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Chinese journal of natural medicines
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- Author:
- Hong-Gang WANG; Fu-Kang LUO; Xiang LEI; Yun-Da YAO; Guo-Chao LIAO; Zhong-Qiu LIU; Zhi-Hong JIANG; Hua ZHOU; Peng WU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.9 pp. 707-712
- ISSN:
- 1875-5364
- Subject:
- Callicarpa nudiflora; Oriental traditional medicine; anti-inflammatory activity; dexamethasone; diterpenoids; leaves; nitric oxide; spectral analysis
- Abstract:
- ... Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudif ...
- DOI:
- 10.1016/S1875-5364(19)30085-8
- https://doi.org/10.1016/S1875-5364(19)30085-8
- Author:
- Run-Jia XU; Shuo-Han FEI; Lin-Yan CHEN; Gan WANG; Ming LIU; Wen-Sheng ZHANG; Xiu-Wen YAN; Ren LAI; Chuan-Bin SHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.6 pp. 413-423
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; analgesia; analgesic effect; daidzein; dietary supplements; drugs; genistein; heat; hypersensitivity; inhibitory concentration 50; mice; neurons; pain; sodium channels; soybean products
- Abstract:
- ... Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains unclear. Voltage-gated sodium channels (VGSCs) play important roles in excitability of pain sensing neurons and many of them are important nociceptors. Here, we ...
- DOI:
- 10.1016/S1875-5364(19)30049-4
- https://doi.org/10.1016/S1875-5364(19)30049-4
- Author:
- Li-Li FENG; Li-Sha XU; Meng-Meng GUO; Wei HUANG; Jia-Zhen ZHU; Ling-Dong KONG; Xu-Dong WU; Qiang XU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.5 pp. 363-371
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; anti-inflammatory activity; flavonoids; gene expression regulation; in vivo studies; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; lungs; macrophages; messenger RNA; mice; phenotype; protective effect; protein content; sepsis (infection); signal transduction; survival rate; toxicity; transcription factors; tumor necrosis factor-alpha
- Abstract:
- ... Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2’, 4’, 5’-pentamethoxyflavanone (abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious ...
- DOI:
- 10.1016/S1875-5364(19)30042-1
- https://doi.org/10.1016/S1875-5364(19)30042-1
- Author:
- Ji-Chao ZHOU; Xiao-Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.11 pp. 835-841
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Verrucomicrobia; bacteria; drugs; feces; humans; intestinal microorganisms; intestines; metabolic diseases; metabolic syndrome; metabolism; metagenomics; mucins; probiotics; therapeutics
- Abstract:
- ... The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metageno ...
- DOI:
- 10.1016/S1875-5364(19)30101-3
- https://doi.org/10.1016/S1875-5364(19)30101-3
- Author:
- Xin-Ya XU; Dong-Ying WANG; Chuen-Fai KU; Yang ZHAO; Han CHENG; Kang-Lun LIU; Li-Jun RONG; Hong-Jie ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 945-952
- ISSN:
- 1875-5364
- Subject:
- Human immunodeficiency virus 1; Justicia procumbens; Oriental traditional medicine; acetates; antiretroviral properties; chemical structure; cytotoxicity; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5 ...
- DOI:
- 10.1016/S1875-5364(19)30117-7
- https://doi.org/10.1016/S1875-5364(19)30117-7
- Author:
- Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
- Abstract:
- ... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
- DOI:
- 10.1016/S1875-5364(19)30008-1
- https://doi.org/10.1016/S1875-5364(19)30008-1
- Author:
- Wei WANG; Qing-Bin LIU; Wei JING
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 252-263
- ISSN:
- 1875-5364
- Subject:
- Astragalus membranaceus; Oriental traditional medicine; asthma; blood serum; childhood; children; density gradient centrifugation; flow cytometry; formononetin; genistein; high performance liquid chromatography; immunoglobulin E; interleukin-17; interleukin-23; isoquercitrin; isorhamnetin; kaempferol; lung function; mononuclear leukocytes; quercetin; remission; swine; therapeutics; transforming growth factor beta
- Abstract:
- ... Astragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two combination group (control group, the combination of budesonide and terbutaline) and A. membranaceus group (treatment group, the combination of budesonide, terbutal ...
- DOI:
- 10.1016/S1875-5364(19)30029-9
- https://doi.org/10.1016/S1875-5364(19)30029-9
- Author:
- Hao HAN; Zhi-Kai GUO; Bo ZHANG; Mei ZHANG; Jing SHI; Wei LI; Rui-Hua JIAO; Ren-Xiang TAN; Hui-Ming GE
- Source:
- Chinese journal of natural medicines 2019 v.17 no.6 pp. 475-480
- ISSN:
- 1875-5364
- Subject:
- Micrococcus luteus; Oriental traditional medicine; Streptomyces; X-ray diffraction; acetylcholinesterase; antimicrobial properties; biochemical pathways; culture media; multigene family; nuclear magnetic resonance spectroscopy; phenazines; spectral analysis
- Abstract:
- ... Three new phenazine-type compounds, named phenazines SA—SC (1—3), together with four new natural products (4—7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and an ...
- DOI:
- 10.1016/S1875-5364(19)30055-X
- https://doi.org/10.1016/S1875-5364(19)30055-X
- Author:
- Meng-Ting LIU; Yan HE; Ling SHEN; Zheng-Xi HU; Yong-Hui ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 935-944
- ISSN:
- 1875-5364
- Subject:
- Bipolaris; Enterococcus faecalis; Oriental traditional medicine; X-ray diffraction; antimicrobial properties; circular dichroism spectroscopy; fungi; moieties; spectral analysis
- Abstract:
- ... Bipolarins A–H (1–8), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and 13C NMR calculations. Additionally, ...
- DOI:
- 10.1016/S1875-5364(19)30116-5
- https://doi.org/10.1016/S1875-5364(19)30116-5
- Author:
- Shao-Peng HUANG; Xin GUAN; Guo-Yin KAI; Ya-Zhou XU; Yuan XU; Hao-Jie WANG; Tao PANG; Lu-Yong ZHANG; Ying LIU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.5 pp. 372-380
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; anti-inflammatory activity; atherosclerosis; drugs; inducible nitric oxide synthase; inflammation; interleukin-10; interleukin-1beta; interleukin-6; macrophages; mitogen-activated protein kinase; non-specific protein-tyrosine kinase; phosphorylation; rheumatoid arthritis; signal transduction; transactivators; tumor necrosis factor-alpha
- Abstract:
- ... Macrophages play an important role in inflammation, and excessive and chronic activation of macrophages leads to systemic inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In this paper, we explored the anti-inflammatory effect of broussonin E, a novel phenolic compound isolated from the barks ofBroussonetia kanzinoki, and its underlying molecular mechanisms. We discovered t ...
- DOI:
- 10.1016/S1875-5364(19)30043-3
- https://doi.org/10.1016/S1875-5364(19)30043-3
- Author:
- Zhen-Zhen LIU; Hong-Bo WENG; Li-Jie ZHANG; Ling-Yu PAN; Wei SUN; Hai-Xia CHEN; Mei-Yu CHEN; Tao ZENG; Yun-Yi ZHANG; Dao-Feng CHEN; Hong LI
- Source:
- Chinese journal of natural medicines 2019 v.17 no.9 pp. 641-649
- ISSN:
- 1875-5364
- Subject:
- Bupleurum; Oriental traditional medicine; Toll-like receptor 4; actin; albumins; animal disease models; blood serum; collagen; creatinine; diabetes; excretion; fibronectins; fibrosis; inflammation; interleukin-6; kidney diseases; kidneys; mice; muscles; necrosis; neoplasms; nucleoproteins; oral administration; polysaccharides; renal function; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Bupleurum polysaccharides (BPs) is isolated from Bupleurum smithii var. parvifolium, a key traditional Chinese medicine. The study was to investigate the effects of BPs on diabetic kidney injury. After two intraperitoneal injections of streptozotozin (STZ) 100 mg·kg−1, renal injury in diabetic mice was induced and BPs was orally administrated at dosages of 30 and 60 mg·kg−1·d−1. The STZ injected m ...
- DOI:
- 10.1016/S1875-5364(19)30078-0
- https://doi.org/10.1016/S1875-5364(19)30078-0
12. Cangumycins A–F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces
- Author:
- Lei WANG; Li WANG; Zhi ZHOU; Yong-Jiang WANG; Jian-Ping HUANG; Ya-Tuan MA; Yang LIU; Sheng-Xiong HUANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 982-987
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Streptomyces; T-lymphocytes; X-ray diffraction; cell proliferation; culture media; humans; immunosuppression; inhibitory concentration 50; spectral analysis
- Abstract:
- ... Cangumycins A–F (1–6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B ...
- DOI:
- 10.1016/S1875-5364(19)30121-9
- https://doi.org/10.1016/S1875-5364(19)30121-9
- Author:
- Qi CHEN; Ke-Xin ZHANG; Tai-Yuan LI; Xuan-Mei PIAO; Mei-Lan LIAN; Ren-Bo AN; Jun JIANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.6 pp. 461-468
- ISSN:
- 1875-5364
- Subject:
- Cardamine; Oriental traditional medicine; anti-inflammatory activity; cytoplasm; flower extracts; flowers; fluorescent antibody technique; gene expression regulation; histopathology; immunocytochemistry; in vivo studies; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; macrophages; medicinal plants; messenger RNA; mice; models; nitric oxide; prostaglandins; protein synthesis; signal transduction; staining; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... In the present study, we investigated anti-inflammatory effect of Cardamine komarovii flower (CKF) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). We determined the effect of CKF methanolic extracts on LPS-induced pro-inflammatory mediators NO and prostaglandin E2 (PGE2), production of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), and related protein expression levels of MyD88/ ...
- DOI:
- 10.1016/S1875-5364(19)30053-6
- https://doi.org/10.1016/S1875-5364(19)30053-6
- Author:
- Ya-Mei LIU; Wang-Yang LI; Liang-Liang XU; Li-Juan YU; Yi-Wen LUO; Xi-Can LI; Xun-Chao ZHANG; Yun-Pu XIONG; Hong-Tai CHEN; Jun-Lang ZHU; Chen CHEN; Yu-Lu XIE; Dong-Feng CHEN; Bin WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.7 pp. 506-516
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bone diseases; bone formation; cell transplantation; essential oils; mesenchymal stromal cells; messenger RNA; myosin light chains; phosphorylation; small interfering RNA
- Abstract:
- ... MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catha ...
- DOI:
- 10.1016/S1875-5364(19)30072-X
- https://doi.org/10.1016/S1875-5364(19)30072-X
15. Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology
- Author:
- Xiao-Rui CHENG; Chun-Hui QI; Tong-Xing WANG; Wen-Xia ZHOU; Yong-Xiang ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.2 pp. 103-121
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; chemical constituents of plants; immunomodulation; kidneys; medicinal properties; pharmacokinetics; quality control; toxicology
- Abstract:
- ... Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokine ...
- DOI:
- 10.1016/S1875-5364(19)30013-5
- https://doi.org/10.1016/S1875-5364(19)30013-5
- Author:
- Qin-Feng ZHU; Qin-Shi ZHAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 887-891
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bioactive properties; biodiversity; chemical composition; ferns and fern allies; flora; phytochemicals; terrestrial ecosystems
- Abstract:
- ... Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and evolution. The Chinese lycophytes and ferns flora, with approximately 2000 species, contributes a substantial component to the global lycophytes and ferns diversity, with estimates of 12 000 species. Among them, about 433 species are medicinally recorded a ...
- DOI:
- 10.1016/S1875-5364(19)30108-6
- https://doi.org/10.1016/S1875-5364(19)30108-6
- Author:
- Shi-Hui DONG; Yan WU; Jian-Min YUE
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 924-927
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Vernonia; aerial parts; chemical composition; nuclear magnetic resonance spectroscopy; pregnanes; sesquiterpenoids; spectral analysis
- Abstract:
- ... A new sesquiterpenoid and two pregnane steroids, named vernobockolide C (1) and vernobockones A and B (2 and 3), respevtively, along with a known sesquiterpenoid, 7, 10-epoxy-11-hydroxy-bisabol-2-en-15-al, were isolated from the aerial part of Vernonia bockiana. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially 2D NMR (HSQC, HMBC, and ROESY). This s ...
- DOI:
- 10.1016/S1875-5364(19)30114-1
- https://doi.org/10.1016/S1875-5364(19)30114-1
- Author:
- Xiao-Tong WANG; Hai-Liang LIU; Xi YU; Can WANG; Li-Li GUI; Xiao-Yu WANG; Yong-Qing HUA; Jie ZHENG; Min HONG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.7 pp. 525-534
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; animal models; atopic dermatitis; dendritic cells; ears; enzyme-linked immunosorbent assay; epithelium; flow cytometry; fluorescein; fluorescent antibody technique; humans; inflammation; interleukins; isothiocyanates; keratinocytes; lymphocytes; mice; transcription factor NF-kappa B; transmission electron microscopes; tumor necrosis factor-alpha
- Abstract:
- ... This study aimed to investigate the mechanisms of Yu-Ping-Feng-San (YPFS) on attenuating allergic inflammation in the initial stage of atopic dermatitis (AD). AD mouse model was established with fluorescein isothiocyanate (FITC) sensitization and elicitation. Epithelial barrier structure was observed with transmission electron microscope. The populations of dendritic cells (DCs) and group 2 innate ...
- DOI:
- 10.1016/S1875-5364(19)30074-3
- https://doi.org/10.1016/S1875-5364(19)30074-3
- Author:
- Lan-Yun MIAO; Thi Thanh Huyen CHU; Ping LI; Yan JIANG; Hui-Jun LI
- Source:
- Chinese journal of natural medicines 2019 v.17 no.6 pp. 435-445
- ISSN:
- 1875-5364
- Subject:
- Actaea racemosa; Oriental traditional medicine; adulterants; blood chemistry; blood serum; dietary supplements; females; gas chromatography-mass spectrometry; histopathology; markets; menopause; metabolic diseases; metabolites; metabolomics; micro-computed tomography; ovariectomy; rats
- Abstract:
- ... In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies ...
- DOI:
- 10.1016/S1875-5364(19)30051-2
- https://doi.org/10.1016/S1875-5364(19)30051-2
- Author:
- Yuan WANG; Jing LIN; Qi WANG; Kun SHANG; De-Bing PU; Rui-Han ZHANG; Xiao-Li LI; Xiao-Chang DAI; Xing-Jie ZHANG; Wei-Lie XIAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 953-962
- ISSN:
- 1875-5364
- Subject:
- Callicarpa; Oriental traditional medicine; anti-inflammatory activity; diterpenoids; lactones; nitric oxide; nuclear magnetic resonance spectroscopy; phytochemicals
- Abstract:
- ... Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A–F (1–6), together with seven analogues (7–13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharid ...
- DOI:
- 10.1016/S1875-5364(19)30118-9
- https://doi.org/10.1016/S1875-5364(19)30118-9
- Author:
- Yan-Yan CHEN; Yu-Jie CAO; Yu-Ping TANG; Shi-Jun YUE; Jin-Ao DUAN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.11 pp. 871-880
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; adverse effects; colon; constipation; emodin; excretion; glycyrrhizin; kidneys; licorice; liver; metabolites; pharmacodynamics; pharmacokinetics; therapeutics; tissue distribution
- Abstract:
- ... Dahuang-Gancao decoction (DGD) is a classical formula, which is commonly used for reliving constipation in Chinese clinic. The aim of this study was to investigate the pharmacodynamic, pharmacokinetic and tissue distribution alternations of DGD in normal and constipation mice. DGD exhibited stronger purgative effect in constipation mice by the increased fecal excretion and reduced first defection ...
- DOI:
- 10.1016/S1875-5364(19)30104-9
- https://doi.org/10.1016/S1875-5364(19)30104-9
- Author:
- Shuai-Jun HU; Hao-Yu HU; Han GAO; Xia LIU; Shi-Lin CHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.10 pp. 738-745
- ISSN:
- 1875-5364
- Subject:
- DNA barcoding; Oriental traditional medicine; adulterants; adulterated products; genetic distance; phylogeny; prediction; quantitative polymerase chain reaction
- Abstract:
- ... Herba Anoectochili is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the similar morphological characteristics of Herba Anoectochili and its adulterants, traditional identification techniques often fail to distinguish between them accurately, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distin ...
- DOI:
- 10.1016/S1875-5364(19)30090-1
- https://doi.org/10.1016/S1875-5364(19)30090-1
- Author:
- Zhen-Zhen ZHOU; Hong-Jie ZHU; Cheng-Long YANG; Yan-Jun LIU; Nan JIANG; Yong-Sheng XIAO; Li-Yun SHI; Rui-Hua JIAO; Hui-Ming GE; Ren-Xiang TAN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.5 pp. 387-393
- ISSN:
- 1875-5364
- Subject:
- Daldinia; Oriental traditional medicine; circular dichroism spectroscopy; genes; interleukin-6; macrophages; metabolites; spectral analysis; tumor necrosis factor-alpha
- Abstract:
- ... Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene express ...
- DOI:
- 10.1016/S1875-5364(19)30045-7
- https://doi.org/10.1016/S1875-5364(19)30045-7
- Author:
- Xiao-Dan MEIm; Yan-Feng CAO; Yan-Yun CHE; Jing LI; Zhan-Peng SHANG; Wen-Jing ZHAO; Yan-Jiang QIAO; Jia-Yu ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 59-80
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Salvia miltiorrhiza; adverse effects; chemical composition; chemical constituents of plants; diterpenoids; herbal medicines; lipophilicity; medicinal properties; phenolic acids; rhizomes; water solubility; China; Japan
- Abstract:
- ... Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic di ...
- DOI:
- 10.1016/S1875-5364(19)30010-X
- https://doi.org/10.1016/S1875-5364(19)30010-X
- Author:
- Wei LIU; Ran YAN; Liang ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 600-607
- ISSN:
- 1875-5364
- Subject:
- Dendrobium; Oriental traditional medicine; blood serum; dysbiosis; enzyme-linked immunosorbent assay; immunomodulators; interferon-gamma; interleukin-6; intestinal microorganisms; macrophages; mice; patients; phagocytosis; polysaccharides; ribosomal RNA; sequence analysis; toxicity testing; tumor necrosis factor-alpha; viability
- Abstract:
- ... To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, E ...
- DOI:
- 10.1016/S1875-5364(19)30062-7
- https://doi.org/10.1016/S1875-5364(19)30062-7
- Author:
- Yan YAN; Qiang LI; Hui-Zhi DU; Chen-Xi SHEN; Ai-Ping LI; Xiang-Ping PEI; Chen-Hui DU; Xue-Mei QIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.7 pp. 551-560
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; acetonitrile; animal models; brain; chemical species; dopamine; gamma-aminobutyric acid; glutamic acid; herbal medicines; monitoring; monoamines; neurotransmitters; norepinephrine; rats; serotonin; sleep disorders; tandem mass spectrometry; ultra-performance liquid chromatography; China
- Abstract:
- ... Ziziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the role of ZSS aqueous extract in the treatment of insomnia, an UPLC-ESI- MS/MS method was developed an ...
- DOI:
- 10.1016/S1875-5364(19)30077-9
- https://doi.org/10.1016/S1875-5364(19)30077-9
- Author:
- Yu-Ru TONG; Yi-Feng ZHANG; Yu-Jun ZHAO; Tian-Yuan HU; Jia-Dian WANG; Lu-Qi HUANG; Wei GAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 575-584
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; RNA interference; Tripterygium wilfordii; acetyl coenzyme A; active sites; biochemical pathways; biosynthesis; complementary DNA; electrostatic interactions; gene overexpression; genes; hydroxymethylglutaryl-CoA synthase; terpenoids
- Abstract:
- ... 3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the biosynthesis of terpenes in Tripterygium wilfordii. The full-length cDNA and a 515 bp RNAi target fragment of TwHMGS were ligated into the pH7WG2D and pK7GWIWG2D vectors to respectively overexpress and silence, TwHMGS was overexpressed and silenced in T. wilfordii suspension cells us ...
- DOI:
- 10.1016/S1875-5364(19)30059-7
- https://doi.org/10.1016/S1875-5364(19)30059-7
- Author:
- Li-Feng LI; Tin-Long WONG; Quan-Bin HAN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 883-886
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bioactive properties; chemical analysis; polysaccharides; research and development
- Abstract:
- ... Polysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and development of new drugs and health products. However, there are rarely successful cases. ...
- DOI:
- 10.1016/S1875-5364(19)30107-4
- https://doi.org/10.1016/S1875-5364(19)30107-4
- Author:
- Mei-Yu LIN; Zhong-Lan YUAN; Dan-Dan HU; Gan-Hai HU; Ri-Li ZHANG; Hua ZHONG; Lan YAN; Yuan-Ying JIANG; Juan SU; Yan WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 616-623
- ISSN:
- 1875-5364
- Subject:
- Caenorhabditis elegans; Candida albicans; Galleria mellonella; Oriental traditional medicine; adhesion; antifungal properties; biofilm; fungi; gene expression; gene expression regulation; genes; human umbilical vein endothelial cells; hydrophobicity; hyphae; minimum inhibitory concentration; models; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; scanning electron microscopy; toxicity; virulence
- Abstract:
- ... Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. This work aimed to investigate the activity of loureirin A against Candida albicans biofilms. 2, 3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT)reduction assay and scanning electron microscopy were used to investigate the anti-biofilm effect. Minimal inhibitory concentration te ...
- DOI:
- 10.1016/S1875-5364(19)30064-0
- https://doi.org/10.1016/S1875-5364(19)30064-0
- Author:
- Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
- ISSN:
- 1875-5364
- Subject:
- Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
- Abstract:
- ... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
- DOI:
- 10.1016/S1875-5364(19)30032-9
- https://doi.org/10.1016/S1875-5364(19)30032-9
- Author:
- Guang-Hui HUANG; Chun LEI; Ke-Xin ZHU; Jing-Ya LI; Jia LI; Ai-Jun HOU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 963-969
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Rhododendron; X-ray diffraction; enantiomers; high performance liquid chromatography; meroterpenoids; protein-tyrosine-phosphatase; spectroscopy
- Abstract:
- ... Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new ...
- DOI:
- 10.1016/S1875-5364(19)30119-0
- https://doi.org/10.1016/S1875-5364(19)30119-0
- Author:
- Zi-Kai GENG; Ya-Qun LI; Qing-Hua CUI; Rui-Kun DU; Jing-Zhen TIAN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.9 pp. 650-662
- ISSN:
- 1875-5364
- Subject:
- Influenza A virus; Oriental traditional medicine; Toll-like receptor 7; drugs; histopathology; immune response; immune system; inflammation; lungs; mice; oseltamivir; respiratory tract diseases; signal transduction; survival rate; tumor necrosis factor-alpha
- Abstract:
- ... Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate anti-IAV activity in vitro. GGD was more effective when given before the viral inf ...
- DOI:
- 10.1016/S1875-5364(19)30079-2
- PubMed:
- 31526500
- PubMed Central:
- PMC7128581
- https://doi.org/10.1016/S1875-5364(19)30079-2
- Author:
- Yu-Ze LI; Bei SONG; Xu-Dong ZHENG; Wen-Li HUANG; Hua-Wei ZHANG; Yi JIANG; Zheng-Gang YUE; Xiao-Mei SONG; Jian-Li LIU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 624-630
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; cytotoxicity; human cell lines; humans; inhibitory concentration 50; neoplasm cells; physicochemical properties; rhizomes; roots; saponins; spectral analysis
- Abstract:
- ... Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J–N (1–5), together with four known furostanol saponins (6–9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values ...
- DOI:
- 10.1016/S1875-5364(19)30065-2
- https://doi.org/10.1016/S1875-5364(19)30065-2
- Author:
- Jian ZHANG; Hua LI; Yong LI; Zi-Wei LI; Chen-Chen SANG; Mei-Hua GAO; Dong-Mei ZHANG; Xiao-Qi ZHANG; Wen-Cai YE
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 918-923
- ISSN:
- 1875-5364
- Subject:
- Alstonia scholaris; Oriental traditional medicine; alkaloids; arteries; circular dichroism spectroscopy; potassium chloride; roots; spectral analysis; vasodilator agents
- Abstract:
- ... Four new corynanthe-type alkaloids, meloslines C–F (1–4), together with four known ones (5–8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries prec ...
- DOI:
- 10.1016/S1875-5364(19)30113-X
- https://doi.org/10.1016/S1875-5364(19)30113-X
- Author:
- Dan YANG; Zhong-Quan CHENG; Cheng-Ting ZI; Liu YANG; Fa-Wu DONG; Jiang-Miao HU; Jun ZHOU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 900-905
- ISSN:
- 1875-5364
- Subject:
- Dendrobium; Oriental traditional medicine; glycosides; sesquiterpenoids; spectroscopy; stems
- Abstract:
- ... Three new sesquiterpene glycosides with alloaromadendrane and ylangene-derived type aglycones, named dendrofindlayanosides A–C (1–3), one new cyclopacamphane type sesquiterpene named dendrofindlayanobilin A (4), together with five known compounds have been isolated from stems of Dendrobium findlayanum. Their structures were determined on the basis of spectroscopic and chemical methods. ...
- DOI:
- 10.1016/S1875-5364(19)30110-4
- https://doi.org/10.1016/S1875-5364(19)30110-4
- Author:
- Li-Li ZHU; Luo-Di FAN; Ming-Hua HU; Fang-Li MA; Jin QI
- Source:
- Chinese journal of natural medicines 2019 v.17 no.7 pp. 535-544
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; adverse effects; anemia; animal models; antioxidant activity; blood serum; bone marrow; catalase; cyclophosphamide; drug therapy; enzyme activity; enzyme-linked immunosorbent assay; glutathione peroxidase; granulocyte-macrophage colony-stimulating factor; high performance liquid chromatography; malondialdehyde; mass spectrometry; mice; pharmacology; protective effect; spleen; splenocytes; superoxide dismutase; thymus gland
- Abstract:
- ... The aim of this study is to investigate the protective effects of a small molecular fraction (SMF) of Polygoni multiflori Radix Praeparata (PMRP) in a cyclophosphamide (CTX) induced anemia mouse model. Small molecular fraction of PMRP was prepared and identified by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In pharmacology, we examined the p ...
- DOI:
- 10.1016/S1875-5364(19)30075-5
- https://doi.org/10.1016/S1875-5364(19)30075-5
- Author:
- Ling-Na KONG; Xiang LIN; Cheng HUANG; Tao-Tao MA; Xiao-Ming MENG; Chao-Jie HU; Qian-Qian WANG; Yan-Hui LIU; Qing-Ping SHI; Jun LI
- Source:
- Chinese journal of natural medicines 2019 v.17 no.2 pp. 122-130
- ISSN:
- 1875-5364
- Subject:
- Citrus; Oriental traditional medicine; antioxidants; bioavailability; fruit peels; hesperetin; hesperidin; inducible nitric oxide synthase; interferon-gamma; interleukin-10; macrophages; pathogenesis; phenotype; protein content; signal transduction; transforming growth factor beta; water solubility
- Abstract:
- ... Macrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as macrophage polarization, of which play an important role in the pathogenesis of many diseases. Numerous studies have proved that Hesperidin (HDN), a traditional Chinese medicine, ext ...
- DOI:
- 10.1016/S1875-5364(19)30014-7
- https://doi.org/10.1016/S1875-5364(19)30014-7
- Author:
- Fa-Liang AN; Yong YIN; Jun LUO; Ling-Yi KONG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 912-917
- ISSN:
- 1875-5364
- Subject:
- Heynea velutina; Oriental traditional medicine; carcinoma; fruits; humans; limonoids
- Abstract:
- ... Six new trichilin-type limonoids (1–6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1H NMR, 13C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human p ...
- DOI:
- 10.1016/S1875-5364(19)30112-8
- https://doi.org/10.1016/S1875-5364(19)30112-8
- Author:
- Mei-Yu CHEN; Hong LI; Xiao-Xiao LU; Li-Jun LING; Hong-Bo WENG; Wei SUN; Dao-Feng CHEN; Yun-Yi ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.3 pp. 187-197
- ISSN:
- 1875-5364
- Subject:
- Houttuynia cordata; Influenza A virus; Oriental traditional medicine; Toll-like receptors; Vibrio; goblet cells; homeostasis; hypoxia; hypoxia-inducible factor 1; inflammation; interleukin-10; interleukin-1beta; intestinal microorganisms; intestines; lungs; mice; oral administration; polysaccharides
- Abstract:
- ... Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg−1(d−1. H1N1 infection caused pulmonary and intestinal injury and gut microbiota imba ...
- DOI:
- 10.1016/S1875-5364(19)30021-4
- PubMed:
- 30910055
- PubMed Central:
- PMC7128561
- https://doi.org/10.1016/S1875-5364(19)30021-4
- Author:
- Lu-Lin CHEN; Can-Hui CHEN; Xing-Xian ZHANG; Yi WANG; Shu-Fang WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.11 pp. 803-821
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; biochemical pathways; chemical composition; flavonoids; gastrointestinal system; metabolites; monoterpenoids; oral administration; organic acids and salts; prototypes; triterpenoid saponins
- Abstract:
- ... Gui-Zhi-Jia-Ge-Gen-Tang (GZJGGT) is a traditional Chinese medicine (TCM) prescription commonly used to treat cervical spondylopathy, scapulohumeral periarthritis, etc. Though it is widely applied in clinical practice, the effective constituents of GZJGGT remain unclear. This was the first report on the identification of the chemical constituents from GZJGGT in vitro and in vivo using LC-IT-MS comb ...
- DOI:
- 10.1016/S1875-5364(19)30099-8
- https://doi.org/10.1016/S1875-5364(19)30099-8
- Author:
- Fei-Fei FENG; Peng CHENG; Chao SUN; Hui WANG; Wei WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.10 pp. 768-777
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Paris polyphylla; antineoplastic activity; apoptosis; autophagy; carcinogenesis; cell growth; cell proliferation; cisplatin; enzyme inhibitors; humans; lung neoplasms; oncogene proteins; phosphoprotein phosphatase
- Abstract:
- ... Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC). CIP2A plays an ‘oncogenic nexus’ to participate in the tumorigenesis and chemoresistance in several cancer types. AKT and mTORC1 overactivation are detected in NSCLC and many other cancers. Previous studies found that the CIP2 ...
- DOI:
- 10.1016/S1875-5364(19)30093-7
- https://doi.org/10.1016/S1875-5364(19)30093-7
- Author:
- Qi-Hang ZHOU; Ya-Di ZHU; Feng ZHANG; Yun-Qing SONG; Shou-Ning JIA; Liang ZHU; Sheng-Quan FANG; Guang-Bo GE
- Source:
- Chinese journal of natural medicines 2019 v.17 no.11 pp. 858-870
- ISSN:
- 1875-5364
- Subject:
- Cullen corylifolium; Oriental traditional medicine; bioactive properties; biochemical pathways; chemical structure; dried fruit; dysentery; herbal medicines; herbs; human diseases; humans; mechanism of action; rheumatoid arthritis; risk; therapeutics; Asia
- Abstract:
- ... Psoraleae Fructus (the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheum ...
- DOI:
- 10.1016/S1875-5364(19)30103-7
- https://doi.org/10.1016/S1875-5364(19)30103-7
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Wen-Xia GONG; Yu-Zhi ZHOU; Xue-Mei QIN; Guan-Hua DU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 264-274
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; calcium; cell viability; corticosterone; lactate dehydrogenase; mitochondria; neuroprotective effect; rats; rhizomes; sesquiterpenoids; therapeutics
- Abstract:
- ... Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromocytoma (PC12) cells. Our re ...
- DOI:
- 10.1016/S1875-5364(19)30030-5
- https://doi.org/10.1016/S1875-5364(19)30030-5
- Author:
- Lin CHEN; Jia-Luo HUANG; Lei ZHANG; Hai-Yan TIAN; Sheng YIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 298-302
- ISSN:
- 1875-5364
- Subject:
- Jatropha podagrica; Oriental traditional medicine; anti-inflammatory activity; carbon; diterpenoids; inhibitory concentration 50; lipopolysaccharides; macrophages; nitric oxide; quercetin; spectroscopy; stems
- Abstract:
- ... Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2–9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory a ...
- DOI:
- 10.1016/S1875-5364(19)30033-0
- https://doi.org/10.1016/S1875-5364(19)30033-0
- Author:
- Yi LING; Lin-Lin TENG; Juan HUA; De-Sen LI; Shi-Hong LUO; Yan-Chun LIU; Yan LIU; Sheng-Hong LI
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 892-899
- ISSN:
- 1875-5364
- Subject:
- Caenorhabditis elegans; Oriental traditional medicine; antilipemic agents; bioactive properties; biosynthesis; gene expression regulation; genes; lipid metabolism; metabolic diseases; mutants; obesity; sequence analysis; stearoyl-CoA desaturase; trichomes; unsaturated fatty acids
- Abstract:
- ... Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, sig ...
- DOI:
- 10.1016/S1875-5364(19)30109-8
- https://doi.org/10.1016/S1875-5364(19)30109-8
- Author:
- Wei-Wei QIN; Li WANG; Zheng JIAO; Bin WANG; Cheng-Yu WANG; Li-Xuan QIAN; Wei-Lin QI; Ming-Kang ZHONG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.3 pp. 218-226
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bilirubin; blood sampling; coronary disease; models; patients; pharmacokinetics; sodium; sulfonates
- Abstract:
- ... This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic an ...
- DOI:
- 10.1016/S1875-5364(19)30024-X
- https://doi.org/10.1016/S1875-5364(19)30024-X
- Author:
- Gao-Song WU; Hou-Kai LI; Wei-Dong ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.5 pp. 321-330
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; biomarkers; coronary artery disease; early diagnosis; metabolites; metabolomics; modernization; myocardial infarction; patients; physiological state; precision medicine; risk factors
- Abstract:
- ... Traditional Chinese Medicine (TCM) is the treasure of Chinese Nation and gained the gradual acceptance of the international community. However, the methods and theories of TCM understanding of diseases are lack of appropriate modern scientific characterization systems. Moreover, traditional risk factors cannot promote to detection and prevent those patients with coronary artery disease (CAD) who h ...
- DOI:
- 10.1016/S1875-5364(19)30037-8
- https://doi.org/10.1016/S1875-5364(19)30037-8
- Author:
- Ying-Qun JIANG; E-Hu LIU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 561-574
- ISSN:
- 1875-5364
- Subject:
- Malvaceae; Oriental traditional medicine; alkaloids; analgesics; bark; bioactive properties; blood lipids; diarrhea; fever; flavonoids; fruits; heat stroke; indigestion; insect bites and stings; insects; jaundice; leaves; organic acids and salts; pharmacology; quality control; roots; shrubs; toxicology; triterpenoids; China; South East Asia
- Abstract:
- ... The shrub Microcos paniulata (MPL; Tiliaceae), distributed in south China, south and southeast Asia, yields a phytomedicine used to treat heat stroke, fever, dyspepsia, diarrhea, insect bites and jaundice. Phytochemical investigations on different parts of MPL indicate the presence of flavonoids, alkaloids, triterpenoids and organic acids. The MPL leaves, fruits, barks and roots extracts showed an ...
- DOI:
- 10.1016/S1875-5364(19)30058-5
- https://doi.org/10.1016/S1875-5364(19)30058-5
- Author:
- Guang ZHAO; Yu-Zhen ZHUO; Li-Hua CUI; Cai-Xia LI; Sha-Yan CHEN; Dan LI; Jun-Hong LIU; Di-Hua LI; Nai-Qiang CUI; Shu-Kun ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.5 pp. 355-362
- ISSN:
- 1875-5364
- Subject:
- C-reactive protein; Oriental traditional medicine; Western blotting; amylases; blood serum; body weight; chemokine CCL2; colorimetry; diamine oxidase; enzyme-linked immunosorbent assay; histopathology; ileum; interleukin-1beta; lungs; models; myeloperoxidase; necrosis; neoplasms; occludins; pancreas; pancreatitis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; staining; surfactants; taurocholic acid; therapeutics; tight junctions; transcription factor NF-kappa B; tumor necrosis factor-alpha; vena cava
- Abstract:
- ... Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present study, rat SAP model was induced by retrograde injection of 3.5% sodium taurocho ...
- DOI:
- 10.1016/S1875-5364(19)30041-X
- https://doi.org/10.1016/S1875-5364(19)30041-X
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