and biophysical research communications 2012 v.418 no.3 pp. 445-450
ISSN:
0006-291X
Subject:
Western blotting; animal injuries; bile; chronic hepatitis C; complement; enzyme-linked immunosorbent assay; fibrosis; gene expression; genes; immunohistochemistry; inflammation; liver; messenger RNA; mice; models; protein synthesis; radioimmunoassays; reverse transcriptase polymerase chain reaction; toxicity; tumor necrosis factor-alpha
Abstract:
... Fibrogenesis represents the universal response of the liver to chronic liver injury. Complement factor C5 has been linked to fibrosis in murine toxic liver injury and human chronic hepatitis C. C5 may also play a central role in chronic cholestatic disorders, since the BA receptor FXR has been characterized as an activator of the C3 gene. We aimed to investigate, whether C5 deficiency is able to p ...
DOI:
10.1016/j.bbrc.2012.01.036

9. Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury

Author:
Yi Wang; Minhao Chen
Source:
Biochemical and biophysical research communications 2018 v.505 no.1 pp. 151-156
ISSN:
0006-291X
Subject:
adults; animal injuries; astrocytes; cell cycle; cell proliferation; cyclins; fluorescent antibody technique; models; neoplasms; phosphorylation; protein content; protein-serine-threonine kinases; rats; small interfering RNA; spinal cord; staining
Abstract:
... Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute spinal cord injury (SCI) model in adult rats and investigated the dynamic changes ...
DOI:
10.1016/j.bbrc.2018.09.025

10. Erythropoietin promotes oligodendrogenesis and myelin repair following lysolecithin-induced injury in spinal cord slice culture

Author:
Yun Kyung Cho; Gunha Kim; Serah Park; Ju Hee Sim; You Jin Won; Chang Ho Hwang; Jong Yoon Yoo; Hea Nam Hong
Source:
Biochemical and biophysical research communications 2012 v.417 no.2 pp. 753-759
ISSN:
0006-291X
Subject:
animal injuries; erythropoietin; models; myelin sheath; non-specific protein-tyrosine kinase; spinal cord; stem cells
Abstract:
... Here, we sought to delineate the effect of EPO on the remyelination processes using an in vitro model of demyelination. We report that lysolecithin-induced demyelination elevated EPO receptor (EpoR) expression in oligodendrocyte progenitor cells (OPCs), facilitating the beneficial effect of EPO on the formation of oligodendrocytes (oligodendrogenesis). In the absence of EPO, the resultant remyelin ...
DOI:
10.1016/j.bbrc.2011.12.029

11. FBW7 protects against spinal cord injury by mitigating inflammation-associated neuronal apoptosis in mice

Author:
Min Chen; Yu-ting Gao; Wei-xin Li; Jian-chun Wang; Yun-Peng He; Zhi-wen Li; Guo-sheng Gan; Bo Yuan
Source:
Biochemical and biophysical research communications 2020 v.532 no.4 pp. 576-583
ISSN:
0006-291X
Subject:
WD40 repeats; animal injuries; apoptosis; caspase-3; death; inflammation; mice; necrosis; neoplasms; neurons; pathogenesis; research; spinal cord; ubiquitin-protein ligase
Abstract:
... Spinal cord injury (SCI) leads to severe and long-lasting neurological disability. Presently, the lack of effective therapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. F-box and WD repeat domain-containing protein 7 (FBW7, also known as FBXW7) is a type of E3 ubiquitin ligase complex, and plays essential roles in regulating different pathological and physi ...
DOI:
10.1016/j.bbrc.2020.08.071

12. FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK

Author:
Pengfei Zhao; Wang Chao; Weiguo Li
Source:
Biochemical and biophysical research communications 2019 v.514 no.2 pp. 558-564
ISSN:
0006-291X
Subject:
abnormal behavior; animal injuries; animal models; death; interleukin-6; mitogen-activated protein kinase; neuroglia; rats; spinal cord; staining; surgery; tissues; tumor necrosis factor-alpha; ubiquitin-protein ligase
Abstract:
... Traumatic spinal cord injury (SCI) is a major cause of death and lifelong disability in the world. However, the pathological process of SCI has not been fully understood. F-box/WD repeat-containing protein 5 (FBXW5), a subunit of the SCF-type E3 ubiquitin ligase complex, plays an essential role in regulating various pathologies. However, little is known about the effects of FBXW5 on the progressio ...
DOI:
10.1016/j.bbrc.2019.04.086

13. FTO knockdown alleviates hypoxia-induced PC12 cell injury by stabilizing GADD45B in an IGF2BP2-dependent manner

Author:
Dan Wang; Yu Li; Xiaoxiao Xu; Shixin Zhao; Zhen Wang; Jiahao Yang; Xi Zhang; Junwei Pan; Yisheng Wang; Ming Liu
Source:
Biochemical and biophysical research communications 2022 v.619 pp. 166-172
ISSN:
0006-291X
Subject:
RNA; animal injuries; hypoxia; methyltransferases; models; neurodevelopment; obesity; research; spinal cord
Abstract:
... RNA N6-methyladenosine (m6A) level is closely associated with neurodevelopment and central nervous system dysfunctions including spinal cord injury (SCI). M6A level can be dynamically regulated by m6A methyltransferases and demethylases. In this text, the roles of m6A demethylase FTO alpha-ketoglutarate dependent dioxygenase (FTO) in SCI development along with its m6A-dependent regulatory mechanis ...
DOI:
10.1016/j.bbrc.2022.06.039

14. Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1

Author:
Nayanendu Saha; Momchil V. Kolev; Mariya Semavina; Juha Himanen; Dimitar B. Nikolov
Source:
Biochemical and biophysical research communications 2011 v.413 no.1 pp. 92-97
ISSN:
0006-291X
Subject:
animal injuries; axons; cell free system; gangliosides; glycoproteins; myelin sheath; sialic acids
Abstract:
... Upon spinal cord injury, the myelin inhibitors, including the myelin-associated glycoprotein (MAG), Nogo-A and the oligodendrocyte myelin glycoprotein (OMgp), bind to and signal via a single neuronal receptor/co-receptor complex comprising of Nogo receptor 1(NgR1)/LINGO-1 and p75 or TROY, impeding regeneration of injured axons. We employed a cell-free system to study the binding of NgR1 to its co- ...
DOI:
10.1016/j.bbrc.2011.08.060

15. Harnessing the chondroitin sulfate-binding characteristics of human lactoferrin to neutralize neurite outgrowth inhibition

Author:
Masao Nakamura; Takumi Matsuzaki; Ami Iimori; Atsushi Sato
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 1076-1082
ISSN:
0006-291X
Subject:
animal injuries; chondroitin sulfate; dose response; drugs; ganglia; growth retardation; heparan sulfate; heparin; humans; lactoferrin; neurites; research; thermal stability
Abstract:
... Human lactoferrin (hLF) is a glycosaminoglycan (GAG)-binding protein involved in various biological functions. It consists of two globular functional domains, referred to as the N- and C-lobes. Both heparin (HP) and heparan sulfate (HS) bind to the N-lobe domain of hLF. Although some biological functions of hLF such as neuroprotective effects and cancer growth inhibition are regulated by its bindi ...
DOI:
10.1016/j.bbrc.2020.10.005

16. Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

Author:
Xue Chen; Xin-Yao Yin; Ya-Yu Zhao; Chen-Chun Wang; Pan Du; Yi-Chi Lu; Hong-Bo Jin; Cheng-Cheng Yang; Jia-Lu Ying
Source:
Biochemical and biophysical research communications 2021 v.568 pp. 103-109
ISSN:
0006-291X
Subject:
animal injuries; astrocytes; cell transplantation; humans; neural stem cells; neurons; oligodendroglia; research
Abstract:
... At present, stem cell transplantation has a significant therapeutic effect on spinal cord injury (SCI), however, it is still challenging for the seed cells selection. In this study, in order to explore cells with wide neural repair potentials, we selected the pluripotent stem cells multilineage-differentiating stress-enduring (Muse) cells, inducing the in vitro differentiation of human Muse cells ...
DOI:
10.1016/j.bbrc.2021.06.070

17. Intradiencephalon injection of histamine inhibited the recovery of locomotor function of spinal cord injured zebrafish

Author:
Shu-Bing Huang; Hou-De Zhao; Lin-Fang Wang; Meng-Fei Sun; Ying-Li Zhu; Yi-Bo Wu; Yi-Da Xu; Shi-Xiao Peng; Chun Cui; Yan-Qin Shen
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 275-280
ISSN:
0006-291X
Subject:
Danio rerio; adults; animal injuries; animal models; fluorescent antibody technique; histamine; humans; insulin-like growth factor I; interleukin-1beta; neuroglia; neurotrophins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; spinal cord; tumor necrosis factor-alpha
Abstract:
... Human spinal cord injury (SCI) usually causes irreversible disability beneath the injured site due to poor neural regeneration. On the contrary, zebrafish show significant regenerative ability after SCI, thus is usually worked as an animal model for studying neuroregeneration. Most of the previous SCI studies focused on the local site of SCI, the supraspinal-derived signals were rarely mentioned. ...
DOI:
10.1016/j.bbrc.2017.05.158

18. Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury

Author:
Xiaochen Yuan; Qingbin Wu; Peng Wang; Yingli Jing; Haijiang Yao; Yinshan Tang; Ruiqin Han; Weili He; Zhigang Li; Honggang Zhang; Ruijuan Xiu
Source:
Biochemical and biophysical research communications 2019 v.514 no.3 pp. 1023-1029
ISSN:
0006-291X
Subject:
animal injuries; apoptosis; inflammation; interleukin-7; macrophages; neuroglia; neurons; spinal cord; therapeutics
Abstract:
... It has been previously reported that the blockade of interleukin-7 receptor (IL-7R) promotes functional recovery following spinal cord injury (SCI), however, the direct function and molecular mechanism of IL-7 involved in this pathogenic process are unclear. Here, we report that, contrary to IL-7R blockade, the intraspinal administration of IL-7 limits functional recovery following SCI. In additio ...
DOI:
10.1016/j.bbrc.2019.04.159

19. Knockdown of FSTL1 inhibits oxLDL-induced inflammation responses through the TLR4/MyD88/NF-κB and MAPK pathway

Author:
Junxia Guo; Wanqian Liang; Jianhua Li; Jingning Long
Source:
Biochemical and biophysical research communications 2016 v.478 pp. 1528-1533
ISSN:
0006-291X
Subject:
Toll-like receptor 4; animal injuries; anti-inflammatory activity; atherosclerosis; coronary vessels; endothelial cells; enzyme-linked immunosorbent assay; inflammation; interleukin-6; interleukin-8; low density lipoprotein; messenger RNA; mitogen-activated protein kinase; models; protective effect; reverse transcriptase polymerase chain reaction; secretion; signal transduction; tumor necrosis factor-alpha
Abstract:
... Activation of inflammation by oxidized low-density lipoprotein (oxLDL) has been implicated in the development of atherosclerosis. Follistatin-like protein 1 (FSTL1) play a central role in the inflammation process and modulate cardiovascular disorders. However, little is known about the effects of FSTL1 on the inflammation induced by oxLDL. The aim of this study was to evaluate the anti-inflammator ...
DOI:
10.1016/j.bbrc.2016.08.138

20. Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress

Author:
Dongfang Yang; Tingting Shu; Haosen Zhao; Yang Sun; Weibing Xu; Guanjun Tu
Source:
Biochemical and biophysical research communications 2020 v.523 no.3 pp. 719-725
ISSN:
0006-291X
Subject:
DNA; DNA damage; animal injuries; apoptosis; caspase-3; comet assay; death; flow cytometry; fluorescent antibody technique; macrophage migration inhibitory factors; models; neurons; oxidative stress; rats; research; therapeutics
Abstract:
... Parthanatos is a form of regulated cell death (RCD) that is closely linked to DNA damage, which is a common consequence of oxidative stress due to central nervous trauma, such as spinal cord injury (SCI). The mechanism by which apoptosis-inducing factor (AIF) mediates DNA strand breaks in parthanatos was not clear until the discovery of the nuclease function of MIF. A previous study suggested that ...
DOI:
10.1016/j.bbrc.2019.12.115

21. Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis

Author:
Ji-Li Li; Ying-Lin Liang; Yan-Jun Wang
Source:
Biochemical and biophysical research communications 2019 v.516 no.3 pp. 991-998
ISSN:
0006-291X
Subject:
IKappaB kinase; animal injuries; apoptosis; arachidonate 12-lipoxygenase; caspase-3; cell movement; cell proliferation; gene overexpression; inflammation; knockout mutants; mice; models; neoplasm cells; nerve tissue; neuroglia; platelet aggregation; protective effect; spinal cord; therapeutics; transcription factor NF-kappa B; transgenic animals
Abstract:
... Spinal cord injury (SCI) is terrible damage leading to the deficiencies and results in infinite inconvenience to sufferers. The effective treatment for SCI still meets a larger number of problems. Herein, the underlying molecular mechanism and novel therapy of SCI are urgently to investigate. Arachidonate 12-lipoxygenase (ALOX12) is widely expressed in various cell types and plays important role i ...
DOI:
10.1016/j.bbrc.2019.06.118

22. Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth

Author:
Ken Kotaka; Jun Nagai; Kenneth Hensley; Toshio Ohshima
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 759-764
ISSN:
0006-291X
Subject:
animal injuries; animal models; brain; cultured cells; histology; intraperitoneal injection; macrophage activation; metabolites; mice; neurites; neurodegenerative diseases; neuroglia; phenotype; regrowth; serotonin; spinal cord; sulfur amino acids; therapeutics
Abstract:
... The mammalian central nervous system (CNS) has limited regenerative ability after injury, largely due to scar formation and axonal growth inhibitors. Experimental suppression of neuroinflammation encourages recovery from spinal cord injury (SCI), yet practical means for pharmacologically treating SCI have remained elusive. Lanthionine ketimine (LK) is a natural brain sulfur amino acid metabolite w ...
DOI:
10.1016/j.bbrc.2016.12.069

23. Lithium chloride contributes to blood–spinal cord barrier integrity and functional recovery from spinal cord injury by stimulating autophagic flux

Author:
Minji Tong; Zili He; Xiaoxiao Lin; Yulong Zhou; Qingqing Wang; Zengming Zheng; Jian Chen; Huazi Xu; Naifeng Tian
Source:
Biochemical and biophysical research communications 2018 v.495 no.4 pp. 2525-2531
ISSN:
0006-291X
Subject:
animal injuries; animal models; autophagy; chloroquine; dyes; fluorescent antibody technique; lithium chloride; neurons; occludins; permeability; protein degradation; research; therapeutics; tight junctions
Abstract:
... Blood–spinal cord barrier (BSCB) disruption following spinal cord injury (SCI) significantly compromises functional neuronal recovery. Autophagy is a potential therapeutic target when seeking to protect the BSCB. We explored the effects of lithium chloride (LiCl) on BSCB permeability and autophagy-induced SCI both in a rat model of SCI and in endothelial cells subjected to oxygen–glucose deprivati ...
DOI:
10.1016/j.bbrc.2017.12.119

24. Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury

Author:
Chen Wang; Chang Liu; Kai Gao; Haosen Zhao; Zipeng Zhou; Zhaoliang Shen; Yue Guo; Zhuo Li; Tianchen Yao; Xifan Mei
Source:
Biochemical and biophysical research communications 2016 pp. -
ISSN:
0006-291X
Subject:
Western blotting; animal injuries; apoptosis; autophagy; caspase-3; fluorescent antibody technique; inflammation; metformin; morbidity; motor neurons; nervous system diseases; neuroprotective effect; noninsulin-dependent diabetes mellitus; phosphorylation; rats; signal transduction; spinal cord; staining; transcription factor NF-kappa B
Abstract:
... Spinal cord injury (SCI) is one of the most serious nervous system disorders characterised by high morbidity and disability. Inflammatory and autophagy responses play an important role in the development of SCI. Metformin, a first-line drug for type-2 diabetes, features autophagy promotion as well as anti-inflammatory and anti-apoptotic properties in the nervous system. In this study, we investiga ...
DOI:
10.1016/j.bbrc.2016.05.148

25. MiR-429 regulates blood−spinal cord barrier permeability by targeting Krüppel-like factor 6

Author:
Rui Sun; Lihao Ge; Yang Cao; Wenmao Wu; Yu Wu; Honggang Zhu; Jiuwei Li; Deshui Yu
Source:
Biochemical and biophysical research communications 2020 v.525 no.3 pp. 740-746
ISSN:
0006-291X
Subject:
animal injuries; blood; cell death; inflammation; neurons; occludins; permeability; protein synthesis; research; tight junctions; transcription factors
Abstract:
... The blood−spinal cord barrier (BSCB) is an effective, tightly-connected tissue that reduces secondary spinal cord injury (SCI) by decreasing blood cell infiltration, inflammation, and neuronal cell death during primary SCI. However, the methods and molecular mechanisms of BSCB openness remain elusive. In the present study, we found that microRNA429 (miR-429) plays a vital role in the opening of th ...
DOI:
10.1016/j.bbrc.2020.02.138

26. MicroRNA-7 promotes motor function recovery following spinal cord injury in mice

Author:
Myungsik Yoo; Aleta Murphy; Eunsung Junn
Source:
Biochemical and biophysical research communications 2021 v.573 pp. 80-85
ISSN:
0006-291X
Subject:
Adeno-associated virus 1; adults; animal injuries; axons; death; genes; hindlimbs; humans; microRNA; research; spinal cord; therapeutics; viruses
Abstract:
... Spinal cord injury (SCI) is a devastating neurological condition for which there are no effective therapies. Following an initial injury, there is a cascade of multiple downstream events termed secondary injury. Thus, therapeutic approaches targeting a single pathway may not offer the best solution for treating SCI. One of the most attractive properties of microRNAs (miR) as potential therapeutics ...
DOI:
10.1016/j.bbrc.2021.08.020

27. Microglial Hv1 exacerbates secondary damage after spinal cord injury in mice

Author:
Xuefei Li; Rui Liu; Zhiyuan Yu; Dan He; Weifeng Zong; Minghuan Wang; Minjie Xie; Wei Wang; Xiang Luo
Source:
Biochemical and biophysical research communications 2020 v.525 no.1 pp. 208-215
ISSN:
0006-291X
Subject:
animal injuries; apoptosis; chondroitin sulfate; interleukin-1beta; models; neuroglia; neuroprotective effect; proteoglycans; research; stroke; therapeutics; tumor necrosis factor-alpha
Abstract:
... The pathological process of spinal cord injury (SCI) is complex, particularly during secondary damage that triggers a multiphasic glial reaction consisting of both detrimental and beneficial effects. Deletion of a novel voltage-gated proton channel (Hv1) functionally expressed in microglia has been shown to confer neuroprotection during ischemic stroke. Here, we hypothesized that microglial Hv1 ma ...
DOI:
10.1016/j.bbrc.2020.02.012

28. Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells

Author:
Jianqiao Li; Xiaoyun Chen; Wei Xiao; Wei Ma; Tao Li; Juan Huang; Xialin Liu; Xiaoling Liang; Shibo Tang; Yan Luo
Source:
Biochemical and biophysical research communications 2011 v.404 no.1 pp. 349-356
ISSN:
0006-291X
Subject:
microscopy; diabetic retinopathy; quantitative polymerase chain reaction; animal injuries; endothelial cells; glucose; reactive oxygen species; flow cytometry; peptides; Western blotting; cytochrome c; mitochondria; retina; caspase-3
Abstract:
... PURPOSE: To investigate the effect of mitochondria-targeted antioxidant peptide SS31 on prevention of high glucose-induced injury on human retinal endothelial cells (HRECs). METHODS: Cultured P3–P5 HRECs were divided into three groups: 5mM glucose group, 30mM glucose group and 30mM glucose co-treated with 100nM SS31 group. 24 and 48h after treatment, Annexin V-FITC/PI staining was used to evaluate ...
DOI:
10.1016/j.bbrc.2010.11.122
PubMed:
21134355

29. NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy

Author:
Jin Shang; Ya Zhang; Yumin Jiang; Zhenzhen Li; Yiqi Duan; Luyao Wang; Jing Xiao; Zhanzheng Zhao
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
animal injuries; biopsy; diabetic nephropathy; endothelial cells; glucose; immunohistochemistry; intracellular signaling peptides and proteins; mitogen-activated protein kinase; signal transduction; staining
Abstract:
... Endothelial-to-mesenchymal transition (EndMT) of glomerular vascular endothelial cells (GEnCs) is now considered to play a critical role in diabetic nephropathy (DN). NOD2 is newly discovered to be closely related to DN renal injury. However, the relationship between NOD2 and EndMT of GEnCs has never been reported. In the present study, we found that NOD2 over-expression was positively correlated ...
DOI:
10.1016/j.bbrc.2017.01.155

30. Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury

Author:
Jun Gu; Yingjie Ni; Lin Xu; Hongliang Xu; Zhengdong Cai
Source:
Biochemical and biophysical research communications 2016 v.469 pp. 1097-1103
ISSN:
0006-291X
Subject:
Western blotting; animal injuries; astrocytes; cell cycle; cell proliferation; embryonic stem cells; fluorescence; immunohistochemistry; models; pathophysiology; proliferating cell nuclear antigen; spinal cord; staining; transcription factors
Abstract:
... Previous research had reported transcription factors Nanog expressed in pluripotent embryonic stem cells (ESCS) that played an important role in regulating the cell proliferation. Nanog levels are frequently elevated in ESCS, but the role in the spinal cord was not clear. To examine the biological relevance of Nanog, we studied its properties in spinal cord injury model. The expression of Nanog an ...
DOI:
10.1016/j.bbrc.2015.12.053

31. Neuronal glycosylation differentials in normal, injured and chondroitinase-treated environments

Author:
Michelle Kilcoyne; Shashank Sharma; Niamh McDevitt; Claire O’Leary; Lokesh Joshi; Siobhán S. McMahon
Source:
Biochemical and biophysical research communications 2012 v.420 no.3 pp. 616-622
ISSN:
0006-291X
Subject:
animal injuries; astrocytes; central nervous system; chondroitin sulfate; coculture; cytochemistry; data collection; extracellular matrix; gene expression; genes; glycosylation; lectins; neurons; neutralization; proteoglycans
Abstract:
... Glycosylation is found ubiquitously throughout the central nervous system (CNS). Chondroitin sulphate proteoglycans (CSPGs) are a group of molecules heavily substituted with glycosaminoglycans (GAGs) and are found in the extracellular matrix (ECM) and cell surfaces. Upon CNS injury, a glial scar is formed, which is inhibitory for axon regeneration. Several CSPGs are up-regulated within the glial s ...
DOI:
10.1016/j.bbrc.2012.03.047

32. Overexpression of TUSC7 inhibits the inflammation caused by microglia activation via regulating miR-449a/PPAR-γ

Author:
Yanbo Yu; Mengye Zhu; Yong Zhao; Mu Xu; Mizhen Qiu
Source:
Biochemical and biophysical research communications 2018 v.503 no.2 pp. 1020-1026
ISSN:
0006-291X
Subject:
RNA; animal injuries; inflammation; interleukin-1beta; luciferase; models; neuroglia; rats; reporter genes; spinal cord; tissues; tumor necrosis factor-alpha
Abstract:
... The aim of this study was to investigate the mechanisms of TUSC7/miR-449a/PPAR-γ axis on the inflammation induced by microglia activation.A compressive spinal cord injury (SCI) model was established. The expressions of TUSC7, miR-449a PPAR-γ, TNF-α and IL-1β in spinal cord tissues of SCI rats and HAPI cells were determined. The interaction of TUSC7 and miR-449a was tested by RIP and RNA pull-down ...
DOI:
10.1016/j.bbrc.2018.06.111

33. PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes

Author:
Jinbo Liu; Lijian Du
Source:
Biochemical and biophysical research communications 2015 v.467 pp. 197-203
ISSN:
0006-291X
Subject:
RNA; animal injuries; astrocytes; mitochondria; models; reactive oxygen species; spinal cord; transcription factor NF-kappa B
Abstract:
... Mitochondrial dysfunction is a direct target of hypoxic/ischemic stress in astrocytes, which results in the increased production of reactive oxygen species (ROS). Previous reports showed that ROS can activate NF-kB in spinal cord astrocytes, which occurs as a secondary injury during the pathological process of spinal cord injury (SCI). Protein kinase RNA (PKR)-like ER kinase (PERK) plays an import ...
DOI:
10.1016/j.bbrc.2015.10.007

34. PTEN-silencing combined with ChABC-overexpression in adipose-derived stem cells promotes functional recovery of spinal cord injury in rats

Author:
Tao Lu; Wang Peng; Yan Liang; Miao Li; Dong-Sheng Li; Kai-Hui Du; Jing-Hui Zhu; Jian-Huang Wu
Source:
Biochemical and biophysical research communications 2020 v.532 no.3 pp. 420-426
ISSN:
0006-291X
Subject:
animal injuries; flow cytometry; genes; hindlimbs; hyperplasia; research; therapeutics; viability
Abstract:
... The efficiency of cell therapy after spinal cord injury (SCI) depend on the survival of transplanted cells. However, sterile microenvironment and glial scar hyperplasia extremely reduce their numbers. Our previous study found overexpression of ChABC gene is positively correlated to migration ability. Expression of PTEN gene is closely associated with proliferation. However, whether manipulation of ...
DOI:
10.1016/j.bbrc.2020.08.085

35. Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats

Author:
Jian Zhao; Ailang Pang; Saige Yin; Meifeng Yang; Xuemei Zhang; Rong Zhang; Jingfei Liu; Yuanqi Gu; Shanshan Li; Yan Hu; Yue Zhang; Yingchun Ba; Buliang Meng; Xinwang Yang
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 124-130
ISSN:
0006-291X
Subject:
adults; animal injuries; glutathione; intraperitoneal injection; ischemia; malondialdehyde; neurons; nitric oxide; oxidative stress; reperfusion injury; research; spinal cord; superoxide dismutase; therapeutics; tyrosine
Abstract:
... At present, there are no satisfactory therapeutic drugs for the functional recovery of spinal cord injury (SCI). We previously identified a novel peptide (OM-LV20) that accelerated the regeneration of injured skin tissues of mice and exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats. Here, the intraperitoneal injection of OM-LV20 (1 μg/kg) markedly improved motor ...
DOI:
10.1016/j.bbrc.2022.02.017

36. RETRACTED: DNMT inhibitor (decitabine) attenuates tuberculosis-induced spine injury by modulating the expression of microRNA-155 and matrix metalloproteinase-13 via suppressing the hypermethylation of IDH mutant

Author:
Yi Luo; Wenkun Zhang
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
DNA methylation; animal injuries; bisulfites; blood serum; collagen; intervertebral disks; luciferase; matrix metalloproteinase 13; mutants; pathogenesis; promoter regions; quantitative polymerase chain reaction; research; tuberculosis
Abstract:
... MiR-155 regulates the expression of MMP13, which is involved in the pathogenesis of tuberculosis (TB) associated spine injury (more specifically intervertebral disc damage). Quantitative real-time PCR was performed to analyze the expression of miR-155 and MMP13 mRNA under different conditions. Bisulfite sequencing PCR was carried out to examine the DNA methylation status of miR-155 promoter region ...
DOI:
10.1016/j.bbrc.2022.03.081

37. Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats

Author:
Hao Liu; Marie E. Rose; Sherman Culver; Xiecheng Ma; C. Edward Dixon; Steven H. Graham
Source:
Biochemical and biophysical research communications 2016 v.472 pp. 648-655
ISSN:
0006-291X
Subject:
agonists; animal injuries; brain; inflammation; macrophages; memory; models; neuroglia; neurons; neuroprotective effect; peroxisome proliferator-activated receptors; rats; spatial variation; spinal cord; stroke; tumor necrosis factor-alpha
Abstract:
... Rosiglitazone, a potent peroxisome proliferator-activated receptor (PPAR)-γ agonist, has been shown to confer neuroprotective effects in stroke and spinal cord injury, but its role in the traumatic brain injury (TBI) is still controversial. Using a controlled cortical impact model in rats, the current study was designed to determine the effects of rosiglitazone treatment (6 mg/kg at 5 min, 6 h and ...
DOI:
10.1016/j.bbrc.2016.03.003

38. S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury

Author:
Hai-Bin Tang; Xiao-Jian Jiang; Chen Wang; Shi-Chang Liu
Source:
Biochemical and biophysical research communications 2018 v.498 no.4 pp. 830-836
ISSN:
0006-291X
Subject:
animal injuries; astrocytes; blood-brain barrier; locomotion; neurons; receptors; spinal cord; stromal cells; therapeutics
Abstract:
... Pericytes have long been regarded merely to maintain structural and functional integrity of blood-brain barrier (BBB). Nevertheless, it has also been identified as a component of scar-forming stromal cells after spinal cord injury (SCI). In process of enlargement of spinal cavity after SCI, the number of pericytes increased and outnumbered astrocytes. However, the mechanism of proliferation of per ...
DOI:
10.1016/j.bbrc.2018.03.065

39. Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury

Author:
Yuji Guo; Shangming Liu; Xianghong Zhang; Liyan Wang; Xiaoli Zhang; Aijun Hao; Aiqing Han; Jie Yang
Source:
Biochemical and biophysical research communications 2014 v.446 pp. 830-835
ISSN:
0006-291X
Subject:
animal injuries; genes; mice; neurogenesis; neurons; spinal cord; stem cells; therapeutics
Abstract:
... We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression in the injured spinal cord. Sox11 was mainly located in endogenous neural stem c ...
DOI:
10.1016/j.bbrc.2014.02.103

40. Sting is a critical regulator of spinal cord injury by regulating microglial inflammation via interacting with TBK1 in mice

Author:
Yue-yi Wang; Dong Shen; Liu-jun Zhao; Nian Zeng; Teng-hui Hu
Source:
Biochemical and biophysical research communications 2019 v.517 no.4 pp. 741-748
ISSN:
0006-291X
Subject:
animal injuries; drug therapy; genes; inflammation; innate immunity; interferons; interleukin-6; mice; mitogen-activated protein kinase; neuroglia; pathogenesis; phosphorylation; research; spinal cord; transmembrane proteins
Abstract:
... Spinal cord injury (SCI) is a devastating neurological condition that results in progressive tissue loss, secondary to vascular dysfunction and inflammation. Lack of effective pharmacotherapies for SCI is mainly attributable to an incomplete understanding of its pathogenesis. Stimulator of interferon gene (Sting), also known as Transmembrane protein 173 (TMEM173), activates the type I interferon-r ...
DOI:
10.1016/j.bbrc.2019.07.125

41. TMEM16F inhibition limits pain-associated behavior and improves motor function by promoting microglia M2 polarization in mice

Author:
Jing Zhao; Quan-You Gao
Source:
Biochemical and biophysical research communications 2019 v.517 no.4 pp. 603-610
ISSN:
0006-291X
Subject:
animal injuries; functional diversity; inflammation; macrophages; males; metalloproteinases; neuroglia; phenotype; research; spinal cord; therapeutics; transmembrane proteins
Abstract:
... Spinal cord injury (SCI) leads to sensorimotor deficits and autonomic changes. Macrophages and microglia could be polarized into the classically activated pro-inflammatory M1 phenotype or the alternatively activated anti-inflammatory M2 phenotype. Transmembrane protein with unknown function 16F (TMEM16F) exhibits functional diversity and may contribute to microglial function. However, the effects ...
DOI:
10.1016/j.bbrc.2019.07.070

42. TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT

Author:
Wen Xue; Wei Tan; Longjia Dong; Qian Tang; Feng Yang; Xuexing Shi; Dianming Jiang; Yaowen Qian
Source:
Biochemical and biophysical research communications 2020 v.528 no.1 pp. 234-241
ISSN:
0006-291X
Subject:
animal injuries; cell viability; cytokines; humans; immunity; inflammation; lipopolysaccharides; mice; morbidity; necrosis; neoplasms; neurons; research; therapeutics; transfection
Abstract:
... Spinal cord injury (SCI) is a devastating disease and causes tissue loss and neurologic dysfunction, contributing to high morbidity and disability among human. However, the underlying molecular mechanisms still remain unclear. Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TNFAIP8/TIPE family, and has been implicated in different diseases associated with inflammation, infec ...
DOI:
10.1016/j.bbrc.2020.05.029

43. Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response

Author:
Xian-Yong Bai; Xi-Feng Wang; Lian-Shuang Zhang; Peng-Chao Du; Zhang Cao; Yun Hou
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1968-1972
ISSN:
0006-291X
Subject:
animal injuries; animal models; encephalitis; inflammasomes; inflammation; interleukin-10; interleukin-17; interleukin-18; mice; pyrazines; sclerosis; spinal cord; therapeutics
Abstract:
... Multiple sclerosis (MS) is a disabling inflammatory and demyelinating disorder of the central nervous system. Tetramethylpyrazine (TMP) has been demonstrated to ameliorate cerebral ischemic injury and spinal cord injury by inhibiting inflammatory cell activation and pro-inflammatory cytokine production. However, the effects of TMP on MS have not been studied. In this study, we evaluated the effect ...
DOI:
10.1016/j.bbrc.2018.07.143

44. Transient activation of Wnt/β-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice

Author:
Takashi Yamagami; David E. Pleasure; Kit S. Lam; Chengji J. Zhou
Source:
Biochemical and biophysical research communications 2018 v.496 no.4 pp. 1302-1307
ISSN:
0006-291X
Subject:
adults; animal injuries; astrocytes; fibroblasts; fibronectins; mice; models; secretion; spinal cord; transgenic animals
Abstract:
... After traumatic spinal cord injury (SCI), a scar may form with a fibrotic core (fibrotic scar) and surrounding reactive astrocytes (glial scar) at the lesion site. The scar tissue is considered a major obstacle preventing regeneration both as a physical barrier and as a source for secretion of inhibitors of axonal regeneration. Understanding the mechanism of scar formation and how to control it ma ...
DOI:
10.1016/j.bbrc.2018.02.004
PubMed:
29410176
PubMed Central:
PMC5816694

45. Transplantation of mature adipocyte-derived dedifferentiated fat cells promotes locomotor functional recovery by remyelination and glial scar reduction after spinal cord injury in mice

Author:
Hiromi Yamada; Daisuke Ito; Yoshinao Oki; Masato Kitagawa; Taro Matsumoto; Tosihiro Watari; Koichiro Kano
Source:
Biochemical and biophysical research communications 2014 v.454 pp. 341-346
ISSN:
0006-291X
Subject:
adipocytes; adults; animal injuries; astrocytes; females; hindlimbs; immunohistochemistry; mice; models; neurons; neurotrophins; oligodendroglia; spinal cord; staining; therapeutics
Abstract:
... Mature adipocyte-derived dedifferentiated fat cells (DFAT) have a potential to be useful as new cell-source for cell-based therapy for spinal cord injury (SCI), but the mechanisms remain unclear. The objective of this study was to examine whether DFAT-induced functional recovery is achieved through remyelination and/or glial scar reduction in a mice model of SCI. To accomplish this we subjected ad ...
DOI:
10.1016/j.bbrc.2014.10.082

46. VEGF inhibits the inflammation in spinal cord injury through activation of autophagy

Author:
Hongyu Wang; Yansong Wang; Dingding Li; Zhiyuan Liu; Ziming Zhao; Donghe Han; Yajiang Yuan; Jing Bi; Xifan Mei
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 453-458
ISSN:
0006-291X
Subject:
Western blotting; angiogenesis; animal injuries; autophagy; coculture; enzyme-linked immunosorbent assay; in vitro studies; inflammation; interleukin-10; interleukin-1beta; lipopolysaccharides; males; motor neurons; rats; reverse transcriptase polymerase chain reaction; spinal cord; staining; tumor necrosis factor-alpha; vascular endothelial growth factors
Abstract:
... Vascular endothelial growth factor (VEGF) is a secreted mitogen associated with angiogenesis and re-vascularization of spinal cord injury (SCI). VEGF has long been thought to be a potent neurotrophic factor for the survival of spinal cord neuron. However, the neuroprotective mechanism of VEGF is still unclear. The aim of this study was to investigate the effect of VEGF on spinal cord injury and it ...
DOI:
10.1016/j.bbrc.2015.06.146

47. Wnt/β-catenin signaling promotes regeneration after adult zebrafish spinal cord injury

Author:
Nicholas S. Strand; Kimberly K. Hoi; Tien M.T. Phan; Catherine A. Ray; Jason D. Berndt; Randall T. Moon
Source:
Biochemical and biophysical research communications 2016 pp. -
ISSN:
0006-291X
Subject:
Danio rerio; adults; animal injuries; larvae; mammals; spinal cord; tissues
Abstract:
... Unlike mammals, zebrafish can regenerate their injured spinal cord and regain control of caudal tissues. It was recently shown that Wnt/β-catenin signaling is necessary for spinal cord regeneration in the larval zebrafish. However, the molecular mechanisms of regeneration may or may not be conserved between larval and adult zebrafish. To test this, we assessed the role of Wnt/β-catenin signaling a ...
DOI:
10.1016/j.bbrc.2016.07.006

48. A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5

Author:
Weiqi Ling; Xu Xu; Jinbo Liu
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Western blotting; animal injuries; apoptosis; correlation; flow cytometry; gene expression; gene expression regulation; luciferase; messenger RNA; models; necrosis; neurons; protein synthesis; quantitative polymerase chain reaction; rats; spinal cord; therapeutics; transfection
Abstract:
... Spinal cord injury (SCI) is terrible damage resulting in the deficiencies and necrosis of neurology and causes infinite inconvenience to sufferers. The therapy of SCI still meets a larger number of problems. Therefore, the underlying mechanism and novel therapy of acute SCI (ASCI) are urgent to explore.The SCI model was established in rats. The expression of miR-182/miR-7a and PRDM5 at mRNA level ...
DOI:
10.1016/j.bbrc.2017.05.141

49. A circRNA derived from linear HIPK3 relieves the neuronal cell apoptosis in spinal cord injury via ceRNA pattern

Author:
Jingwei Zhao; Xi Qi; Jingyu Bai; Xiang Gao; Liming Cheng
Source:
Biochemical and biophysical research communications 2020 v.528 no.2 pp. 359-367
ISSN:
0006-291X
Subject:
animal injuries; animal models; apoptosis; neurons; rats; research; ribonucleases; spinal cord
Abstract:
... Spinal cord injury (SCI) is a severe disable symptom and has posed a great health threat to many people. Circ-HIPK3 has been reported to modulate the biological behavior of neuronal cells. Thence, in this study, we explored the mechanism of circ-HIPK3 in affecting functions of neuronal cell in SCI. SCI rat model was constructed to evaluate the apoptosis condition of spinal cord tissue. Meanwhile, ...
DOI:
10.1016/j.bbrc.2020.02.108

50. A combination of small molecules directly reprograms mouse fibroblasts into neural stem cells

Author:
Jie Zheng; Kyung-Ah Choi; Phil Jun Kang; Solji Hyeon; Suhyun Kwon; Jai-Hee Moon; Insik Hwang; Yang In Kim; Yoon Sik Kim; Byung Sun Yoon; Gyuman Park; JangBo Lee; SungHoi Hong; Seungkwon You
Source:
Biochemical and biophysical research communications 2016 v.476 pp. 42-48
ISSN:
0006-291X
Subject:
Parkinson disease; animal injuries; astrocytes; chemical compounds; electrophysiology; fibroblasts; gene expression; genetic engineering; mice; neurons; oligodendroglia; somatic cells; spinal cord; stem cells; therapeutics; transcription factors
Abstract:
... The generation of induced neural stem cells (iNSCs) from somatic cells using defined factors provides new avenues for basic research and cell therapies for various neurological diseases, such as Parkinson’s disease, Huntington’s disease, and spinal cord injuries. However, the transcription factors used for direct reprogramming have the potential to cause unexpected genetic modifications, which lim ...
DOI:
10.1016/j.bbrc.2016.05.080

51. lncRNA-Map2k4 sequesters miR-199a to promote FGF1 expression and spinal cord neuron growth

Author:
Hao-ran Lv
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
animal injuries; apoptosis; binding sites; computer software; gene expression regulation; luciferase; neurons; non-coding RNA; occupations; small interfering RNA; spinal cord
Abstract:
... Spinal cord injury (SCI) is a common critical illness in clinical practice. SCI prevention, treatment and rehabilitation have become important topics in today's medical profession. Studies have shown that long noncoding RNAs (lncRNAs) also play an important role in the pathology of SCI. The biology software analysis identified miR-199a binding sites in the lncRNA-Map2k4 and FGF1 sequences, which w ...
DOI:
10.1016/j.bbrc.2017.06.145

52. miR-411 suppresses acute spinal cord injury via downregulation of Fas ligand in rats

Author:
Zong-ming Gong; Zhen-yu Tang; Xiao-liang Sun
Source:
Biochemical and biophysical research communications 2018 v.501 no.2 pp. 501-506
ISSN:
0006-291X
Subject:
animal injuries; animal models; apoptosis; asci; flow cytometry; genes; ligands; luciferase; research
Abstract:
... To explore the role of miR-411/FasL in acute spinal cord injury (ASCI).The ASCI rat model was established, and expression of miR-411 and Fas ligand (FasL) was examined. Basso, Beattie and Bresnahan (BBB) score was used to evaluate the rats' neurological function. PC12 oxygen-glucose deprivation (OGD) model was also established. Gene manipulation (including miR-411 mimic or inhibitor) was used to m ...
DOI:
10.1016/j.bbrc.2018.05.022

53. A new method for primary culture of microglia in rats with spinal cord injury

Author:
Chengjie Wu; Yalan Pan; Lining Wang; Mengmin Liu; Mao Wu; Jianwei Wang; Guanglu Yang; Yang Guo; Yong Ma
Source:
Biochemical and biophysical research communications 2022 v.599 pp. 63-68
ISSN:
0006-291X
Subject:
animal injuries; fluorescent antibody technique; models; neuroglia; research; spinal cord
Abstract:
... At present, the primary culture method of microglia is complicated, and the culture of spinal cord microglia is rare, so we will explore to establish a new and efficient primary culture method of microglia in rats with spinal cord injury (SCI). The SCI model of SD rats was established by modified A11en′s method, and the model of SCI was performed on 1 d, 3 d, 7 d and 14 d respectively. Then the in ...
DOI:
10.1016/j.bbrc.2022.02.027