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Chinese journal of natural medicines
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- Author:
- Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
- ISSN:
- 1875-5364
- Subject:
- Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
- Abstract:
- ... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
- DOI:
- 10.1016/S1875-5364(19)30032-9
- https://doi.org/10.1016/S1875-5364(19)30032-9
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Meng-Yao SUN; Dan-Dan WANG; Jian SUN; Xiao-Hua ZHAO; Si CAI; Qiu-Xue WU; Tao JIE; Zhen-Hua NI; Jian-Yue SUN; Qing-Feng TANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.3 pp. 198-208
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; apoptosis; cell lines; cell proliferation; cisplatin; drug therapy; flow cytometry; humans; mitochondria; models; neoplasm cells; patients; protein synthesis; staining; stomach neoplasms
- Abstract:
- ... Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still diff ...
- DOI:
- 10.1016/S1875-5364(19)30022-6
- https://doi.org/10.1016/S1875-5364(19)30022-6
- Author:
- Qiong ZHANG; Qing-Hong ZHENG; Yi-Shu SANG; Herman Ho-Yung SUNG; Zhi-Da MIN
- Source:
- Chinese journal of natural medicines 2018 v.16 no.12 pp. 946-950
- ISSN:
- 1875-5364
- Subject:
- Melia azedarach; Oriental traditional medicine; X-radiation; X-ray diffraction; bark; cell lines; cytotoxicity; limonoids; neoplasm cells; spectral analysis
- Abstract:
- ... Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1–3 were evaluated for their ...
- DOI:
- 10.1016/S1875-5364(18)30136-5
- https://doi.org/10.1016/S1875-5364(18)30136-5
- Author:
- Gaurav Bhatia; Vikram Dhuna; Kshitija Dhuna; Manpreet Kaur; Jatinder Singh
- Source:
- Chinese journal of natural medicines 2017 v.15 no.11 pp. 834-846
- ISSN:
- 1875-5364
- Subject:
- Bacopa monnieri; Oriental traditional medicine; brain damage; caffeic acid; catechin; cell lines; defense mechanisms; enzymes; fluorescent antibody technique; hydrogen peroxide; memory; models; nerve tissue; neurodegenerative diseases; neuroprotective effect; oxidative stress; polyphenols; quercetin; reverse transcriptase polymerase chain reaction; therapeutics; umbelliferones
- Abstract:
- ... Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present stud ...
- DOI:
- 10.1016/S1875-5364(18)30017-7
- https://doi.org/10.1016/S1875-5364(18)30017-7
- Author:
- Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
- Source:
- Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
- ISSN:
- 1875-5364
- Subject:
- Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
- Abstract:
- ... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
- DOI:
- 10.1016/S1875-5364(18)30010-4
- https://doi.org/10.1016/S1875-5364(18)30010-4
- Author:
- Jia XIONG; Mary H GRACE; Debora ESPOSITO; Slavko KOMARNYTSKY; Fei WANG; Mary Ann LILA
- Source:
- Chinese journal of natural medicines 2017 v.15 no.11 pp. 816-824
- ISSN:
- 1875-5364
- Subject:
- Acacia mearnsii; Oriental traditional medicine; acarbose; alpha-amylase; alpha-glucosidase; anti-inflammatory activity; bark; cell lines; countercurrent chromatography; digestion; enzyme activity; enzyme inhibition; genes; humans; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; interleukin-1beta; lipopolysaccharides; macrophages; mice; nitric oxide; proanthocyanidins; reactive oxygen species
- Abstract:
- ... The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract (B) and fractions (B1-B7) obtained by high-speed counter-current chromatography (HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7 (total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g⁻¹, respec ...
- DOI:
- 10.1016/S1875-5364(18)30015-3
- https://doi.org/10.1016/S1875-5364(18)30015-3
- Author:
- Meng-Qi YANG; Lin-Lan YE; Xiao-Ling LIU; Xiao-Ming QI; Jia-Di LV; Gang WANG; Ulah-Khan FARHAN; Nawaz WAQAS; Ding-Ding CHEN; Lei HAN; Xiao-Hui ZHOU
- Source:
- Chinese journal of natural medicines 2016 v.14 no.6 pp. 434-440
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; calcium; cell lines; cholecystokinin; enzyme-linked immunosorbent assay; ethylene glycol tetraacetic acid; gastrointestinal system; gene silencing; ginger; ion channels; ruthenium red; secretion; serotonin; small interfering RNA
- Abstract:
- ... TRPA1 channels are non-selective cation channels that could be activated by plant-derived pungent products, including gingerol, a main active constituent of ginger. Ginger could improve the digestive function; however whether ginger improves the digestive function through activating TRPA1 receptor in gastrointestinal tract has not been investigated. In the present study, gingerol was used to stimu ...
- DOI:
- 10.1016/S1875-5364(16)30040-1
- https://doi.org/10.1016/S1875-5364(16)30040-1
- Author:
- Yong-Xin WANG; Dan-Ting XUE; Meng LIU; Zheng-Min ZHOU; Jing SHANG
- Source:
- Chinese journal of natural medicines 2016 v.14 no.3 pp. 185-195
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; anaphylaxis; anti-allergic agents; baicalin; beta-N-acetylhexosaminidase; catechin; cell lines; dose response; enzyme-linked immunosorbent assay; gloves; glycyrrhizin; growth retardation; high performance liquid chromatography; histamine; interferon-gamma; interleukin-2; interleukin-4; latex; lymphocytes; manufacturing; mice; models; oleanolic acid; pharmacodynamics; polyphenols; screening; spleen; tea
- Abstract:
- ... The present study aimed at developing a natural compound with anti-allergic effect and stability under latex glove manufacturing conditions and investigating whether its anti-allergic effect is maintained after its addition into the latex. The effects of nine natural compounds on growth of the RBL-2H3 cells and mouse primary spleen lymphocytes were determined using MTT assay. The compounds include ...
- DOI:
- 10.1016/S1875-5364(16)30015-2
- https://doi.org/10.1016/S1875-5364(16)30015-2
- Author:
- Shi-Tang MA; Cheng-Tao FENG; Guo-Liang DAI; Yue SONG; Guo-Liang ZHOU; Xiao-Lin ZHANG; Cheng-Gui MIAO; Hao YU; Wen-Zheng JU
- Source:
- Chinese journal of natural medicines 2015 v.13 no.1 pp. 30-40
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; berberine; bioactive compounds; bioinformatics; cell lines; databases; fish; humans; mechanism of action; models; neoplasm cells; proteins; screening; sepsis (infection)
- Abstract:
- ... The present study was designed to target fish for potential bioactive components contained in a Huang Lian Jie Du decoction (HLJDD) and identify the underlying mechanisms of action for the treatment of sepsis at the molecular level. he bioactive components database of HLJDD was constructed and the sepsis-associated targets were comprehensively investigated. The 3D structures of the PAFR and TXA2R ...
- DOI:
- 10.1016/S1875-5364(15)60004-8
- https://doi.org/10.1016/S1875-5364(15)60004-8
- Author:
- Qi LV; Xian-Yang ZHU; Yu-Feng XIA; Yue DAI; Zhi-Feng WEI
- Source:
- Chinese journal of natural medicines 2015 v.13 no.11 pp. 831-841
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Stephania tetrandra; Western blotting; actin; cell lines; cell proliferation; guanosinetriphosphatase; mitogen-activated protein kinase; patients; phosphatidylinositol 3-kinase; protective effect; rats; rheumatoid arthritis; signal transduction
- Abstract:
- ... Tetrandrine (Tet), the main active constituent of Stephania tetrandra root, has been demonstrated to alleviate adjuvant-induced arthritis in rats. The present study was designed to investigate the effects of Tet on the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and explore the underlying mechanisms. By using cultures of primary FLS isolated from synoviums ...
- DOI:
- 10.1016/S1875-5364(15)30087-X
- https://doi.org/10.1016/S1875-5364(15)30087-X
- Author:
- Sofi Mubashir; Mohd Yousuf Dar; Bashir A. Lone; M. Iqbal Zargar; Wajaht A. Shah
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 567-572
- ISSN:
- 1875-5364
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Caltha palustris; Oriental traditional medicine; anthelmintics; antimicrobial properties; antioxidant activity; antioxidants; cell lines; cervix; colon; cytotoxicity; fecal egg count; gastrointestinal nematodes; lethal concentration 50; leukemia; lungs; mortality; plant extracts; sheep; viability; India
- Abstract:
- ... The methanolic extract obtained from the root portion of Caltha palustris var. alba was evaluated for its anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition (WMI) assay and fecal egg count reduction (FECR) assay, respectively. The extract was subjected to antimicrobial activity using agar-well diffusion method ...
- DOI:
- 10.1016/S1875-5364(14)60087-X
- https://doi.org/10.1016/S1875-5364(14)60087-X
- Author:
- Ashwini Anjana; K.F.H Nazeer Ahamed; V. Ravichandiran; M. Sumithra; Jayaraman Anbu
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 114-120
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Sargassum wightii; antineoplastic activity; antioxidant activity; body weight; cell lines; cell proliferation; flavonoids; hematologic tests; longevity; lymphoma; mice; neoplasm cells
- Abstract:
- ... Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice.The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the a ...
- DOI:
- 10.1016/S1875-5364(14)60018-2
- https://doi.org/10.1016/S1875-5364(14)60018-2
- Author:
- Ravichandran Senthilkumar; Bao-An CHEN; Xiao-Hui CAI; Rong FU
- Source:
- Chinese journal of natural medicines 2014 v.12 no.12 pp. 881-894
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic agents; bioactive compounds; cell lines; humans; leukemia; medicinal plants; multiple drug resistance; neoplasm cells; patients; survival rate; therapeutics
- Abstract:
- ... Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of ...
- DOI:
- 10.1016/S1875-5364(14)60131-X
- https://doi.org/10.1016/S1875-5364(14)60131-X
- Author:
- Min-Yu LIU; Lin XIAO; Geng-Hui CHEN; Yong-Xiang WANG; Wei-Xia XIONG; Fei LI; Ying LIU; Xiao-Ling HUANG; Yi-Fang DENG; Zhen ZHANG; Hai-Yan SUN; Quan-Hai LIU; Ming YIN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.10 pp. 768-776
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Xenorhabdus; allografting; animal models; antineoplastic activity; apoptosis; body weight; cell lines; cyclophosphamide; fluorouracil; granulocyte colony-stimulating factor; hepatoma; humans; inhibitory concentration 50; lung neoplasms; metabolites; mice; neoplasm cells; neutropenia; neutrophils; sarcoma
- Abstract:
- ... JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities.These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY h ...
- DOI:
- 10.1016/S1875-5364(14)60117-5
- https://doi.org/10.1016/S1875-5364(14)60117-5
- Author:
- Zhi-Yao WANG; Wen-Jun HE; Wen-Bing ZHOU; Guang-Zhi ZENG; Zhi-Qi YIN; Shou-Xun ZHAO; Ning-Hua TAN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 619-622
- ISSN:
- 1875-5364
- Subject:
- Candida albicans; Micromelum; Oriental traditional medicine; Staphylococcus; antimicrobial properties; bacteria; cell lines; chemical composition; cytotoxicity; fungi; high performance liquid chromatography; leaves; mass spectrometry; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; phenylpropanoids; scopoletin; silica gel; stems
- Abstract:
- ... To investigate the chemical and bioactive constituents from the stems and leaves of Micromelum integerrimum.The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and HPLC. Their structures were mainly elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy and mass spectrometry. Their cytotoxicity and antimicrobial activities were tested by the SRB and turbid ...
- DOI:
- 10.1016/S1875-5364(14)60094-7
- https://doi.org/10.1016/S1875-5364(14)60094-7
- Author:
- Ran XU; Hai-Qin XIE; Lu-Lu DENG; Jian-Xin ZHANG; Fu-Mei YANG; Jian-Hua LIU; Xiao-Jiang HAO; Yuan-Hu ZHANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 623-627
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bufadienolides; cell lines; chromatography; cytotoxicity; inhibitory concentration 50; neoplasm cells; spectroscopy
- Abstract:
- ... To study the bufadienolides in the Chinese traditional drug “Ch'an Su” and their cytotoxic activity.Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.Compound 1 (bufalin 3 ...
- DOI:
- 10.1016/S1875-5364(14)60095-9
- https://doi.org/10.1016/S1875-5364(14)60095-9
- Author:
- Dan LIU; Wei QU; Ling ZHAO; Fu-Qin GUAN; Jing-Yu LIANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 139-141
- ISSN:
- 1875-5364
- Subject:
- Alpinia officinarum; Oriental traditional medicine; biochemical pathways; cell lines; chemical composition; chemical reactions; chromatography; cytotoxicity; humans; inhibitory concentration 50; rhizomes; spectral analysis
- Abstract:
- ... To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.A dimeric diarylheptanoid, named alpinin B (1), along with three known diaryl ...
- DOI:
- 10.1016/S1875-5364(14)60022-4
- https://doi.org/10.1016/S1875-5364(14)60022-4
- Author:
- Ji-Feng LIU; Hui-Juan LI; Jing-Min ZHANG; Li-Xia WANG; Ya-Feng WANG; Meng-Qi LIU; Yue-Feng BI; Yan-Bing ZHANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.6 pp. 477-480
- ISSN:
- 1875-5364
- Subject:
- Illicium henryi; Oriental traditional medicine; cell lines; chemical composition; fruits; gels; hepatitis B antigens; secretion; sesquiterpenoids; silica gel; spectral analysis; surface antigens
- Abstract:
- ... To study the chemical constituents of the fruits of Illicium henryi.Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses.Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone (1), cycloparvifloralone (2), 2α-hydroxycyc ...
- DOI:
- 10.1016/S1875-5364(14)60074-1
- https://doi.org/10.1016/S1875-5364(14)60074-1