Journal: Chinese journal of natural medicines / Subject: Oriental traditional medicine

1. Anti-inflammatory effects of Abelmoschus manihot (L.) Medik. on LPS-induced cystitis in mice: potential candidate for cystitis treatment based on classic use

Author:: Su ZHOU; Kai-Kai FAN; Li-Fei GU; Bo-Yang YU; Cheng-Zhi CHAI
Source:: Chinese journal of natural medicines 2022 v.20 no.5 pp. 321-331
ISSN:: 1875-5364
Subject:: Abelmoschus manihot; Oriental traditional medicine; anti-inflammatory activity; bladder; cystitis; edema; heat; histopathology; homeopathic drugs; interleukin-6; lipopolysaccharides; mice; necrosis; neoplasms; protective effect; urine
Abstract:: ... Abelmoschus manihot (L.) Medik. (A. manihot) is a traditional Chinese herbal medicine with a variety of pharmacological properties. It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract irritation by clearing away heat and diuretic effect. However, its pharmacological action on urinary tract infections has not been investigated. The present study ...
DOI:: 10.1016/S1875-5364(22)60140-7
: https://doi.org/10.1016/S1875-5364(22)60140-7

2. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza)

Author:: Wei GAO; Yi WANG; Ru WANG; Yi-Hai WANG; Jing-Wen XU; Xiang-Jiu HE
Source:: Chinese journal of natural medicines 2022 v.20 no.7 pp. 541-550
ISSN:: 1875-5364
Subject:: Alocasia macrorrhizos; Oriental traditional medicine; antineoplastic activity; apoptosis; neoplasms; phytochemicals; piperidines; rhizomes; spectroscopy; toxicity testing; wild plants
Abstract:: ... The rhizome of giant taro (Alocasia macrorrhiza (L.) Schott), which is a highly adaptable wild plant, is a traditional Chinese herbal medicine. In the current study, the antiproliferative constituents of giant taro were investigated and six new (1−6) and four known piperidine alkaloids (7−10) were isolated from its rhizomes. Their chemical structures and absolute configurations were elucidated usi ...
DOI:: 10.1016/S1875-5364(22)60165-1
: https://doi.org/10.1016/S1875-5364(22)60165-1

3. Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation

Author:: Ying-Ying WANG; Jia-Yuan LI; Chang-Liang YAO; Jian-Qing ZHANG; Yang YU; Shuai YAO; Min GAO; Shi-Fei WU; Wen-Long WEI; Qi-Rui BI; De-An GUO
Source:: Chinese journal of natural medicines 2022 v.20 no.7 pp. 551-560
ISSN:: 1875-5364
Subject:: Achyranthes japonica; Oriental traditional medicine; electrospray ionization mass spectrometry; liver; phytoecdysteroids; ultra-performance liquid chromatography
Abstract:: ... Achyranthes bidentata Blume is widely used as a traditional Chinese medicine with the effects of nourishing the liver and kidneys and strengthening muscles and bones. In this work, a rapid and simple strategy was developed for characterizing phytoecdysteroids by ultra-high-performance liquid chromatography coupled with liner ion trap-Orbitrap mass spectrometry using electrospray ionization in the ...
DOI:: 10.1016/S1875-5364(22)60185-7
: https://doi.org/10.1016/S1875-5364(22)60185-7

4. Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation

Author:: Fei-Peng DUAN; Yi-Sheng LI; Tian-Yong HU; Xin-Quan PAN; Fang MA; Yue FENG; Shu-Qi QIU; Yi-Qing ZHENG
Source:: Chinese journal of natural medicines 2022 v.20 no.6 pp. 443-457
ISSN:: 1875-5364
Subject:: Dendrobium nobile; Oriental traditional medicine; T-lymphocytes; allergic rhinitis; antibiotics; cell differentiation; dysbiosis; eosin; inflammation; interleukin-10; interleukin-17; interleukin-4; interleukin-6; intestinal microorganisms; lungs; mice; nose; risk; therapeutics
Abstract:: ... Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis. Hence, regulating the balance of intestinal flora may be useful for preventing and treating allergic rhinitis. However, the underlying mechanism is unclear. Dendrobium nobile (Shihu) exhibits anti-inflammatory and immune activities. Hence, in this study, we investigated the mechanism v ...
DOI:: 10.1016/S1875-5364(22)60168-7
: https://doi.org/10.1016/S1875-5364(22)60168-7

5. Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics

Author:: Si-Li ZHENG; Dong-Ning ZHANG; Yan-Fen DUAN; Fang HUANG; Lin-Tao HAN; Guo-Yan MO
Source:: Chinese journal of natural medicines 2022 v.20 no.5 pp. 364-377
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; amino acids; dextran sulfate; dysbiosis; dysentery; enteritis; gene expression regulation; genes; intestinal microorganisms; intestines; lipids; metabolism; metabolites; metabolomics; mice; prediction; therapeutics; China
Abstract:: ... Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis (AE) and bacillary dysentery in Xinjiang (China) for many years. However, the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is unclear. This study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequ ...
DOI:: 10.1016/S1875-5364(22)60158-4
: https://doi.org/10.1016/S1875-5364(22)60158-4

6. Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation

Author:: Bao-Yue ZHANG; Yi-Fu ZHENG; Jun ZHAO; De KANG; Zhe WANG; Lv-Jie XU; Ai-Lin LIU; Guan-Hua DU
Source:: Chinese journal of natural medicines 2022 v.20 no.5 pp. 332-351
ISSN:: 1875-5364
Subject:: Bayesian theory; Oriental traditional medicine; algorithms; antineoplastic activity; chemical structure; computer simulation; databases; flavonoids; genes; prediction; terpenoids; therapeutics
Abstract:: ... Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes, and multi-target drugs provide a promising therapy idea for the treatment of cancer. Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs. In this paper, 50 tumor-related targets were collect ...
DOI:: 10.1016/S1875-5364(22)60180-8
: https://doi.org/10.1016/S1875-5364(22)60180-8

7. Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet

Author:: Zhao-Dong LI; Fang-Yuan QI; Fan LI
Source:: Chinese journal of natural medicines 2022 v.20 no.2 pp. 120-132
ISSN:: 1875-5364
Subject:: Bacteroidetes; Deferribacteres; Macrococcus; Oriental traditional medicine; Tenericutes; Vagococcus; Vibrio; apoptosis; caspase-3; disulfides; dysbiosis; glutathione; interleukin-6; intestinal microorganisms; metabolites; metabolomics; naphthalene; pathogenesis; rheumatoid arthritis; serotonin; sialic acid; therapeutics; thromboxanes
Abstract:: ... Wantong Jingu Tablet (WJT), a mixture of traditional Chinese medicine, was reported to relieve the symptoms of rheumatoid arthritis (RA), but its pharmacological mechanism was not completely understood. The aim of this study was to investigate the therapeutic mechanisms of WJT for RA in vivo. The effects of WJT on joint pathology, as well as the levels of Bax, Bcl-2, caspase-3, cleaved-caspase-3, ...
DOI:: 10.1016/S1875-5364(21)60080-8
: https://doi.org/10.1016/S1875-5364(21)60080-8

8. Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway

Author:: Shu-Ping CHEN; Tian-Hong HU; Qing ZHOU; Tian-Peng CHEN; Dong YIN; Huan HE; Qing HUANG; Ming HE
Source:: Chinese journal of natural medicines 2022 v.20 no.1 pp. 22-32
ISSN:: 1875-5364
Subject:: Adenoviridae; Lonicera japonica; Oriental traditional medicine; antidotes; apoptosis; arginine; blood circulation; blood stasis; cell viability; cyclosporine; dextran; endothelium; free radical scavengers; heat; iron overload; mitochondria; models
Abstract:: ... Iron overload injury is considered to be a part of blood stasis syndrome of arthralgia in traditional Chinese medicine. Its primary therapies include clearing heat and detoxification, activating blood circulation, and removing blood stasis. Lonicera japonica flos (LJF) has long been known as an excellent antipyretic and antidote. Luteoloside (Lut) is one of the main components of LJF and exhibits ...
DOI:: 10.1016/S1875-5364(21)60110-3
: https://doi.org/10.1016/S1875-5364(21)60110-3

9. Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii

Author:: Hai-Yan DUAN; Jian WANG; Liang-Ping ZHA; Hua-Sheng PENG; Yu-Ping ZHAO; Yuan YUAN; Lu-Qi HUANG
Source:: Chinese journal of natural medicines 2022 v.20 no.2 pp. 133-138
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Pueraria montana var. thomsonii; biosynthesis; biotransformation; catalysts; chalcone; daidzein; databases; enzyme activity; formononetin; genistein; glycosylation; medicinal plants; medicinal properties; sequence analysis
Abstract:: ... Pueraria thomsonii has long been used in traditional Chinese medicine. Isoflavonoids are the principle pharmacologically active components, which are primarily observed as glycosyl-conjugates and accumulate in P. thomsonii roots. However, the molecular mechanisms underlying the glycosylation processes in (iso)flavonoid biosynthesis have not been thoroughly elucidated. In the current study, an O-gl ...
DOI:: 10.1016/S1875-5364(21)60105-X
: https://doi.org/10.1016/S1875-5364(21)60105-X

10. Probiotics with anti-type 2 diabetes mellitus properties: targets of polysaccharides from traditional Chinese medicine

Author:: Lun WU; Yue GAO; Yang SU; Jing LI; Wen-Chen REN; Qiu-Hong WANG; Hai-Xue KUANG
Source:: Chinese journal of natural medicines 2022 v.20 no.9 pp. 641-655
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; active ingredients; blood glucose; diabetes mellitus; glucose; glycemic effect; human health; intestinal microorganisms; lipid metabolism; people; polysaccharides; probiotics
Abstract:: ... Traditional Chinese medicine polysaccharides is a biologically active ingredient that is not easy to be digested. It is fermented by intestinal microflora to promote qualitative and selective changes in the composition of the intestinal microbiome, which often result in beneficial effects on the health of the host. People call it “prebiotics”. In this review, we systematically summarized the anti- ...
DOI:: 10.1016/S1875-5364(22)60210-3
: https://doi.org/10.1016/S1875-5364(22)60210-3

11. Sesquiterpenoids from the leaves of Sarcandra glabra

Author:: Yong-Yue WANG; Qiu-Rong LI; Jun CHI; Ji-Xin LI; Ling-Yi KONG; Jun LUO
Source:: Chinese journal of natural medicines 2022 v.20 no.3 pp. 215-220
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Sarcandra glabra; circular dichroism spectroscopy; lipopolysaccharides; nitric oxide; sesquiterpenoids; spectral analysis
Abstract:: ... Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane (1–5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1–2 were rare N-containing eudesm ...
DOI:: 10.1016/S1875-5364(21)60102-4
: https://doi.org/10.1016/S1875-5364(21)60102-4

12. Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis

Author:: Shan HUANG; Li LIU; Hui-Fang MEI; Qian-Wen ZHANG; Xi ZHANG; Xiao-Ting XU; Xin-Zhi WANG; Xin HUANG; Tao WANG; Zhen-Zhou JIANG; Lu-Yong ZHANG; Li-Xin SUN
Source:: Chinese journal of natural medicines 2021 v.19 no.3 pp. 188-194
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Tripterygium; alkaline phosphatase; bile; blood serum; cholestasis; females; fluorescent antibody technique; hepatocytes; hepatotoxicity; immunoblotting; liver; occludins; permeability; quantitative polymerase chain reaction; tight junctions; transmission electron microscopy
Abstract:: ... Triptolide (TP), an active component of Tripterygium wilfordiiHook. f. (TWHF), has been widely used for centuries as a traditional Chinese medicine. However, the clinical application of TP has been restricted due to multitarget toxicity, such as hepatotoxicity. In this study, 28 days of oral TP administration (100, 200, or 400 μg·kg–¹·d–¹) induced the occurrence of cholestasis in female Wistar rat ...
DOI:: 10.1016/S1875-5364(21)60020-1
: https://doi.org/10.1016/S1875-5364(21)60020-1

13. Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods

Author:: Hai-Zhen LIANG; Zhi-Yong DU; Shuo YUAN; Meng-Qiu LU; Jian-Yong XING; Qing MA; Zheng-Zhou HAN; Peng-Fei TU; Yong JIANG
Source:: Chinese journal of natural medicines 2021 v.19 no.9 pp. 713-720
ISSN:: 1875-5364
Subject:: Murraya exotica; Murraya paniculata; Oriental traditional medicine; chemometrics; cluster analysis; high performance liquid chromatography; mass spectrometry; pharmacology; principal component analysis
Abstract:: ... There are two source plants for the traditional Chinese medicine Murrayae Folium et Cacumen (MFC) in Chinese Pharmacopoeia, i.e. Murraya exotica L. and M. paniculata (L.) Jack. Herein, a chemical comparison of M. exotica and M. paniculata by high performance liquid chromatography (HPLC) fingerprint analysis coupled with chemometrics and network pharmacology was performed. The main peaks in the fin ...
DOI:: 10.1016/S1875-5364(21)60087-0
: https://doi.org/10.1016/S1875-5364(21)60087-0

14. Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS

Author:: Wei LIU; Jian HUANG; Feng ZHANG; Cong-Cong ZHANG; Rong-Sheng LI; Yong-Li WANG; Chao-Ran WANG; Xin-Miao LIANG; Wei-Dong ZHANG; Ling YANG; Ping LIU; Guang-Bo GE
Source:: Chinese journal of natural medicines 2021 v.19 no.4 pp. 305-320
ISSN:: 1875-5364
Subject:: COVID-19 infection; Oriental traditional medicine; blood serum; brain; flavonoids; heart; hospitals; kidneys; liver; lungs; medicinal properties; metabolites; oral administration; patients; spleen; triterpenoid saponins
Abstract:: ... Qing-Fei-Pai-Du decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People’s Republic of China. The latest clinical study showed that early treatment with QFPDD was associated with favorable outcomes for patient recovery, viral shedding, hospital stay, and course of the disease. However, the ef ...
DOI:: 10.1016/S1875-5364(21)60031-6
: https://doi.org/10.1016/S1875-5364(21)60031-6

15. Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice

Author:: Xiao-Jing XU; Jin-Bo LONG; Kai-Yu JIN; Li-Bing CHEN; Xiao-Yan LU; Xiao-Hui FAN
Source:: Chinese journal of natural medicines 2021 v.19 no.10 pp. 772-783
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; brain; choroid plexus; infarction; ischemia; mice; neutrophils; parenchyma (animal tissue); pharmacology; stroke; transcriptome; China
Abstract:: ... Danshen-Chuanxiongqin Injection (DCI) is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in China. However, its underlying mechanisms remain completely understood. The current study was designed to explore the protective mechanisms of DCI against cerebral ischemic stroke through integrating whole-transcriptome sequencing coupled with network pharmacology ...
DOI:: 10.1016/S1875-5364(21)60083-3
: https://doi.org/10.1016/S1875-5364(21)60083-3

16. Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic

Author:: Huan-Yu GUO; Zhen-Ya LU; Bo ZHAO; Wen-Wei JIANG; Yan-Hua XIONG; Kai WANG
Source:: Chinese journal of natural medicines 2021 v.19 no.1 pp. 36-45
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; adhesion; atherosclerosis; blood serum; cell adhesion; cell cycle; cell proliferation; cyclin-dependent kinase; flow cytometry; fluorescent antibody technique; hemodynamics; intercellular adhesion molecule-1; lipid metabolism; smooth muscle
Abstract:: ... Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoction (BNFY) is a traditional Chinese medicine compound that can treat cardiovascular ...
DOI:: 10.1016/S1875-5364(21)60004-3
: https://doi.org/10.1016/S1875-5364(21)60004-3

17. Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials

Author:: Hyuk-Ku Kwon; Ting Zhang; Xuan Gao Wu; Jing Yi Qiu; Sunmin Park
Source:: Chinese journal of natural medicines 2021 v.19 no.5 pp. 339-350
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; meta-analysis; odds ratio; placebos; quality of life; risk assessment; stroke; systematic review; therapeutics
Abstract:: ... The management of post-stroke complications plays an important role in the quality of life. Di-Tan Decoction (DTD; 涤痰汤) is a widely used traditional Chinese medicine. This study incorporated systematic review and meta-analysis to evaluate the efficacy of DTD in post-stroke neurological disorders. Randomized clinical trials (RCTs) were searched from English, Chinese and Korean electronic medical da ...
DOI:: 10.1016/S1875-5364(21)60035-3
: https://doi.org/10.1016/S1875-5364(21)60035-3

18. Honokiol: A naturally occurring lignan with pleiotropic bioactivities

Author:: Cheng CHEN; Qing-Wen ZHANG; Yang YE; Li-Gen LIN
Source:: Chinese journal of natural medicines 2021 v.19 no.7 pp. 481-490
ISSN:: 1875-5364
Subject:: Magnolia; Oriental traditional medicine; adipocytes; angiogenesis; antineoplastic agents; apoptosis; bioavailability; blood-brain barrier; cardiovascular system; cell cycle; honokiol; inflammation; insulin resistance; liver; nervous system; oxidative stress; therapeutics; toxicity; trees
Abstract:: ... Honokiol is the dominant biphenolic compound isolated from the Magnolia tree, and has long been considered as the active constituent of the traditional Chinese herb, ‘Houpo’, which is widely used to treat symptoms due to ‘stagnation of qi’. Pharmacological studies have shown that honokiol possesses a wide range of bioactivities without obvious toxicity. Honokiol protects the liver, kidneys, nervou ...
DOI:: 10.1016/S1875-5364(21)60047-X
: https://doi.org/10.1016/S1875-5364(21)60047-X

19. Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats

Author:: Cui-Ping LIAO; Xing-Chao LIU; Shi-Qi DONG; Ming AN; Lu ZHAO; Ai-Jie ZHANG; Jian-Feng LIU; Wen-Bin HOU; Hui-Rong FAN; Chang-Xiao LIU
Source:: Chinese journal of natural medicines 2021 v.19 no.10 pp. 758-771
ISSN:: 1875-5364
Subject:: Berberis; Oriental traditional medicine; berberine; computer software; dehydrogenation; demethylation; dysentery; enteritis; hydroxylation; hypertension; inflammation; intestinal microorganisms; metabolites; methylation; small intestine
Abstract:: ... Berberis amurensis (Berberidaceae) is a traditional Chinese medicine, which is often used to treat hypertension, inflammation, dysentery and enteritis. It contains alkaloids, mainly including berberine, berbamine, magnoflorine, jatrorrhizine and palmatine. Berberis amurensis extracts (BAEs) is often orally taken. Oral herbs might be metabolized by intestinal bacteria in the small intestine. Howeve ...
DOI:: 10.1016/S1875-5364(21)60082-1
: https://doi.org/10.1016/S1875-5364(21)60082-1

20. Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy

Author:: Jian-Zhi WU; Ya-Jing LI; Guang-Rui HUANG; Bing XU; Fei ZHOU; Run-Ping LIU; Feng GAO; Jun-De GE; Ya-Jie CAI; Qi ZHENG; Xiao-Jiaoyang LI
Source:: Chinese journal of natural medicines 2021 v.19 no.4 pp. 241-254
ISSN:: 1875-5364
Subject:: Angelica sinensis; Ligusticum sinense; Oriental traditional medicine; actin; bile acids; carbon tetrachloride; collagen; fibronectins; fibrosis; histopathology; inflammation; interleukin-6; ligands; liver; liver cirrhosis; mitogen-activated protein kinase; models; muscles; necrosis; neoplasms; pain; pharmacology; rhizomes; signal transduction
Abstract:: ... Angelicae Sinensis Radix (Danggui) and Ligusticum Chuanxiong Rhizoma (Chuan Xiong) herb-pair (DC) have been frequently used in Traditional Chinese medicine (TCM) prescriptions for hundreds of years to prevent vascular diseases and alleviate pain. However, the mechanism of DC herb-pair in the prevention of liver fibrosis development was still unclear. In the present study, the effects and mechanism ...
DOI:: 10.1016/S1875-5364(21)60026-2
: https://doi.org/10.1016/S1875-5364(21)60026-2

21. Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway

Author:: Meng-Meng ZHANG; Deng-Ke YIN; Xue-Lin RUI; Fu-Ping SHAO; Jia-Cheng LI; Li XU; Ye YANG
Source:: Chinese journal of natural medicines 2021 v.19 no.12 pp. 912-920
ISSN:: 1875-5364
Subject:: Bacteroidetes; Lactobacillus; Oriental traditional medicine; Proteobacteria; Western blotting; azoxymethane; colitis; colon; colorectal neoplasms; feces; fluorescent antibody technique; histopathology; immunity; immunohistochemistry; inflammation; interleukin-4; interleukin-6; intestinal microorganisms; mice; nucleotide sequences; protective effect; protein synthesis; sodium sulfate
Abstract:: ... Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possible protective mechanism of PNS on a colitis-associated colorectal cancer (CAC) mouse model induced by azoxymethane (AOM)/dextran sodium sulfate (DSS). The macr ...
DOI:: 10.1016/S1875-5364(22)60143-2
: https://doi.org/10.1016/S1875-5364(22)60143-2

22. Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibition of acylcarnitine in rats

Author:: Huan-Huan REN; Zheng NIU; Rui GUO; Min FU; Hai-Ru LI; Xuan-Yu ZHANG; Li YAO
Source:: Chinese journal of natural medicines 2021 v.19 no.2 pp. 120-133
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Rhodiola crenulata; Western blotting; animal models; autophagy; beta oxidation; blood serum; echocardiography; enzymes; hemodynamics; hypertension; lipidomics; lungs; phosphatidylcholines; protein content; pulmonary artery; signal transduction; sphingomyelins; therapeutics
Abstract:: ... Pulmonary arterial hypertension (PAH) is a devastating pulmonary circulation disease lacking high-efficiency therapeutics. The present study aims to decipher the therapeutic mechanism of Rhodiola crenulata, a well-known traditional chinese medicine with cardiopulmonary protection capacity, on PAH by exploiting functional lipidomics. The rat model with PAH was successfully established for first, fo ...
DOI:: 10.1016/S1875-5364(21)60013-4
: https://doi.org/10.1016/S1875-5364(21)60013-4

23. Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology

Author:: Hao-Nan ZHOU; Hao-Yu LI; Wen-Hua XU; Yan-Yi WEI; Rui-Xin YU; Wei WANG; Yuan-Ming CHEN
Source:: Chinese journal of natural medicines 2021 v.19 no.1 pp. 28-35
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; gene ontology; osteoporosis; pharmacology; therapeutics
Abstract:: ... Osteoporosis is a health problem to cause global concern. A lot of methods have been used to prevent and treat osteoporosis, but there is still a lack of effective treatment for osteoporosis owing to limited understanding of its mechanism. Therefore, the aim of this present study is to explore the underlying mechanism of Wuling Powder, a traditional Chinese medicine on treating osteoporosis. In th ...
DOI:: 10.1016/S1875-5364(21)60003-1
: https://doi.org/10.1016/S1875-5364(21)60003-1

24. TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches

Author:: Xin WANG; Zi-Yi WANG; Jia-Hui ZHENG; Shao LI
Source:: Chinese journal of natural medicines 2021 v.19 no.1 pp. 1-11
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; biomarkers; biomedical research; pharmacology
Abstract:: ... Traditional Chinese medicine (TCM) is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases. The holistic view of TCM coincides with the new generation of medical research paradigm characterized by network and system. TCM gave birth to a new method featuring holistic and systematic “network target”, a core theory and method of network pharm ...
DOI:: 10.1016/S1875-5364(21)60001-8
: https://doi.org/10.1016/S1875-5364(21)60001-8

25. Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis

Author:: Qi-Shun GENG; Rui-Juan LIU; Zhi-Bo SHEN; Qian WEI; Yuan-Yuan ZHENG; Lan-Qi JIA; Long-Hao WANG; Li-Feng LI; Jun LI; Wen-Hua XUE
Source:: Chinese journal of natural medicines 2021 v.19 no.12 pp. 930-943
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; adverse effects; amino acid metabolism; biosynthesis; cancer therapy; flow cytometry; fluorouracil; glycerophospholipids; head; homeostasis; interleukin-17; isoleucine; leucine; linoleic acid; metabolites; metabolomics; models; neck; necrosis; neoplasms; quality of life; radiotherapy; signal transduction; spleen; transcriptome; transcriptomics; valine; China
Abstract:: ... Oral mucositis (OM) caused by cancer therapy is the most common adverse reaction in the radiotherapy of head and neck tumors. In severe cases, it can lead to the interruption of treatment, which affects the control of the disease and the quality of life. Shuanghua Baihe Tablet (SBT) is a traditional Chinese medicine (TCM) formula, which is administerd to treat OM in China. It has been clinically e ...
DOI:: 10.1016/S1875-5364(22)60150-X
: https://doi.org/10.1016/S1875-5364(22)60150-X

26. A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces

Author:: Min GU; Yi-Ping YUAN; Zi-Nan QIN; Yan XU; Nan-Nan SHI; Yan-Ping WANG; Hua-Qiang ZHAI; Zhong-Zhi QIAN
Source:: Chinese journal of natural medicines 2021 v.19 no.7 pp. 551-560
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Rehmannia; catalpol; cluster analysis; herbal medicines; high performance liquid chromatography; quality control; quantitative analysis; t-test; verbascoside; China
Abstract:: ... The quality control of Chinese herbal medicine is a current challenge for the internationalization of traditional Chinese medicine. Traditional quality evaluation methods lack quantitative analysis, while modern quality evaluation methods ignore the origins and appearance traits. Therefore, an integrated quality evaluation method is urgent in need. Raw Rehmanniae Radix (RRR) is commonly used in Ch ...
DOI:: 10.1016/S1875-5364(21)60056-0
: https://doi.org/10.1016/S1875-5364(21)60056-0

27. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

Author:: Dou-Dou XU; Xiao-Ying HOU; Ou WANG; Di WANG; Dan-Ting LI; Si-Yuan QIN; Bo LV; Xiao-Min DAI; Zun-Jian ZHANG; Jian-Bo WAN; Feng-Guo XU
Source:: Chinese journal of natural medicines 2021 v.19 no.5 pp. 364-375
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; baicalin; cancer therapy; cell movement; cell proliferation; diarrhea; gastrointestinal system; glycyrrhizin; macrophages; models; toxicity; toxicity testing; xenotransplantation
Abstract:: ... Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to scre ...
DOI:: 10.1016/S1875-5364(21)60034-1
: https://doi.org/10.1016/S1875-5364(21)60034-1

28. Advances on hormone-like activity of Panax ginseng and ginsenosides

Author:: Mei TIAN; Lin-Nan LI; Rui-Rong ZHENG; Li YANG; Zheng-Tao WANG
Source:: Chinese journal of natural medicines 2020 v.18 no.7 pp. 526-535
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Panax ginseng; active ingredients; ginsenosides; herbs; in vivo studies; phytosterols; steroid hormones; structure-activity relationships; triterpenoid saponins
Abstract:: ... Traditional Chinese medicine (TCM) has been paid much attentions due to the prevention and treatment of steroid hormone disorders. Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most valuable herbs in complementary and alternative medicines around the world. A series of dammarane triterpenoid saponins, also known as phytosteroids, were reported as the primary ingredient ...
DOI:: 10.1016/S1875-5364(20)30063-7
: https://doi.org/10.1016/S1875-5364(20)30063-7

29. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

Author:: Shuai HUANG; Shuang-Mei ZHAO; Lian-Hai SHAN; Xian-Li ZHOU
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 81-89
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; caspase-9; colorectal neoplasms; human diseases; mitogen-activated protein kinase; neoplasm cells; proteins; pyrrolizidine alkaloids; signal transduction
Abstract:: ... Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with t ...
DOI:: 10.1016/S1875-5364(20)30009-1
: https://doi.org/10.1016/S1875-5364(20)30009-1

30. Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice

Author:: Xin-Yu LIU; Guan-Nan CHEN; Guo-Ming DU; Yue PAN; Wu-Qi SONG; Ting-Wang JIANG; Hai-Liang LIU
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 186-195
ISSN:: 1875-5364
Subject:: Berberis vulgaris; Oriental traditional medicine; alanine transaminase; animal models; aspartate transaminase; blood serum; cell proliferation; cholesterol; enzyme inhibition; gene expression; hepatocytes; histopathology; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; liver; liver diseases; macrophages; mechanism of action; messenger RNA; mice; mitogen-activated protein kinase; phosphorylation; protective effect; quantitative polymerase chain reaction; staining; therapeutics; transcription factor NF-kappa B; triacylglycerols
Abstract:: ... Alcoholic liver disease (ALD) has become one of the leading causes of death in the world. Berbamine (BM), a natural product mainly derived from Berberis vulgaris L, possesses multiple bioactivities as a traditional medicine. However, the protective effect of BM on ALD remains unknown. In this study, we investigated the effect of BM on ethanol-induced hepatic injury in mice and its underlying mecha ...
DOI:: 10.1016/S1875-5364(20)30020-0
: https://doi.org/10.1016/S1875-5364(20)30020-0

31. Bufalin-induced cardiotoxicity: new findings into mechanisms

Author:: Min LI; Xi-Jie WANG; Qi ZHAO; Jia-Xian WANG; Hong-Yan XING; Yi-Zhe ZHANG; Xue-Xia ZHANG; Yang-Yang ZHI; Hua LI; Jing MA
Source:: Chinese journal of natural medicines 2020 v.18 no.7 pp. 550-560
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; action potentials; adverse effects; cardiomyocytes; cardiotoxicity; drug development; duration; humans; ion channels; patients; sodium; toxicology
Abstract:: ... Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine preparations. The cardiotoxicity clearly limits its application to patients living in countries. Hence, an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse reactions. We investigate the cardiot ...
DOI:: 10.1016/S1875-5364(20)30065-0
: https://doi.org/10.1016/S1875-5364(20)30065-0

32. CO as a therapeutic agent: discovery and delivery forms

Author:: Xiao-Xiao YANG; Bo-Wen KE; Wen LU; Bing-He WANG
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 284-295
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; carbon monoxide; chemistry; inflammation; therapeutics; toxic substances; toxicity
Abstract:: ... Carbon monoxide (CO) as one of the three important endogenously produced signaling molecules, termed as “gasotransmitter,” has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO's evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver ...
DOI:: 10.1016/S1875-5364(20)30036-4
: https://doi.org/10.1016/S1875-5364(20)30036-4

33. Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae

Author:: Long-Fang GUO; Gao-Ran LIU; Ling LIU
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 261-267
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Pestalotiopsis; cytotoxicity; endophytes; fungi; moieties; sesquiterpenoids; spectral analysis
Abstract:: ... Two new caryophyllene-type sesquiterpenoids, pestathenols A (1) and B (2) and one new α-furanone, pestatheranone A (6), along with five known compounds (3–5, 7 and 8) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae. Their structures were unambiguously established by extensive spectroscopic analyses. The absolute configuration of the 5,6-diol moiety in ...
DOI:: 10.1016/S1875-5364(20)30032-7
: https://doi.org/10.1016/S1875-5364(20)30032-7

34. Complete chloroplast genome of Salvia plebeia: organization, specific barcode and phylogenetic analysis

Author:: Ning CUI; Bao-Sheng LIAO; Cong-Lian LIANG; Shi-Feng LI; Hao ZHANG; Jiang XU; Xi-Wen LI; Shi-Lin Chen
Source:: Chinese journal of natural medicines 2020 v.18 no.8 pp. 563-572
ISSN:: 1875-5364
Subject:: DNA barcoding; Oriental traditional medicine; Salvia plebeia; Trigona; amino acids; barcoding; chloroplast genome; chloroplasts; codon usage; genomic libraries; information; intergenic DNA; length; phylogeny; population; tandem repeat sequences
Abstract:: ... Salvia plebeia has been in use as traditional Chinese medicine (TCM) for more than 500 years. In this study, the complete chloroplast (cp) genome of S. plebeia was sequenced, assembled and compared to those of other five published Salvia cp genomes. It was found that the cp genome structure of S. plebeia was well conserved and had a total size of 151 062 bp. Four parameters were used to display th ...
DOI:: 10.1016/S1875-5364(20)30068-6
: https://doi.org/10.1016/S1875-5364(20)30068-6

35. Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry

Author:: Zi-Han LIU; Yu-Qi WANG; Xiao-Dan MEI; Fei WANG; Xian-Zhao YANG; Xiao-Dong LI; Feng JIANG; Jia-Yu ZHANG
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 148-160
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; chemical composition; chlorogenic acid; esterification; flavonoids; fumigation; heat; high performance liquid chromatography; iridoid glycosides; mass spectrometry; quality control; sulfates; sulfites; sulfur; ultra-performance liquid chromatography
Abstract:: ... Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical constituent analysis of organic acids, flavonoids, iridoids and new-generated comp ...
DOI:: 10.1016/S1875-5364(20)30015-7
: https://doi.org/10.1016/S1875-5364(20)30015-7

36. Construction and application of carbohydrate microarrays to detect foodborne bacteria

Author:: Jing HU; Yong XIAO; Shu-An SHAO; Rui GU; Qi-Min SHI; Zhong-Hua LIU; Jian YIN
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 219-225
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Salmonella enterica; adhesins; alleles; allelic variation; bacteria; binding capacity; infectious diseases; mannose; microarray technology; pathogens; patients; polysaccharides; rapid methods; serotypes; virulent strains
Abstract:: ... The rapid detection of pathogenic bacteria is vital for the prevention of outbreaks of infectious diseases, including infections by the common foodborne bacteria E.coli and Salmonella Carbohydrate microarrays have been developed as a powerful method to investigate carbohydrate-protein interaction with only very small amounts of glycans, which show great potential for detect the carbohydrate mediat ...
DOI:: 10.1016/S1875-5364(20)30024-8
: https://doi.org/10.1016/S1875-5364(20)30024-8

37. Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

Author:: Jong-Eun Lee; Sung Sik Yoon; Jae-Wook Lee; Eun-Yi Moon
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 114-122
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; apoptosis; autophagy; blood serum; curcumin; eukaryotic cells; glioblastoma; human diseases; neoplasm cells; starvation; survival rate; therapeutics
Abstract:: ... Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human cancers. Autophagy promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic cells. Here, we investigated whether varying levels of autophagic flux in glioblastoma lead to different efficacies of curcumin treatment using U87MG and A172 human glioblastoma cells. The number of LC3 punct ...
DOI:: 10.1016/S1875-5364(20)30012-1
: https://doi.org/10.1016/S1875-5364(20)30012-1

38. Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway

Author:: Yong-Shen REN; Yao ZHENG; Huan DUAN; Lei LEI; Xin DENG; Xin-Qiao LIU; Zhi-Nan MEI; Xu-Kun DENG
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 103-113
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Taraxacum; acetaminophen; alanine transaminase; alkaline phosphatase; apoptosis; aspartate transaminase; biomarkers; blood serum; caspase-9; enzyme inhibition; gene expression regulation; genes; glutathione; hepatocytes; hepatotoxicity; histopathology; inducible nitric oxide synthase; interleukin-1beta; liver; malondialdehyde; mice; mitochondria; mitogen-activated protein kinase; necrosis; oxidative stress; polyphenols; prostaglandin synthase; protein synthesis; signal transduction; staining; superoxide dismutase; tumor necrosis factor-alpha
Abstract:: ... We investigated the liver protective activity of dandelion polyphenols (DP) against acetaminophen (APAP; Paracetamol)-induced hepatotoxicity. Mice were acclimated for 1 week and randomly divided into the following groups (n = 9 per group): Control, APAP, APAP + DP (100 mg·kg⁻¹), APAP + DP (200 mg·kg⁻¹), and APAP + DP (400 mg·kg⁻¹) groups. Mice were pretreated with DP (100, 200, and 400 mg·kg⁻¹) by ...
DOI:: 10.1016/S1875-5364(20)30011-X
: https://doi.org/10.1016/S1875-5364(20)30011-X

39. Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation

Author:: Cheng-Zhi LIU; Wei CHEN; Mei-Xia WANG; Ying WANG; Li-Qing CHEN; Feng ZHAO; Ya SHI; Hui-Jun LIU; Xiao-Bing DOU; Chao LIU; Huan CHEN
Source:: Chinese journal of natural medicines 2020 v.18 no.6 pp. 446-459
ISSN:: 1875-5364
Subject:: Actinomyces; Anaerovorax; Bilophila; Collinsella; Coprococcus; Dendrobium officinale; Escherichia; Fusobacterium; Lactobacillus; Oriental traditional medicine; Otus; Panax quinquefolius; Shigella; Slackia; Solobacterium; Streptococcus; Sutterella; cell-mediated immunity; diabetes; digestive system; dogs; dysbiosis; genes; humoral immunity; intestinal microorganisms; macrophages; mice; microbial communities; monocytes; prebiotics; probiotics; short chain fatty acids
Abstract:: ... Dendrobium officinale Kimura et Migo (D. officinale) is a famous traditional Chinese medicine (TCM). A mixture of D. officinale and American ginseng has been shown to enhance cell-mediated immunity, humoral immunity, and monocyte/macrophage functions in mice. Here, the effects of a D. officinale and American ginseng mixture on the structure of gut microbial community in dogs were examined using hi ...
DOI:: 10.1016/S1875-5364(20)30052-2
: https://doi.org/10.1016/S1875-5364(20)30052-2

40. Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway

Author:: Sheng-Nan ZHOU; Jian ZHANG; Qiu-Yue REN; Rong-Fei YAO; Peng LIU; Bai CHANG
Source:: Chinese journal of natural medicines 2020 v.18 no.8 pp. 612-619
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; animal models; aorta; extracellular matrix; fibrosis; proteins; rats; signal transduction
Abstract:: ... Macroangiopathy is a complication of Type II Diabetes Mellitus (T2DM), which is mainly caused by fibrosis of blood vessels. Using T2DM rat models, we investigated whether the traditional Chinese medicine, Di-Dang Decoction (DDD), exhibited anti-fibrotic actions on great vessels. T2DM rats were randomly divided into non-intervention group, early-, middle-, late-stage DDD intervention groups and con ...
DOI:: 10.1016/S1875-5364(20)30073-X
: https://doi.org/10.1016/S1875-5364(20)30073-X

41. Effect of quercetin on chondrocyte phenotype and extracellular matrix expression

Author:: Zhi-Peng GUI; Yue HU; Yu-Ning ZHOU; Kai-Li LIN; Yuan-Jin XU
Source:: Chinese journal of natural medicines 2020 v.18 no.12 pp. 922-933
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; assays; cartilage; chondrogenesis; dose response; extracellular matrix; fluorescent antibody technique; genes; glycosaminoglycans; histology; in vivo studies; liver; phenotype; quercetin; rats; scaffolding proteins; secretion; signal transduction; silk proteins; staining; tissue repair
Abstract:: ... Due to the poor repair ability of cartilage tissue, regenerative medicine still faces great challenges in the repair of large articular cartilage defects. Quercetin is widely applied as a traditional Chinese medicine in tissue regeneration including liver, bone and skin tissues. However, the evidence for its effects and internal mechanisms for cartilage regeneration are limited. In the present stu ...
DOI:: 10.1016/S1875-5364(20)60036-X
: https://doi.org/10.1016/S1875-5364(20)60036-X

42. Fatty liver diseases, mechanisms, and potential therapeutic plant medicines

Author:: Jia-Zhen ZHU; Hong-Wei YI; Wei HUANG; Tao PANG; Hui-Ping ZHOU; Xu-Dong WU
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 161-168
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; cytokines; energy metabolism; fatty liver; glucose; hyperlipidemia; insulin; lipid metabolism; lipids; liver; pathogenesis; plant products; therapeutics; thyroid hormones; transcription factors
Abstract:: ... The liver is an important metabolic organ and controls lipid, glucose and energy metabolism. Dysruption of hepatic lipid metabolism is often associated with fatty liver diseases, including nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver diseases (AFLD) and hyperlipidemia. Recent studies have uncovered the contribution of hormones, transcription factors, and inflammatory cytokines t ...
DOI:: 10.1016/S1875-5364(20)30017-0
: https://doi.org/10.1016/S1875-5364(20)30017-0

43. Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201

Author:: Jie-Yi LONG; Jun-Feng WANG; Sheng-Rong LIAO; Xiu-Ping LIN; Xue-Feng ZHOU; Yun-Qiu LI; Bin YANG; Yong-Hong LIU
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 250-255
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Penicillium; X-ray diffraction; cytotoxicity; fungi; inhibitory concentration 50; lactones; spectroscopy; steroids
Abstract:: ... Penicildiones A–D (1–4), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the 1% NaCl PDB substrate. Their structures were determined through spectroscopic me ...
DOI:: 10.1016/S1875-5364(20)30030-3
: https://doi.org/10.1016/S1875-5364(20)30030-3

44. Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments

Author:: Hao-Nan WANG; Zheng SHEN; Qing LIU; Xiao-Ying HOU; Yan CAO; Da-Hui LIU; Hong JIANG; Hong-Zhi DU
Source:: Chinese journal of natural medicines 2020 v.18 no.11 pp. 860-871
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antioxidants; dietary supplements; dynamics; extracts; foods; hepatoprotective effect; ingredients; materials; pharmacokinetics; quality control; research and development; tea; vegetables
Abstract:: ... Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine (TCM) and in chemical medicine, as well as in cosmetic ingredients, nutraceuticals and food products. Isochlorogenic acid (ICGA), which has medicinal value, has been discovered in various plants. As a widespread natural medicine, ICGA should be the subject of further research and deve ...
DOI:: 10.1016/S1875-5364(20)60029-2
: https://doi.org/10.1016/S1875-5364(20)60029-2

45. Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury

Author:: Tao-Guang HUO; Ying FANG; Ying-Hua ZHANG; Cong FENG; Hong JIANG
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 138-147
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; arsenic; carnitine; cell membrane structures; choline; energy metabolism; glycyrrhetinic acid; hepatoprotective effect; hepatotoxicity; ingredients; liver; lysophosphatidylcholine; mass spectrometry; metabolites; metabolomics; methylation; mice; nicotinamide; oxidative stress; phenylalanine; proline; tissues; ultra-performance liquid chromatography
Abstract:: ... Glycyrrhetinic acid (GA) is the bioactive ingredient in Glycyrrhizae Radix et Rhizoma. Our previous study has reported that GA has protective effect on realgar-induced hepatotoxicity. However, the details of the hepatoprotective mechanisms of GA on realgar-induced liver injury remain to be elucidated. In the study, mice were divided into control, GA-control, realgar, and co-treated groups. Their l ...
DOI:: 10.1016/S1875-5364(20)30014-5
: https://doi.org/10.1016/S1875-5364(20)30014-5

46. MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer

Author:: Xiao FU; Neng TANG; Wei-Qi XIE; Liang MAO; Yu-Dong QIU
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 178-185
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; breast neoplasms; drug therapy; enzymes; gene expression; glucose; glycolysis; lactic acid; messenger RNA; neoplasm cells; pancreatic neoplasms; secretion; transmembrane proteins; tumor suppressor proteins
Abstract:: ... Enhanced glucose metabolism is one of the hallmarks of pancreatic cancer. MUC1, a transmembrane protein, is a global regulator of glucose metabolism and essential for progression of pancreatic cancer. To clarify the role of MUC1 in glucose metabolism, we knocked out MUC1 in Capan-1 and CFPAC-1 cells. MUC1 knockout (KO) cells uptook less glucose and secreted less lactate with a much lower prolifera ...
DOI:: 10.1016/S1875-5364(20)30019-4
: https://doi.org/10.1016/S1875-5364(20)30019-4

47. Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three original species of Pyrrosiae Folium

Author:: Chu-Hong YANG; Xia LIU; Ying-Xian CUI; Li-Ping NIE; Yu-Lin LIN; Xue-Ping WEI; Yu WANG; Hui YAO
Source:: Chinese journal of natural medicines 2020 v.18 no.8 pp. 573-581
ISSN:: 1875-5364
Subject:: DNA barcoding; Oriental traditional medicine; Pyrrosia; adulterants; chloroplast genes; chloroplast genome; genetic markers; herbal medicines; high-throughput nucleotide sequencing; leaves; medicinal plants; nucleotide sequences; phylogeny; plant identification; species identification
Abstract:: ... Pyrrosia petiolosa, Pyrrosia lingua and Pyrrosia sheareri are recorded as original plants of Pyrrosiae Folium (PF) and commonly used as Chinese herbal medicines. Due to the similar morphological features of PF and its adulterants, common DNA barcodes cannot accurately distinguish PF species. Knowledge of the chloroplast (cp) genome is widely used in species identification, molecular marker and phy ...
DOI:: 10.1016/S1875-5364(20)30069-8
: https://doi.org/10.1016/S1875-5364(20)30069-8

48. Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

Author:: Guang-Chan JING; Di LIU; Yu-Qin LIU; Meng-Ren ZHANG
Source:: Chinese journal of natural medicines 2020 v.18 no.9 pp. 704-713
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; acetylcysteine; apoptosis; cells; cognition; cognitive disorders; culture media; glucose; membrane potential; mitochondria; mitochondrial membrane; models; neurons; neuroprotective effect; oxidative stress; rats; research; signal transduction
Abstract:: ... Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ (60 mg·kg⁻¹)-induced diabetic rats into control group, diabetic model group and NF ...
DOI:: 10.1016/S1875-5364(20)60009-7
: https://doi.org/10.1016/S1875-5364(20)60009-7

49. New meroterpenoid compounds from the culture of mushroom Panus lecomtei

Author:: Si-Xian WANG; Rui-Lin ZHAO; Cui GUO; Bao-Song CHEN; Huan-Qin DAI; Gao-Qiang LIU; Hong-Wei LIU
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 268-272
ISSN:: 1875-5364
Subject:: Bacillus subtilis; Escherichia coli; Mycobacterium bovis BCG; Oriental traditional medicine; Pseudomonas aeruginosa; Staphylococcus aureus; antibacterial properties; biochemical pathways; meroterpenoids; mushrooms; nuclear magnetic resonance spectroscopy; pathogens; spectral analysis
Abstract:: ... Two new meroterpenoid compounds (1 and 2) together with five known meroterpenoid derivatives (3–7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1–7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcu ...
DOI:: 10.1016/S1875-5364(20)30033-9
: https://doi.org/10.1016/S1875-5364(20)30033-9

50. Nitric oxide donating anti-glaucoma drugs: advances and prospects

Author:: Yu-Jie MAO; Jian-Bing WU; Ze-Qiu YANG; Yi-Hua ZHANG; Zhang-Jian HUANG
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 275-283
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; blindness; blood flow; drugs; eyes; glaucoma; markets; nerve tissue; nitric oxide; therapeutics
Abstract:: ... Glaucoma is a disease that causes irreversible blindness. Reducing intraocular pressure (IOP) is the main treatment at present. Nitric oxide (NO), an endogenous gas signaling molecule, can increase aqueous humor outflow facility, inhibit aqueous humor production thereby reducing IOP, as well as regulate eye blood flow and protect the optic nerve. Therefore, NO donating anti-glaucoma drugs have bro ...
DOI:: 10.1016/S1875-5364(20)30035-2
: https://doi.org/10.1016/S1875-5364(20)30035-2

51. Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity

Author:: Qing-Qing SHEN; Jing-Jing WANG; Debmalya ROY; Li-Xin SUN; Zhen-Zhou JIANG; Lu-Yong ZHANG; Xin HUANG
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 196-205
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Rheum officinale; Tripterygium wilfordii; adverse effects; aristolochic acids; biomarkers; drugs; nephritis; nephrotoxicity; proximal tubules; risk; toxins; transporters; xenobiotics
Abstract:: ... With the internationally growing popularity of traditional Chinese medicine (TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephriti ...
DOI:: 10.1016/S1875-5364(20)30021-2
: https://doi.org/10.1016/S1875-5364(20)30021-2

52. Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats

Author:: Li YAO; Yu-Xia YANG; Hui CAO; Huan-Huan REN; Zheng NIU; Ling SHI
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 308-320
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; animal models; biochemical pathways; biosynthesis; drugs; glycolysis; hypertension; lipid metabolism; metabolites; metabolomics; phosphorylation; pulmonary artery; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; signal transduction; sphingolipids; sphingosine; steroid hormones; therapeutics; unsaturated fatty acids
Abstract:: ... Osthole is observed to have the capacity to treat pulmonary arterial hypertension (PAH) in rats, but molecular mechanism is still unknown. The present study aims to discover therapeutic targets and explore therapeutic mechanism of osthole against PAH from metabolic perspective. A rat model with PAH was successfully established with MCT, following osthole administration, then untargeted metabolomic ...
DOI:: 10.1016/S1875-5364(20)30038-8
: https://doi.org/10.1016/S1875-5364(20)30038-8

53. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats

Author:: Xin-Gang LI; Jian NI; Su SHEN; Xiao-Ping WANG; Jing-Chen TIAN
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 234-240
ISSN:: 1875-5364
Subject:: Forsythia suspensa; Oriental traditional medicine; azithromycin; blood sampling; drugs; high performance liquid chromatography; laboratory animals; males; mycoplasmosis; nonlinear mixed effects models; pharmacokinetics; plant extracts; rats; tandem mass spectrometry; China
Abstract:: ... Azithromycin and Chinese medicine forsythia are often used together to treat pediatric mycoplasma infections in China. We aimed to investigate the pharmacokinetic interaction of Forsythia suspensa extract and azithromycin after single and co-intravenous administration in rats. Male Sprague-Dawley rats received single (Forsythia suspensa extract or azithromycin) treatment or co-administration of Fo ...
DOI:: 10.1016/S1875-5364(20)30026-1
: https://doi.org/10.1016/S1875-5364(20)30026-1

54. Prodrugs of hydrogen sulfide and related sulfur species: recent development

Author:: Zheng-Nan YUAN; Yue-Qin ZHENG; Bing-He WANG
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 296-307
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; cell communication; glutathione; hydrogen sulfide; sulfur
Abstract:: ... Hydrogen sulfide (H₂S) is commonly referred to as the third gasotransmitter with firmly established physiological roles. Prodrug approaches have been broadly applied to deliver H₂S for various applications and mechanistic studies. Since S-persulfidation and glutathionylation are known to be important in cellular signaling by sulfur species, there have been interests in developing donors of persulf ...
DOI:: 10.1016/S1875-5364(20)30037-6
: https://doi.org/10.1016/S1875-5364(20)30037-6

55. Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang ShuaiLao Pian treated mid-adult mice

Author:: Shu-Qing GONG; Ting-Ting YE; Mei-Xia WANG; Zhu-Ping HONG; Li LIU; Huan CHEN; Jing QIAN
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 90-102
ISSN:: 1875-5364
Subject:: Bacteroidetes; Firmicutes; Oriental traditional medicine; anti-aging properties; bacteria; brain; brown adipose tissue; butyrates; digestive system; dopamine; enzyme-linked immunosorbent assay; feces; gas chromatography; intestinal microorganisms; mice; neurons; ribosomal RNA; sequence analysis; white adipose tissue
Abstract:: ... With the occurrence of aging process, decreased neuron dopamine, disrupted brown adipose tissue (BAT) remodeling and decreased butyrate level all reflect a weak host healthy in certain degree. Nevertheless, the signs of mid-adult gut microbiota, and its association with host healthy are not well understood. In current study, we deemed to illustrate the associations of age, neuron dopamine, BAT rem ...
DOI:: 10.1016/S1875-5364(20)30010-8
: https://doi.org/10.1016/S1875-5364(20)30010-8

56. Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism

Author:: Fang-He LI; Xiao-Lou HUANG; Hui WANG; Shu-Wen GUO; Ping LI
Source:: Chinese journal of natural medicines 2020 v.18 no.10 pp. 779-792
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; angiogenesis; animal models; blood lipids; cardiac output; cells; drugs; echocardiography; gene expression; glucose; inflammation; lipid metabolism; lipid metabolism disorders; lipids; mitochondria; myocardial ischemia; myocardium; protective effect; rats; signal transduction; staining; surgery
Abstract:: ... Yi-Qi-Huo-Xue Decoction (YQHX) is the recombination of Dang-Gui-Bu-Xue Decoction (DBD), which is one of the well-known traditional Chinese Medicine (TCM) prescription, and has long been shown to have significant protective effects against myocardial ischemic injury. In previous studies, we found that YQHX could regulate lipid and glucose metabolism, promote angiogenesis, attenuate inflammatory res ...
DOI:: 10.1016/S1875-5364(20)60018-8
: https://doi.org/10.1016/S1875-5364(20)60018-8

57. Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats

Author:: Zhi-Jian LI; Abulizi Abudumijiti; Deng-Qiu XU; Maimaiti Youlidouzi; Aibai Silafu; Zhen-Zhou JIANG; Guo-Lin ZHAO; Tao WANG; Refukati Aiximujiang; Maimaiti Zulikaer; Simayi Yiliyaer; Chun-Yu CAO; Lu-Yong ZHANG
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 123-137
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; bile; bile secretion; biochemical pathways; bone fractures; cytochrome P-450; drugs; ethanol; gene expression regulation; glutathione; hepatotoxicity; histopathology; laboratory animals; liver; osteoporosis; pathogenesis; peroxisome proliferator-activated receptor alpha; protein composition; protein synthesis; proteomics; rats; tissues
Abstract:: ... Fructus Psoraleae, which is commonly consumed for the treatment of osteoporosis, bone fracture, and leucoderma, induces liver injury. This study investigated the pathogenesis of the ethanol extract of Fructus Psoraleae (EEFP)-induced liver injury in rats. EEFP (1.35, 1.80, and 2.25 g·kg⁻¹) was administrated to Sprague Dawley (SD) rats for 30 d. We measured liver chemistries, histopathology, and qu ...
DOI:: 10.1016/S1875-5364(20)30013-3
: https://doi.org/10.1016/S1875-5364(20)30013-3

58. Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19

Author:: Yu-Jie DAI; Shi-Yao WAN; Shuai-Shuai GONG; Jin-Cheng LIU; Fang LI; Jun-Ping KOU
Source:: Chinese journal of natural medicines 2020 v.18 no.12 pp. 881-889
ISSN:: 1875-5364
Subject:: Coronavirus infections; Oriental traditional medicine; Orthocoronavirinae; administrative management; antiviral agents; human health; immunomodulation; information; literature; mining; mortality; patients; pneumonia; China
Abstract:: ... Coronavirus disease-2019 (COVID-19) is a new highly infectious disease caused by a novel coronavirus. Recently, the number of new cases infected pneumonia in the world continues to increase, which has aroused great concern from the international community. At present, there are no small-molecule specific anti-viral drugs for the treatment. The high mortality rate seriously threatens human health. ...
DOI:: 10.1016/S1875-5364(20)60031-0
: https://doi.org/10.1016/S1875-5364(20)60031-0

59. Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology

Author:: Jia-Yun SHENG; Si-Qi WANG; Kao-Hua LIU; Bo ZHU; Qiao-Yan ZHANG; Lu-Ping QIN; Jian-Jun WU
Source:: Chinese journal of natural medicines 2020 v.18 no.6 pp. 401-416
ISSN:: 1875-5364
Subject:: Japan; Oriental traditional medicine; Rubus chingii; active ingredients; alkaloids; antioxidants; extracts; flavonoids; fruits; history; information; kidneys; leaves; medicinal properties; organic acids and salts; phenylpropanoids; quality control; research; steroids; supply; terpenoids; toxicity; China
Abstract:: ... Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits (Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate t ...
DOI:: 10.1016/S1875-5364(20)30048-0
: https://doi.org/10.1016/S1875-5364(20)30048-0

60. Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice

Author:: Hong-Wei YI; Xiao-Xiao ZHU; Xiao-Li HUANG; Yu-Zhu LAI; Yue TANG
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 169-177
ISSN:: 1875-5364
Subject:: Bifidobacterium longum; Oriental traditional medicine; alanine transaminase; alcohols; aspartate transaminase; blood serum; enzyme activity; genes; hepatocytes; high fat diet; hyperlipidemia; inflammation; interleukin-1beta; interleukin-6; lipids; lipogenesis; messenger RNA; mice; oxidative stress; peroxisome proliferator-activated receptor alpha; protective effect; selenium; superoxide dismutase; tumor necrosis factor-alpha
Abstract:: ... The objective of this study was to verify the protective effect of Bifidobacterium longum (BL) and the synergistical effect of Selenium and BL on alcohol plus high fat diet (HFD) induced hepatic injury in mice. We also want to explore the mechanism of Selenium-enriched Bifidobacterium longum (SeBL). C57BL/6 mice were treated with alcohol plus HFD with or without different dosage of BL or SeBL for ...
DOI:: 10.1016/S1875-5364(20)30018-2
: https://doi.org/10.1016/S1875-5364(20)30018-2

61. Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats

Author:: Rui-Juan CHEN; Qing-Lin RUI; Qiong WANG; Fang TIAN; Jian WU; Xiang-Qing KONG
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 226-233
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; apoptosis; blood serum; cardiomyocytes; cell viability; inflammation; interleukins; intraperitoneal injection; laboratory animals; lipopolysaccharides; mitogen-activated protein kinase; mitogen-activated protein kinase kinase; protective effect; rats; sepsis (infection); signal transduction; tumor necrosis factor-alpha
Abstract:: ... Shenfu injection (SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide (LPS)-induced myocardial inflammation and apoptosis. Experiments were carried out in Sprague-Dawley (SD) rats treated with LPS or LPS + SFI, and in H9C2 cardiomyocytes. The sepsis-associated myocardial in ...
DOI:: 10.1016/S1875-5364(20)30025-X
: https://doi.org/10.1016/S1875-5364(20)30025-X

62. Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis

Author:: Dong-Shun LI; Quan-Fei HUANG; Li-Huan GUAN; Hui-Zhen ZHANG; Xi LI; Kai-Li FU; Yi-Xin CHEN; Jian-Bo WAN; Min HUANG; Hui-Chang BI
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 211-218
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Schisandra; bile; blood serum; ethanol; excretion; feces; genomics; hepatoprotective effect; intestinal microorganisms; intestines; intrahepatic cholestasis; lithocholic acid; liver; liver diseases; liver regeneration; metabolome; metabolomics; mice; secretion
Abstract:: ... Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases. We previously reported the ethanol extract of Schisandra sphenanthera (Wuzhi tablet, WZ) can significantly protect against lithocholic acid (LCA)-induced intrahepatic cholestasis in mice, partially due to the activation of PXR pathway and promotion of liver regeneration. However, the ef ...
DOI:: 10.1016/S1875-5364(20)30023-6
: https://doi.org/10.1016/S1875-5364(20)30023-6

63. Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3

Author:: Pei QIU; Run-Lin CAI; Lin LI; Zhi-Gang SHE
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 256-260
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Penicillium; X-ray diffraction; acetates; alpha-glucosidase; deoxynojirimycin; endophytes; fungi; inhibitory concentration 50; spectral analysis
Abstract:: ... Three new isocoumarin derivatives, (S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one (1), (S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one (2) and (R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl) propyl acetate (3), along with four known compounds (4–7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the bas ...
DOI:: 10.1016/S1875-5364(20)30031-5
: https://doi.org/10.1016/S1875-5364(20)30031-5

64. Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP)

Author:: Hong-Zhi DU; Xiao-Ying HOU; Yu-Huan MIAO; Bi-Sheng HUANG; Da-Hui LIU
Source:: Chinese journal of natural medicines 2020 v.18 no.3 pp. 206-210
ISSN:: 1875-5364
Subject:: Coronavirinae; Oriental traditional medicine; patients; plague; pneumonia
Abstract:: ... The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medicine has accumulated a solid theoretical foundation of plague in ancient and recen ...
DOI:: 10.1016/S1875-5364(20)30022-4
: https://doi.org/10.1016/S1875-5364(20)30022-4

65. Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019

Author:: Yan XING; Ying-Rong HUA; Jing SHANG; Wei-Hong GE; Jun LIAO
Source:: Chinese journal of natural medicines 2020 v.18 no.12 pp. 941-951
ISSN:: 1875-5364
Subject:: COVID-19 infection; Oriental traditional medicine; active ingredients; angiotensin-converting enzyme inhibitors; anti-inflammatory activity; antiviral properties; apigenin; drug therapy; immune response; injection; interleukin-6; luteolin; medical treatment; mitogen-activated protein kinase; proteinases; quercetin; rutin; salvianolic acid; tumor necrosis factors; viral proteins
Abstract:: ... As a representative drug for the treatment of severe community-acquired pneumonia and sepsis, Xuebijing (XBJ) injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019 (COVID-19), but its treatment mechanism for COVID-19 is still unclear. Therefore, this study aims to explore the potential mechanism of XBJ injection in the treatment of COVID-19 emp ...
DOI:: 10.1016/S1875-5364(20)60038-3
: https://doi.org/10.1016/S1875-5364(20)60038-3

66. The cardiovascular protective effect and mechanism of calycosin and its derivatives

Author:: Li PAN; Xuan-Fen ZHANG; Wan-Sheng WEI; Jing ZHANG; Zhen-Zhen LI
Source:: Chinese journal of natural medicines 2020 v.18 no.12 pp. 907-915
ISSN:: 1875-5364
Subject:: Astragalus membranaceus; Oriental traditional medicine; adverse effects; alkaloids; anti-inflammatory activity; antioxidant activity; antioxidants; apoptosis; arrhythmia; cardiomyocytes; cardioprotective effect; cell proliferation; death; developing countries; drug therapy; endothelial cells; enzymes; flavonoids; ingredients; modernization; morbidity; mortality; myocardial infarction; research; saponins; synthesis
Abstract:: ... Cardiovascular disease is the main cause of mortality and morbidity in the world, especially in developing countries. Drug therapy is one of the main ways to treat cardiovascular diseases. Among them, great progress has been made in the treatment of cardiovascular diseases with traditional Chinese medicine. In terms of experimental research, the mechanism of traditional Chinese medicine in the tre ...
DOI:: 10.1016/S1875-5364(20)60034-6
: https://doi.org/10.1016/S1875-5364(20)60034-6

67. The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis

Author:: Qiu-Mei FAN; Wen-Tong ZHAO; Renyikun YUAN; Qin-Qin WANG; Li-Feng ZHANG; Hong-Wei GAO; Jing LENG; Shi-Lin YANG
Source:: Chinese journal of natural medicines 2020 v.18 no.7 pp. 508-516
ISSN:: 1875-5364
Subject:: Ilex; Oriental traditional medicine; Tomentella; antineoplastic activity; apoptosis; butanol; death; ethyl acetate; extraction; herbal medicines; lactate dehydrogenase; lead; lung neoplasms; neoplasm cells; reactive oxygen species; viability
Abstract:: ... Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades. Pileostegia tomentella Hand. Mazz is a traditional Chinese medicine called “Zhongliuteng” (ZLT) in the pharmacopeia, which has been proved to possess a potent anti-tumor effect on various cancers. In this study, the effects of ZLT N-butano ...
DOI:: 10.1016/S1875-5364(20)30061-3
: https://doi.org/10.1016/S1875-5364(20)30061-3

68. A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059

Author:: Zhong-Hui HUANG; Xiao LIANG; Shu-Hua QI
Source:: Chinese journal of natural medicines 2020 v.18 no.4 pp. 243-249
ISSN:: 1875-5364
Subject:: Bacillus amyloliquefaciens; Mycosphaerella; Oriental traditional medicine; acid hydrolysis; alkaline hydrolysis; amides; amino acids; aromatic compounds; bacteria; biofilm; chelating agents; circular dichroism spectroscopy; culture media; fungi; iron; quantum mechanics; siderophores; spectral analysis
Abstract:: ... Mycosphazine A (1), a new iron(III) chelator of coprogen-type siderophore, and mycosphamide A (2), a new cyclic amide benzoate, together with six known aryl amides (3–8), were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059. Alkaline hydrolysis of 1 afforded a new epimer of dimerum acid, mycosphazine B (1a), and a new bi-fusarinine-type siderophore ...
DOI:: 10.1016/S1875-5364(20)30029-7
: https://doi.org/10.1016/S1875-5364(20)30029-7

69. A review of the phytochemistry and pharmacological activities of Ephedra herb

Author:: Shuang-Man MIAO; Qi ZHANG; Xiao-Bao BI; Jin-Long CUI; Meng-Liang WANG
Source:: Chinese journal of natural medicines 2020 v.18 no.5 pp. 321-344
ISSN:: 1875-5364
Subject:: Ephedra; Oriental traditional medicine; active ingredients; alkaloids; cough; drug therapy; essential oils; flavonoids; history; immune system; infection; medicinal properties; polysaccharides; precision; research; tannins; technology
Abstract:: ... Ephedra herb is a traditional Chinese medicine with a long history. Conventionally, it was used as a folk phytomedicine in many ancient medical books and traditional prescriptions. Up to date, a variety of specific ingredients have been found in Ephedra herb, mainly including alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds. These compo ...
DOI:: 10.1016/S1875-5364(20)30040-6
: https://doi.org/10.1016/S1875-5364(20)30040-6

70. 3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

Author:: Hong-Gang WANG; Fu-Kang LUO; Xiang LEI; Yun-Da YAO; Guo-Chao LIAO; Zhong-Qiu LIU; Zhi-Hong JIANG; Hua ZHOU; Peng WU
Source:: Chinese journal of natural medicines 2019 v.17 no.9 pp. 707-712
ISSN:: 1875-5364
Subject:: Callicarpa nudiflora; Oriental traditional medicine; anti-inflammatory activity; dexamethasone; diterpenoids; leaves; nitric oxide; spectral analysis
Abstract:: ... Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudif ...
DOI:: 10.1016/S1875-5364(19)30085-8
: https://doi.org/10.1016/S1875-5364(19)30085-8

71. 3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels

Author:: Run-Jia XU; Shuo-Han FEI; Lin-Yan CHEN; Gan WANG; Ming LIU; Wen-Sheng ZHANG; Xiu-Wen YAN; Ren LAI; Chuan-Bin SHEN
Source:: Chinese journal of natural medicines 2019 v.17 no.6 pp. 413-423
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; analgesia; analgesic effect; daidzein; dietary supplements; drugs; genistein; heat; hypersensitivity; inhibitory concentration 50; mice; neurons; pain; sodium channels; soybean products
Abstract:: ... Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains unclear. Voltage-gated sodium channels (VGSCs) play important roles in excitability of pain sensing neurons and many of them are important nociceptors. Here, we ...
DOI:: 10.1016/S1875-5364(19)30049-4
: https://doi.org/10.1016/S1875-5364(19)30049-4

72. 5, 7, 2’, 4’, 5’-Pentamethoxyflavanone regulates M1/M2 macrophage phenotype and protects the septic mice

Author:: Li-Li FENG; Li-Sha XU; Meng-Meng GUO; Wei HUANG; Jia-Zhen ZHU; Ling-Dong KONG; Xu-Dong WU; Qiang XU
Source:: Chinese journal of natural medicines 2019 v.17 no.5 pp. 363-371
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; anti-inflammatory activity; flavonoids; gene expression regulation; in vivo studies; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; lungs; macrophages; messenger RNA; mice; phenotype; protective effect; protein content; sepsis (infection); signal transduction; survival rate; toxicity; transcription factors; tumor necrosis factor-alpha
Abstract:: ... Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2’, 4’, 5’-pentamethoxyflavanone (abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious ...
DOI:: 10.1016/S1875-5364(19)30042-1
: https://doi.org/10.1016/S1875-5364(19)30042-1

73. Akkermansia muciniphila: a promising target for the therapy of metabolic syndrome and related diseases

Author:: Ji-Chao ZHOU; Xiao-Wei ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.11 pp. 835-841
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Verrucomicrobia; bacteria; drugs; feces; humans; intestinal microorganisms; intestines; metabolic diseases; metabolic syndrome; metabolism; metagenomics; mucins; probiotics; therapeutics
Abstract:: ... The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metageno ...
DOI:: 10.1016/S1875-5364(19)30101-3
: https://doi.org/10.1016/S1875-5364(19)30101-3

74. Anti-HIV lignans from Justicia procumbens

Author:: Xin-Ya XU; Dong-Ying WANG; Chuen-Fai KU; Yang ZHAO; Han CHENG; Kang-Lun LIU; Li-Jun RONG; Hong-Jie ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 945-952
ISSN:: 1875-5364
Subject:: Human immunodeficiency virus 1; Justicia procumbens; Oriental traditional medicine; acetates; antiretroviral properties; chemical structure; cytotoxicity; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5 ...
DOI:: 10.1016/S1875-5364(19)30117-7
: https://doi.org/10.1016/S1875-5364(19)30117-7

75. Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Author:: Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
Source:: Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
Abstract:: ... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
DOI:: 10.1016/S1875-5364(19)30008-1
: https://doi.org/10.1016/S1875-5364(19)30008-1

76. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells

Author:: Wei WANG; Qing-Bin LIU; Wei JING
Source:: Chinese journal of natural medicines 2019 v.17 no.4 pp. 252-263
ISSN:: 1875-5364
Subject:: Astragalus membranaceus; Oriental traditional medicine; asthma; blood serum; childhood; children; density gradient centrifugation; flow cytometry; formononetin; genistein; high performance liquid chromatography; immunoglobulin E; interleukin-17; interleukin-23; isoquercitrin; isorhamnetin; kaempferol; lung function; mononuclear leukocytes; quercetin; remission; swine; therapeutics; transforming growth factor beta
Abstract:: ... Astragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two combination group (control group, the combination of budesonide and terbutaline) and A. membranaceus group (treatment group, the combination of budesonide, terbutal ...
DOI:: 10.1016/S1875-5364(19)30029-9
: https://doi.org/10.1016/S1875-5364(19)30029-9

77. Bioactive phenazines from an earwig-associated Streptomyces sp.

Author:: Hao HAN; Zhi-Kai GUO; Bo ZHANG; Mei ZHANG; Jing SHI; Wei LI; Rui-Hua JIAO; Ren-Xiang TAN; Hui-Ming GE
Source:: Chinese journal of natural medicines 2019 v.17 no.6 pp. 475-480
ISSN:: 1875-5364
Subject:: Micrococcus luteus; Oriental traditional medicine; Streptomyces; X-ray diffraction; acetylcholinesterase; antimicrobial properties; biochemical pathways; culture media; multigene family; nuclear magnetic resonance spectroscopy; phenazines; spectral analysis
Abstract:: ... Three new phenazine-type compounds, named phenazines SA—SC (1—3), together with four new natural products (4—7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and an ...
DOI:: 10.1016/S1875-5364(19)30055-X
: https://doi.org/10.1016/S1875-5364(19)30055-X

78. Bipolarins A–H, eight new ophiobolin-type sesterterpenes with antimicrobial activity from fungus Bipolaris sp. TJ403-B1

Author:: Meng-Ting LIU; Yan HE; Ling SHEN; Zheng-Xi HU; Yong-Hui ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 935-944
ISSN:: 1875-5364
Subject:: Bipolaris; Enterococcus faecalis; Oriental traditional medicine; X-ray diffraction; antimicrobial properties; circular dichroism spectroscopy; fungi; moieties; spectral analysis
Abstract:: ... Bipolarins A–H (1–8), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and 13C NMR calculations. Additionally, ...
DOI:: 10.1016/S1875-5364(19)30116-5
: https://doi.org/10.1016/S1875-5364(19)30116-5

79. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway

Author:: Shao-Peng HUANG; Xin GUAN; Guo-Yin KAI; Ya-Zhou XU; Yuan XU; Hao-Jie WANG; Tao PANG; Lu-Yong ZHANG; Ying LIU
Source:: Chinese journal of natural medicines 2019 v.17 no.5 pp. 372-380
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; anti-inflammatory activity; atherosclerosis; drugs; inducible nitric oxide synthase; inflammation; interleukin-10; interleukin-1beta; interleukin-6; macrophages; mitogen-activated protein kinase; non-specific protein-tyrosine kinase; phosphorylation; rheumatoid arthritis; signal transduction; transactivators; tumor necrosis factor-alpha
Abstract:: ... Macrophages play an important role in inflammation, and excessive and chronic activation of macrophages leads to systemic inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In this paper, we explored the anti-inflammatory effect of broussonin E, a novel phenolic compound isolated from the barks ofBroussonetia kanzinoki, and its underlying molecular mechanisms. We discovered t ...
DOI:: 10.1016/S1875-5364(19)30043-3
: https://doi.org/10.1016/S1875-5364(19)30043-3

80. Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling

Author:: Zhen-Zhen LIU; Hong-Bo WENG; Li-Jie ZHANG; Ling-Yu PAN; Wei SUN; Hai-Xia CHEN; Mei-Yu CHEN; Tao ZENG; Yun-Yi ZHANG; Dao-Feng CHEN; Hong LI
Source:: Chinese journal of natural medicines 2019 v.17 no.9 pp. 641-649
ISSN:: 1875-5364
Subject:: Bupleurum; Oriental traditional medicine; Toll-like receptor 4; actin; albumins; animal disease models; blood serum; collagen; creatinine; diabetes; excretion; fibronectins; fibrosis; inflammation; interleukin-6; kidney diseases; kidneys; mice; muscles; necrosis; neoplasms; nucleoproteins; oral administration; polysaccharides; renal function; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Bupleurum polysaccharides (BPs) is isolated from Bupleurum smithii var. parvifolium, a key traditional Chinese medicine. The study was to investigate the effects of BPs on diabetic kidney injury. After two intraperitoneal injections of streptozotozin (STZ) 100 mg·kg−1, renal injury in diabetic mice was induced and BPs was orally administrated at dosages of 30 and 60 mg·kg−1·d−1. The STZ injected m ...
DOI:: 10.1016/S1875-5364(19)30078-0
: https://doi.org/10.1016/S1875-5364(19)30078-0

81. Cangumycins A–F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces

Author:: Lei WANG; Li WANG; Zhi ZHOU; Yong-Jiang WANG; Jian-Ping HUANG; Ya-Tuan MA; Yang LIU; Sheng-Xiong HUANG
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 982-987
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Streptomyces; T-lymphocytes; X-ray diffraction; cell proliferation; culture media; humans; immunosuppression; inhibitory concentration 50; spectral analysis
Abstract:: ... Cangumycins A–F (1–6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B ...
DOI:: 10.1016/S1875-5364(19)30121-9
: https://doi.org/10.1016/S1875-5364(19)30121-9

82. Cardamine komarovii flower extract reduces lipopolysaccharide-induced acute lung injury by inhibiting MyD88/TRIF signaling pathways

Author:: Qi CHEN; Ke-Xin ZHANG; Tai-Yuan LI; Xuan-Mei PIAO; Mei-Lan LIAN; Ren-Bo AN; Jun JIANG
Source:: Chinese journal of natural medicines 2019 v.17 no.6 pp. 461-468
ISSN:: 1875-5364
Subject:: Cardamine; Oriental traditional medicine; anti-inflammatory activity; cytoplasm; flower extracts; flowers; fluorescent antibody technique; gene expression regulation; histopathology; immunocytochemistry; in vivo studies; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; macrophages; medicinal plants; messenger RNA; mice; models; nitric oxide; prostaglandins; protein synthesis; signal transduction; staining; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... In the present study, we investigated anti-inflammatory effect of Cardamine komarovii flower (CKF) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). We determined the effect of CKF methanolic extracts on LPS-induced pro-inflammatory mediators NO and prostaglandin E2 (PGE2), production of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), and related protein expression levels of MyD88/ ...
DOI:: 10.1016/S1875-5364(19)30053-6
: https://doi.org/10.1016/S1875-5364(19)30053-6

83. Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling

Author:: Ya-Mei LIU; Wang-Yang LI; Liang-Liang XU; Li-Juan YU; Yi-Wen LUO; Xi-Can LI; Xun-Chao ZHANG; Yun-Pu XIONG; Hong-Tai CHEN; Jun-Lang ZHU; Chen CHEN; Yu-Lu XIE; Dong-Feng CHEN; Bin WANG
Source:: Chinese journal of natural medicines 2019 v.17 no.7 pp. 506-516
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; bone diseases; bone formation; cell transplantation; essential oils; mesenchymal stromal cells; messenger RNA; myosin light chains; phosphorylation; small interfering RNA
Abstract:: ... MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catha ...
DOI:: 10.1016/S1875-5364(19)30072-X
: https://doi.org/10.1016/S1875-5364(19)30072-X

84. Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology

Author:: Xiao-Rui CHENG; Chun-Hui QI; Tong-Xing WANG; Wen-Xia ZHOU; Yong-Xiang ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.2 pp. 103-121
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; chemical constituents of plants; immunomodulation; kidneys; medicinal properties; pharmacokinetics; quality control; toxicology
Abstract:: ... Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokine ...
DOI:: 10.1016/S1875-5364(19)30013-5
: https://doi.org/10.1016/S1875-5364(19)30013-5

85. Chemical constituents and biological activities of lycophytes and ferns

Author:: Qin-Feng ZHU; Qin-Shi ZHAO
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 887-891
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; bioactive properties; biodiversity; chemical composition; ferns and fern allies; flora; phytochemicals; terrestrial ecosystems
Abstract:: ... Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and evolution. The Chinese lycophytes and ferns flora, with approximately 2000 species, contributes a substantial component to the global lycophytes and ferns diversity, with estimates of 12 000 species. Among them, about 433 species are medicinally recorded a ...
DOI:: 10.1016/S1875-5364(19)30108-6
: https://doi.org/10.1016/S1875-5364(19)30108-6

86. Chemical constituents from Vernonia bockiana

Author:: Shi-Hui DONG; Yan WU; Jian-Min YUE
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 924-927
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Vernonia; aerial parts; chemical composition; nuclear magnetic resonance spectroscopy; pregnanes; sesquiterpenoids; spectral analysis
Abstract:: ... A new sesquiterpenoid and two pregnane steroids, named vernobockolide C (1) and vernobockones A and B (2 and 3), respevtively, along with a known sesquiterpenoid, 7, 10-epoxy-11-hydroxy-bisabol-2-en-15-al, were isolated from the aerial part of Vernonia bockiana. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially 2D NMR (HSQC, HMBC, and ROESY). This s ...
DOI:: 10.1016/S1875-5364(19)30114-1
: https://doi.org/10.1016/S1875-5364(19)30114-1

87. Chinese medicine Yu-Ping-Feng-San attenuates allergic inflammation by regulating epithelial derived pro-allergic cytokines

Author:: Xiao-Tong WANG; Hai-Liang LIU; Xi YU; Can WANG; Li-Li GUI; Xiao-Yu WANG; Yong-Qing HUA; Jie ZHENG; Min HONG
Source:: Chinese journal of natural medicines 2019 v.17 no.7 pp. 525-534
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; animal models; atopic dermatitis; dendritic cells; ears; enzyme-linked immunosorbent assay; epithelium; flow cytometry; fluorescein; fluorescent antibody technique; humans; inflammation; interleukins; isothiocyanates; keratinocytes; lymphocytes; mice; transcription factor NF-kappa B; transmission electron microscopes; tumor necrosis factor-alpha
Abstract:: ... This study aimed to investigate the mechanisms of Yu-Ping-Feng-San (YPFS) on attenuating allergic inflammation in the initial stage of atopic dermatitis (AD). AD mouse model was established with fluorescein isothiocyanate (FITC) sensitization and elicitation. Epithelial barrier structure was observed with transmission electron microscope. The populations of dendritic cells (DCs) and group 2 innate ...
DOI:: 10.1016/S1875-5364(19)30074-3
: https://doi.org/10.1016/S1875-5364(19)30074-3

88. Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies

Author:: Lan-Yun MIAO; Thi Thanh Huyen CHU; Ping LI; Yan JIANG; Hui-Jun LI
Source:: Chinese journal of natural medicines 2019 v.17 no.6 pp. 435-445
ISSN:: 1875-5364
Subject:: Actaea racemosa; Oriental traditional medicine; adulterants; blood chemistry; blood serum; dietary supplements; females; gas chromatography-mass spectrometry; histopathology; markets; menopause; metabolic diseases; metabolites; metabolomics; micro-computed tomography; ovariectomy; rats
Abstract:: ... In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies ...
DOI:: 10.1016/S1875-5364(19)30051-2
: https://doi.org/10.1016/S1875-5364(19)30051-2

89. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

Author:: Yuan WANG; Jing LIN; Qi WANG; Kun SHANG; De-Bing PU; Rui-Han ZHANG; Xiao-Li LI; Xiao-Chang DAI; Xing-Jie ZHANG; Wei-Lie XIAO
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 953-962
ISSN:: 1875-5364
Subject:: Callicarpa; Oriental traditional medicine; anti-inflammatory activity; diterpenoids; lactones; nitric oxide; nuclear magnetic resonance spectroscopy; phytochemicals
Abstract:: ... Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A–F (1–6), together with seven analogues (7–13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharid ...
DOI:: 10.1016/S1875-5364(19)30118-9
: https://doi.org/10.1016/S1875-5364(19)30118-9

90. Comparative pharmacodynamic, pharmacokinetic and tissue distribution of Dahuang-Gancao decoction in normal and experimental constipation mice

Author:: Yan-Yan CHEN; Yu-Jie CAO; Yu-Ping TANG; Shi-Jun YUE; Jin-Ao DUAN
Source:: Chinese journal of natural medicines 2019 v.17 no.11 pp. 871-880
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; adverse effects; colon; constipation; emodin; excretion; glycyrrhizin; kidneys; licorice; liver; metabolites; pharmacodynamics; pharmacokinetics; therapeutics; tissue distribution
Abstract:: ... Dahuang-Gancao decoction (DGD) is a classical formula, which is commonly used for reliving constipation in Chinese clinic. The aim of this study was to investigate the pharmacodynamic, pharmacokinetic and tissue distribution alternations of DGD in normal and constipation mice. DGD exhibited stronger purgative effect in constipation mice by the increased fecal excretion and reduced first defection ...
DOI:: 10.1016/S1875-5364(19)30104-9
: https://doi.org/10.1016/S1875-5364(19)30104-9

91. DNA barcoding and rapid identification of the precious herb Herba Anoectochili

Author:: Shuai-Jun HU; Hao-Yu HU; Han GAO; Xia LIU; Shi-Lin CHEN
Source:: Chinese journal of natural medicines 2019 v.17 no.10 pp. 738-745
ISSN:: 1875-5364
Subject:: DNA barcoding; Oriental traditional medicine; adulterants; adulterated products; genetic distance; phylogeny; prediction; quantitative polymerase chain reaction
Abstract:: ... Herba Anoectochili is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the similar morphological characteristics of Herba Anoectochili and its adulterants, traditional identification techniques often fail to distinguish between them accurately, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distin ...
DOI:: 10.1016/S1875-5364(19)30090-1
: https://doi.org/10.1016/S1875-5364(19)30090-1

92. Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

Author:: Zhen-Zhen ZHOU; Hong-Jie ZHU; Cheng-Long YANG; Yan-Jun LIU; Nan JIANG; Yong-Sheng XIAO; Li-Yun SHI; Rui-Hua JIAO; Hui-Ming GE; Ren-Xiang TAN
Source:: Chinese journal of natural medicines 2019 v.17 no.5 pp. 387-393
ISSN:: 1875-5364
Subject:: Daldinia; Oriental traditional medicine; circular dichroism spectroscopy; genes; interleukin-6; macrophages; metabolites; spectral analysis; tumor necrosis factor-alpha
Abstract:: ... Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene express ...
DOI:: 10.1016/S1875-5364(19)30045-7
: https://doi.org/10.1016/S1875-5364(19)30045-7

93. Danshen: a phytochemical and pharmacological overview

Author:: Xiao-Dan MEIm; Yan-Feng CAO; Yan-Yun CHE; Jing LI; Zhan-Peng SHANG; Wen-Jing ZHAO; Yan-Jiang QIAO; Jia-Yu ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.1 pp. 59-80
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Salvia miltiorrhiza; adverse effects; chemical composition; chemical constituents of plants; diterpenoids; herbal medicines; lipophilicity; medicinal properties; phenolic acids; rhizomes; water solubility; China; Japan
Abstract:: ... Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic di ...
DOI:: 10.1016/S1875-5364(19)30010-X
: https://doi.org/10.1016/S1875-5364(19)30010-X

94. Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice

Author:: Wei LIU; Ran YAN; Liang ZHANG
Source:: Chinese journal of natural medicines 2019 v.17 no.8 pp. 600-607
ISSN:: 1875-5364
Subject:: Dendrobium; Oriental traditional medicine; blood serum; dysbiosis; enzyme-linked immunosorbent assay; immunomodulators; interferon-gamma; interleukin-6; intestinal microorganisms; macrophages; mice; patients; phagocytosis; polysaccharides; ribosomal RNA; sequence analysis; toxicity testing; tumor necrosis factor-alpha; viability
Abstract:: ... To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, E ...
DOI:: 10.1016/S1875-5364(19)30062-7
: https://doi.org/10.1016/S1875-5364(19)30062-7

95. Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS

Author:: Yan YAN; Qiang LI; Hui-Zhi DU; Chen-Xi SHEN; Ai-Ping LI; Xiang-Ping PEI; Chen-Hui DU; Xue-Mei QIN
Source:: Chinese journal of natural medicines 2019 v.17 no.7 pp. 551-560
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; acetonitrile; animal models; brain; chemical species; dopamine; gamma-aminobutyric acid; glutamic acid; herbal medicines; monitoring; monoamines; neurotransmitters; norepinephrine; rats; serotonin; sleep disorders; tandem mass spectrometry; ultra-performance liquid chromatography; China
Abstract:: ... Ziziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the role of ZSS aqueous extract in the treatment of insomnia, an UPLC-ESI- MS/MS method was developed an ...
DOI:: 10.1016/S1875-5364(19)30077-9
: https://doi.org/10.1016/S1875-5364(19)30077-9

96. Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii

Author:: Yu-Ru TONG; Yi-Feng ZHANG; Yu-Jun ZHAO; Tian-Yuan HU; Jia-Dian WANG; Lu-Qi HUANG; Wei GAO
Source:: Chinese journal of natural medicines 2019 v.17 no.8 pp. 575-584
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; RNA interference; Tripterygium wilfordii; acetyl coenzyme A; active sites; biochemical pathways; biosynthesis; complementary DNA; electrostatic interactions; gene overexpression; genes; hydroxymethylglutaryl-CoA synthase; terpenoids
Abstract:: ... 3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the biosynthesis of terpenes in Tripterygium wilfordii. The full-length cDNA and a 515 bp RNAi target fragment of TwHMGS were ligated into the pH7WG2D and pK7GWIWG2D vectors to respectively overexpress and silence, TwHMGS was overexpressed and silenced in T. wilfordii suspension cells us ...
DOI:: 10.1016/S1875-5364(19)30059-7
: https://doi.org/10.1016/S1875-5364(19)30059-7

97. Difficulties in research of Chinese medicine polysaccharides

Author:: Li-Feng LI; Tin-Long WONG; Quan-Bin HAN
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 883-886
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; bioactive properties; chemical analysis; polysaccharides; research and development
Abstract:: ... Polysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and development of new drugs and health products. However, there are rarely successful cases. ...
DOI:: 10.1016/S1875-5364(19)30107-4
: https://doi.org/10.1016/S1875-5364(19)30107-4

98. Effect of loureirin A against Candida albicans biofilms

Author:: Mei-Yu LIN; Zhong-Lan YUAN; Dan-Dan HU; Gan-Hai HU; Ri-Li ZHANG; Hua ZHONG; Lan YAN; Yuan-Ying JIANG; Juan SU; Yan WANG
Source:: Chinese journal of natural medicines 2019 v.17 no.8 pp. 616-623
ISSN:: 1875-5364
Subject:: Caenorhabditis elegans; Candida albicans; Galleria mellonella; Oriental traditional medicine; adhesion; antifungal properties; biofilm; fungi; gene expression; gene expression regulation; genes; human umbilical vein endothelial cells; hydrophobicity; hyphae; minimum inhibitory concentration; models; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; scanning electron microscopy; toxicity; virulence
Abstract:: ... Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. This work aimed to investigate the activity of loureirin A against Candida albicans biofilms. 2, 3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT)reduction assay and scanning electron microscopy were used to investigate the anti-biofilm effect. Minimal inhibitory concentration te ...
DOI:: 10.1016/S1875-5364(19)30064-0
: https://doi.org/10.1016/S1875-5364(19)30064-0

99. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Author:: Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
Source:: Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
ISSN:: 1875-5364
Subject:: Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
Abstract:: ... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
DOI:: 10.1016/S1875-5364(19)30032-9
: https://doi.org/10.1016/S1875-5364(19)30032-9

100. Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum

Author:: Guang-Hui HUANG; Chun LEI; Ke-Xin ZHU; Jing-Ya LI; Jia LI; Ai-Jun HOU
Source:: Chinese journal of natural medicines 2019 v.17 no.12 pp. 963-969
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Rhododendron; X-ray diffraction; enantiomers; high performance liquid chromatography; meroterpenoids; protein-tyrosine-phosphatase; spectroscopy
Abstract:: ... Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new ...
DOI:: 10.1016/S1875-5364(19)30119-0
: https://doi.org/10.1016/S1875-5364(19)30119-0

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1. Anti-inflammatory effects of Abelmoschus manihot (L.) Medik. on LPS-induced cystitis in mice: potential candidate for cystitis treatment based on classic use

2. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza)

3. Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation

4. Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation

5. Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics

6. Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation

7. Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet

8. Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway

9. Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii

10. Probiotics with anti-type 2 diabetes mellitus properties: targets of polysaccharides from traditional Chinese medicine

11. Sesquiterpenoids from the leaves of Sarcandra glabra

12. Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis

13. Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods

14. Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS

15. Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice

16. Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic

17. Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials

18. Honokiol: A naturally occurring lignan with pleiotropic bioactivities

19. Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats

20. Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy

21. Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway

22. Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibition of acylcarnitine in rats

23. Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology

24. TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches

25. Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis

26. A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces

27. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

28. Advances on hormone-like activity of Panax ginseng and ginsenosides

29. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

30. Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice

31. Bufalin-induced cardiotoxicity: new findings into mechanisms

32. CO as a therapeutic agent: discovery and delivery forms

33. Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae

34. Complete chloroplast genome of Salvia plebeia: organization, specific barcode and phylogenetic analysis

35. Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry

36. Construction and application of carbohydrate microarrays to detect foodborne bacteria

37. Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

38. Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway

39. Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation

40. Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway

41. Effect of quercetin on chondrocyte phenotype and extracellular matrix expression

42. Fatty liver diseases, mechanisms, and potential therapeutic plant medicines

43. Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201

44. Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments

45. Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury

46. MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer

47. Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three original species of Pyrrosiae Folium

48. Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

49. New meroterpenoid compounds from the culture of mushroom Panus lecomtei

50. Nitric oxide donating anti-glaucoma drugs: advances and prospects

51. Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity

52. Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats

53. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats

54. Prodrugs of hydrogen sulfide and related sulfur species: recent development

55. Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang ShuaiLao Pian treated mid-adult mice

56. Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism

57. Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats

58. Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19

59. Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology

60. Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice

61. Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats

62. Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis

63. Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3

64. Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP)

65. Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019

66. The cardiovascular protective effect and mechanism of calycosin and its derivatives

67. The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis

68. A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059

69. A review of the phytochemistry and pharmacological activities of Ephedra herb

70. 3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects