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... Measuring body composition is an important issue to phenotype patients with obesity and to follow the nutritional care efficiency. Bioelectrical Impedance Analysis (BIA) is a simple and rapid technique. However, validity of BIA in patients with obesity remains controversial. Thus, we aimed to evaluate the validity of several BIA equations to assess body composition in a large cohort of patients wi ...
... Although malnutrition remains a global public health concern, and has proved to be a major contributor to death and illness, there has been a foundational lack of a gold standard for diagnostic testing for clinical application. The Global Leadership Initiative on Malnutrition (GLIM) criteria were established to normalize the diagnosis of malnutrition, but their use remains controversial. Therefore ...
Andrew Wilhelmsen; Amanda Davies; Joanne Mallinson; Pardeep Pabla; Robert Jones; Elliott A. Palmer; Warwick B. Dunn; Gordon W. Moran; Francis B. Stephens; Kostas Tsintzas
... Obesity and insulin resistance are associated with an impaired sensitivity to anabolic stimuli such as dietary protein (anabolic resistance). Omega-3 polyunsaturated fatty acids (n-3 PUFA) may be protective against the deleterious effects of saturated fatty acids (SFA) on insulin resistance. However, the contribution of excess fat consumption to anabolic and insulin resistance and the interaction ...
... The World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) updated their cancer prevention recommendations in 2018. Adherence to these recommendations has been associated with lower cancer risk and mortality. However, adherence in relation to Cancer of Unknown Primary (CUP) risk has not been studied. This study investigates whether adherence to the WCRF/AICR recommenda ...
adipocytes; adipose tissue; adiposity; body mass index; breast neoplasms; clinical nutrition; computed tomography; fibrosis; health services; inflammation; lipid content; mortality; prognosis; risk; standard deviation; vertebrae; California
Abstract:
... Computed tomography (CT) scans can measure quantity and distribution of adipose tissue, which are associated with breast cancer prognosis. As a novel prognostic marker, radiodensity of adipose tissue has been examined in multiple cancer types, but never in breast cancer. Lower density indicates larger adipocytes with greater lipid content, whereas higher density can reflect inflammation, fibrosis, ...
COVID-19 infection; anabolism; body composition; body mass index; body weight; calf circumference; catabolism; clinical nutrition; creatine; hand strength; health services; immune response; immune system; leucine; malnutrition; mitochondria; muscles; omega-3 fatty acids; patients; physical activity; polyphenols; skeletal muscle; ultrasonics
Abstract:
... Low muscle mass and malnutrition are prevalent conditions among adults of all ages, with any body weight or body mass index, and with acute or chronic conditions, including COVID-19. This article synthesizes the latest research advancements in muscle health and malnutrition, and their impact on immune function, and clinical outcomes. We provide a toolkit of illustrations and scientific information ...
clinical nutrition; cross-sectional studies; diagnostic techniques; etiology; leadership; lean body mass; malnutrition; nutrition risk assessment; patients; phenotype; surgery; weight loss
Abstract:
... The Global Leadership Initiative on Malnutrition (GLIM) has suggested a process for the diagnosis of malnutrition. The process consists of applying an existing screening tool for malnutrition screening, followed by malnutrition diagnostics, and finally categorization of malnutrition severity (moderate or severe) according to specific GLIM criteria. However, it is not known how well the GLIM proces ...
... To investigate potential biases that exist in available epidemiological evidence resulting in negative associations or underestimation of cardiovascular (CV) risk associated with alcohol consumption.UK Biobank involved baseline data collection from 22 assessment centres across the United Kingdom. The cohort consisted of 333 259 alcohol consumers and 21 710 never drinkers. Participants were followe ...
Gözde Gürdeniz; Matti Uusitupa; Kjeld Hermansen; Markku J. Savolainen; Ursula Schwab; Marjukka Kolehmainen; Lea Brader; Lieselotte Cloetens; Karl-Heinz Herzig; Janne Hukkanen; Fredrik Rosqvist; Stine Marie Ulven; Ingibjörg Gunnarsdóttir; Inga Thorsdottir; Matej Oresic; Kaisa S. Poutanen; Ulf Risérus; Björn Åkesson; Lars Ove Dragsted
... Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.During 18–24 weeks of intervention, 200 participants with me ...
Ruixin Zhu; Mikael Fogelholm; Elli Jalo; Sally D. Poppitt; Marta P. Silvestre; Grith Møller; Maija Huttunen-Lenz; Gareth Stratton; Jouko Sundvall; Ian A. Macdonald; Teodora Handjieva-Darlenska; Svetoslav Handjiev; Santiago Navas-Carretero; J. Alfredo Martinez; Roslyn Muirhead; Jennie Brand-Miller; Anne Raben
... Low-energy diet replacement is an effective tool to induce large and rapid weight loss and improve metabolic health, but in the long-term individuals often experience significant weight regain. Little is known about the role of animal-based foods in weight maintenance and metabolic health. We aimed to examine longitudinal associations of animal-based foods with weight maintenance and glycaemic and ...
anti-inflammatory activity; breakfast; canola oil; chocolate; clinical nutrition; diet; inflammation; olives; red meat; red wines; risk
Abstract:
... Systemic inflammation plays a role in peripheral artery disease (PAD), and therefore, an anti-inflammatory diet may reduce PAD risk. We examined the association between the anti-inflammatory diet and PAD risk by smoking status, a trigger of systemic inflammation. The study was based on two cohorts of 82 295 Swedish adults aged 45–83 years (38 823 women from Swedish Mammography Cohort and 45 472 me ...
... Proper dietary habits are a vital element of cardiovascular (CV) treatment, and - according to the current guidelines - a diet rich in antioxidants is generally recommended. It remains, however, inconclusive whether antioxidant nutrients should be supplemented for CV health, and if so, in which form and dosage. Currently available data suggest that vitamin E may be essential in preventing CVD, esp ...
... Sarcopenia is a disabling muscular multifactorial disease involving the oxidation process in old-young adults. We aimed to evaluate the relationship between antioxidant-rich foods (A-RF) and sarcopenia (muscle mass, strength, and function) based on observational studies (OS), and to assess the effectiveness of antioxidant interventions in ≥55-year-old adults via randomized controlled trials (RCTs) ...
National Health and Nutrition Examination Survey; body composition; clinical nutrition; data collection; dual-energy X-ray absorptiometry; humans; model validation; muscles; nationalities and ethnic groups; neural networks; regression analysis; risk
Abstract:
... Lean muscle and fat mass in the human body are important indicators of the risk of cardiovascular and metabolic diseases. Techniques such as dual-energy X-ray absorptiometry (DXA) accurately measure body composition, but they are costly and not easily accessible. Multiple linear regression (MLR) models have been developed to estimate body composition using simple demographic and anthropometric mea ...
... Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft dysfunction and allograft rejection after transplantation. Excessive free radical production and massive consumption of endogenous antioxidants are common mechanisms underlying I/R injury and are implicated in posttransplant organ damage and reduced graft viability. Ascorbic Acid (AA) is an essential micronutrient i ...
Lorena Arribas; Aida Sabaté-Llobera; Mónica Cos Domingo; Miren Taberna; Maria Sospedra; Lisa Martin; Ana Regina González-Tampán; Natalia Pallarés; Ricard Mesía; Vickie E. Baracos
abdomen; adipose tissue; body composition; chest; clinical nutrition; computed tomography; head and neck squamous cell carcinoma; males; muscles; radiology; skeletal muscle; standard deviation
Abstract:
... Computed tomography images acquired during routine cancer care provide an opportunity to determine body composition with accuracy and precision. Quantification of skeletal muscle is of interest owing to its association with clinical outcomes. However, the standards of precision testing considered mandatory in other areas of radiology are lacking from the literature in this area. We aim to describe ...
Jonathan P. Bennett; Yong En Liu; Brandon K. Quon; Nisa N. Kelly; Michael C. Wong; Samantha F. Kennedy; Dominic C. Chow; Andrea K. Garber; Ethan J. Weiss; Steven B. Heymsfield; John A. Shepherd
automation; body mass index; body size; clinical nutrition; dual-energy X-ray absorptiometry; females; lean body mass; metabolic syndrome; nationalities and ethnic groups; obesity; physical activity; sarcopenia; scanners; waist
Abstract:
... The accurate assessment of total body and regional body circumferences, volumes, and compositions are critical to monitor physical activity and dietary interventions, as well as accurate disease classifications including obesity, metabolic syndrome, sarcopenia, and lymphedema. We assessed body composition and anthropometry estimates provided by a commercial 3-dimensional optical (3DO) imaging syst ...
... Nutrition may be important for recovery from critical illness. Gastrointestinal dysfunction is a key barrier to nutrition delivery in the Intensive Care Unit (ICU) and metabolic rate is elevated exacerbating nutritional deficits. Whether these factors persist following ICU discharge is unknown. We assessed whether delayed gastric emptying (GE) and impaired glucose absorption persist post-ICU disch ...
... The association between body composition parameters measured on computed tomography (CT) and severity of acute pancreatitis (AP) is conflicting because these composition parameters vary considerably by sex and age. We previously developed normative body composition data, in healthy subjects. Z-score calculated from the normative data gives age and sex adjusted body composition parameters. We studi ...
body composition; clinical nutrition; cohort studies; confidence interval; equations; food frequency questionnaires; genome; mortality; obesity; protein intake; regression analysis; risk; sarcopenia; skeletal muscle; whey protein
Abstract:
... Changes in body composition during aging include decreased muscle mass and increased fat mass. Women with low muscle mass with abdominal obesity (LMAO), in particular, could be at higher risk of morbidities and mortality than those with either sarcopenia or obesity alone. Dairy products, which contain whey protein and all essential amino acids, could have a beneficial role in preserving muscle mas ...
Internet; analysis of covariance; animals; body mass index; clinical nutrition; cohort studies; cross-sectional studies; diabetes; eating habits; employment; energy intake; food frequency questionnaires; hand strength; household income; hyperlipidemia; hypertension; muscles; mushrooms; physical activity; China
Abstract:
... Edible mushrooms can be referred to as a “super food” and are recommended as a valuable constituent of the daily diet. Animal studies have suggested that mushroom intake can increase muscle endurance due to its abundant nutrients, and anti-inflammatory properties. However, no studies have explored the association between edible mushrooms consumption and muscle strength in the general population. W ...
National Health and Nutrition Examination Survey; body fat; clinical nutrition; cohort studies; food security; muscle strength; muscle tissues; regression analysis; risk factors; sarcopenia
Abstract:
... Aging alters biological processes resulting in body fat redistribution, loss of lean muscle mass, and reduced muscle strength, termed sarcopenia. Nutrition is an important modifiable risk factor in the development of sarcopenia. Food insecurity refers to limited or uncertain access to enough food for an active, healthy life, and is prevalent among older adults. The objective of this study was to e ...
National Health and Nutrition Examination Survey; bone density; bone health; bone resorption; carbohydrate intake; carbohydrates; clinical nutrition; cross-sectional studies; diet recall; energy intake; high protein diet; metabolism; nutrient density; risk
Abstract:
... Although it is well known dietary factors are closely correlated with bone health, the association between macronutrients intake distribution and bone mineral density (BMD) is still unclear. The aims of this study were to investigate how macronutrients distribution was correlated with BMD, and to evaluate how the substitution between macronutrients could be associated with BMD. We conducted a cros ...
... Evidence for a role of single nutrition or foods on ovarian cancer (OC) survival has been limited and inconclusive. Due to the potentially complex interactions in dietary, we applied dietary patterns to this study to firstly explore the relationship between the pre-diagnosis overall diet and OC survival.The prospective cohort study was conducted among 853 OC patients aged 18–79 years during 2015–2 ...
... Sarcopenia is a risk factor for adverse outcomes in older adults, but this has yet to be confirmed in chronic kidney disease (CKD). We conducted a systematic review to investigate the association between sarcopenia and its traits with mortality, hospitalization, and end-stage kidney disease (ESKD) progression in CKD patients. Five electronic databases were searched, including MEDLINE and Embase. O ...
... The Global Leadership Initiative on Malnutrition (GLIM) was convened by several of the major global clinical nutrition societies. This tool used the phenotypic and etiologic criteria to diagnose the malnutrition in adults. This meta-analysis aimed to examine the association between malnutrition defined by the GLIM and survival outcomes in patients with cancer. Two independent authors comprehensive ...
... Insulin and insulin-like growth factor (IGF)-1 signaling is a proposed mechanism linking dietary protein and major chronic diseases. However, it is unclear whether animal and plant proteins are associated with biomarkers of insulin and IGF axis. We analyzed a total of 14,709 participants from Nurses’ Health Study and Health Professionals Follow-up Study who had provided a blood sample. Detailed di ...
COVID-19 infection; body mass index; clinical nutrition; databases; death; mortality; neoplasms; noninsulin-dependent diabetes mellitus; overweight; respiratory tract diseases; risk; underweight
Abstract:
... Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19. The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. Data from 12,137 patients (age 60.0 ± 16.2 years, 59% male ...
... Evidence linking the use of omega-3 PUFA supplements with incident dementia is scarce. We aim to assess the relationship between fish oil supplementation and incident dementia risk among older adults with different apolipoprotein E (APOE) genotypes in a large population-based cohort. We included 215,083 participants (average age: 64.1 ± 2.9 y) without dementia at baseline from UK Biobank study. Fi ...
... Due to the beneficial effect of folate on cardiovascular disease (CVD), folic acid supplementation is a more common practice among people at high-risk of CVD. However, long-term prospective investigations regarding the association of folate-intake with CVD-mortality and all-cause mortality among this specific population are still lacking. Therefore, this study aims to assess the association of fol ...
... The intensity and duration of the catabolic phase in COVID-19 patients can differ between survivors and non-survivors. The purpose of the study was to assess the determinants of, and association between, nitrogen balance trajectories and outcome in critically ill COVID-19 patients. This retrospective monocentric observational study involved patients admitted to the intensive care unit (ICU) of the ...
... The neuroprotective roles of uric acid are still controversial. One possible explanation is that previous studies included participants with hyperuricemia, which might interfere with clarifying the association. Therefore, this study aimed to investigate the prospective association between plasma uric acid levels and cognitive function among non-hyperuricemia adults. A total of 7828 participants fr ...
... Inflammation is involved in the progression and prognosis of cancer because it can affect the physical status and prognosis of patients. Among numerous systemic inflammatory markers, the optimal prognostic indicator of older adults with cancer is still unclear. We aimed to identify an ideal inflammatory immune marker in older adults with cancer and assess the survival outcome combined with eastern ...
... Diet and genetic predisposition to adiposity are independent predictors of body composition, yet few cohort studies have examined the association between overall diet quality indices, genetic risk and body composition. This study examined the prospective association of three diet quality indices and a polygenic risk score (PRS) with trunk fat mass, total fat mass, lean mass and bone mineral conten ...
... Carnitine biosynthesis has been related to fatty acid oxidation, a process probably exerting neuroprotective effects. However, the role of carnitine biosynthesis in the development of ischemic stroke (IS) remains unclear. We aimed to examine the associations between plasma markers of carnitine biosynthesis and the IS risk. We performed a case-control study nested in a community-based cohort (2013– ...
Ruixin Zhu; Thomas M. Larsen; Sally D. Poppitt; Marta P. Silvestre; Mikael Fogelholm; Elli Jalo; Katja A. Hätönen; Maija Huttunen-Lenz; Moira A. Taylor; Liz Simpson; Kelly A. Mackintosh; Melitta A. McNarry; Santiago Navas-Carretero; J. Alfredo Martinez; Teodora Handjieva-Darlenska; Svetoslav Handjiev; Mathijs Drummen; Margriet S. Westerterp-Plantenga; Tony Lam; Pia S. Vestentoft; Roslyn Muirhead; Jennie Brand-Miller; Anne Raben
... The association of quantity and quality of carbohydrate sources with appetite during long-term weight-loss maintenance (WLM) after intentional weight loss (WL) is unclear. We aimed to investigate longitudinal associations of quantity and quality of carbohydrate sources with changes in subjective appetite sensations during WLM. This secondary analysis evaluated longitudinal data from the 3-year WLM ...
... Limited evidence exists regarding the prospective associations between amino acids and insulin resistance. In addition, amino acids have been suggested to promote insulin resistance with the requirement of obesity in animal studies, but the interaction between amino acids and obesity on the development of insulin resistance has not been examined in epidemiological studies. We aimed to investigate ...
arginine; cisplatin; clinical nutrition; compliance; confidence interval; drug therapy; head and neck neoplasms; nucleotides; risk reduction; soluble fiber
Abstract:
... The benefits of immunonutrition in patients with head and neck cancer (HNC), especially for those undergoing definitive concurrent chemoradiation (CCRT), remain unclear. We evaluated the benefits of immunonutrition regarding the prevention of severe oral mucositis. Secondary objectives included assessments of other treatment-related toxicities, changes of nutritional and inflammatory marker levels ...
... Whilst the cardioprotective effects of blueberry intake have been shown in prospective studies and short-term randomized controlled trials (RCTs), it is unknown whether anthocyanin-rich blueberries can attenuate the postprandial, cardiometabolic dysfunction which follows energy-dense food intakes; especially in at-risk populations. We therefore examined whether adding blueberries to a high-fat/hig ...
adiposity; body mass index; bone density; childhood; childhood obesity; clinical nutrition; computer software; dual-energy X-ray absorptiometry; fat mass index; head; infancy; lean body mass; morbidity; public health; risk
Abstract:
... Childhood obesity is a global public health threat, with an alarming rise in incidence. Obesity at young age has short-term and long-term morbidity. It is, therefore, important to accurately assess body composition throughout infancy and childhood to identify excess adiposity. However, reference values for age 2–5 years, needed to interpret measurements and identify young children at risk, are lac ...
... Sarcopenia, as assessed by body composition, can affect morbidity and survival in several gastrointestinal cancer. However, the impact of sarcopenia, referring to both quantity and quality of skeletal muscle, in biliary tract cancer (BTC) is debatable. We aimed to investigate the impact of sarcopenia on morbidity and mortality in patients with BTC.Electronic databases and trial registries were sea ...
COVID-19 infection; clinical nutrition; complications (disease); disease severity; lifestyle; malnutrition; nutritional status; obesity; pandemic; public health; risk; Europe
Abstract:
... With prolonged pandemic conditions, and emerging evidence but persisting low awareness of the importance of nutritional derangements, ESPEN has promoted in close collaboration with World Health Organization-Europe a call for papers on all aspects relating COVID-19 and nutrition as well as nutritional care, in the Society Journals Clinical Nutrition and Clinical Nutrition ESPEN. Although more COVID ...
Lei Fan; Xiangzhu Zhu; Shan Sun; Chang Yu; Xiang Huang; Reid Ness; Laura L. Dugan; Lihua Shu; Douglas L. Seidner; Harvey J. Murff; Anthony A. Fodor; M. Andrea Azcarate-Peril; Martha J. Shrubsole; Qi Dai
... Ketogenic medium-chain-fatty acids (MCFAs) with profound health benefits are commonly found in dairy products, palm kernel oil and coconut oil. We hypothesize that magnesium (Mg) supplementation leads to enhanced gut microbial production of MCFAs and, in turn, increased circulating MCFAs levels. We tested this hypothesis in the Personalized Prevention of Colorectal Cancer Trial (PPCCT) (NCT0110516 ...
breast neoplasms; breasts; clinical nutrition; drug therapy; fasting; fearfulness; low calorie diet; neoplasm cells; nutritional intervention; nutritional status; patient compliance; patients; toxicity; weight loss
Abstract:
... Experimental studies in cancer cell lines and tumour-bearing animals support the concept that a short-period fasting could potentiate the effect of antineoplastic chemotherapy due to a particular metabolic adaptation normal cells whereas cancer cells would remain particularly sensitive to the toxic effects of the therapy. The potential of such approach is actually emphasized by the media but data ...
... Metal elements have been associated with a wide range of clinical outcomes. The available epidemiological evidence for these associations is often inconsistent and suffers from confounding and reverse causation. We aimed to explore the broad clinical effects of varying blood metal element levels and possible underlying mechanisms. We performed a two-sample Mendelian randomization (MR) analysis by ...
Esther Molina-Montes; Miguel Rodríguez-Barranco; Ana Ching-López; Reyes Artacho; José María Huerta; Pilar Amiano; Cristina Lasheras; Conchi Moreno-Iribas; Ana Jimenez-Zabala; María-Dolores Chirlaque; Aurelio Barricarte; Leila Luján-Barroso; Antonio Agudo; Paula Jakszyn; José Ramón Quirós; María José Sánchez
... The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Knowledge is limited on the relationship between circadian genes, chronotype, sleeping patterns, chronutrition and obesity. The aim was to explore these associations within the EPIC-Spain cohort study. There were 3183 subjects with informati ...
Nikolaos Perakakis; Alexander Kokkinos; Angeliki M. Angelidi; Dimitrios Tsilingiris; Anna Gavrieli; Maria Yannakoulia; Nicholas Tentolouris; Christos S. Mantzoros
... Proglucagon-derived peptides (PGDPs) secreted by the gut and pancreas play a major role in metabolism. We measured concentrations of five PGDPs in response to per os (PO) or intravenous (IV) glucose or lipid intake and a mixed meal test (MMT) consumed by subjects with normal weight, overweight or obesity. GLP-1, oxyntomodulin and glicentin (gut-secreted PGDPs) and glucagon and MPGF (pancreas-secre ...
... Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to utilize Mendelian randomization to decipher the potential causal associations of vitamin C with risk of digestive system cancers. Ten genetic variants previously found to be significantly as ...
... Acute thiamine deficiency can occur in patients with or without history of alcohol abuse and can lead to life-threatening complications. Clinical diagnosis is challenging, often resulting in delayed recognition and treatment. Patients may present with heterogenous symptoms, more diverse than the historical neurological description. Cerebral MRI can contribute to the diagnosis in patients with neur ...
... The new indirect calorimeter developed in the framework of the ICALIC project was first evaluated in ventilation mode. This second phase aimed to compare its ease of use and precision with another commonly used device in spontaneously breathing adult patients using a canopy hood or a face mask. The time required to measure resting energy expenditure (REE) with Q-NRG® in canopy and face mask mode w ...
alcohol drinking; body mass index; clinical nutrition; digestive system neoplasms; myeloma; ovarian neoplasms; risk
Abstract:
... Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee consumption with a broad range of cancers. Twelve independent genetic variants proxied coffee consumption. Genetically-predicted risk of any cancer (59,647 cases) and 22 site-specific cancers ...
... In patients suffering from disease-related and socioeconomic malnutrition and being discharged from hospital, continuity of care is challenging. Lack of adequate nutrition may lead to increase in morbidity and mortality. The aim of this study was to overcome the handicap of limited nutrition access in this category of patients and to study its consequences on clinical outcome. Hospitalized patient ...
body mass index; breast neoplasms; clinical nutrition; cohort studies; colorectal neoplasms; hand strength; lung neoplasms; lungs; prediction; prognosis; regression analysis
Abstract:
... Decreased muscle strength, as measured by absolute handgrip strength (HGS), is associated with poor outcomes in patients with cancer. The ability of HGS to predict cancer prognosis may be affected by its absolute or relative representation. It is not clear whether absolute or relative HGS is more appropriate for the prognostic assessment of cancer. We conducted a multicenter prospective cohort stu ...
... Established supportive care to reduce the toxicity of neoadjuvant chemotherapy (NAC) is lacking. This multicenter randomized study compared the administration of synbiotics combined with enteral nutrition (EN) versus that of prophylactic antibiotics as supportive care treatment for patients with esophageal cancer undergoing NAC. Patients with advanced esophageal cancer scheduled to receive NAC wer ...
Nicole Kiss; Belinda Steer; Marian de van der Schueren; Jenelle Loeliger; Roohallah Alizadehsani; Lara Edbrooke; Irene Deftereos; Erin Laing; Abbas Khosravi
body mass index; clinical nutrition; etiology; food intake; hospitals; inflammation; leadership; malnutrition; metastasis; mortality; muscle tissues; muscles; observational studies; people; phenotype; risk; weight loss
Abstract:
... The Global Leadership Initiative on Malnutrition (GLIM) criteria require validation in various clinical populations. This study determined the prevalence of malnutrition in people with cancer using all possible diagnostic combinations of GLIM etiologic and phenotypic criteria and determined the combinations that best predicted mortality and unplanned hospital admission within 30 days. The GLIM cri ...
... The Global Leadership Initiative on Malnutrition (GLIM) proposed a two-step approach for the malnutrition diagnosis: screening to identify “at risk” patients by any validated nutritional screening tool (NST), followed by a detailed nutritional assessment for diagnosis and grading the severity of malnutrition. Since there are several validated NST, this study aimed to evaluate the complementarity o ...
... Major burns develop acute trace element (TE) deficiencies due to exudative losses of copper, selenium, and zinc from the wounds. A repletion strategy has been shown to decrease infectious and surgical complications. The TE doses have been adapted over time and the last adaptation, was not followed by the expected changes. The study aims at identifying the causes of the failure. Retrospective cohor ...
... The Controlling Nutritional Status (CONUT) score is designed to assess the immune-nutritional status of patients. Poor nutritional status and inflammation may facilitate the development of hepatic encephalopathy (HE) in cirrhotic patients. However, it remains unknown whether the CONUT score is related to and can be used as a predictive marker for HE. The aim of this study was to investigate the as ...
... The role of prophylactic vitamin D supplementation in prevention and treatment of respiratory infections and other related pathologies has been extensively explored with conflicting results. The aim of this systematic review and meta-analysis was to evaluate the prophylactic and therapeutic effects of vitamin D administration on respiratory infections. A systematic search was performed and randomi ...
Chinese people; adults; clinical nutrition; confidence interval; metastasis; model validation; muscle tissues; muscles; patients; prediction; surgery; New England region
Abstract:
... Survival estimation for patients with spinal metastasis is crucial to treatment decisions. Psoas muscle area (PMA), a surrogate for total muscle mass, has been proposed as a useful survival prognosticator. However, few studies have validated the predictive value of decreased PMA in an Asian cohort or its predictive value after controlling for existing preoperative scoring systems (PSSs). In this s ...
body composition; body mass index; clinical nutrition; computed tomography; computer software; cross-sectional studies; diet therapy; humans; information systems; malnutrition; prognosis; radiology; skeletal muscle; vertebrae; China
Abstract:
... Skeletal muscle mass loss is an important aspect of malnutrition and is closely related to adverse clinical outcomes. Computed tomography (CT) is the gold standard for analysing muscle mass, and the skeletal muscle index at the third lumbar vertebra (L3-SMI), measured using CT, is an important indicator to evaluate total skeletal tissue. The aims of this study were to establish reference values fo ...
Lorenzo M. Donini; Luca Busetto; Stephan C. Bischoff; Tommy Cederholm; Maria D. Ballesteros-Pomar; John A. Batsis; Juergen M. Bauer; Yves Boirie; Alfonso J. Cruz-Jentoft; Dror Dicker; Stefano Frara; Gema Frühbeck; Laurence Genton; Yftach Gepner; Andrea Giustina; Maria Cristina Gonzalez; Ho-Seong Han; Steven B. Heymsfield; Takashi Higashiguchi; Alessandro Laviano; Andrea Lenzi; Ibolya Nyulasi; Edda Parrinello; Eleonora Poggiogalle; Carla M. Prado; Javier Salvador; Yves Rolland; Ferruccio Santini; Mireille J. Serlie; Hanping Shi; Cornel C. Sieber; Mario Siervo; Roberto Vettor; Dennis T. Villareal; Dorothee Volkert; Jianchun Yu; Mauro Zamboni; Rocco Barazzoni
adipose tissue; adiposity; body mass index; clinical nutrition; data collection; metabolism; obesity; sarcopenia; sedentary lifestyle; skeletal muscle; waist circumference
Abstract:
... Loss of skeletal muscle mass and function (sarcopenia) is common in individuals with obesity due to metabolic changes associated with a sedentary lifestyle, adipose tissue derangements, comorbidities (acute and chronic diseases), and during the ageing process. Co-existence of excess adiposity and low muscle mass/function is referred to as sarcopenic obesity (SO), a condition increasingly recognize ...
Roland Wedekind; Joseph A. Rothwell; Vivian Viallon; Pekka Keski-Rahkonen; Julie A. Schmidt; Veronique Chajes; Vna Katzke; Theron Johnson; Maria Santucci de Magistris; Vittorio Krogh; Pilar Amiano; Carlotta Sacerdote; Daniel Redondo-Sánchez; José María Huerta; Anne Tjønneland; Pratik Pokharel; Paula Jakszyn; Rosario Tumino; Eva Ardanaz; Torkjel M. Sandanger; Anna Winkvist; Johan Hultdin; Matthias B. Schulze; Elisabete Weiderpass; Marc J. Gunter; Inge Huybrechts; Augustin Scalbert
... Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) ...
Anna C.H. Willemsen; Annemieke Kok; Laura W.J. Baijens; Jan Paul de Boer; Remco de Bree; Lot A. Devriese; Chantal M.L. Driessen; Carla M.L. van Herpen; Frank J.P. Hoebers; Johannes H.A.M. Kaanders; Rebecca T. Karsten; Sander M.J. van Kuijk; Roy I. Lalisang; Arash Navran; Susanne R. Pereboom; Annemie M.W.J. Schols; Chris H.J. Terhaard; Ann Hoeben
clinical nutrition; cohort studies; decision making; diet; head and neck squamous cell carcinoma; medical facilities; models; mouth; parotid gland; radiotherapy; risk; telemedicine; texture; toxicity; tube feeding; Netherlands
Abstract:
... Patients who receive chemoradiotherapy or bioradiotherapy (CRT/BRT) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) often experience high toxicity rates interfering with oral intake, causing tube feeding (TF) dependency. International guidelines recommend gastrostomy insertion when the expected use of TF exceeds 4 weeks. We aimed to develop and externally validate a prediction ...
Maha Al Fify; Ben Nichols; Lefkothea Arailoudi Alexiadou; Fiona Stefanowicz; Janis Armstrong; Richard K. Russell; Adrian Raudaschl; Naina Pinto; Andrew Duncan; Anthony Catchpole; Peter Galloway; Dinesh Talwar; Konstantinos Gerasimidis
... Interpretation of blood micronutrient levels requires age-appropriate reference intervals. This study developed age-dependent micronutrient centiles for healthy children (HC) and explored their utility in sick children. 244 blood samples were collected from normal HC who underwent tests for acute illness. Age-dependent, centile charts were fitted for zinc, copper, magnesium and selenium in plasma ...
... Pro-inflammatory diet interacting with gut microbiome might trigger for Crohn's disease (CD). We aimed to investigate the relationship between dietary inflammatory potential and microflora/metabolites change and their link with CD. The dietary inflammatory potential was assessed using a dietary inflammatory index (DII) based on the Food Frequency Questionnaire from 150 new-onset CD patients and 28 ...
... Individuals with food addiction (FA) may experience addictive behaviours like those observed in other substances of abuse, which may affect their dietary intake habits. In fact, previous studies have reported associations between FA and dietary patterns, but this evidence has not been quantitatively summarised before. Therefore, this study aimed to explore differences in dietary intakes among adul ...
... Increased fruit and vegetable consumption (FVC) beneficially impacts hypertension, yet researchers have not synthesized the effects of FVC interventions on blood pressure (BP) among overweight or obese individuals. Therefore, we aimed to examine if diets with increased FVC decrease BP in overweight and obese persons and explore effects of moderators, study methods, participants, intervention, and ...
Western diets; adulthood; biomarkers; blood; blood pressure; clinical nutrition; food frequency questionnaires; healthy diet; insulin resistance; longitudinal studies; metabolic syndrome; principal component analysis; prospective studies; risk; young adults; Australia
Abstract:
... Whether early young adulthood dietary patterns predict the risk of metabolic syndrome (MetS) and diabetes-related endpoints prior to middle age remains unknown. We examined the prospective associations of dietary patterns in early young adulthood with MetS and diabetes-related endpoints at later young adulthood. We used data of young adults from a long running birth cohort in Australia. The Wester ...
... Numerous studies have evaluated the effects of dietary protein on specific health outcomes. The aim of our umbrella review was to summarize the existing evidence between the intake of dietary proteins and multiple health outcomes, and assess their strength and validity. Our study was registered at PROSPERO (No. CRD42021255938). We systematically searched PubMed, Embase, and Web of Science database ...
... Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing cancer treatment side effects, affecting 20–70% of patients despite routine antiemetic prescription. Although dietary modifications are routinely recommended in clinical practice, there is lack of data synthesis to determine which dietary strategies for managing CINV are supported by quality evidence. This systematic re ...
... Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, may influence VAT volume. We aimed to determine the effects of isocaloric diets differing in either “cellularity”, a novel marker of dietary carbohydrate quality, or carbohydrate amount on visceral f ...
... Despite animal studies revealing a causal link between the gut microbiota and skeletal muscle mass, the role of the gut microbiome and its metabolites in humans having low muscle mass remains unclear. Eighty-eight subjects older than 65 years were measured for sarcopenia-related parameters, including body composition, grip strength, gait speed and flexibility. Participants were divided into normal ...
... Studies using the Global Leadership Initiative on Malnutrition (GLIM) criteria for patients with liver cirrhosis are limited. This study aimed to assess the impact of malnutrition according to the GLIM criteria on the outcomes of patients awaiting a liver transplant (LTx) and compare these criteria with Subjective Global Assessment (SGA). This retrospective observational study included adult patie ...
Levi Teigen; Prince P. Mathai; Sharon Lopez; Michael Matson; Baila Elkin; Daria Kozysa; Amanda J. Kabage; Matthew Hamilton; Byron P. Vaughn; Michael J. Sadowsky; Alexander Khoruts
... Hydrogen sulfide (H₂S) is a toxic end-product of microbial fermentation produced in the colon that may play a role in the pathogenesis of several diseases, including ulcerative colitis and colon cancer. However, the effect of diet interventions on intestinal burden of H₂S gas exposure remains poorly understood. Determine the effect of short-term (1-week) plant- and animal-based eating patterns on ...
adiposity; bottle feeding; breast feeding; clinical nutrition; dual-energy X-ray absorptiometry; fat mass index; lean body mass; lysophospholipids; metabolites; ultrasonics; visceral fat
Abstract:
... Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (E ...
... Aspiration pneumonia (AP) is a public health concern among older adults. Previous studies have reported the association between oral intake initiation within 48 h after hospital admission and better in-hospital outcomes among patients with AP. We investigated the association between initiation of oral intake within 24 h and in-hospital outcomes of older patients with AP undergoing dysphagia rehabi ...
... Omega-3 supplements are widely used for cardiovascular (CV) protection. We performed an updated meta-analysis for omega-3 and CV outcomes. Random-effects meta-analysis including double-blind RCTs with duration ≥1 year, evaluating omega-3 supplements in 4 a priori defined categories (<1, 1, 2, ≥3 of 1g capsules/day) on all-cause mortality, cardiac death, myocardial infarction and stroke, reporting ...
adults; body water; carbon dioxide; clinical nutrition; energy expenditure; intravenous injection; isotopes; parenteral feeding; reference standards; surgery
Abstract:
... Doubly labelled water (DLW) is considered the reference standard method of measuring total energy expenditure (TEE), but there is limited information on its use in the Intensive Care Unit (ICU) and acute care setting. This scoping review aims to systematically summarize the available literature on TEE measured using DLW in these contexts.Four online databases (MEDLINE, Embase, Emcare and CINAHL) w ...
... Although both dynapenia and abdominal obesity have negative impact on physical function and health, few prospective studies evaluate the association of dynapenic abdominal obesity (D/AO) with gait speed and falls. Our aim was to examine the combined effect of low muscle strength and abdominal obesity on long-term gait speed and falls in older adults. We used longitudinal data from the English Long ...
Mette M. Berger; Alan Shenkin; Anna Schweinlin; Karin Amrein; Marc Augsburger; Hans-Konrad Biesalski; Stephan C. Bischoff; Michael P. Casaer; Kursat Gundogan; Hanna-Liis Lepp; Angélique M.E. de Man; Giovanna Muscogiuri; Magdalena Pietka; Loris Pironi; Serge Rezzi; Cristina Cuerda
... Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in common pathologies, with significant deficiencies impacting the outcome. This guideline aims to provide information for daily clinical nutrition practice regarding assessment of MN status, monitoring, and prescription. It proposes a consensus term ...
Dorothee Volkert; Anne Marie Beck; Tommy Cederholm; Alfonso Cruz-Jentoft; Lee Hooper; Eva Kiesswetter; Marcello Maggio; Agathe Raynaud-Simon; Cornel Sieber; Lubos Sobotka; Dieneke van Asselt; Rainer Wirth; Stephan C. Bischoff
... Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats. To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration. Further, to a ...
Stephan C. Bischoff; Peter Austin; Kurt Boeykens; Michael Chourdakis; Cristina Cuerda; Cora Jonkers-Schuitema; Marek Lichota; Ibolya Nyulasi; Stéphane M. Schneider; Zeno Stanga; Loris Pironi
... This ESPEN practical guideline will inform physicians, nurses, dieticians, pharmacists, caregivers and other home enteral nutrition (HEN) providers in a concise way about the indications and contraindications for HEN, as well as its implementation and monitoring. This guideline will also inform interested patients requiring HEN. Home parenteral nutrition is not included but will be addressed in a ...
K. Veldscholte; M.A.N. Veen; R.D. Eveleens; R.C.J. de Jonge; I. Vanhorebeek; J. Gunst; M.P. Casaer; P.J. Wouters; Gonzalo Garcia Guerra; G. Van den Berghe; K.F.M. Joosten; S.C.A.T. Verbruggen
... Hypophosphatemia during critical illness has been associated with adverse outcome. The reintroduction of enteral or parenteral nutrition, leading to refeeding hypophosphatemia (RFH), has been presented as potential risk factor. We investigated the occurrence of early RFH, its association with clinical outcome, and the impact of early parenteral nutrition (PN) on the development of early RFH in ped ...
academic achievement; anisotropy; batteries; birth weight; brain; breast feeding; clinical nutrition; diffusivity; head circumference; infancy; microstructure
Abstract:
... Exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) mic ...
... Early electrolyte and mineral imbalances have emerged as a conspicuous problem in very preterm babies since the revision of nutrition guidelines and the eventual implementation of early aggressive parenteral nutrition (PN). We opted to carry out a study with the introduction of phosphorus as sodium glycerophosphate in PN from the first day onward to reveal the impact on serum phosphorus and calciu ...
bone density; bone metabolism; clinical nutrition; dietary calcium; genome-wide association study; haplotypes; linkage disequilibrium; loci; males; osteoporosis; pathogenesis; risk; tyrosine
Abstract:
... Osteoporosis is the most common bone disease and is characterized by low bone mineral density (BMD) and a high risk of fracture. Despite advances in our understanding of the pathogenesis of osteoporosis, complex gene–environment interactions that influence osteoporosis development remain largely unexplored. In this study, we aimed to identify genetic loci associated with low BMD and to evaluate th ...
Claudio Ricci; Francesco Serbassi; Carlo Ingaldi; Laura Alberici; Davide Giovanni Grego; Di Mauro Daniela; Emilio De Raffele; Valentina Vicennati; Loris Pironi; Anna Simona Sasdelli; Riccardo Casadei
... Malnutrition is a well-recognized risk factor for major surgery-related complications, but the impact of preoperative nutritional therapy is still debated due to a lack of high-level evidence. The study aims to evaluate the role of preoperative malnutrition in the postoperative course of patients who underwent pancreatic resection. This is a retrospective study involving 488 patients who underwent ...
blood pressure; blood serum; body fat; body mass index; body weight; childhood; children; clinical nutrition; education; energy intake; glucose; insulin; lean body mass; principal component analysis; waist circumference
Abstract:
... Ultra-processed foods (UPF) consumption has increased greatly over the last decades but its impact on health remains unclear. This study aimed to evaluate the prospective effect of different degrees of food processing on children's cardiometabolic profile. Children from the Portuguese population-based birth cohort Generation XXI evaluated at 7 and 10 years of age (y), with dietary information at 7 ...
... Gestational diabetes mellitus (GDM) is one of the most common complication of pregnancy that has significant impacts on both mother and her offspring health. The present study aimed to examine the effect of carbohydrate counting, carbohydrate counting combined with DASH, and control dietary interventions on glycemic control, and maternal and neonatal outcomes.A total of 75 pregnant women with GDM ...
... Patients who undergo gastrectomy often have a high risk of postoperative complications. This study aimed to investigate the effects of n-3 polyunsaturated fatty acids (PUFAs) on immune function, the inflammatory response, nutritional status, and rehabilitation of patients with gastric cancer. A total of 120 patients with gastric cancer who underwent elective radical gastrectomy in the Department o ...
... Recent evidence suggests that gut microbiota may represent an important factor to affect the development of obesity and obesity-related diseases. Although several randomized controlled trials (RCTs) have explored the ability of Lactobacillus to improve metabolic parameters in adults who are overweight or obese, their findings have been inconsistent and require further analysis. Therefore, this sys ...
body fat; clinical nutrition; dietary protein; muscles; people; protein intake; randomized clinical trials; skeletal muscle
Abstract:
... Resistance training and a sufficient amount of dietary protein have been suggested to build up and maintain muscle mass, strength and function into old age. As there is still no consensus on the optimum amount of protein intake in older people, this study aims to evaluate first whether it is achievable to double the recommended amount, which is 1 g/kg BW/d in German speaking countries, via food ad ...
C-reactive protein; alpha-linolenic acid; cholesterol; clinical nutrition; dialysis; elderly; high density lipoprotein; hyperlipidemia; inflammation; kidney diseases; lipid composition; low density lipoprotein; meta-analysis; morbidity; mortality; systematic review; vegetables
Abstract:
... Inflammation and dyslipidemia are traditional risk factors and well-known causes of morbidity and mortality in chronic kidney disease (CKD). Alpha-linolenic acid (ALA), an essential fatty acid mainly found in vegetable sources, has been associated with anti-inflammatory effects and improving lipid profile. This systematic review and meta-analysis investigate the effects of supplementation with veg ...
clinical nutrition; databases; death; head circumference; low birth weight; meta-analysis; neonatal mortality; placebos; pregnancy; premature birth; progeny; risk; risk reduction; small for gestational age
Abstract:
... Vitamin D deficiency during pregnancy is common across the world. The effects of maternal vitamin D supplementation on offspring health were contradict from previous studies. This study was conducted to update the effects of vitamin D supplementation during pregnancy on offspring health with new evidence. A systematic search of Medline, Embase, the Cochrane Database of Systematic Reviews, Clinical ...
Samanta Mattos; Michelle Rabello da Cunha; Maria Inês Barreto Silva; Fabiano Serfaty; Mika P. Tarvainen; Márcia Regina Simas Torres Klein; Mario Fritsch Neves
... The effects of calorie restriction and physical activity on autonomic regulation and cardiac vagal control in overweight and obese individuals remain inconsistent. Thus, this systematic review aimed to evaluate the weight loss effects through lifestyle changes on heart rate variability (HRV) markers in overweight and obese subjects. A systematic search for studies published up to November 2021 was ...
body mass index; clinical nutrition; diet; encephalopathy; liver cirrhosis; meta-analysis; mortality; muscle tissues; placebos; serum albumin; systematic review
Abstract:
... Branched chain amino acids' (BCAAs) beneficial role in the management of hepatic encephalopathy is already well established, whereas a number of randomized clinical trials (RCTs) have showed promising results examining BCAA supplementation in the management of other aspects of liver cirrhosis. Current results in the light of BCAAs’ biochemical properties make them an attractive supplementation opt ...
... Patients chronically infected with hepatitis B virus (HBV) are at high risk of liver fibrosis, cirrhosis and liver cancer, despite recent therapeutic advances. It is therefore crucial to find non-pharmaceutical options for liver fibrosis prevention in this population. Using cross-sectional data from the ANRS CO22 Hepather cohort, we aimed to identify socio-demographic and modifiable risk factors f ...
... Dietary pattern is a comprehensive assessment of diet that may reflect the interrelationships between foods. Analysis on actual dietary pattern and metabolic syndrome (MetS) risk are insufficient. This study examined the prospective association between empirically identified dietary patterns and MetS risk in adults aged 40 years or older. A total of 11,305 participants (58,318 person-years) withou ...
... Predicting the risk of early limiting toxicity (ELT) is major challenge for the clinician seeking an effective, safe treatment for older patients with cancer. The Cancer and Aging Research Group (CARG) and CRASH (Chemotherapy Risk Assessment Scale for High-Age Patients) toxicity scores were designed to predict chemotherapy-related toxicity. Elevated resting energy expenditure (REE) may predispose ...