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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Subject term humans Remove constraint Subject term: humans Subject term infectious diseases Remove constraint Subject term: infectious diseases
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1. Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans

Author:
Bomi Hwang; Jaeyong Cho; In-sok Hwang; Hong-Guang Jin; Eun-Rhan Woo; Dong Gun Lee
Source:
Biochemical and biophysical research communications 2011 v.410 no.3 pp. 489-493
ISSN:
0006-291X
Subject:
Candida albicans; Sambucus; antifungal properties; erythrocytes; flow cytometry; fluorescence; fungi; humans; infectious diseases; iodides; lipid bilayers; mechanism of action; medicinal plants; medicinal properties; plasma membrane; propidium
Abstract:
... Lariciresinol is an enterolignan precursor isolated from the herb Sambucus williamsii, a folk medicinal plant used for its therapeutic properties. In this study, the antifungal properties and mode of action of lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To under ...
DOI:
10.1016/j.bbrc.2011.06.004

2. Cysteine-rich secretory protein 3 inhibits hepatitis C virus at the initial phase of infection

Author:
Uk Lee; Young Ran Nam; Jung Sook Ye; Kyoung Jin Lee; Nari Kim; Chul Hyun Joo
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 1076-1082
ISSN:
0006-291X
Subject:
Hepatitis C virus; acute course; chronic hepatitis; culture media; exocrine glands; gene expression regulation; genes; glycoproteins; hepatoma; humans; infectious diseases; liver cirrhosis; messenger RNA; mice; microarray technology; virus replication
Abstract:
... Hepatitis C virus (HCV) affects 2–3% of the global population. Approximately one-quarter of acute infections cause chronic hepatitis that leads to liver cirrhosis or hepatocellular carcinoma. The major obstacle of current research is the extremely narrow host tropism of HCV. A single HCV strain can replicate in the Huh7 human hepatoma cell line. Huh7 cells can be adapted under selective pressure i ...
DOI:
10.1016/j.bbrc.2014.06.106

3. A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells

Author:
Hiroshi Hamana; Kiyomi Shitaoka; Hiroyuki Kishi; Tatsuhiko Ozawa; Atsushi Muraguchi
Source:
Biochemical and biophysical research communications 2016 v.474 pp. 709-714
ISSN:
0006-291X
Subject:
gene therapy; infectious diseases; complementary DNA; T-lymphocytes; antigens; humans; neoplasms; immunotherapy; luciferase; reverse transcriptase polymerase chain reaction; transcription (genetics); mice; signal peptide; receptors; Human gammaherpesvirus 4
Abstract:
... T-cell receptor (TCR) gene therapy is a promising approach for the treatment of infectious diseases and cancers. However, the paired cloning and functional assays of antigen-specific TCRα and TCRβ is time-consuming and laborious. In this study, we developed a novel, rapid and efficient antigen-specific TCR-cloning system by combining three technologies: multiplex one-step RT-PCR, transcriptionally ...
DOI:
10.1016/j.bbrc.2016.05.015

4. Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections

Author:
Chun Wu; Gang Xu; Shang-Yi A. Tsai; William J. Freed; Chun-Ting Lee
Source:
Biochemical and biophysical research communications 2017 v.482 pp. 282-288
ISSN:
0006-291X
Subject:
amino acid metabolism; apoptosis; databases; energy; gene expression; gene expression regulation; gene regulatory networks; genes; humans; infectious diseases; insulin; insulin resistance; muscles; noninsulin-dependent diabetes mellitus; oxidative phosphorylation; pathogenesis; patients; skeletal muscle; transcription (genetics); transcriptome
Abstract:
... Skeletal muscle insulin resistance is considered to be the primary defect involved in type 2 diabetes mellitus (T2DM). Despite transcriptome studies in limited T2DM human subjects suggesting an association of T2DM with impaired oxidative phosphorylation in muscle, its molecular pathogenesis remains largely unknown. To identify dysregulated genes and gene networks that are associated with T2DM in h ...
DOI:
10.1016/j.bbrc.2016.11.055

5. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

6. Discovery of Leishmania donovani topoisomerase IB selective inhibitors by targeting protein-protein interactions between the large and small subunits

Author:
Hyeryon Lee; Kyung-Hwa Baek; Trong-Nhat Phan; I Seul Park; Sangchul Lee; Jiho Kim; Joo Hwan No
Source:
Biochemical and biophysical research communications 2021 v.569 pp. 193-198
ISSN:
0006-291X
Subject:
DNA topoisomerase; Leishmania donovani; antileishmanial properties; catalytic activity; drugs; enzyme activity; humans; infectious diseases; protein-protein interactions; research; synthetic peptides; therapeutics; toxicity; visceral leishmaniasis
Abstract:
... Visceral leishmaniasis (VL) is a fatal infectious disease caused by viscerotropic parasitic species of Leishmania. Current treatment options are often ineffective and toxic, and more importantly, there are no clinically validated drug targets available to develop next generation therapeutics against VL. Topoisomerase IB (TopIB) is an essential enzyme for Leishmania survival. The enzyme is organize ...
DOI:
10.1016/j.bbrc.2021.07.019