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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Subject exosomes Remove constraint Subject: exosomes Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. IL- 1β/ATF3-mediated induction of Ski2 expression enhances hepatitis B virus x mRNA degradation

Author:
Fumihiro Shiromoto; Hussein H. Aly; Haruka Kudo; Koichi Watashi; Asako Murayama; Noriyuki Watanabe; Xin Zheng; Takanobu Kato; Kazuaki Chayama; Masamichi Muramatsu; Takaji Wakita
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1854-1860
ISSN:
0006-291X
Subject:
Hepatitis B virus; exosomes; hepatoma; inflammation; interleukin-1beta; messenger RNA; transcription factors
Abstract:
... Hepatitis B virus (HBV) -x protein is a transcriptional regulator required for the HBV life cycle. HBx also induces complications in the host such as hepatocellular carcinoma. We previously showed that HBx mRNA is degraded by the Ski2/RNA exosome complex. In the present study, we report the regulation of this system through the control of Ski2 expression. We identified interleukin (IL) -1β as an i ...
DOI:
10.1016/j.bbrc.2018.07.126

2. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74

Author:
Nobuhiro Hiraishi; Yo-ichi Ishida; Masami Nagahama
Source:
Biochemical and biophysical research communications 2015 v.467 pp. 534-540
ISSN:
0006-291X
Subject:
RNA; RNA helicases; adenosinetriphosphatase; amino acid sequences; biogenesis; cell nucleolus; exosomes; protein subunits; proteomics; regulatory proteins; ribosomal proteins; ribosomes; sequence homology; yeasts
Abstract:
... Nuclear VCP-like 2 (NVL2) is a chaperone-like nucleolar ATPase of the AAA (ATPase associated with diverse cellular activities) family, which exhibits a high level of amino acid sequence similarity with the cytosolic AAA-ATPase VCP/p97. These proteins generally act on macromolecular complexes to stimulate energy-dependent release of their constituents. We previously showed that NVL2 interacts with ...
DOI:
10.1016/j.bbrc.2015.09.160

3. ASCs -derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury

Author:
Jia Fang; Wulong Liang
Source:
Biochemical and biophysical research communications 2021 v.572 pp. 125-130
ISSN:
0006-291X
Subject:
exosomes; hepatocytes; liver; liver failure; liver transplant; mesenchymal stromal cells; quercetin; research; vitamin A
Abstract:
... Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms. Despite the unique ability of the liver to heal itself, there is still no effective treatment except liver transplantation for chronic liver injury or even liver failure caused by acute liver injury. Stem cell-derived exosomes are ideal drug carriers due to their unique immunomodulatory eff ...
DOI:
10.1016/j.bbrc.2021.07.059

4. Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells

Author:
Yoshimi Fukushima; Masaaki Okamoto; Kana Ishikawa; Takahisa Kouwaki; Hirotake Tsukamoto; Hiroyuki Oshiumi
Source:
Biochemical and biophysical research communications 2018 v.500 no.3 pp. 744-750
ISSN:
0006-291X
Subject:
Toll-like receptor 3; cell communication; dendritic cells; double-stranded RNA; exosomes; humans; innate immunity; macrophages; microRNA; small interfering RNA
Abstract:
... Pattern-recognition receptors (PRRs) recognizes viral RNAs and trigger the innate immune responses. Toll-like receptor 3 (TLR3), a PRR, recognizes viral double-stranded RNA (dsRNA) in endolysosomes, whereas cytoplasmic dsRNA is sensed by another PRR, MDA5. TLR3 and MDA5 utilize TICAM-1 and MAVS, respectively, to trigger the signal for inducing innate immune responses. Extracellular vesicles (EVs) ...
DOI:
10.1016/j.bbrc.2018.04.146

5. Adiponectin is partially associated with exosomes in mouse serum

Author:
Worrawalan Phoonsawat; Ayako Aoki-Yoshida; Takeshi Tsuruta; Kei Sonoyama
Source:
Biochemical and biophysical research communications 2014 v.448 pp. 261-266
ISSN:
0006-291X
Subject:
Western blotting; adipocytes; adiponectin; animal disease models; blood serum; cell communication; centrifugation; enzyme-linked immunosorbent assay; exosomes; leptin; lipids; messenger RNA; metabolic diseases; mice; microRNA; obesity; octoxynol; peptidase K; protein content; resistin; transmembrane proteins
Abstract:
... Exosomes are membrane vesicles 30–120nm in diameter that are released by many cell types and carry a cargo of proteins, lipids, mRNA, and microRNA. Cultured adipocytes reportedly release exosomes that may play a role in cell-to-cell communication during the development of metabolic diseases. However, the characteristics and function of exosomes released from adipocytes in vivo remain to be elucida ...
DOI:
10.1016/j.bbrc.2014.04.114

6. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Author:
Lin Ren; Zi-jun Song; Qing-wei Cai; Rui-xin Chen; Yang Zou; Qiang Fu; Yuan-yuan Ma
Source:
Biochemical and biophysical research communications 2019 v.508 no.1 pp. 138-144
ISSN:
0006-291X
Subject:
acid phosphatase; age; apoptosis; blood serum; bone marrow; bone resorption; caspase-3; caspase-9; cell lines; cytochrome c; exosomes; genes; hypoxia; mesenchymal stromal cells; messenger RNA; models; monocytes; osteoclasts; protein content; staining; therapeutics
Abstract:
... Age-related skeletal changes is closely associated with imbalanced bone remodeling characterized by elevated osteocyte apoptosis and osteoclast activation. Since osteocytes are the commander of bone remodeling, attenuating increased osteocyte apoptosis may improve age-related bone loss. Exosomes, derived from mesenchymal stem cells, hold promising potential for cell-free therapy due to multiple ab ...
DOI:
10.1016/j.bbrc.2018.11.109

7. Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury

Author:
Yun Bai; Yu-di Han; Xin-long Yan; Jing Ren; Quan Zeng; Xiao-dong Li; Xue-tao Pei; Yan Han
Source:
Biochemical and biophysical research communications 2018 v.500 no.2 pp. 310-317
ISSN:
0006-291X
Subject:
angiogenesis; apoptosis; blood; coculture; eosin; exosomes; human umbilical vein endothelial cells; hydrogen peroxide; image analysis; immunohistochemistry; inflammation; ischemia; mesenchymal stromal cells; staining; stem cells; therapeutics
Abstract:
... Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization.To investiga ...
DOI:
10.1016/j.bbrc.2018.04.065

8. Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

Author:
Wenjun Hu; Zeyuan Ru; Wen Xiao; Zhiyong Xiong; Cheng Wang; Changfei Yuan; Xiaoping Zhang; Hongmei Yang
Source:
Biochemical and biophysical research communications 2018 v.506 no.1 pp. 122-129
ISSN:
0006-291X
Subject:
adipocytes; adipose tissue; cachexia; enzyme inhibitors; exosomes; lipolysis; lung neoplasms; mice; muscular atrophy; neoplasm cells; skeletal muscle; weight loss
Abstract:
... Cancer-associated cachexia (CAC) is a disorder characterized by unintended weight loss due to skeletal muscle wasting and adipose tissue loss. Although muscle atrophy in this condition has been well studied, the mechanisms underlying adipose tissue loss, which include browning, have not been investigated in detail. In this respect, though recent studies have shown that exosomes from cancer cells c ...
DOI:
10.1016/j.bbrc.2018.09.139

9. Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

Author:
Ting Liu; Yu-Chen Sun; Peng Cheng; Hui-Ge Shao
Source:
Biochemical and biophysical research communications 2019 v.515 no.2 pp. 352-358
ISSN:
0006-291X
Subject:
adipocytes; adipose tissue; agonists; exosomes; hepatocytes; insulin resistance; macrophages; mice; microRNA; myocytes; noninsulin-dependent diabetes mellitus; therapeutics
Abstract:
... Obesity-associated insulin resistance is a forerunner of type 2 diabetes. Macrophages reside within adipose tissue (ATMs) have been reported to regulate insulin sensitivity through secreting miRNAs containing exosomes. Here, we show that miR-29a is increased in obese ATMs derived exosomes (ATMs-Exos) and can be transferred into adipocytes, myocytes and hepatocytes causing insulin resistance in vit ...
DOI:
10.1016/j.bbrc.2019.05.113

10. Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

Author:
Mijung Lee; Jae-Jun Ban; Ki Yoon Kim; Gye Sun Jeon; Wooseok Im; Jung-Joon Sung; Manho Kim
Source:
Biochemical and biophysical research communications 2016 v.479 pp. 434-439
ISSN:
0006-291X
Subject:
Western blotting; amyotrophic lateral sclerosis; brain stem; cortex; death; exosomes; immunocytochemistry; mice; mitochondria; models; motor neurons; phenotype; spinal cord; stem cells; superoxide dismutase; therapeutics
Abstract:
... Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that involves the death of motor neurons in the cortex, brain stem, and spinal cord. Adipose-derived stem cells (ADSCs) are considered as a perspective remedy for therapy of neurodegenerative diseases including ALS. Stem cells secrete various factors which can modulate a hostile environment, called paracrine effect. Exosomes are small ...
DOI:
10.1016/j.bbrc.2016.09.069

11. Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats

Author:
Haidong Wu; Sheng He; Wei Zhang; Ying Huang; Qiang Zhang; Dan Liu
Source:
Biochemical and biophysical research communications 2022 v.608 pp. 82-89
ISSN:
0006-291X
Subject:
adipose tissue; exosomes; heat stress; hospitals; inflammation; luciferase; obesity; quantitative polymerase chain reaction; rats; research; therapeutics; transcription factor NF-kappa B
Abstract:
... miR-495 and miR-142–3p suppress inflammatory response. Circ_0075932 is overexpressed in the burned skin of obese individuals and is involved in the regulation of PUM2 and AuroraA kinase, thus activating the NF-kB pathway. Obesity significantly influences the length of hospital stay for paediatric burn patients, who present symptoms of slower healing or greater functional impairment. In this study, ...
DOI:
10.1016/j.bbrc.2022.03.145

12. Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion

Author:
Wenjin Zhang; Xiaoyan Zhang; Lei Zhang; Dan Xu; NanNan Cheng; Yong Tang; Yan Peng
Source:
Biochemical and biophysical research communications 2020 v.526 no.2 pp. 341-348
ISSN:
0006-291X
Subject:
astrocytes; cell adhesion; central nervous system; direct contact; exosomes; gene ontology; integrins; interphase; myelination; oligodendroglia; research; secretion
Abstract:
... Many degenerative diseases of the central nervous system (CNS) are associated with demyelination. Oligodendrocyte precursor cells (OPCs) are potential stem cells that can differentiate into oligodendrocytes (OLs) and promote myelination. Promoting the proliferation of OPCs is key to stimulating remyelination and treating neurodegenerative diseases. Herein, we report that astrocytes (ASTs) could in ...
DOI:
10.1016/j.bbrc.2020.03.092

13. Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes

Author:
Yuichi Kariba; Tatsuya Yoshizawa; Yoshifumi Sato; Tomonori Tsuyama; Eiichi Araki; Kazuya Yamagata
Source:
Biochemical and biophysical research communications 2020 v.530 no.3 pp. 500-507
ISSN:
0006-291X
Subject:
brown adipocytes; brown adipose tissue; coculture; cold; cold stress; exosomes; gene expression; lipogenesis; liver; microRNA; neurons; neurotransmitters; norepinephrine; research; sympathetic nervous system
Abstract:
... Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a regulator of hepatic lipogenesis under cold stress conditions. Norepinephrine, a sympathetic nervous system neurotransmitter mediating cold-ind ...
DOI:
10.1016/j.bbrc.2020.05.090

14. CD109 is a component of exosome secreted from cultured cells

Author:
Hiroki Sakakura; Shinji Mii; Sumitaka Hagiwara; Takuya Kato; Noriyuki Yamamoto; Hideharu Hibi; Masahide Takahashi; Yoshiki Murakumo
Source:
Biochemical and biophysical research communications 2016 v.469 pp. 816-822
ISSN:
0006-291X
Subject:
Western blotting; coprecipitation; culture media; cultured cells; exosomes; gels; glycoproteins; humans; keratinocytes; mass spectrometry; messenger RNA; microRNA; microscopy
Abstract:
... Exosomes are 50–100-nm-diameter membrane vesicles released from various types of cells. Exosomes retain proteins, mRNAs and miRNAs, which can be transported to surrounding cells. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, and is released from the cell surface to the culture medium in vitro. Recently, it was reported that secreted CD109 from the cell surface downregulates transf ...
DOI:
10.1016/j.bbrc.2015.12.063

15. Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes

Author:
Hyoeun Kim; Nuri Yun; Dasom Mun; Ji-Young Kang; Seung-Hyun Lee; Hyelim Park; Hyewon Park; Boyoung Joung
Source:
Biochemical and biophysical research communications 2018 v.499 no.4 pp. 803-808
ISSN:
0006-291X
Subject:
RNA; cell lines; cell viability; exosomes; genetic engineering; glycosylation; heart; heart diseases; liver; mice; spleen; therapeutics; tissues; toxicity
Abstract:
... Naturally occurring RNA carriers such as exosomes might be an untapped source of effective delivery vehicles. However, if exosomes are to be exploited for therapeutic applications, they must target specific tissues or cell types to avoid off-target effects. This study evaluated whether genetic modification of exosomes could enhance exosome delivery to heart cells and heart tissue without toxicity. ...
DOI:
10.1016/j.bbrc.2018.03.227

16. Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway

Author:
Xi Zhang; Lin Chen; Bo Xiao; Hengxin Liu; Yingjun Su
Source:
Biochemical and biophysical research communications 2019 v.511 no.3 pp. 551-558
ISSN:
0006-291X
Subject:
RNA-binding proteins; adipocytes; adipose tissue; apoptosis; circular RNA; exons; exosomes; gene overexpression; humans; inflammation; keratinocytes; non-specific serine/threonine protein kinase; tissue repair; transcription factor NF-kappa B
Abstract:
... It remains unclear why obese persons displayed a slower wound healing rate than the normal. In this study, we found that has_circ_0075932, a single-exon circular RNA, was outstandingly expressed in human normal adipose tissue and overexpressed in burned skin of obese persons compared with that of non-obese persons. Circ_0075932 overexpression or silencing in dermal keratinocytes had no obvious eff ...
DOI:
10.1016/j.bbrc.2019.02.082

17. Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting

Author:
Yu-di Han; Yun Bai; Xin-long Yan; Jing Ren; Quan Zeng; Xiao-dong Li; Xue-tao Pei; Yan Han
Source:
Biochemical and biophysical research communications 2018 v.497 no.1 pp. 305-312
ISSN:
0006-291X
Subject:
adipocytes; angiogenesis; animal models; blood; exosomes; fluorescent antibody technique; human umbilical vein endothelial cells; immunohistochemistry; in vitro studies; inflammation; staining; stem cells; stromal cells; subcutaneous fat
Abstract:
... Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting.A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft samp ...
DOI:
10.1016/j.bbrc.2018.02.076

18. Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

Author:
Xianjun Xu; Jinnian Cheng; Shengzheng Luo; Xiaoyuan Gong; Dan Huang; Jingxian Xu; Yueqin Qian; Xinjian Wan; Hui Zhou
Source:
Biochemical and biophysical research communications 2020 v.524 no.3 pp. 649-655
ISSN:
0006-291X
Subject:
bile; coculture; deoxycholic acid; exosomes; fluorescent antibody technique; inflammation; intestines; intragastric administration; lectins; macrophages; metaplasia; organoids; parasympatholytics; quantitative polymerase chain reaction; research; risk factors; stomach; stomach neoplasms; ultracentrifugation
Abstract:
... Spasmolytic polypeptide-expressing metaplasia (SPEM) is an important risk factor for the occurrence of gastric cancer. It may be driven by a chronic inflammatory environment in which macrophage is involved. Studies have shown that intestinal metaplasia may originate from SPEM, and bile acid-induced chronic inflammation plays an important role in the process of intestinal metaplasia. However, wheth ...
DOI:
10.1016/j.bbrc.2020.01.159

19. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes

Author:
Hina Daikuzono; Masaya Yamazaki; Yoshifumi Sato; Takashi Takahashi; Kazuya Yamagata
Source:
Biochemical and biophysical research communications 2021 v.578 pp. 170-176
ISSN:
0006-291X
Subject:
Western blotting; adults; antigens; blood serum; diagnostic techniques; europium; exosomes; fluorescence; fluorescent antibody technique; research; tyrosine
Abstract:
... Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly expressed in a wide variety of hematological and solid cancers, but is low or absent in adult tissues. Here, we show that ROR1 is released with exosomes from ROR1-positive cancer cells. We also developed a simple dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) to detect cancer-derived ROR1-positive exosomes, which ...
DOI:
10.1016/j.bbrc.2021.08.054

20. Development of exosome surface display technology in living human cells

Author:
Zachary Stickney; Joseph Losacco; Sophie McDevitt; Zhiwen Zhang; Biao Lu
Source:
Biochemical and biophysical research communications 2016 v.472 pp. 53-59
ISSN:
0006-291X
Subject:
cell communication; exosomes; fluorescence; genes; humans; image analysis; monitoring; proteins; secretion; therapeutics; transfection; vaccines
Abstract:
... Surface display technology is an emerging key player in presenting functional proteins for targeted drug delivery and therapy. Although a number of technologies exist, a desirable mammalian surface display system is lacking. Exosomes are extracellular vesicles that facilitate cell–cell communication and can be engineered as nano-shuttles for cell-specific delivery. In this study, we report the dev ...
DOI:
10.1016/j.bbrc.2016.02.058