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- Author:
- Tianmu He; Qiyi Wang; Jingwen Ao; Kuan Chen; Xiaofei Li; Jianyong Zhang; Cancan Duan
- Source:
- Food and chemical toxicology 2022 v.163 pp. 112986
- ISSN:
- 0278-6915
- Subject:
- Mylabris; Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; bioactive compounds; cantharidin; caspase-3; cytotoxicity; endoplasmic reticulum; endoplasmic reticulum stress; nephrotoxicity; renal function; toxicology
- Abstract:
- ... Mylabris, as a natural product of traditional Chinese medicine (TCM), exhibiting typical antitumor activity, and cantharidin (CTD) is the major bioactive component. However, drug-induced nephrotoxicity (DIN) extremely limited its clinical application. In this study, we proved that activation of the endoplasmic reticulum (ER) stress-dependent PERK/CHOP pathway exerts a toxic role in rats and HK-2 c ...
- DOI:
- 10.1016/j.fct.2022.112986
- https://doi.org/10.1016/j.fct.2022.112986
- Author:
- Rili Hao; Yang Jiang; Feng Li; Dongxiao Sun-Waterhouse; Dapeng Li
- Source:
- Food and chemical toxicology 2021 v.158 pp. 112654
- ISSN:
- 0278-6915
- Subject:
- Western blotting; apoptosis; bioactive compounds; body weight; cadmium; caffeic acid; heavy metals; histology; honey bees; human health; inflammation; pollutants; propolis; protective effect; spleen; toxicity; toxicology
- Abstract:
- ... Cadmium (Cd) is a toxic heavy metal pollutant that can be accumulated in organs including the spleen, thereby threatening human health. In this study, the effect of caffeic acid phenethyl ester (CAPE, a bioactive component of honeybee propolis) on CdCl₂-induced spleen toxicity and underlying mechanisms were examined in mice. Histological examinations revealed that CAPE (10 μmol/kg/day b.w.) could ...
- DOI:
- 10.1016/j.fct.2021.112654
- https://doi.org/10.1016/j.fct.2021.112654
- Author:
- Shanmugaraj Gowrishankar; Sankar Muthumanickam; Arumugam Kamaladevi; Chandrasekar Karthika; Ravi Jothi; Pandi Boomi; Dharuman Maniazhagu; Shunmugiah Karutha Pandian
- Source:
- Food and chemical toxicology 2021 v.148 pp. 111966
- ISSN:
- 0278-6915
- Subject:
- COVID-19 infection; Eucalyptus globulus; Justicia adhatoda; Severe acute respiratory syndrome coronavirus 2; Vitex negundo; bioactive compounds; breathing; computer simulation; drugs; ellagic acid; etiological agents; glycoproteins; hydrogen; pandemic; phytochemicals; prediction; proteinase inhibitors; proteinases; public health; steam; structural proteins; therapeutics; toxicology
- Abstract:
- ... COVID-19, the presently prevailing global public health emergency has culminated in international instability in economy. This unprecedented pandemic outbreak pressingly necessitated the trans-disciplinary approach in developing novel/new anti-COVID-19 drugs especially, small molecule inhibitors targeting the seminal proteins of viral etiological agent, SARS-CoV-2. Based on the traditional medicin ...
- DOI:
- 10.1016/j.fct.2020.111966
- https://doi.org/10.1016/j.fct.2020.111966
- Author:
- Yongqiu Cai; Hooi Ren Lim; Kuan Shiong Khoo; Hui-Suan Ng; Yanxue Cai; Jihui Wang; Andy Tak-Yee Chan; Pau Loke Show
- Source:
- Food and chemical toxicology 2021 v.158 pp. 112607
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; biomass; biorefining; dietary supplements; functional foods; human health; immunomodulation; metabolites; microalgae; nanocapsules; solubility; therapeutics; toxicology; value added
- Abstract:
- ... Microalgae metabolites include biologically active compounds with therapeutic effects such as anticancer, anti-inflammatory and immunomodulation effects. One of the most recent focuses is on utilizing microalgae lipid-based biologically active compounds in food applications. However, most microalgae biological active compounds in their natural forms have common drawbacks like low solubility, low p ...
- DOI:
- 10.1016/j.fct.2021.112607
- https://doi.org/10.1016/j.fct.2021.112607
- Author:
- Tianmu He; Jingxian Liu; Xiaoning Wang; Cancan Duan; Xiaofei Li; Jianyong Zhang
- Source:
- Food and chemical toxicology 2020 v.146 pp. 111845
- ISSN:
- 0278-6915
- Subject:
- Mylabris; antineoplastic activity; apoptosis; bioactive compounds; biomarkers; cantharidin; caspase-3; metabolomics; nephrotoxicity; phosphatidylcholines; phosphatidylethanolamines; protein synthesis; sphingolipids; therapeutics; toxicology
- Abstract:
- ... Cantharidin (CTD) is the major bioactive compound in Mylabris and has been shown to exhibit antitumor activity. However, its clinical application is relatively limited due to its potential toxic effects, especially nephrotoxicity. In this study, a UHPLC-QE/MS based metabolomics approach combined with network pharmacology was used to investigate the mechanism of CTD-induced nephrotoxicity in HK-2 c ...
- DOI:
- 10.1016/j.fct.2020.111845
- https://doi.org/10.1016/j.fct.2020.111845
- Author:
- Lei Chen; Xiujun Lin; Xiaowei Xu; Lihao Wang; Hui Teng; Hui Cao
- Source:
- Food and chemical toxicology 2020 v.135 pp. 110953
- ISSN:
- 0278-6915
- Subject:
- Sonchus oleraceus; animal disease models; anti-inflammatory activity; bioactive compounds; blood glucose; diabetes; gastrointestinal system; glycemic effect; insulin; interleukin-6; liver; medicinal plants; metformin; polyphenols; rats; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Edible Sonchus oleraceus Linn is a medicinal plant with many bioactivities such as anti-diabetic activity and anti-inflammatory activity. However, the main bioactive components such as polyphenols in S. oleraceus Linn are poorly absorbed in gastrointestinal tract and rapidly metabolized. Thereby, a self-emulsifying delivery system containing S. oleraceus Linn extracts (SSEDDS) was introduced to ev ...
- DOI:
- 10.1016/j.fct.2019.110953
- https://doi.org/10.1016/j.fct.2019.110953
- Author:
- Kannan RR. Rengasamy; Mohamad Fawzi Mahomoodally; Muhammad Zakariyyah Aumeeruddy; Gokhan Zengin; Jianbo Xiao; Doo Hwan Kim
- Source:
- Food and chemical toxicology 2020 v.135 pp. 111013
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; drugs; enzyme activity; enzymes; etiology; foods; macroalgae; mechanism of action; medicinal properties; metabolites; noninfectious diseases; toxicity
- Abstract:
- ... Seaweeds are among the significant currently exploited marine plant resources which are gaining full applications in culinary, cosmetic, pharmaceutical, and biotechnological processes. Much attention has been devoted to seaweeds based on their proven health benefits and is considered as a rich source of structurally different bioactive metabolites for the discovery of novel functional food-based p ...
- DOI:
- 10.1016/j.fct.2019.111013
- https://doi.org/10.1016/j.fct.2019.111013
- Author:
- Renata Giacomeli; Flavia Elizabete Guerra Teixeira; Felipe Barbosa Carvalho; Camila Oliveira Pacheco; Alcides José Martins Parisotto; Ana Claudia Funguetto Ribeiro; Marcelo Gomes de Gomes; Sandra Elisa Haas
- Source:
- Food and chemical toxicology 2020 v.144 pp. 111625
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; blood; body weight changes; curcumin; dietary supplements; fetal development; fetus; food intake; histopathology; liver; nanocapsules; organogenesis; placenta; polymers; pregnancy; toxicity; toxicology
- Abstract:
- ... This study was designed to examine fetal and maternal toxicity of curcumin (CURC) loaded lipid-core nanocapsules (LNC) prepared with poly(ϵ-caprolactone) as a polymer, administered during the organogenesis period. Free CURC and CURC loaded-LNC (C-LNC) (2 mg/kg), blank LNC (B-LNC) and saline (CONTROL) were administered per oral route from the 7° to 13° gestational day (GD). Dams were evaluated dail ...
- DOI:
- 10.1016/j.fct.2020.111625
- https://doi.org/10.1016/j.fct.2020.111625
- Author:
- Vanessa Vieira; Carla Pereira; Rui M.V. Abreu; Ricardo C. Calhelha; Maria José Alves; João A.P. Coutinho; Olga Ferreira; Lillian Barros; Isabel C.F.R. Ferreira
- Source:
- Food and chemical toxicology 2020 v.137 pp. 111189
- ISSN:
- 0278-6915
- Subject:
- Gram-positive bacteria; Juglans regia; anti-inflammatory activity; antibacterial properties; antioxidant activity; bioactive compounds; cell culture; cell lines; chemical constituents of plants; coumaric acids; crop production; cytotoxicity; flavonols; hemolysis; hulls; naphthalene; neoplasms; nitric oxide; thiobarbituric acid-reactive substances; walnuts; wastes
- Abstract:
- ... Juglans regia L. (walnut) green husks are an important fraction of waste resulting from the walnut production, thus representing an interesting natural matrix to explore as a source of bioactive compounds. In this work, the hydroethanolic extract of walnut green husks was studied considering the phytochemical composition and the biological activity using different cell model assays, most of them e ...
- DOI:
- 10.1016/j.fct.2020.111189
- https://doi.org/10.1016/j.fct.2020.111189
- Author:
- Aziz A. Fallah; Elham Sarmast; Parichehr Fatehi; Tina Jafari
- Source:
- Food and chemical toxicology 2020 v.135 pp. 110922
- ISSN:
- 0278-6915
- Subject:
- C-reactive protein; adhesion; adiponectin; anthocyanins; bioactive compounds; inflammation; intercellular adhesion molecule-1; interleukin-1beta; interleukin-6; meta-analysis; randomized clinical trials; systematic review; tumor necrosis factor-alpha; vascular cell adhesion molecules
- Abstract:
- ... Anthocyanins are natural bioactive compounds that have several health benefits. This systematic review and meta-analysis assessed the impact of dietary anthocyanins on markers of systemic and vascular inflammation. Meta-analysis of 32 randomised controlled trials indicated that dietary anthocyanins significantly decreased levels of C-reactive protein (CRP; −0.33 mg/l, 95% CI: −0.55 to −0.11, P = 0 ...
- DOI:
- 10.1016/j.fct.2019.110922
- https://doi.org/10.1016/j.fct.2019.110922
- Author:
- Yutong Dong; Fei Pei; Anxiang Su; Katherine Z. Sanidad; Gaoxing Ma; Liyan Zhao; Qiuhui Hu
- Source:
- Food and chemical toxicology 2020 v.135 pp. 110944
- ISSN:
- 0278-6915
- Subject:
- Flammulina velutipes; Fourier transform infrared spectroscopy; bioactive compounds; galactose; glucuronic acid; high performance liquid chromatography; mannose; polysaccharides; principal component analysis; quality control; regression analysis; rhamnose; scanning electron microscopy; xylose
- Abstract:
- ... Polysaccharides are known as one of the most important bioactive compounds in Flammulina velutipes. However, there is no accurate and comprehensive assessment method to evaluate and authenticate F. velutipes polysaccharides (FVPs) from different sources. In this study, a multiple fingerprint analysis method including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-I ...
- DOI:
- 10.1016/j.fct.2019.110944
- https://doi.org/10.1016/j.fct.2019.110944
- Author:
- Lovro Sinkovič; Marijan Nečemer; Nives Ogrinc; Dragan Žnidarčič; David Stopar; Rajko Vidrih; Vladimir Meglič
- Source:
- Food and chemical toxicology 2020 v.136 pp. 111109
- ISSN:
- 0278-6915
- Subject:
- Cichorium intybus; analytical methods; bioactive compounds; biomarkers; carbon; case studies; chicory; crop production; cultivars; greenhouse experimentation; mineral fertilizers; nitrogen; organic production; stable isotopes; sulfur
- Abstract:
- ... Organic crop production has become a highly attractive way of production over the world and thus the need for robust analytical techniques for their authentication. The main aim of this study is to identify appropriate biomarkers to discriminate between organic and conventionally grown chicory. Chicory is an appreciated leafy vegetable among producers and consumers, especially due to its undemandi ...
- DOI:
- 10.1016/j.fct.2019.111109
- https://doi.org/10.1016/j.fct.2019.111109
- Author:
- Patrick Wellington da Silva dos Santos; Ana Rita Thomazela Machado; Rone Aparecido De Grandis; Diego Luis Ribeiro; Katiuska Tuttis; Marco Morselli; Alexandre Ferro Aissa; Matteo Pellegrini; Lusânia Maria Greggi Antunes
- Source:
- Food and chemical toxicology 2020 v.136 pp. 111047
- ISSN:
- 0278-6915
- Subject:
- DNA damage; DNA methylation; antineoplastic agents; apoptosis; binding sites; bioactive compounds; cancer therapy; carcinogenesis; cell cycle checkpoints; cell proliferation; chemoprevention; enzyme inhibition; epigenetics; gene expression; gene expression regulation; genes; hepatoma; histone deacetylase; human cell lines; human diseases; mechanism of action; mitotic spindle apparatus; neoplasm cells; sulforaphane; toxicity; transcription factors; transcriptome
- Abstract:
- ... Abnormal epigenetic alterations are one of the keystones of cancer development. Epigenetic targeting drugs have become a promising and effective cancer therapy strategy. However, due to the high toxicity and unclear mechanisms of action of these drugs, natural compounds that cause epigenetic modulation have also been studied. Sulforaphane (SFN) is a promising bioactive compound for epigenetic targ ...
- DOI:
- 10.1016/j.fct.2019.111047
- https://doi.org/10.1016/j.fct.2019.111047
- Author:
- Mohamad Fawzi Mahomoodally; Elwira Sieniawska; Kouadio Ibrahime Sinan; Marie Carene Nancy Picot-Allain; Serife Yerlikaya; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Ismail Senkardes; Kannan RR. Rengasamy; Gokhan Zengin
- Source:
- Food and chemical toxicology 2020 v.135 pp. 111052
- ISSN:
- 0278-6915
- Subject:
- Rhododendron; alpha-glucosidase; antineoplastic agents; antioxidants; bioactive compounds; cell lines; cell viability; cholinesterase; cytotoxicity; enzyme inhibition; enzyme inhibitors; epigallocatechin; ethnobotany; ethyl acetate; growth retardation; inhibitory concentration 50; lung neoplasms; methanol; neoplasm cells; poisoning; secondary metabolites; structure-activity relationships; viability assays
- Abstract:
- ... Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of ‘mad honey’ poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. l ...
- DOI:
- 10.1016/j.fct.2019.111052
- https://doi.org/10.1016/j.fct.2019.111052
- Author:
- Mabel Guevara; Eduardo Tejera; Gabriel A. Iturralde; Tatiana Jaramillo-Vivanco; María G. Granda-Albuja; Silvana Granja-Albuja; Celestino Santos-Buelga; Ana M. González-Paramás; José M. Álvarez-Suarez
- Source:
- Food and chemical toxicology 2019 v.131 pp. 110594
- ISSN:
- 0278-6915
- Subject:
- anti-inflammatory activity; antioxidants; ascorbic acid; bioactive compounds; carotenoids; chlorogenic acid; cytokines; cytotoxicity; enzymes; glycosides; heat treatment; macrophages; polyphenols; protective effect; quercetin; toxicology; Ecuador
- Abstract:
- ... The phytochemical composition and the antioxidant and anti-inflammatory activities of a mixture of 23 plants, named Horchata, traditionally consumed in Ecuador, have been evaluated. The study was carried out using the hydroalcoholic extract (HHext) and infusion (IHext) of the horchata plant mixture. It was verified that thermal treatment affected the contents of vitamin C and carotenoids, but hard ...
- DOI:
- 10.1016/j.fct.2019.110594
- https://doi.org/10.1016/j.fct.2019.110594
- Author:
- Naiara Stefanello; Roselia Maria Spanevello; Sabina Passamonti; Lisiane Porciúncula; Carla Denise Bonan; Ayodeji Augustine Olabiyi; João Batista Teixeira da Rocha; Charles Elias Assmann; Vera Maria Morsch; Maria Rosa Chitolina Schetinger
- Source:
- Food and chemical toxicology 2019 v.123 pp. 298-313
- ISSN:
- 0278-6915
- Subject:
- adenosine; adenosine triphosphate; antioxidants; beverages; bioactive compounds; caffeine; central nervous system; chlorogenic acid; coffee beans; diterpenoids; enzyme activity; homeostasis; neurons; purinergic receptors; toxicology; trigonelline
- Abstract:
- ... Coffee is a drink prepared from roasted coffee beans and is lauded for its aroma and flavour. It is the third most popular beverage in the world. This beverage is known by its stimulant effect associated with the presence of methylxanthines. Caffeine, a purine-like molecule (1,3,7 trymetylxantine), is the most important bioactive compound in coffee, among others such as chlorogenic acid (CGA), dit ...
- DOI:
- 10.1016/j.fct.2018.10.005
- https://doi.org/10.1016/j.fct.2018.10.005
- Author:
- Dariusz Jedrejek; Bernadetta Lis; Agata Rolnik; Anna Stochmal; Beata Olas
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- chemical constituents of plants; coumaric acids; cytotoxicity; anticoagulant activity; blood platelets; sesquiterpenoid lactones; free radical scavengers; amino acids; inositols; bioactive compounds; anticoagulants; mass spectrometry; blood plasma; Taraxacum officinale; antioxidant activity; oxidation; liquid chromatography; roots; protective effect
- Abstract:
- ... Although the majority of potentially bioactive components of dandelion root have been described, revealing the presence of hydroxycinnamic acids (HCAs) and sesquiterpene lactones (SLs), new compounds are still being discovered, an example of which are the recently characterized 4-hydroxyphenylacetate inositol esters (PIEs). In this work, the dandelion root was separated into five preparations (A-E ...
- DOI:
- 10.1016/j.fct.2019.02.017
- https://doi.org/10.1016/j.fct.2019.02.017
- Author:
- Giuseppe Chichiriccò; Claudio Ferrante; Luigi Menghini; Lucia Recinella; Sheila Leone; Annalisa Chiavaroli; Luigi Brunetti; Simonetta Di Simone; Maurizio Ronci; Pierpaolo Piccone; Barbara Lanza; Stefania Cesa; Annamaria Poma; Giulia Vecchiotti; Giustino Orlando
- Source:
- Food and chemical toxicology 2019 v.126 pp. 7-14
- ISSN:
- 0278-6915
- Subject:
- Artemia; Crocus sativus; anthers; antioxidant activity; bioactive compounds; byproducts; cell lines; cell movement; chemical constituents of plants; cytotoxicity; fatty acid composition; lipopolysaccharides; long chain fatty acids; malondialdehyde; mutagens; nitrites; protective effect; rats; reactive oxygen species; saffron; tissue repair; toxicology
- Abstract:
- ... Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isol ...
- DOI:
- 10.1016/j.fct.2019.01.040
- https://doi.org/10.1016/j.fct.2019.01.040
- Author:
- Beata Olas; Magdalena Bryś
- Source:
- Food and chemical toxicology 2019 v.127 pp. 31-41
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; blood platelets; caffeine; cyclic AMP; disease control; endothelial cells; energy drinks; enzymes; fibrinolysis; models; monitoring; platelet activation; reactive oxygen species; risk; thrombosis
- Abstract:
- ... Hemostasis is a process which encompasses the clotting, fibrinolysis, blood platelet activation and endothelial cell function. Certain dietary components may modulate some elements of hemostasis, particularly blood platelet function, and modify the progression of cardiovascular diseases. The aim of this review paper is to provide an overview of current knowledge of the role of coffee, energy drink ...
- DOI:
- 10.1016/j.fct.2019.02.039
- https://doi.org/10.1016/j.fct.2019.02.039
- Author:
- Jiaming Tu; Dingding Shi; Lingrong Wen; Yueming Jiang; Yupeng Zhao; Jiali Yang; Huiling Liu; Guangrong Liu; Bao Yang
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110730
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; anti-inflammatory activity; antioxidant activity; antioxidants; bioactive compounds; bioavailability; cell viability; diet; furans; inhibitory concentration 50; leaves; median effective concentration; moieties; mulberries; resveratrol; vegetables; viability assays
- Abstract:
- ... Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified ...
- DOI:
- 10.1016/j.fct.2019.110730
- https://doi.org/10.1016/j.fct.2019.110730
- Author:
- Gokhan Zengin; Claudio Ferrante; Ismail Senkardes; Reneta Gevrenova; Dimitrina Zheleva-Dimitrova; Luigi Menghini; Giustino Orlando; Lucia Recinella; Annalisa Chiavaroli; Sheila Leone; Luigi Brunetti; Carene Marie Nancy Picot-Allain; Kannan RR. Rengasamy; Mohamad Fawzi Mahomoodally
- Source:
- Food and chemical toxicology 2019 v.127 pp. 237-250
- ISSN:
- 0278-6915
- Subject:
- Rubus sanctus; alpha-amylase; alpha-glucosidase; antioxidant activity; bioactive compounds; bioassays; cholinesterase; colitis; colorectal neoplasms; cosmetics; coumaric acids; data collection; drugs; ethyl acetate; flavonoids; functional foods; humans; hydroxybenzoic acids; leaves; methanol; models; neoplasm cells; protective effect; tissue repair; triterpenoid saponins
- Abstract:
- ... In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ...
- DOI:
- 10.1016/j.fct.2019.03.041
- https://doi.org/10.1016/j.fct.2019.03.041
- Author:
- Oludemi Taofiq; Francisca Rodrigues; Lillian Barros; Maria F. Barreiro; Isabel C.F.R. Ferreira; M. Beatriz P.P. Oliveira
- Source:
- Food and chemical toxicology 2019 v.127 pp. 228-236
- ISSN:
- 0278-6915
- Subject:
- Ganoderma lucidum; Pleurotus ostreatus; bioactive compounds; cell lines; cosmetics; ears; fibroblasts; industry; ingredients; keratinocytes; mushrooms; permeability; phenolic acids; raw materials; swine; toxicity; wastes
- Abstract:
- ... Mushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH as ...
- DOI:
- 10.1016/j.fct.2019.03.045
- https://doi.org/10.1016/j.fct.2019.03.045
- Author:
- Nibedita Pradhan; Sabnam Parbin; Chahat Kausar; Swayamsiddha Kar; Shradha Mawatwal; Laxmidhar Das; Moonmoon Deb; Dipta Sengupta; Rohan Dhiman; Samir Kumar Patra
- Source:
- Food and chemical toxicology 2019 v.130 pp. 161-173
- ISSN:
- 0278-6915
- Subject:
- Paederia foetida; antineoplastic activity; apoptosis; beta-sitosterol; bioactive compounds; cadherins; cell lines; chromatin; diet; disease course; drugs; enzyme activity; enzymes; epigenetics; gene expression; gene silencing; humans; immune response; interleukin-10; interleukin-6; leaves; lupeol; neoplasm cells; prostatic neoplasms; protein content; therapeutics; toxicology; tumor necrosis factor-alpha; tumor suppressor genes
- Abstract:
- ... Aberrant epigenetic modifications are responsible for tumor development and cancer progression; however, readily reversible. Bioactive molecules from diets are promising to cure cancer by modulating epigenetic marks and changing immune response. These compounds specifically target the activity of DNMTs and HDACs to cure various human cancers. In view of this, we investigated the anticancer and epi ...
- DOI:
- 10.1016/j.fct.2019.05.016
- https://doi.org/10.1016/j.fct.2019.05.016
- Author:
- Haroon Khan; Muhammad Zafar; Seema Patel; SM Mukarrum Shah; Anupam Bishayee
- Source:
- Food and chemical toxicology 2019 v.130 pp. 207-218
- ISSN:
- 0278-6915
- Subject:
- active ingredients; alpha-glucosidase; amino acids; anti-inflammatory agents; bioactive compounds; databases; enzyme inhibition; enzyme inhibitors; noninsulin-dependent diabetes mellitus; pesticides; pharmacology; polymers; screening; toxicology
- Abstract:
- ... α-glucosidase inhibition is a rational approach in the effective management of type 2 diabetes. Several inhibitors of this enzyme class are in clinical use, but are riddled with efficacy, potency and safety challenges. For this reason, new effective α-glucosidase inhibitors are under investigation. Compounds with 1, 3, 4-oxadiazole nucleus have shown preclinical efficacy as α-glucosidase inhibitor ...
- DOI:
- 10.1016/j.fct.2019.05.006
- https://doi.org/10.1016/j.fct.2019.05.006
- Author:
- Lei Chen; Kang Li; Qian Liu; José L. Quiles; Rosanna Filosa; Mohammad Amjad Kamal; Fang Wang; Guoyin Kai; Xiaobo Zou; Hui Teng; Jianbo Xiao
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; bioactive compounds; cyanidin; fruit extracts; human cell lines; hydrogen peroxide; metabolic detoxification; oxidative stress; protective effect; protein synthesis; proteins; raspberries; signal transduction
- Abstract:
- ... The aim of the present study was to explore the protective effects of raspberry and its bioactive compound cyanidin 3-O-glucoside against H2O2-induced oxidative stress in HepG2 cells. We established a model of oxidative stress in HepG2 cells induced by H2O2 and examined the protein expression of Keap1/Nrf2. The antioxidant activity of raspberry extract was carried out measuring the level of reacti ...
- DOI:
- 10.1016/j.fct.2019.110781
- https://doi.org/10.1016/j.fct.2019.110781
- Author:
- Hong Duan; Zeng Dong; Han Li; Wan-rong Li; Shu-xiang Shi; Qing Wang; Wen-gen Cao; Xue-mei Fang; Ai-dong Fang; Ke-feng Zhai
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- bee pollen; bees; bioactive compounds; computer software; flavonoids; high performance liquid chromatography; ingredients; pollen; pollen sampling; quality control; quantitative analysis; China
- Abstract:
- ... Bee pollens constitute a large number of flavonoids and thus possess great medicinal value. However, different varieties of bee pollen flavonoids vary with different species and their content also differ greatly in different region. Herein, the aim of present research is to establish a method based on high performance liquid chromatography (HPLC) for quantitative analysis of flavonoids compounds a ...
- DOI:
- 10.1016/j.fct.2019.110831
- https://doi.org/10.1016/j.fct.2019.110831
- Author:
- Shivraj Hariram Nile; Arti Nile; Enkhtaivan Gansukh; Venkidasamy Baskar; Guoyin Kai
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110659
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Withania somnifera; antioxidant activity; antioxidants; bioactive compounds; cell viability; cytotoxicity; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; maceration; medicinal properties; microwave treatment; solid phase extraction; temperature; therapeutics; uterine cervical neoplasms
- Abstract:
- ... Subcritical water extraction (SWE) applied to analyses the bioactives from ashwagandha (W. somnifera) at varying temperature (100–200 °C) and extraction time (10–30 min). The effect of temperature and time has been investigated in terms of extraction yield (EY), total phenolic content (TPC), cytotoxicity, antioxidant, and enzyme inhibitory activities. The withanosides and withanolides responsible ...
- DOI:
- 10.1016/j.fct.2019.110659
- https://doi.org/10.1016/j.fct.2019.110659
- Author:
- Mercedes Cano; Angelica Guerrero-Castilla; Seyed Mohammad Nabavi; Antonio Ayala; Sandro Argüelles
- Source:
- Food and chemical toxicology 2019 v.131 pp. 110544
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; cell senescence; diterpenoids; flavonoids; inflammation; longevity; mitogen-activated protein kinase; mitogens; models; toxicology
- Abstract:
- ... Aging is a multifactorial universal process characterized by a gradual decrease in physiological and biochemical functions. Given that life expectancy is on the rise, a better understanding of molecular mechanisms of the aging process is necessary in order to develop anti-aging interventions. Uncontrolled cellular senescence promotes persistent inflammation and accelerates the aging process by dec ...
- DOI:
- 10.1016/j.fct.2019.05.052
- https://doi.org/10.1016/j.fct.2019.05.052
- Author:
- Adriana Trifan; Alexandru Vasincu; Simon Vlad Luca; Christiana Neophytou; Evelyn Wolfram; Sebastian E.W. Opitz; Daciana Sava; Laura Bucur; Bogdan I. Cioroiu; Anca Miron; Ana Clara Aprotosoaie; Oana Cioanca; Monica Hancianu; Alexandra Jitareanu; Andreas I. Constantinou
- Source:
- Food and chemical toxicology 2019 v.134 pp. -
- ISSN:
- 0278-6915
- Subject:
- Cystoseira; DNA; DNA fragmentation; acetone; antioxidant activity; antioxidants; apoptosis; bioactive compounds; coasts; colon; cytotoxicity; dietary supplements; drugs; epithelium; human cell lines; macroalgae; methanol; neoplasm cells; neoplasms; Black Sea; Romania
- Abstract:
- ... The Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coast of Romania. The 70% acetone, methanol and water ...
- DOI:
- 10.1016/j.fct.2019.110820
- https://doi.org/10.1016/j.fct.2019.110820
- Author:
- Doo Hwan Kim; Gyun Seok Park; Arti Shivraj Nile; Young Deuk Kwon; Gansukh Enkhtaivan; Shivraj Hariram Nile
- Source:
- Food and chemical toxicology 2019 v.125 pp. 313-321
- ISSN:
- 0278-6915
- Subject:
- Dianthus superbus; antineoplastic activity; antioxidants; antiviral properties; bioactive compounds; butanol; cell lines; chemical analysis; computer simulation; cyclic peptides; dose response; enzyme inhibition; ethyl acetate; glucosides; influenza; inhibitory concentration 50; isorhamnetin; liquid chromatography; medicinal plants; membrane glycoproteins; neoplasm cells; neoplasms; quercetin; rutin; sialidase; tandem mass spectrometry; therapeutics; viruses; Asia
- Abstract:
- ... Dianthus superbus (DS) is a traditional medicinal herb well known for its medicinal and therapeutic potential and widely distributed in various Asian countries. The ethyl acetate (EA), butanol (Bu) and distilled water (DW) extracts of DS assessed for extraction of bioactive compounds and their biological activities. The chemical analysis was done using LC-MS/MS and antioxidant, anticancer and anti ...
- DOI:
- 10.1016/j.fct.2019.01.013
- https://doi.org/10.1016/j.fct.2019.01.013
- Author:
- Fatima Bouhtit; Mehdi Najar; Douâa Moussa Agha; Rahma Melki; Mustapha Najimi; Khalid Sadki; Philippe Lewalle; Abdellah Hamal; Laurence Lagneaux; Makram Merimi
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; carvacrol; cytotoxicity; essential oils; human health; medicinal plants; mesenchymal stromal cells; oxidative stress; stem cells; therapeutics; thymol; traditional medicine; viability
- Abstract:
- ... Mesenchymal stromal cells (MSCs) represent a progenitor cell population with several biological properties. MSCs are thus of therapeutic interest for cell-based therapy but great efforts are needed to enhance their efficiency and safety. Herbal remedies and in particular their bioactive molecules, are potential candidates for improving human health. The novelty and originality of this study is to ...
- DOI:
- 10.1016/j.fct.2019.110844
- https://doi.org/10.1016/j.fct.2019.110844
- Author:
- Alfonso Varela-López; Maurizio Battino; María D. Navarro-Hortal; Francesca Giampieri; Tamara Y. Forbes-Hernández; José M. Romero-Márquez; Ricardo Collado; José L. Quiles
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acids; autophagy; bioactive compounds; bone marrow; brain; calcium; cardiotoxicity; cell lines; clinical trials; dietary minerals; doxorubicin; drug therapy; homeostasis; kidneys; liver; mechanism of action; neoplasm cells; neoplasms; nutrients; omega-3 fatty acids; protective effect; selenium; testes; toxicity; vitamin A; vitamin E
- Abstract:
- ... Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated f ...
- DOI:
- 10.1016/j.fct.2019.110834
- https://doi.org/10.1016/j.fct.2019.110834
- Author:
- Daniela Ribeiro; Marisa Freitas; Artur M.S. Silva; Félix Carvalho; Eduarda Fernandes
- Source:
- Food and chemical toxicology 2018 v.120 pp. 681-699
- ISSN:
- 0278-6915
- Subject:
- antioxidants; bioactive compounds; carbonyl compounds; carotenoids; diet; humans; lipids; nitrogen; oxidation; oxidative stress; oxygen; plant pigments; toxicology
- Abstract:
- ... Carotenoids are lipid soluble plant pigments that make part of human daily diet. These compounds are able to react with diverse reactive species and originate a myriad of oxidation products that have similar or even more reactivity than their parent compounds. These products may be short-chain carbonyl compounds and, the commonly designated, apo-carotenoids. The effects fo these products in the hu ...
- DOI:
- 10.1016/j.fct.2018.07.060
- https://doi.org/10.1016/j.fct.2018.07.060
- Author:
- Fangfang Lang; Jinfeng Qu; Haiqin Yin; Lanyu Li; Yuanyuan Zhi; Yanping Liu; Zhenghui Fang; Enkui Hao
- Source:
- Food and chemical toxicology 2018 v.121 pp. 631-638
- ISSN:
- 0278-6915
- Subject:
- Angelica sinensis; animal ovaries; antioxidant activity; apoptosis; bioactive compounds; cell viability; dose response; epigenetics; flow cytometry; glutamate-cysteine ligase; humans; mitochondria; neoplasm cells; ovarian neoplasms; oxidative stress; quinones; small interfering RNA; toxicology; transferases; uridine diphosphate
- Abstract:
- ... Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress ...
- DOI:
- 10.1016/j.fct.2018.09.041
- https://doi.org/10.1016/j.fct.2018.09.041
- Author:
- Rosa Palmeri; Lucia Parafati; Cristina Restuccia; Biagio Fallico
- Source:
- Food and chemical toxicology 2018 v.118 pp. 355-360
- ISSN:
- 0278-6915
- Subject:
- Opuntia; antioxidant activity; bacteria; beef; bioactive compounds; cold storage; color; dipping; food preservation; food spoilage; fruit extracts; fruits; microbial growth; polyphenols; shelf life; storage time; texture; toxicology
- Abstract:
- ... The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content.The extract was then applied by dippi ...
- DOI:
- 10.1016/j.fct.2018.05.044
- https://doi.org/10.1016/j.fct.2018.05.044
- Author:
- Francesca Giampieri; José L. Quiles; Francisco J. Orantes-Bermejo; Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Cristina Sánchez-González; Juan Llopis; Lorenzo Rivas-García; Sadia Afrin; Alfonso Varela-López; Danila Cianciosi; Patricia Reboredo-Rodriguez; Cristina Torres Fernández-Piñar; Ruben Calderón Iglesias; Roberto Ruiz; Silvia Aparicio; Jorge Crespo; Luis Dzul Lopez; Jianbo Xiao; Maurizio Battino
- Source:
- Food and chemical toxicology 2018 v.112 pp. 126-133
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; beeswax; bioactive compounds; byproducts; carbohydrates; cytotoxicity; dose response; flavonoids; hepatoma; human cell lines; human health; in vivo studies; liver; mitochondria; polyphenols; recycling; viability
- Abstract:
- ... During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 ...
- DOI:
- 10.1016/j.fct.2017.12.041
- https://doi.org/10.1016/j.fct.2017.12.041
- Author:
- Ammad Ahmad Farooqi; Sumbul Khalid; Fatima Tahir; Uteuliev Yerzhan Sabitaliyevich; Ilhan Yaylim; Rukset Attar; Baojun Xu
- Source:
- Food and chemical toxicology 2018 v.119 pp. 98-105
- ISSN:
- 0278-6915
- Subject:
- Momordica charantia; anti-inflammatory activity; antineoplastic activity; bioactive compounds; carcinogenesis; cell cycle; cell lines; drugs; health promotion; mice; neoplasm cells; neoplasms; precision medicine; regulatory proteins; signal transduction; toxicology
- Abstract:
- ... Research over decades has progressively explored pharmacological actions of bitter gourd (Momordica charantia). Biologically and pharmacologically active molecules isolated from M. charantia have shown significant anti-cancer activity in cancer cell lines and xenografted mice. In this review spotlight was set on the bioactive compounds isolated from M. charantia that effectively inhibited cancer d ...
- DOI:
- 10.1016/j.fct.2018.05.024
- https://doi.org/10.1016/j.fct.2018.05.024
- Author:
- Dorota Wrześniok; Zuzanna Rzepka; Michalina Respondek; Artur Beberok; Jakub Rok; Karolina Szczepanik; Ewa Buszman
- Source:
- Food and chemical toxicology 2018 v.120 pp. 566-570
- ISSN:
- 0278-6915
- Subject:
- apoptosis; beverages; bioactive compounds; caffeine; cell lines; cell viability; chemoprevention; colorimetry; epidemiological studies; glutathione; homeostasis; humans; melanocytes; melanoma; public health; risk; thiols; toxicology
- Abstract:
- ... Coffee is one of the most popular beverages consumed worldwide and therefore even small effects of coffee bioactive compounds on cellular homeostasis could have a large impact on public health. Recent cohort health studies have shown an impressive inverse correlation between caffeinated coffee consumption and malignant melanoma risk. The aim of presented study was to examine the effect of caffeine ...
- DOI:
- 10.1016/j.fct.2018.07.049
- https://doi.org/10.1016/j.fct.2018.07.049
- Author:
- Graziela Bragueto Escher; Jânio Sousa Santos; Neiva Deliberali Rosso; Mariza Boscacci Marques; Luciana Azevedo; Mariana Araújo Vieira do Carmo; Heitor Daguer; Luciano Molognoni; Leonardo do Prado-Silva; Anderson S. Sant'Ana; Marcia Cristina da Silva; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.118 pp. 439-453
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Centaurea cyanus; anthocyanins; antihypertensive effect; antioxidant activity; bioactive compounds; cell death; cell lines; corolla; coumarin; cytotoxicity; ferulic acid; functional properties; inhibitory concentration 50; isoquercitrin; lipid peroxidation; p-coumaric acid; pH; plant extracts; reactive oxygen species; statistical analysis; temperature
- Abstract:
- ... This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, ...
- DOI:
- 10.1016/j.fct.2018.05.046
- https://doi.org/10.1016/j.fct.2018.05.046
- Author:
- Andrei Mocan; Alina Diuzheva; Simone Carradori; Vasil Andruch; Chiara Massafra; Cadmiel Moldovan; Cristian Sisea; Jacobus P. Petzer; Anél Petzer; Susi Zara; Guya Diletta Marconi; Gokhan Zengin; Gianina Crișan; Marcello Locatelli
- Source:
- Food and chemical toxicology 2018 v.119 pp. 189-198
- ISSN:
- 0278-6915
- Subject:
- Prunus domestica; alpha-glucosidase; bioactive compounds; cultivars; cytotoxicity; enzyme inhibition; fibroblasts; food industry; humans; leaves; liquid-phase microextraction; microwave treatment; phenolic compounds; quantitative analysis; toxicology
- Abstract:
- ... In the present work, fourteen cultivars of Prunus domestica were analyzed to investigate their phenolic pattern with the purpose of using the leaves as potential resources of bioactive compounds in the pharmaceutical and food industry. Microwave-assisted extraction (MAE), dispersive liquid–liquid microextraction and sugaring-out liquid–liquid extraction techniques were optimized in order to obtain ...
- DOI:
- 10.1016/j.fct.2018.04.045
- https://doi.org/10.1016/j.fct.2018.04.045
- Author:
- Abishek B. Santhakumar; Maurizio Battino; José M. Alvarez-Suarez
- Source:
- Food and chemical toxicology 2018 v.113 pp. 49-65
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; atherosclerosis; bioactive compounds; bioavailability; cardioprotective effect; chronic diseases; clinical trials; epidemiological studies; fruits; hemostasis; lipid metabolism; longevity; polyphenols; toxicology; vegetables
- Abstract:
- ... Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several ...
- DOI:
- 10.1016/j.fct.2018.01.022
- https://doi.org/10.1016/j.fct.2018.01.022
- Author:
- Huifang Ge; Yazhen Chen; Jicheng Chen; Jingjing Tian; Xiaofeng Liang; Lei Chen
- Source:
- Food and chemical toxicology 2018 v.119 pp. 417-424
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ligusticum sinense; Oriental traditional medicine; antioxidant activity; bioactive compounds; cardiovascular diseases; digestion; dose response; ethanol; ferulic acid; free radical scavengers; hydroxyl radicals; intestines; liquids; oxidative stress; polyphenols; pyrazines; rhizomes; toxicology
- Abstract:
- ... The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastr ...
- DOI:
- 10.1016/j.fct.2017.12.035
- https://doi.org/10.1016/j.fct.2017.12.035
- Author:
- Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
- Source:
- Food and chemical toxicology 2018 v.113 pp. 303-313
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
- Abstract:
- ... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
- DOI:
- 10.1016/j.fct.2017.12.031
- https://doi.org/10.1016/j.fct.2017.12.031
- Author:
- S.A. Petropoulos; A. Karkanis; N. Martins; I.C.F.R. Ferreira
- Source:
- Food and chemical toxicology 2018 v.114 pp. 155-169
- ISSN:
- 0278-6915
- Subject:
- basins; bioactive compounds; biosynthesis; climate change; halophytes; herbs; indigenous species; pharmaceutical industry; salinity; secondary metabolites; toxicology; traditional medicine
- Abstract:
- ... Wild native species are usually grown under severe and stressful conditions, while a special category includes halophytic species that are tolerant to high salinity levels. Native halophytes are valuable sources of bioactive molecules whose content is higher in saline than normal conditions, since the adaptation to salinity mechanisms involve apart from changes in physiological functions the biosy ...
- DOI:
- 10.1016/j.fct.2018.02.031
- https://doi.org/10.1016/j.fct.2018.02.031
- Author:
- Laércio Galvão Maciel; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Heitor Daguer; Luciano Molognoni; Mereci Mendes de Almeida; Daniel Granato; Neiva Deliberali Rosso
- Source:
- Food and chemical toxicology 2018 v.113 pp. 187-197
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Hibiscus sabdariffa; antioxidant activity; ascorbic acid; bioactive compounds; calyx; cell lines; color; cytotoxicity; electrospray ionization mass spectrometry; inhibitory concentration 50; lethal concentration 50; liquid chromatography; myrtillin; neoplasm cells; pH; temperature
- Abstract:
- ... Hibiscus sabdariffa calyx is a rich source of anthocyanins and other bioactive compounds but no study reported the effects of experimental conditions on the extraction of these chemical compounds. Therefore, the effects of time and extraction temperature on the bioactive compounds and antioxidant activity of Hibiscus sabdariffa calyx were evaluated. In addition, the effects of copigmentation and p ...
- DOI:
- 10.1016/j.fct.2018.01.053
- https://doi.org/10.1016/j.fct.2018.01.053
- Author:
- Azzurra Stefanucci; Gokhan Zengin; Marcello Locatelli; Giorgia Macedonio; Chin-Kun Wang; Ettore Novellino; M.Fawzi Mahomoodally; Adriano Mollica
- Source:
- Food and chemical toxicology 2018 v.118 pp. 181-189
- ISSN:
- 0278-6915
- Subject:
- Capparis spinosa; acetylcholinesterase; active ingredients; antioxidant activity; bioactive compounds; buds; cholinesterase; chromatography; enzyme inhibition; essential oils; fatty acids; free radical scavengers; medicinal plants; phenolic compounds; provenance; rutin; toxicology; Italy; Morocco; Turkey (country)
- Abstract:
- ... Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of differen ...
- DOI:
- 10.1016/j.fct.2018.05.003
- https://doi.org/10.1016/j.fct.2018.05.003
- Author:
- Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.120 pp. 479-490
- ISSN:
- 0278-6915
- Subject:
- lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
- Abstract:
- ... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
- DOI:
- 10.1016/j.fct.2018.07.043
- https://doi.org/10.1016/j.fct.2018.07.043
- Author:
- Xiao-Jing Hu; You-Bo Zhang; Zi-Jing Zhao; Lei Zhang; Qi Wang; Xiu-Wei Yang
- Source:
- Food and chemical toxicology 2018 v.111 pp. 385-392
- ISSN:
- 0278-6915
- Subject:
- Cullen corylifolium; acetates; bioactive compounds; biotransformation; carboxylation; cell lines; cytotoxicity; epoxidation reactions; fruits; humans; hydroxylation; inhibitory concentration 50; liver microsomes; medicinal properties; metabolic detoxification; metabolites; oxidation; rats; tandem mass spectrometry
- Abstract:
- ... Bakuchiol, one of bioactive compounds isolated from the dried ripe fruits of Psoralea corylifolia L., possesses a variety of pharmacological activities. In this study, the metabolites of bakuchiol in rat liver microsomes as well as their cytotoxicities were studied. A total of eight metabolites were isolated and identified as 14-carboxylbakuchiol (M1), 14,15-dihydroxybakuchiol (M2), 12,13-dihydrox ...
- DOI:
- 10.1016/j.fct.2017.11.048
- https://doi.org/10.1016/j.fct.2017.11.048
- Author:
- Radu Claudiu Fierascu; Milen I. Georgiev; Irina Fierascu; Camelia Ungureanu; Sorin Marius Avramescu; Alina Ortan; Mihaela Ioana Georgescu; Anca Nicoleta Sutan; Anca Zanfirescu; Cristina Elena Dinu-Pirvu; Bruno Stefan Velescu; Valentina Anuta
- Source:
- Food and chemical toxicology 2018 v.111 pp. 44-52
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Arctium lappa; Aspergillus niger; Penicillium; Veronica persica; aerial parts; anti-inflammatory activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; chromosome aberrations; fungi; high performance liquid chromatography; inflammation; meristems; models; roots; toxicology
- Abstract:
- ... The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the ...
- DOI:
- 10.1016/j.fct.2017.11.008
- https://doi.org/10.1016/j.fct.2017.11.008
- Author:
- Petya Dimitrova; Kalina Alipieva; Tsvetinka Grozdanova; Svetlana Simova; Vassya Bankova; Milen I. Georgiev; Milena P. Popova
- Source:
- Food and chemical toxicology 2018 v.111 pp. 605-615
- ISSN:
- 0278-6915
- Subject:
- DNA; NAD ADP-ribosyltransferase; T-lymphocytes; Verbascum; aerial parts; apoptosis; bioactive compounds; bioactive properties; cell cycle checkpoints; cell growth; cell proliferation; colorimetry; concanavalin A; cytokines; flow cytometry; human cell lines; humans; interferon-gamma; interphase; iridoid glycosides; methanol; mice; mitogen-activated protein kinase; phosphorylation; saponins; toxicology
- Abstract:
- ... The Verbascum species are widely used traditional herb remedies against respiratory, inflammatory conditions and disorders. In the present study methanol extract of the aerial parts of the endemic Verbascum nobile Velen, was investigated and two novel iridoid glycosides 1 and 2, together with nine known constituents: iridoids, phenylethanoids, and saponins characteristic of Verbascum genus were id ...
- DOI:
- 10.1016/j.fct.2017.11.060
- https://doi.org/10.1016/j.fct.2017.11.060