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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Subject term CD8-positive T-lymphocytes Remove constraint Subject term: CD8-positive T-lymphocytes
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1. IL- 15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

Author:
Elise K. Heon; Hasi Wulan; Loch P. Macdonald; Adel O. Malek; Glenn H. Braunstein; Connie G. Eaves; Mark D. Schattner; Peter M. Allen; Michael O. Alexander; Cynthia A. Hawkins; Dermot W. McGovern; Richard L. Freeman; Eitan P. Amir; Jason D. Huse; Jeffrey S. Zaltzman; Noah P. Kauff; Paul G. Meyers; Michelle H. Gleason; Michael G. Overholtzer; Sam S. Wiseman; Catherine D. Streutker; Sylvia W. Asa; Timothy P. McAlindon; Polly O. Newcomb; Poul M. Sorensen; Oliver A. Press
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 360-366
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; antibodies; apoptosis; breast neoplasms; cell culture; cell proliferation; interferon-gamma; interleukin-10; interleukin-15; interleukin-2; therapeutics
Abstract:
... IL-15 has pivotal roles in the control of CD8+ memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 ...
DOI:
10.1016/j.bbrc.2015.06.162

2. 2B4⁺ CD8⁺ T cells play an inhibitory role against constrained HIV epitopes

Author:
Kim N. Aldy; Nathan C. Horton; Porunelloor A. Mathew; Stephen O. Mathew
Source:
Biochemical and biophysical research communications 2011 v.405 no.3 pp. 503-507
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Human immunodeficiency virus; acquired immunodeficiency syndrome; cytotoxicity; disease course; epitopes; influenza; interferon-gamma; peptides; receptors; secretion; viruses
Abstract:
... Cytotoxic T cells play a critical role in the control of HIV and the progression of infected individuals to AIDS. 2B4 (CD244) is a member of the SLAM family of receptors that regulate lymphocyte development and function. The expression of 2B4 on CD8⁺ T cells was shown to increase during AIDS disease progression. However, the functional role of 2B4⁺ CD8⁺ T cells against HIV infection is not known. ...
DOI:
10.1016/j.bbrc.2011.01.062
PubMed:
21256826
PubMed Central:
PMC3063451

3. IL- 32γ induces chemotaxis of activated T cells via dendritic cell-derived CCL5

Author:
Mi Hye Son; Mi Young Jung; Seulah Choi; Daeho Cho; Tae Sung Kim
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 30-35
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Crohn disease; antibodies; bioactive properties; cell movement; chemokine CCL2; chemokine CCL4; chemokine CCL5; chemotaxis; dose response; immune response; immunomodulators; interleukins; mitogen-activated protein kinase; neutralization; rheumatoid arthritis; transcription factor NF-kappa B; vasculitis
Abstract:
... Interleukin (IL)-32 has been associated with a variety of inflammatory diseases including rheumatoid arthritis, vasculitis and Crohn’s disease. We have previously reported that IL-32γ, the IL-32 isoform with the highest biological activity, could act as an immune modulator through regulation of dendritic cell (DC) functions in immune responses. Cell locomotion is crucial for induction of an effect ...
DOI:
10.1016/j.bbrc.2014.05.052

4. AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes

Author:
Shefalee K. Bhavsar; Katja Merches; Diwakar Bobbala; Florian Lang
Source:
Biochemical and biophysical research communications 2012 v.425 no.1 pp. 6-12
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; alanine; cell death; cell viability; consensus sequence; cytokines; encephalitis; glycogen synthase kinases; lithium; mice; mutants; phosphorylation; serine
Abstract:
... Survival and function of T-lymphocytes critically depends on phosphoinositide (PI) 3 kinase. PI3 kinase signaling includes the PKB/Akt and SGK dependent phosphorylation and thus inhibition of glycogen synthase kinase GSK3α,β. Lithium, a known unspecific GSK3 inhibitor protects against experimental autoimmune encephalomyelitis. The present study explored, whether Akt/SGK-dependent regulation of GSK ...
DOI:
10.1016/j.bbrc.2012.07.030

5. Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria enhances antigen-specific immune responses

Author:
Hiroaki Suzuki; Kenta Jounai; Konomi Ohshio; Toshio Fujii; Daisuke Fujiwara
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1315-1321
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Lactococcus lactis; Toll-like receptor 9; antagonists; antigens; coculture; dendritic cells; humoral immunity; immune response; immunoglobulin G; in vitro studies; lactic acid bacteria; macrophages; major histocompatibility complex; mice; oral administration; viruses
Abstract:
... Lactic acid bacteria (LAB) have been reported to have beneficial effects on protective immunity against viruses and pathogenic bacteria by activating innate immune cells such as dendritic cells (DC) or macrophages. However, little is known about whether LAB contributes to antigen-specific immune responses. Because plasmacytoid DC (pDC) links innate and acquired immunity, here we investigated wheth ...
DOI:
10.1016/j.bbrc.2018.07.042

6. Analysis of T cell receptor repertoire in monozygotic twins concordant and discordant for chronic hepatitis B infection

Author:
Qiong Jiang; Yao Liu; Baoyan Xu; Wenhong Zheng; Xiaomei Xiang; Xiaoqin Tang; Hui Dong; Yongwen Chen; Chenhui Wang; Guohong Deng; Qing Mao; Xiaoyun Shang; Yuzhang Wu
Source:
Biochemical and biophysical research communications 2018 v.497 no.1 pp. 153-159
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; antigens; biomarkers; chronic hepatitis B; genes; high-throughput nucleotide sequencing; immunotherapy; patients; prognosis; seroconversion; twins
Abstract:
... Due to their identical inheritance and shared surroundings, identical twins have been the recommended group for studying the susceptibility and prognosis of diseases. Here, CD8⁺ T cell receptor beta (TCRβ) chains were analyzed by high-throughput sequencing in three pairs of healthy identical twins and chronic hepatitis B patients. The data showed a high level of similarity in the TCR repertoire of ...
DOI:
10.1016/j.bbrc.2018.02.043

7. Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice

Author:
Kaori Noguchi; Naganori Kamiyama; Shinya Hidano; Yoshiko Gendo; Akira Sonoda; Takashi Ozaki; Haruna Hirose; Nozomi Sachi; Benjawan Saechue; Sotaro Ozaka; Yuki Eshita; Kazuhiro Mizukami; Kenji Kawano; Takashi Kobayashi
Source:
Biochemical and biophysical research communications 2018 v.504 no.1 pp. 245-250
ISSN:
0006-291X
Subject:
CCR2 receptor; CCR6 receptor; CD8-positive T-lymphocytes; Toll-like receptors; chemokine CCL2; chemokine CCL20; dendritic cells; innate immunity; interferon-gamma; ligands; mice; salivary glands; secretion
Abstract:
... Sialadenitis is an inflammatory condition affecting the salivary glands including the parotid, submandibular, and sublingual glands. There are several different types of sialadenitis, each with different sites of predilection. However, the pathogenic mechanism underlying the tissue specificity of sialadenitis is largely unknown. TRAF6 is a cytoplasmic adaptor protein that is necessary for the acti ...
DOI:
10.1016/j.bbrc.2018.08.162

8. CD160 expression defines a uniquely exhausted subset of T lymphocytes in HTLV-1 infection

Author:
Chioma Ezinne Chibueze; Makoto Yoshimitsu; Naomichi Arima
Source:
Biochemical and biophysical research communications 2014 v.453 pp. 379-384
ISSN:
0006-291X
Subject:
CCR7 receptor; CD8-positive T-lymphocytes; Primate T-lymphotropic virus 1; adults; carrier state; chronic diseases; cytotoxicity; immune response; ligands; lymphoma; memory; neoplasm cells; viruses
Abstract:
... HTLV-1 infection is a life-long retroviral infection. Chronic viral antigenic stimulation induces persistent infection which results in a clinically asymptomatic carrier state. Only a minor proportion of infected individuals develop adult T cell leukemia/lymphoma (ATLL) or HTLV-1-associated myelopathy/tropical spastic myelopathy (HAM/TSP). This is dependent on a balance of host and genetic factors ...
DOI:
10.1016/j.bbrc.2014.09.084

9. CD4 T cell dependent tumor immunity stimulated by dendritic cell based vaccine

Author:
Sheng Zhang; Wenfeng Li; Zuguang Xia; Yixiang Mao
Source:
Biochemical and biophysical research communications 2011 v.413 no.2 pp. 294-298
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; antigens; autoimmunity; dendritic cells; humans; immunization; interleukin-12; melanoma; mice; models; neoplasm cells; vaccines
Abstract:
... CD8 CTLs have been accountable for the major effector cells responsible for the rejection of tumor cells. And CD40 signaling and IL-12 have been shown to be the essential pathways involved in the activation process. Immunizing mice with dendritic cells transduced with an adenovirus expressing the human melanoma antigen gp100, an immunization strategy of xenoimmunization, stimulated potent tumor pr ...
DOI:
10.1016/j.bbrc.2011.08.089

10. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

11. CD8+ T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype

Author:
Trang Thi Thu Hau; Midori Nakamura-Hoshi; Yoshiaki Kanno; Takushi Nomura; Masako Nishizawa; Sayuri Seki; Hiroshi Ishii; Ai Kawana-Tachikawa; William W. Hall; Lan Anh Nguyen Thi; Tetsuro Matano; Hiroyuki Yamamoto
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 213-217
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Human immunodeficiency virus; Macaca mulatta; Simian immunodeficiency virus; alleles; antigens; haplotypes; major histocompatibility complex; mutation; nucleotide sequences; virus replication
Abstract:
... In human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections, host major histocompatibility complex class I (MHC-I) genotypes have a great impact on viral replication and MHC-I-associated viral genome mutations are selected under CD8+ T-cell pressure. Association of MHC-I genotypes with HIV/SIV control has been investigated at MHC-I allele levels but not fully at haplot ...
DOI:
10.1016/j.bbrc.2019.03.003

12. CD8+CD25+ T cells reduce atherosclerosis in apoE(−/−) mice

Author:
Jianchang Zhou; Paul C. Dimayuga; Xiaoning Zhao; Juliana Yano; Wai Man Lio; Portia Trinidad; Tomoyuki Honjo; Bojan Cercek; Prediman K. Shah; Kuang-Yuh Chyu
Source:
Biochemical and biophysical research communications 2014 v.443 pp. 864-870
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; atherosclerosis; diet; flow cytometry; hypercholesterolemia; mice; phenotype
Abstract:
... It is increasingly evident that CD8+ T cells are involved in atherosclerosis but the specific subtypes have yet to be defined. CD8+CD25+ T cells exert suppressive effects on immune signaling and modulate experimental autoimmune disorders but their role in atherosclerosis remains to be determined. The phenotype and functional role of CD8+CD25+ T cells in experimental atherosclerosis were investigat ...
DOI:
10.1016/j.bbrc.2013.12.057

13. Combined blockade of Tim-3 and MEK inhibitor enhances the efficacy against melanoma

Author:
Yang Liu; Pengcheng Cai; Ning Wang; Qianwen Zhang; Fenghua Chen; Liang Shi; Yang Zhang; Lin Wang; Lihua Hu
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; antineoplastic activity; apoptosis; cell proliferation; immunity; immunotherapy; melanoma; mice; mitogen-activated protein kinase; monoclonal antibodies; patients
Abstract:
... Insights into the role of the mitogen-activated protein kinase (MAPK) pathway and immune checkpoints have led combined targeted therapy and immunotherapy to be a promising regimen. Trametinib, as a mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor, has demonstrated effectiveness in patients with advanced melanoma. T cell immunoglobulin- and mucin-domain-containing molecule-3 ...
DOI:
10.1016/j.bbrc.2017.01.128

14. Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice

Author:
Guangwu Xu; Tameka Smith; Finn Grey; Ann B. Hill
Source:
Biochemical and biophysical research communications 2013 v.437 pp. 287-291
ISSN:
0006-291X
Subject:
antigens; melanoma; antibodies; Murid betaherpesvirus 1; vaccines; Cytomegalovirus; mice; immune response; vaccination; glycoproteins; CD8-positive T-lymphocytes; anticarcinogenic activity
Abstract:
... Cytomegalovirus (CMV) induces strong and long-lasting immune responses, which make it an attractive candidate for a cancer vaccine vector. In this study, we tested whether a tumor antigen expressed in CMV can induce a strong anti-tumor effect. We expressed an unmodified melanoma antigen, mouse tyrosinase-related protein 2 (TRP2), in mouse cytomegalovirus (MCMV). Prophylactic vaccination of the mic ...
DOI:
10.1016/j.bbrc.2013.06.068
PubMed:
23811402
PubMed Central:
PMC3756148

15. Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity

Author:
Chen Yan; Leng Jie; Wang Yongqi; Xiao Weiming; Xi Juqun; Ding Yanbing; Qian Li; Pan Xingyuan; Ji Mingchun; Gong Weijuan
Source:
Biochemical and biophysical research communications 2015 v.463 pp. 336-343
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; chitosan; cytotoxicity; gene fusion; gene transfer; genes; humans; immunity; interleukin-15; intramuscular injection; mice; nanoparticles; neoplasm cells; plasmids; therapeutics; vaccines; zeta potential
Abstract:
... Nanoparticles are becoming promising carriers for gene delivery because of their high capacity in gene loading and low cell cytotoxicity. In this study, a chitosan-based nanoparticle encapsulated within a recombinant pcDNA3.1-dsNKG2D-IL-15 plasmid was generated. The fused dsNKG2D-IL-15 gene fragment consisted of double extracellular domains of NKG2D with IL-15 gene at downstream. The average diame ...
DOI:
10.1016/j.bbrc.2015.05.065

16. Ectopic expression of anti-HIV-1 shRNAs protects CD8+ T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation

Author:
Masakazu Kamata; Patrick Y. Kim; Hwee L. Ng; Gene-Errol E. Ringpis; Emiko Kranz; Joshua Chan; Sean O'Connor; Otto O. Yang; Irvin S.Y. Chen
Source:
Biochemical and biophysical research communications 2015 v.463 pp. 216-221
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; HIV infections; Human immunodeficiency virus 1; antigens; antiviral properties; cell proliferation; chimerism; clinical trials; in vitro studies; monitoring; patients; receptors; viral load
Abstract:
... Chimeric antigen receptors (CARs) are artificially engineered receptors that confer a desired specificity to immune effector T cells. As an HIV-1-specific CAR, CD4ζ CAR has been extensively tested in vitro as well as in clinical trials. T cells modified with this CAR mediated highly potent anti-HIV-1 activities in vitro and were well-tolerated in vivo, but exerted limited effects on viral load and ...
DOI:
10.1016/j.bbrc.2015.05.026
PubMed:
25998390
PubMed Central:
PMC4686265

17. Endogenous IL-33 exerts CD8+ T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model

Author:
Yulong Xia; Tatsukuni Ohno; Naoto Nishii; Arundhati Bhingare; Hidetake Tachinami; Yoshihisa Kashima; Shigenori Nagai; Hirohisa Saito; Susumu Nakae; Miyuki Azuma
Source:
Biochemical and biophysical research communications 2019 v.518 no.2 pp. 331-336
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; chemokines; colorectal neoplasms; dendritic cells; immunotherapy; interleukin-1; models; neutrophils; research
Abstract:
... Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family. IL-33 and its receptor ST2 axis exert conflicting anti-tumor and pro-tumor effects in various tumors. In this study, we examined the role of endogenously produced IL-33 in the colon-26 tumor model, in which involvement of the IL-33:ST2 pathway was negligible on the tumor side. We found that the generation of regulatory T c ...
DOI:
10.1016/j.bbrc.2019.08.058

18. Hierarchy of multiple viral CD8+ T-cell epitope mutations in sequential selection in simian immunodeficiency infection

Author:
Nana Afia Asante Ntim; Hiroshi Ishii; Moe Jomori; Hiroyuki Yamamoto; Tetsuro Matano; Takushi Nomura
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 124-130
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; HIV infections; Simian immunodeficiency virus; disease progression; early selection; epitopes; haplotypes; immunosuppression; major histocompatibility complex; models; mutation; research; virus replication
Abstract:
... CD8⁺ T-cell responses exert strong suppressive pressure on viral replication and select for viral escape mutations in HIV infection. Multiple viral epitopes restricted by major histocompatibility complex class I (MHC-I) are targeted by CD8⁺ T cells. Sequential selection of viral escape mutations in individual epitope-coding regions could result in failure in CD8⁺ T cell-based viral control leading ...
DOI:
10.1016/j.bbrc.2022.03.108

19. IGF-1 resist oxidative damage to HaCaT and depigmentation in mice treated with H2O2

Author:
Cui-ping Guan; Qing-tian Li; Hongyan Jiang; Qing-wei Geng; Wen Xu; Liu-yu Li; A.-E. Xu
Source:
Biochemical and biophysical research communications 2018 v.503 no.4 pp. 2485-2492
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; CXCR3 receptor; chemokine CXCL10; endoplasmic reticulum; hair follicles; hydrogen peroxide; immunosuppression; insulin-like growth factor I; interferon-gamma; interleukin-2; melanocytes; mice; patients; secretion
Abstract:
... Vitiligo, an acquired pigmentary disorder of the skin, is characterized by a chronic and progressive loss of melanocyte from the epidermis and follicular reservoir. Growth factor of surrounding cells impacted on melanocytes survival. In this study, lower level of IGF-1 in the lesion was found than that in the donor area of vitiligo patients. IGF-1 improved activation of Nrf2, and inhibited ROS gen ...
DOI:
10.1016/j.bbrc.2018.07.004

20. Identification of SIV Nef CD8+ T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model

Author:
Takushi Nomura; Hiroyuki Yamamoto; Naofumi Takahashi; Taeko K. Naruse; Akinori Kimura; Tetsuro Matano
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 942-947
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; HIV infections; Human immunodeficiency virus; Macaca; Simian immunodeficiency virus; epitopes; haplotypes; major histocompatibility complex; models; mutation; viral load
Abstract:
... Virus-specific CD8+ T-cell responses are crucial for the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. Multiple studies on HIV-infected individuals and SIV-infected macaques have indicated association of several major histocompatibility complex class I (MHC-I) genotypes with lower viral loads and delayed AIDS progression. Understanding of the vi ...
DOI:
10.1016/j.bbrc.2014.06.072

21. Identification of immunodominant CD8 epitope in the stalk domain of influenza B viral hemagglutinin

Author:
Abenaya Muralidharan; Caroline Gravel; Amparo Duran; Louise Larocque; Changgui Li; Adrian Zetner; Gary Van Domselaar; Lisheng Wang; Xuguang Li
Source:
Biochemical and biophysical research communications 2018 v.502 pp. 226-231
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; binding capacity; cell-mediated immunity; cytotoxicity; hemagglutinins; human diseases; immunodominant epitopes; influenza; interleukin-2; major histocompatibility complex; mice; splenocytes; tumor necrosis factor-alpha; vaccines; viruses
Abstract:
... Human infections by type B influenza virus constitute about 25% of all influenza cases. The viral hemagglutinin is comprised of two subunits, HA1 and HA2. While HA1 is constantly evolving in an unpredictable fashion, the HA2 subunit is highly conserved, making it a potential candidate for a universal vaccine. However, immunodominant epitopes in the HA2 subunit remain largely unknown. To delineate ...
DOI:
10.1016/j.bbrc.2018.05.148

22. Increased angiopoietin-like 4 expression ameliorates inflammatory bowel diseases via suppressing CD8+ T cell activities

Author:
Xiaoyuan Zhang; Jing Tu; Shizhen Ding; Mei Wang; Yanbing Ding; Zhijie Lin; Guotao Lu; Weiming Xiao; Weijuan Gong
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 37-43
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Crohn disease; atherosclerosis; dextran sulfate; macrophages; noninsulin-dependent diabetes mellitus; pathogenesis; protective effect; research; respiratory tract diseases; rheumatoid arthritis; secretion; ulcerative colitis
Abstract:
... Angiopoietin-like 4 (ANGPTL4) is involved in inflammation-associated diseases, such as rheumatoid arthritis, type 2 diabetes, atherosclerosis, and chronic obstructive pulmonary disease. The role of ANGPTL4 in the pathogenesis of inflammatory bowel disease (IBD) remains unknown. Here, the plasma ANGPTL4 levels peaked on days 3 and 5, and expression of ANGPTL4 of inflamed colons peaked on days 5 and ...
DOI:
10.1016/j.bbrc.2022.03.153

23. Increased expression of Tim-3 and its ligand Galectin-9 in rat allografts during acute rejection episodes

Author:
Xinwei Qiao; Ke Jiang; Jun Nie; Kai Fan; Zhikun Zheng; Jianjun Wang; Jinsong Li
Source:
Biochemical and biophysical research communications 2014 v.445 pp. 542-548
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; allografting; animal models; antigens; cytokines; gene expression regulation; graft rejection; histopathology; immunoglobulins; immunologic techniques; messenger RNA; mucins; pathogenesis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction
Abstract:
... The aim of the study is to elucidate the profiles of T-cell immunoglobulin and mucin domain-3 (Tim-3) and its ligand Galecin-9 in acute pulmonary rejection by using a rat model of lung transplantation. Left lung grafts retrieved from Lewis or Fisher 344 rats were orthotopically transplanted into Lewis recipients without any immunosuppressions; the grafts were harvested at day 3, 7 or 10 after tran ...
DOI:
10.1016/j.bbrc.2014.01.167

24. Induction of CD8 T cell cytotoxicity by fecal bacteria from healthy individuals and colorectal cancer patients

Author:
Yanli Lu; Linlin Wang; Jian Zhang; Jun Li; Guohua Wan
Source:
Biochemical and biophysical research communications 2019 v.516 no.3 pp. 1007-1012
ISSN:
0006-291X
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; antigen-presenting cells; colorectal neoplasms; cytotoxicity; epithelium; fecal bacteria; humans; immune response; inducible nitric oxide synthase; metabolites; monocytes; patients; viability
Abstract:
... Commensal microbiota modulates the anti-tumor immune response and alters the tumor infiltration of T cells in numerous human malignancies. Moreover, the existence of commensals and microbial metabolites has been directly observed inside numerous epithelial tumors. Their effects on the host immune system, independent of the pre-existing malignancy, are not completely understood. To resolve this iss ...
DOI:
10.1016/j.bbrc.2019.06.078

25. Intratumoral injection of IFN-β induces chemokine production in melanoma and augments the therapeutic efficacy of anti-PD-L1 mAb

Author:
Jiro Uehara; Takayuki Ohkuri; Akemi Kosaka; Kei Ishibashi; Yui Hirata; Kenzo Ohara; Toshihiro Nagato; Kensuke Oikawa; Naoko Aoki; Yasuaki Harabuchi; Akemi Ishida-Yamamoto; Hiroya Kobayashi
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; CXCR3 receptor; animal models; antineoplastic activity; chemokine CCL5; immunomodulators; in vivo studies; interferon-beta; ligands; melanoma; patients; therapeutics; tissues
Abstract:
... Despite recent advances in treatment for melanoma patients through using immune checkpoint inhibitors, these monotherapies have limitations and additional treatments have been explored. Type I IFNs have been used to treat melanoma and possess immunomodulatory effects including enhancement of T-cell infiltration. T-cell plays a critical role in immune checkpoint therapies via restoration of effecto ...
DOI:
10.1016/j.bbrc.2017.06.072

26. MicroRNA-140 suppresses osteosarcoma tumor growth by enhancing anti-tumor immune response and blocking mTOR signaling

Author:
Xianglu Ji; Enbo Wang; Feng Tian
Source:
Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1342-1348
ISSN:
0006-291X
Subject:
3' untranslated regions; CD8-positive T-lymphocytes; antineoplastic activity; cytotoxicity; gene expression; humans; immune response; immunotherapy; luciferase; mice; microRNA; osteosarcoma; translation (genetics)
Abstract:
... Immune checkpoint blockade is proved to be a promising therapeutic strategy against several human malignancies. MicroRNAs (miRNAs) are ∼22 nucleotide RNAs that play important roles in regulating gene expression, either suppressing its translation or speeding up its degradation. In this study, we demonstrated that miR-140 acts as a critical modulator of PD-L1 and is significantly reduced in osteosa ...
DOI:
10.1016/j.bbrc.2017.11.120

27. Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

Author:
Deok Rim Heo; Sung Jae Shin; Woo Sik Kim; Kyung Tae Noh; Jin Wook Park; Kwang Hee Son; Won Sun Park; Min-Goo Lee; Daejin Kim; Yong Kyoo Shin; In Duk Jung; Yeong-Min Park
Source:
Biochemical and biophysical research communications 2011 v.411 no.3 pp. 642-647
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Mycobacterium tuberculosis; adaptive immunity; dendritic cells; disease course; genes; immune response; interferon-gamma; mitogen-activated protein kinase; morbidity; mortality; signal transduction; tuberculosis
Abstract:
... Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, R ...
DOI:
10.1016/j.bbrc.2011.07.013

28. Natural CD8+25+ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma

Author:
Yufeng Xie; Xueshu Zhang; Tuo Zhao; Wei Li; Jim Xiang
Source:
Biochemical and biophysical research communications 2013 v.438 pp. 152-155
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Western blotting; antibodies; autoimmune diseases; cytotoxicity; electron microscopy; exosomes; flow cytometry; immunity; immunotherapy; melanoma; mice; ovalbumin; ultracentrifugation
Abstract:
... Natural CD4+25+ and CD8+25+ regulatory T (Tr) cells have been shown to inhibit autoimmune diseases. Immune cells secrete exosomes (EXOs), which are crucial for immune regulation. However, immunomodulatory effect of natural Tr cell-secreted EXOs is unknown. In this study, we purified natural CD8+25+ Tr cells from C57BL/6 mouse naive CD8+ T cells, and in vitro amplified them with CD3/CD28 beads. EXO ...
DOI:
10.1016/j.bbrc.2013.07.044

29. Osteopontin attenuates acute gastrointestinal graft-versus-host disease by preventing apoptosis of intestinal epithelial cells

Author:
Kentaro Kawakami; Naoki Minami; Minoru Matsuura; Tomoya Iida; Takahiko Toyonaga; Kanna Nagaishi; Yoshiaki Arimura; Mineko Fujimiya; Toshimitsu Uede; Hiroshi Nakase
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; allografting; apoptosis; cell transplantation; cell viability; colon; flow cytometry; fluorescence; gene expression; hematopoietic stem cells; immune response; interferon-gamma; interleukin-17; interleukin-18; intestinal mucosa; irradiation; ligands; mice; necrosis; osteopontin; pathogenicity; small intestine; splenocytes; tumor necrosis factor-alpha
Abstract:
... Acute graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation, which often targets gastrointestinal (GI) tract. Osteopontin (OPN) plays an important physiological role in the efficient development of Th1 immune responses and cell survival by inhibiting apoptosis. The role of OPN in acute GI-GVHD is poorly understood. In the present study, w ...
DOI:
10.1016/j.bbrc.2017.02.047

30. Over-expression of Stat5b confers protection against diabetes in the non-obese diabetic (NOD) mice via up-regulation of CD4⁺CD25⁺ regulatory T cells

Author:
Yulan Jin; Sharad Purohit; Xueqin Chen; Bing Yi; Jin-Xiong She
Source:
Biochemical and biophysical research communications 2012 v.424 no.4 pp. 669-674
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; diabetes; gene expression regulation; genetically modified organisms; interferon-gamma; interleukin-10; interleukin-2; lymph nodes; mice; mutation; proteins; signal transduction; splenocytes; transgenes; tumor necrosis factor-alpha
Abstract:
... The signal transducers and activators of transcription (STAT) family of proteins play a critical role in cytokine signaling required for fine tuning of immune regulation. Previous reports showed that a mutation (L327M) in the Stat5b protein leads to aberrant cytokine signaling in the NOD mice. To further elaborate the role of Stat5b in diabetes, we established a NOD transgenic mouse that over-expr ...
DOI:
10.1016/j.bbrc.2012.06.162
PubMed:
22789848
PubMed Central:
PMC3990414

31. The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1−/− murine model of ovarian cancer

Author:
Jing Huang; Lei Wang; Zhongyi Cong; Zohreh Amoozgar; Evgeny Kiner; Deyin Xing; Sandra Orsulic; Ursula Matulonis; Michael S. Goldberg
Source:
Biochemical and biophysical research communications 2015 v.463 pp. 551-556
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; adjuvants; animal models; animal ovaries; antineoplastic activity; apoptosis; epithelium; homologous recombination; immunotherapy; interferon-gamma; mice; mutation; natural killer cells; neoplasm cells; ovarian neoplasms; patients; ribose; tumor necrosis factor-alpha; tumor suppressor proteins
Abstract:
... Familial breast and ovarian cancer are often caused by inherited mutations of BRCA1. While current prognoses for such patients are rather poor, inhibition of poly-ADP ribose polymerase 1 (PARP1) induces synthetic lethality in cells that are defective in homologous recombination. BMN 673 is a potent PARP1 inhibitor that is being clinically evaluated for treatment of BRCA-mutant cancers. Using the B ...
DOI:
10.1016/j.bbrc.2015.05.083

32. Polymorphism of stromal cell-derived factor-1 selectively upregulates gene expression and is associated with increased susceptibility to coronary artery disease

Author:
Xiao-Long Gu; Na Ma; Ding-Cheng Xiang; Jun Huang; Zheng-Hua Dong; Hui-Yan Lei; Ru Ding; Zhi-Hua Gong; Yan-Fei Wen; Jian Qiu; Lan Ma
Source:
Biochemical and biophysical research communications 2014 v.443 pp. 932-937
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; alleles; chemokine CXCL12; confidence interval; coronary artery disease; gene expression; gene expression regulation; genotype; hematopoiesis; messenger RNA; monocytes; myocardial infarction; odds ratio; patients; risk factors
Abstract:
... Stromal cell-derived factor-1 (SDF-1) plays critical roles in vascular development and hematopoiesis. Here, we investigated the function of SDF-1 rs1801157G/A polymorphism in various immune cells and examined its association with susceptibility to coronary artery disease (CAD). Protein and mRNA levels of SDF-1 were tested in peripheral CD4+ T cell, CD8+ T cells, monocytes, and natural killer (NK) ...
DOI:
10.1016/j.bbrc.2013.12.065

33. Prognostic significance and functional implication of immune activating receptor NKG2D in gastric cancer

Author:
Fengjuan Lin; Congqi Dai; Xiaoxiao Ge; Wenbo Tang; Ying Lin; Yan Wang; Jin Li
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 619-624
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; immune evasion; ligands; messenger RNA; neoplasm cells; patients; prognosis; quantitative polymerase chain reaction; regression analysis; risk reduction; stomach neoplasms; tissues; China
Abstract:
... NKG2D, an activating receptor expressed on CD8+ T lymphocytes, serves as a co-stimulation molecule by engagement with its ligands MICA/B and ULBPs to trigger immune activation against tumors. Currently, the biological function and clinical significance of NKG2D in gastric cancer remains unexplored. The study aims to investigate the expression of NKG2D in gastric cancer in association with clinical ...
DOI:
10.1016/j.bbrc.2017.04.104

34. Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase

Author:
Kyung Tae Noh; Seung Hoon Chae; Sung Hak Chun; In Duk Jung; Hyun Kyu Kang; Yeong-Min Park
Source:
Biochemical and biophysical research communications 2013 v.431 pp. 348-353
ISSN:
0006-291X
Subject:
non-specific protein-tyrosine kinase; immunosuppression; cytotoxicity; dendritic cells; interferon-gamma; signal transduction; mice; protein kinase C; indoleamine 2,3-dioxygenase; immune response; thymoma; resveratrol; CD8-positive T-lymphocytes; anticarcinogenic activity
Abstract:
... This study showed the potential of resveratrol to inhibit the expression and activity of interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase Cδ (PKCδ). In addition, resveratrol-media ...
DOI:
10.1016/j.bbrc.2012.12.093

35. Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer

Author:
Kazuhisa Tanaka; Yuri Kanesaka; Mariko Takami; Akane Suzuki; Hiroyuki Hosokawa; Atsushi Onodera; Toshiko Kamata; Kaoru Nagato; Toshinori Nakayama; Ichiro Yoshino; Shinichiro Motohashi
Source:
Biochemical and biophysical research communications 2018 v.506 no.1 pp. 27-32
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; alcohol oxidoreductases; antigens; antineoplastic activity; biomarkers; clinical trials; dendritic cells; glycolipids; immunotherapy; interferon-gamma; lung neoplasms; messenger RNA; patients; prostaglandins
Abstract:
... Invariant natural killer T (iNKT) cells exhibit potent antitumor effects upon activation by recognizing a specific glycolipid antigen. We previously performed phase I–II clinical studies to utilize iNKT cells using α-galactosylceramide-pulsed dendritic cells and identified leukotriene B4 12-hydroxydehydrogenase (LTB4DH) as a biomarker highly expressed in T cells derived from non-small cell lung ca ...
DOI:
10.1016/j.bbrc.2018.10.048

36. Site-specific regulation of oral mucosa-recruiting CD8+ T cells in a mouse contact allergy model

Author:
Worawalun Hirunwidchayarat; Emi Furusawa; Siwen Kang; Tatsukuni Ohno; Shunsuke Takeuchi; Sorasun Rungsiyanont; Miyuki Azuma
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; allergens; delayed hypersensitivity; ears; immunopathology; inflammation; interferon-gamma; ligands; mice; models; mucosa
Abstract:
... Contact allergy is a T cell-mediated, delayed-type hypersensitivity generated by contact exposure of an allergen to the skin and mucosal surface. The clinical manifestations of allergic responses between the skin and oral mucosa vary and the differences in immunopathology have not been clarified. We generated hapten-induced contact hypersensitivity (CH) of the buccal mucosa (BM) in parallel studie ...
DOI:
10.1016/j.bbrc.2017.07.012

37. TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells

Author:
N.A. Eustache Oussa; Youssouf Soumounou; Laurent Sabbagh
Source:
Biochemical and biophysical research communications 2013 v.432 pp. 129-134
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; IKappaB kinase; alanine; mutants; phosphorylation; proteomics; receptors; serine; signal transduction; transcription factor NF-kappa B; tumor necrosis factors
Abstract:
... The Tumour Necrosis Factor (TNF) Receptor-associated factor-1 (TRAF1) adaptor protein is a key component in initiating intracellular signalling pathways downstream of TNF receptors (TNFR). More importantly, TRAF1 has a pattern of expression restricted primarily to lymphoid cells and plays an important role in lymphocyte survival. TRAF1 has been shown to be phosphorylated on Serine 139, consequentl ...
DOI:
10.1016/j.bbrc.2013.01.073

38. Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

Author:
Xi Chen; Jin Xu; Qingcheng Guo; Lingfei Wang; Yun Yang; Huaizu Guo; Nana Gu; Dapeng Zhang; Weizhu Qian; Sheng Hou; Jing Li; Jianxin Dai; Yajun Guo; Hao Wang
Source:
Biochemical and biophysical research communications 2016 v.480 pp. 160-165
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal models; antibodies; colorectal neoplasms; interleukin-2; metastasis; mice; remission; splenocytes
Abstract:
... Immunocytokines (antibody-cytokine fusions) have been proved to be a promising class of therapeutic agents for tumors. Anti-PD-L1 antibodies or IL-2 have been used to treat a variety of cancers. Here, in order to remove T cell inhibition and increasing the IL-2 concentration in the tumor microenvironment, we engineered a novel anti-PD-L1 antibody based immunocytokine by fusing hIL-2 to the C-Term ...
DOI:
10.1016/j.bbrc.2016.10.011

39. Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1

Author:
Chao Yuan; Yisheng Zheng; Bo Zhang; LiJuan Shao; Yang Liu; Tian Tian; XiaoBin Gu; Xiangnan Li; KeXing Fan
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 249-255
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; arginase; immunosuppression; immunotherapy; lung neoplasms; models; suppressor cells; thymosin
Abstract:
... Thymosin α1 (Tα1) has been tested for cancer therapy for several years, in most cases, the anti-tumor effect of Tα1 was limited, especially when Tα1 was used as a single agent. The role of Tα1 in cancer treatment and the regulatory mechanisms by which Ta1 takes effects are not yet completely understood. Using a Lewis lung caner model, here we report that Tα1 used alone elevated CD8+ T cells, but f ...
DOI:
10.1016/j.bbrc.2015.06.132

40. Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity

Author:
Akemi Kosaka; Takayuki Ohkuri; Maki Ikeura; Gary Kohanbash; Hideho Okada
Source:
Biochemical and biophysical research communications 2015 v.458 pp. 549-554
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; antigens; chimerism; cytotoxicity; engineering; genetically modified organisms; humans; immune response; immunotherapy; interferon-gamma; mice; microRNA; neoplasms; phenotype; transforming growth factor beta 1; transgenes
Abstract:
... MicroRNAs (miRs) play important roles in regulation of a variety of cell functions, including immune responses. We have previously demonstrated that miR-17-92 expression in T-cells enhances Th1 phenotype and provides a long-term protection against glioblastoma when co-expressed as a transgene in T-cells along with a chimeric antigen receptor. To further elucidate the function of miR-17-92 in tumor ...
DOI:
10.1016/j.bbrc.2015.02.003
PubMed:
25677619
PubMed Central:
PMC4355048

41. Tumor-promoting effect of IL-23 in mammary cancer mediated by infiltration of M2 macrophages and neutrophils in tumor microenvironment

Author:
Wen Nie; Ting Yu; Yaxiong Sang; Xiang Gao
Source:
Biochemical and biophysical research communications 2017 v.482 pp. 1400-1406
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; angiogenesis; autoimmune diseases; carcinogenesis; immune response; immunosuppression; inflammation; interleukin-10; interleukin-23; macrophages; metalloproteinases; metastasis; monitoring; neoplasm cells; neoplasms; neutrophils; tissues; transforming growth factor beta; vascular endothelial growth factors
Abstract:
... Interleukin 23 (IL-23) is an inflammatory cytokine which plays a vital role in autoimmune diseases as well as in tumorigenesis. However, the role of IL-23 in tumor procession is still controversial and the underlying mechanism remains unclear. Here we established a stable cell line overexpressing IL-23 to prove that IL-23 promoted tumor growth and pulmonary metastasis through induction of tumor-re ...
DOI:
10.1016/j.bbrc.2016.12.048

42. Type-I IFN signaling is required for the induction of antigen-specific CD8⁺ T cell responses by adenovirus vector vaccine in the gut-mucosa

Author:
Masaki Shoji; Masashi Tachibana; Kazufumi Katayama; Kyoko Tomita; Sayaka Tsuzuki; Fuminori Sakurai; Kenji Kawabata; Ken J. Ishii; Shizuo Akira; Hiroyuki Mizuguchi
Source:
Biochemical and biophysical research communications 2012 v.425 no.1 pp. 89-93
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; gene expression; lymph nodes; messenger RNA; mucosa; vaccination; vaccines
Abstract:
... Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8⁺ T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8⁺ T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal d ...
DOI:
10.1016/j.bbrc.2012.07.056

43. VSIG4/CRIg directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window

Author:
Amrita Widyagarini; Naoto Nishii; Yohei Kawano; Chenyang Zhang; Miyuki Azuma
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 100-106
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; homeostasis; ligands; phenotype; research
Abstract:
... T-cell responses are fine-tuned by positive and negative co-signal molecules expressed on immune cells and adjacent tissues. VSIG4 is a newly identified member of the B7 family of ligands, which negatively regulates innate inflammatory and CD4⁺ T cell-mediated responses. However, little is known about the direct effects of VSIG4, which are exerted through an unidentified counter-receptor on CD8⁺ T ...
DOI:
10.1016/j.bbrc.2022.04.120

44. A bioluminescence reporter mouse strain for in vivo imaging of CD8+ T cell localization and function

Author:
Yang Guo; Bingyin Wang; Yanjuan Chen; Min Liang; Haijie Wang; Chengji Wang; Hanwen Liang; Yu Zhou; Jun Xi; Lei Ci; Ruilin Sun; Jian Fei; Ruling Shen
Source:
Biochemical and biophysical research communications 2021 v.581 pp. 12-19
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; adaptive immunity; bioluminescence; genome; luciferase; mice; research
Abstract:
... CD8⁺ T cells play a critical role during adaptive immune response, which often change locations and expand or contract in numbers under different states. In the past, many attempts to develop CD8⁺T cells that express luciferase in vivo have involved the use of viral transduction, which has drawbacks of hardly tracked via detection of luciferase signal in untouched natural states. Here, we generate ...
DOI:
10.1016/j.bbrc.2021.10.022

45. A novel MtHSP70-FPR1 fusion protein enhances cytotoxic T lymphocyte responses to cervical cancer cells by activating human monocyte-derived dendritic cells via the p38 MAPK signaling pathway

Author:
Meizhu Xiao; Ying Feng; Guangming Cao; Chongdong Liu; Zhenyu Zhang
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 2108-2116
ISSN:
0006-291X
Subject:
CCR7 receptor; CD8-positive T-lymphocytes; Mycobacterium tuberculosis; Western blotting; antibodies; cell proliferation; cytotoxicity; dendritic cells; enzyme-linked immunosorbent assay; flow cytometry; heat-shock protein 70; humans; immunotherapy; interleukin-12; interleukin-1beta; microbeads; mitogen-activated protein kinase; monocytes; neoplasm cells; peptide receptors; phosphates; protein synthesis; signal transduction; thymidine; umbilical cord; uterine cervical neoplasms
Abstract:
... To evaluate the potential effects of recombinant mycobacterium tuberculosis heat shock protein 70-formyl peptide receptor 1 (MtHSP70-FPR1) fusion protein on human monocyte-derived dendritic cell (moDC) maturation; cytotoxic T lymphocyte (CTL) responses to cervical cancer (CC) cells; and the roles of the p38 MAPK, ERK, and JNK pathways in its transition.Monocytes were positively selected with a MAC ...
DOI:
10.1016/j.bbrc.2018.07.167

46. A strategy of targeting B10 cell by CD19scFv-IL10R for tumor therapy

Author:
Rong Zhao; Min Liu; Xin Li; Hanyu Chen; Jiahui Deng; Chun Huang; Xiao-lian Zhang; Qin Pan
Source:
Biochemical and biophysical research communications 2018 v.506 no.4 pp. 990-996
ISSN:
0006-291X
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; cytotoxicity; genes; hepatoma; immune response; immunosuppression; interleukin-10; mice; plasmids; prognosis; therapeutics
Abstract:
... IL-10 producing B (B10) cells, a subset of regulatory B (Breg) cells, produce IL-10 and play immunosuppressive roles in antitumor immunity. B10 cells are associated with enhanced tumor-aggressiveness and a poorer prognosis. To specifically inhibit the IL-10 secreted by B cells, we constructed the recombinant plasmid pcCD19scFv-IL10R, which contained the gene of anti-CD19 single-chain variable frag ...
DOI:
10.1016/j.bbrc.2018.10.191