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You searched for: Journal Food and chemical toxicology Remove constraint Journal: Food and chemical toxicology Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject antioxidant activity Remove constraint Subject: antioxidant activity
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1. 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells

Author:
Xing Wei; Xuejun Mo; Faliang An; Xiang Ji; Yanhua Lu
Source:
Food and chemical toxicology 2018 v.119 pp. 252-259
ISSN:
0278-6915
Subject:
Myrtaceae; antineoplastic agents; antioxidant activity; buds; drug resistance; glutamate-cysteine ligase; glutathione; glutathione transferase; hepatoma; herbal tea; humans; ingredients; protein subunits; signal transduction; toxicology; tropics
Abstract:
... 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) is a major active constituent of the buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae), a main ingredient of herbal tea in tropical zones. DMC has been reported to significantly reverse drug resistance in BEL-7402/5-FU cells. Glutathione (GSH) and glutathione S-transferase (GST) play important roles in an efflux system that ...
DOI:
10.1016/j.fct.2018.04.001

2. Acute and repeated dose (28 days) oral safety studies of phosphatidyl-hydroxytyrosol

Author:
María-Aránzazu Martínez; Irma Ares; María-Rosa Martínez-Larrañaga; Arturo Anadón; Victor Casado; Luis Vazquez; Diana Martin; Guillermo Reglero; Carlos Torres
Source:
Food and chemical toxicology 2018 v.120 pp. 462-471
ISSN:
0278-6915
Subject:
antioxidant activity; blood; body weight changes; food consumption; functional foods; hematology; histopathology; ingredients; mortality; oral administration; phospholipids; rats; tissue weight; toxicity; toxicity testing
Abstract:
... Phosphatidyl-hydroxytyrosol, a carrier of hydroxytyrosol under the form of phospholipid with high antioxidant capacity, is being actively studied as a potential ingredient of functional foods and supplements. To support the safety, phosphatidyl-hydroxytyrosol has been examined in an acute and in a 28-day repeated dose oral toxicity studies in rats. Phosphatidyl-hydroxytyrosol administered in a sin ...
DOI:
10.1016/j.fct.2018.07.046

3. Antioxidant activity and total phenolic content of ethanolic extract of pomegranate peels, juice and seeds

Author:
Zahra Derakhshan; Margherita Ferrante; Marzieh Tadi; Farnoosh Ansari; Ali Heydari; Motahreh Sadat Hosseini; Gea Oliveri Conti; Elham Khalili Sadrabad
Source:
Food and chemical toxicology 2018 v.114 pp. 108-111
ISSN:
0278-6915
Subject:
Punica granatum; antioxidant activity; beta-carotene; flavonols; food preservatives; herbal medicines; juices; phenolic compounds; pomegranates; seeds; toxicology; Iran; Middle East
Abstract:
... Pomegranate (Punica granatum L.) is extensively cultivated in Middle East especially in Iran. For centuries, this fruit has been used in Iranian herbal medicine. Pomegranate peel, seed and juice contain considerable amounts of phenolic compounds and have antioxidant activity. Pomegranate peels, juice and seeds from three regions of Natanz, Shahreza, and Doorak were obtained. Antioxidant activity, ...
DOI:
10.1016/j.fct.2018.02.023

4. Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of Malaysian propolis and metformin in streptozotocin–induced diabetic rats

Author:
Victor Udo Nna; Ainul Bahiyah Abu Bakar; Md Rizman Md Lazim Md Lazin; Mahaneem Mohamed
Source:
Food and chemical toxicology 2018 v.120 pp. 305-320
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; alpha-glucosidase; animal disease models; anti-inflammatory activity; antioxidant activity; blood glucose; blood serum; caspase-3; diabetes mellitus; enzyme inhibition; ethanol; glycemic effect; histopathology; hydrogen peroxide; hyperglycemia; insulin; interleukin-1beta; males; malondialdehyde; metformin; oxidative stress; pancreas; proliferating cell nuclear antigen; propolis; rats; synergism; toxicology; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Diabetes mellitus is characterized by hyperglycemia which causes oxidative stress. Propolis has been reported to have antihyperglycemic and antioxidant potentials. The present study therefore examined the anti-hyperglycemic, antioxidant and anti-inflammatory activities of Malaysian propolis (MP) using streptozotocin-induced diabetic rats. Ethanol extract of MP showed in vitro antioxidant (DPPH, FR ...
DOI:
10.1016/j.fct.2018.07.028

5. Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies

Author:
Iram Iqbal Hejazi; Rashmin Khanam; Syed Hassan Mehdi; Abdul Roouf Bhat; M.Moshahid Alam Rizvi; Sonu Chand Thakur; Fareeda Athar
Source:
Food and chemical toxicology 2018 v.115 pp. 244-259
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Curculigo orchioides; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; caspase-3; caspase-8; cell culture; chemical constituents of plants; cytotoxicity; ethyl acetate; free radicals; gas chromatography-mass spectrometry; human cell lines; humans; inhibitory concentration 50; mitochondria; neoplasm cells; neoplasms; oxidative stress; proteins
Abstract:
... Plant phytoconstituents have been a valuable source of clinically important anticancer agents. Antioxidant and anticancerous activity of plant Curculigo orchioides Gaertn were explored In vitro antioxidant activity, antioxidant enzyme activity of oxidatively stressed tissue, and cell culture studies on human cancer cell lines HepG2, HeLa and MCF-7 were carried out. Active plant fractions were subj ...
DOI:
10.1016/j.fct.2018.03.013

6. Antioxidative effect and phytochemical profile of natural products from the fruits of “babaçu” (Orbignia speciose) and “buriti” (Mauritia flexuosa)

Author:
Camila B. Nobre; Erlânio O. Sousa; Cícera J. Camilo; Jean F. Machado; João M.F.L. Silva; Jaime R. Filho; Henrique D.M. Coutinho; José G.M. Costa
Source:
Food and chemical toxicology 2018 v.121 pp. 423-429
ISSN:
0278-6915
Subject:
Attalea speciosa; Mauritia flexuosa; antioxidant activity; antioxidants; chelation; flavonoids; fruits; iron; margarine; new products; oxidative stress; phospholipids; tannins; thiobarbituric acid-reactive substances; trees; Brazil
Abstract:
... Orbignya speciosa and Mauritia flexuosa are two native palm tree species found in Brazil. Their fruits are rich in edible fixed oils, which are used for many purposes in industry, such as in the manufacture of soaps, surfactants and margarines. The aim of this work was to characterize the chemical profiles and antioxidant properties of the methanol extracts obtained from the fruits of O. speciosa ...
DOI:
10.1016/j.fct.2018.08.068

7. Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2

Author:
Fangfang Lang; Jinfeng Qu; Haiqin Yin; Lanyu Li; Yuanyuan Zhi; Yanping Liu; Zhenghui Fang; Enkui Hao
Source:
Food and chemical toxicology 2018 v.121 pp. 631-638
ISSN:
0278-6915
Subject:
Angelica sinensis; animal ovaries; antioxidant activity; apoptosis; bioactive compounds; cell viability; dose response; epigenetics; flow cytometry; glutamate-cysteine ligase; humans; mitochondria; neoplasm cells; ovarian neoplasms; oxidative stress; quinones; small interfering RNA; toxicology; transferases; uridine diphosphate
Abstract:
... Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress ...
DOI:
10.1016/j.fct.2018.09.041

8. Application of prickly pear fruit extract to improve domestic shelf life, quality and microbial safety of sliced beef

Author:
Rosa Palmeri; Lucia Parafati; Cristina Restuccia; Biagio Fallico
Source:
Food and chemical toxicology 2018 v.118 pp. 355-360
ISSN:
0278-6915
Subject:
Opuntia; antioxidant activity; bacteria; beef; bioactive compounds; cold storage; color; dipping; food preservation; food spoilage; fruit extracts; fruits; microbial growth; polyphenols; shelf life; storage time; texture; toxicology
Abstract:
... The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content.The extract was then applied by dippi ...
DOI:
10.1016/j.fct.2018.05.044

9. Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?

Author:
Francesca Giampieri; José L. Quiles; Francisco J. Orantes-Bermejo; Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Cristina Sánchez-González; Juan Llopis; Lorenzo Rivas-García; Sadia Afrin; Alfonso Varela-López; Danila Cianciosi; Patricia Reboredo-Rodriguez; Cristina Torres Fernández-Piñar; Ruben Calderón Iglesias; Roberto Ruiz; Silvia Aparicio; Jorge Crespo; Luis Dzul Lopez; Jianbo Xiao; Maurizio Battino
Source:
Food and chemical toxicology 2018 v.112 pp. 126-133
ISSN:
0278-6915
Subject:
antineoplastic activity; antioxidant activity; beeswax; bioactive compounds; byproducts; carbohydrates; cytotoxicity; dose response; flavonoids; hepatoma; human cell lines; human health; in vivo studies; liver; mitochondria; polyphenols; recycling; viability
Abstract:
... During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 ...
DOI:
10.1016/j.fct.2017.12.041

10. l- Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway

Author:
Mingcai Liang; Zhengxuan Wang; Hui Li; Liang Cai; Jianghao Pan; Hongjuan He; Qiong Wu; Yinzhao Tang; Jiapei Ma; Lin Yang
Source:
Food and chemical toxicology 2018 v.115 pp. 315-328
ISSN:
0278-6915
Subject:
antioxidant activity; antioxidants; arginine; body weight; catalase; essential amino acids; genes; glutathione; liver; males; messenger RNA; oral administration; oxidative stress; proteins; rats; superoxide dismutase; toxicology
Abstract:
... Arginine is a conditionally essential amino acid. To elucidate the influence of l-arginine on the activation of endogenous antioxidant defence, male Wistar rats were orally administered daily with l-arginine at different levels of 25, 50, 100 mg/100 g body weight. After 7 and 14 days feeding, the antioxidative capacities and glutathione (GSH) contents in the plasma and in the liver were uniformly ...
DOI:
10.1016/j.fct.2018.03.029

11. Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents

Author:
Andrei Mocan; Gokhan Zengin; Adriano Mollica; Ahmet Uysal; Erdogan Gunes; Gianina Crişan; Abdurrahman Aktumsek
Source:
Food and chemical toxicology 2018 v.112 pp. 448-457
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; active sites; aerial parts; alpha-amylase; alpha-glucosidase; antimutagenic activity; antioxidant activity; apigenin; carboxylic ester hydrolases; chemical composition; enzyme activity; free radical scavengers; high performance liquid chromatography; kaempferol; luteolin; methanol; molecular models; rhizomes; toxicology
Abstract:
... This study gathers information about the effects of different extracts (methanol and water) from rhizomes and aerial parts of Iris schachtii on selected enzymes (cholinesterases, alpha-amylase and alpha-glucosidase, tyrosinase and lipase) as well as of their antioxidant capacities and antimutagenic properties in relation with their phenolic composition. The chemical composition was assessed by det ...
DOI:
10.1016/j.fct.2017.08.004

12. Biological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutin

Author:
Sengul Uysal; Abdurrahman Aktumsek; Carene M.N. Picot-Allain; Hamiyet Unuvar; Adriano Mollica; Milen I. Georgiev; Gokhan Zengin; Mohamad Fawzi Mahomoodally
Source:
Food and chemical toxicology 2018 v.113 pp. 179-186
ISSN:
0278-6915
Subject:
Alzheimer disease; Dianthus; acetylcholinesterase; active sites; alpha-amylase; alpha-glucosidase; amino acids; antioxidant activity; cholinesterase; copper; diabetes; enzyme inhibition; hyperpigmentation; molecular models; neurodegenerative diseases; phenolic compounds; plant extracts; rutin; toxicology
Abstract:
... Extracts (methanol, ethyl acetate, and water) from Dianthus calocephalus Boiss. prepared by different extraction techniques (maceration, Soxhlet, and ultrasonication) were studied for possible inhibitory action against key enzymes (α-amylase, α-glucosidase, acetyl cholinesterase, butyryl cholinesterase, and tyrosinase). Antioxidant potential was established using a battery of assays and phenolic c ...
DOI:
10.1016/j.fct.2018.01.049

13. Can nonalcoholic beer, silicon and hops reduce the brain damage and behavioral changes induced by aluminum nitrate in young male Wistar rats?

Author:
P. Merino; J.A. Santos-López; C.J. Mateos; I. Meseguer; A. Garcimartín; S. Bastida; F.J. Sánchez-Muniz; J. Benedí; M.J. González-Muñoz
Source:
Food and chemical toxicology 2018 v.118 pp. 784-794
ISSN:
0278-6915
Subject:
acetylcholinesterase; aluminum; antioxidant activity; antioxidants; beers; behavior change; brain; brain damage; enzyme activity; enzyme inhibition; gene expression; hops; laboratory animals; males; neurodegenerative diseases; nitrates; poisoning; rats; rearing; silicon; swimming; toxicology
Abstract:
... Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic beer (NABeer), silicon or hops, as well as their ef ...
DOI:
10.1016/j.fct.2018.06.004

14. Caryophyllane sesquiterpenes inhibit DNA-damage by tobacco smoke in bacterial and mammalian cells

Author:
Silvia Di Giacomo; Lorena Abete; Rossana Cocchiola; Gabriela Mazzanti; Margherita Eufemi; Antonella Di Sotto
Source:
Food and chemical toxicology 2018 v.111 pp. 393-404
ISSN:
0278-6915
Subject:
DNA damage; antimutagenic activity; antioxidant activity; beta-caryophyllene; chemoprevention; condensates; genotoxicity; mammals; metabolites; oxidative stress; phosphorylation; toxicology
Abstract:
... In the present study, the ability of the natural sesquiterpene β-caryophyllene (CRY) and its metabolite β-caryophyllene oxide (CRYO) to inhibit the genotoxicity of a condensate of cigarette smoke (CSC) was evaluated both in bacterial and mammalian cells. Also, the inhibition of the CSC-mediated STAT3 phosphorylation and intracellular oxidative stress was evaluated as potential chemopreventive mech ...
DOI:
10.1016/j.fct.2017.11.018

15. Characterization of phenolic extracts from Brava extra virgin olive oils and their cytotoxic effects on MCF-7 breast cancer cells

Author:
Patricia Reboredo-Rodríguez; Carmen González-Barreiro; Beatriz Cancho-Grande; Tamara Y. Forbes-Hernández; Massimiliano Gasparrini; Sadia Afrin; Danila Cianciosi; Alegría Carrasco-Pancorbo; Jesús Simal-Gándara; Francesca Giampieri; Maurizio Battino
Source:
Food and chemical toxicology 2018 v.119 pp. 73-85
ISSN:
0278-6915
Subject:
antioxidant activity; breast neoplasms; cell death; cell viability; cytotoxicity; drug therapy; extra-virgin olive oil; free radicals; gallic acid; isomers; neoplasm cells; oleuropein; phenols; toxicology
Abstract:
... The aim of the present work was to evaluate the phenolic profile of the ‘Brava’ extra virgin olive oil and assess its potential as a “natural adjuvant” in combination with chemotherapy treatment. The total phenol content of the phenolic extracts was 764 mg gallic acid equivalents/kg and the total antioxidant capacity was 2309, 1881 and 2088 μM trolox equivalents/kg determined by Diphenyl-1-picrylh ...
DOI:
10.1016/j.fct.2018.05.026

16. Chemical composition and radical scavenging activity of Amygdalus pedunculata Pall leaves' essential oil

Author:
Cairui Lu; Haoyu Li; Cong Li; Bang Chen; Yehua Shen
Source:
Food and chemical toxicology 2018 v.119 pp. 368-374
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Prunus; alkanes; antioxidant activity; ascorbic acid; chemical composition; essential oils; esters; gas chromatography-mass spectrometry; hydrogen peroxide; hydroxyl radicals; inhibitory concentration 50; iron; ketones; leaves; superoxide anion; ultrasonic treatment
Abstract:
... The main objective of the current study was to investigate the components and radical scavenging activity of essential oil from Amygdalus pedunculata Pall leaves (APEO) extracted by an ultrasound-assisted method. Thirty-eight chemical components were identified in APEO using gas chromatography-mass spectrometry (GC-MS). APEO primarily consisted of alcohols (36.82%), esters (28.81%), ketones (1.47% ...
DOI:
10.1016/j.fct.2018.02.012

17. Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark

Author:
Didier G. Mouho; Andreia P. Oliveira; Charles Guillaume Kodjo; Patrícia Valentão; Angel Gil-Izquierdo; Paula B. Andrade; Zana Adama Ouattara; Yves-Alain Bekro; Federico Ferreres
Source:
Food and chemical toxicology 2018 v.112 pp. 134-144
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ficus exasperata; alpha-amylase; antioxidant activity; bark; cell lines; chemical composition; cytotoxicity; functional foods; high performance liquid chromatography; inhibitory concentration 50; leaf extracts; leaves; medicine; neoplasm cells; nitric oxide; organic acids and salts; plant biochemistry; superoxide anion; trees
Abstract:
... Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The aim of this study was to extend the knowledge on the phytochemistry and biological properties of this species. Aqueous extracts from F. exasperata leave ...
DOI:
10.1016/j.fct.2017.12.043

18. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract

Author:
Graziela Bragueto Escher; Jânio Sousa Santos; Neiva Deliberali Rosso; Mariza Boscacci Marques; Luciana Azevedo; Mariana Araújo Vieira do Carmo; Heitor Daguer; Luciano Molognoni; Leonardo do Prado-Silva; Anderson S. Sant'Ana; Marcia Cristina da Silva; Daniel Granato
Source:
Food and chemical toxicology 2018 v.118 pp. 439-453
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Centaurea cyanus; anthocyanins; antihypertensive effect; antioxidant activity; bioactive compounds; cell death; cell lines; corolla; coumarin; cytotoxicity; ferulic acid; functional properties; inhibitory concentration 50; isoquercitrin; lipid peroxidation; p-coumaric acid; pH; plant extracts; reactive oxygen species; statistical analysis; temperature
Abstract:
... This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, ...
DOI:
10.1016/j.fct.2018.05.046

19. Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti

Author:
Shraddha Rastogi; Chandana Haldar
Source:
Food and chemical toxicology 2018 v.120 pp. 243-252
ISSN:
0278-6915
Subject:
antioxidant activity; bone marrow; catalase; cell viability; immunomodulators; lipid peroxidation; lipopolysaccharides; melatonin; oxidative stress; proteins; quercetin; reactive oxygen species; spleen; stress response; superoxide dismutase; therapeutics; toxicology
Abstract:
... A majority of cellular diseases, independent of their origin, are characterized by a dramatic increase in Reactive Oxygen Species (ROS) in response to stress. In most cases, the uncontrolled detrimental ROS outburst is difficult to handle for the cellular machinery and eventually leads to cell mortality. In this study, we compare the antioxidant efficacy of quercetin and melatonin to find out a be ...
DOI:
10.1016/j.fct.2018.06.062

20. Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Author:
Aleksandra Cvetanović; Gökhan Zengin; Zoran Zeković; Jaroslava Švarc-Gajić; Slavica Ražić; Ana Damjanović; Pavle Mašković; Milan Mitić
Source:
Food and chemical toxicology 2018 v.121 pp. 458-466
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Aronia melanocarpa; antimicrobial properties; antioxidant activity; antioxidants; cell lines; chemical composition; cholinesterase; cytotoxicity; diodes; elastase; enzyme inhibition; flavonoids; high performance liquid chromatography; in vitro studies; leaves; lipid peroxidation; small fruits; stems; temperature
Abstract:
... Preparation of functional products as well as natural-based products requires non-toxic but effective extraction techniques. In this study, subcritical water extraction was used for the extraction of different aronia parts in order to explore their potential. Stems, leaves and berries of Aronia melanocarpa were extracted under the following conditions: temperature 130 °C; pressure 35 bar; time 20  ...
DOI:
10.1016/j.fct.2018.09.045

21. Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury

Author:
Taehyun Roh; Umasankar De; Seong Kwang Lim; Min Kook Kim; Seul Min Choi; Duck Soo Lim; Sungpil Yoon; Sam Kacew; Hyung Sik Kim; Byung-Mu Lee
Source:
Food and chemical toxicology 2018 v.114 pp. 11-22
ISSN:
0278-6915
Subject:
acetaminophen; alanine transaminase; antioxidant activity; antioxidants; apoptosis; aspartate transaminase; betaine; caspase-3; cell viability; cytochrome c; glutathione; hepatoprotective effect; hepatotoxicity; human cell lines; lipid peroxidation; methionine; oxidative stress; protein content; pyridoxine; toxicology
Abstract:
... The detoxifying effect of pyridoxine against acetaminophen (APAP)-induced hepatotoxicity was investigated. HepG2 cells were co-treated with APAP and pyridoxine to compare with betaine or methionine for 24 h. LDH, ALT and AST activities were measured to determine direct cells damage in vitro and in vivo. Lipid peroxidation, antioxidant enzymes activity, and glutathione level were measured. Cytochro ...
DOI:
10.1016/j.fct.2018.02.017

22. Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment

Author:
İlker Öngüç Aycan; Özlem Elpek; Bahar Akkaya; Ebru Kıraç; Hazal Tuzcu; Sabriye Kaya; Nesil Coşkunfırat; Mutay Aslan
Source:
Food and chemical toxicology 2018 v.118 pp. 795-804
ISSN:
0278-6915
Subject:
antioxidant activity; blood serum; creatinine; diclofenac; duodenum; fibrosis; hematocrit; hemoglobin; histopathology; intramuscular injection; kidneys; leukocytes; microscopy; nephrotoxicity; nitrogen; oxygen; rats; stomach; toxicology; urea nitrogen
Abstract:
... The aim of this study was to investigate whether thymoquinone (TQ) could alleviate diclofenac (DCLF)-induced gastrointestinal and renal toxicity in rats. Diclofenac was administered via intramuscular injection twice daily for 5 days and TQ was given by gavage for the same period. Hematological and biochemical profiles were measured with autoanalyzers while reactive oxygen/nitrogen species (ROS/RNS ...
DOI:
10.1016/j.fct.2018.06.038

23. Dietary Se supplementation partially restores the REDOX proteomic map of M. spretus liver exposed to p,p′-DDE

Author:
Noelia Morales-Prieto; Julia Ruiz-Laguna; Nieves Abril
Source:
Food and chemical toxicology 2018 v.114 pp. 292-301
ISSN:
0278-6915
Subject:
DDT (pesticide); animal nutrition; antioxidant activity; diabetes; diet; ethane; exports; fatty liver; foods; hormones; lipogenesis; liver; membrane proteins; metabolites; mice; mitochondria; mosquito-borne diseases; neoplasms; neurotoxicity; protein metabolism; proteomics; reactive oxygen species; risk; selenium; toxicology; xenobiotics
Abstract:
... The toxicity of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), a contaminant and metabolite derivative of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is partially mediated by reactive oxygen species. Protein cysteine-based regulatory switches and subsequent alterations of the overall hepatic metabolism are triggered by p,p′-DDE through the disruption of the cellular redox status. The co ...
DOI:
10.1016/j.fct.2018.02.047

24. Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

Author:
Abishek B. Santhakumar; Maurizio Battino; José M. Alvarez-Suarez
Source:
Food and chemical toxicology 2018 v.113 pp. 49-65
ISSN:
0278-6915
Subject:
antioxidant activity; atherosclerosis; bioactive compounds; bioavailability; cardioprotective effect; chronic diseases; clinical trials; epidemiological studies; fruits; hemostasis; lipid metabolism; longevity; polyphenols; toxicology; vegetables
Abstract:
... Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several ...
DOI:
10.1016/j.fct.2018.01.022

25. Effect of natural polyphenol on the oxidative stability of pecan oil

Author:
Yuan-Yuan Zhang; Fang Zhang; Kiran Thakur; Ao-Te Ci; Hao Wang; Jian-Guo Zhang; Zhao-Jun Wei
Source:
Food and chemical toxicology 2018 v.119 pp. 489-495
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; antioxidants; butylated hydroxyanisole; butylated hydroxytoluene; caffeic acid; catechin; erucic acid; ferulic acid; oils; oxidation; oxidative stability; pecans; polyphenols; protective effect; rutin; tannins; toxicology
Abstract:
... We evaluated the antioxidant activity of natural polyphenols which gives high oxidative stability to the pecan oil. The in vitro DPPH radical scavenging, reducing power and total antioxidant activity of tested antioxidants demonstrated that tannic acid displayed the highest DPPH scavenging activity and provided the largest reducing power. During storage of pecan oil, based on oxidative stability t ...
DOI:
10.1016/j.fct.2017.10.001

26. Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells

Author:
Cong Wang; Xudong Gao; Ramesh Kumar Santhanam; Zhongqin Chen; Yue Chen; Leilei Xu; Chunli Wang; Nicola Ferri; Haixia Chen
Source:
Food and chemical toxicology 2018 v.116 pp. 335-345
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Inonotus obliquus; advanced glycation end products; alpha-amylase; alpha-glucosidase; antioxidant activity; blood glucose; cell viability; chromium; enzyme activity; enzyme inhibition; food industry; functional foods; hemolysis; hydrogen peroxide; hyperglycemia; mitochondria; polysaccharides; protective effect; toxicology
Abstract:
... In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated. Their protective effects against H2O2-induced oxidative damages in hepatic L02 cells were also assessed. Results demonstrated that UIOPC and UIOPS exhibited remarkable DPPH s ...
DOI:
10.1016/j.fct.2018.04.047

27. Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system

Author:
Antonella Smeriglio; Susanna Alloisio; Francesco Maria Raimondo; Marcella Denaro; Jianbo Xiao; Laura Cornara; Domenico Trombetta
Source:
Food and chemical toxicology 2018 v.119 pp. 407-416
ISSN:
0278-6915
Subject:
Citrus; antioxidant activity; anxiety; beta-carotene; bleaching; central nervous system; chemical composition; cytotoxicity; enzyme activity; essential oils; fibroblasts; free radical scavengers; hydrogen; inhibitory concentration 50; limonene; linalool; mice; phytopharmaceuticals; rats; traditional medicine
Abstract:
... The use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potentials as well as for reducing anxiety and stress.The purpose of this work was to evaluate, for the first time, the chemical composition of Citrus lumia ...
DOI:
10.1016/j.fct.2017.12.053

28. Evaluation of antioxidant activities of ethanol extract from Ligusticum subjected to in-vitro gastrointestinal digestion

Author:
Huifang Ge; Yazhen Chen; Jicheng Chen; Jingjing Tian; Xiaofeng Liang; Lei Chen
Source:
Food and chemical toxicology 2018 v.119 pp. 417-424
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ligusticum sinense; Oriental traditional medicine; antioxidant activity; bioactive compounds; cardiovascular diseases; digestion; dose response; ethanol; ferulic acid; free radical scavengers; hydroxyl radicals; intestines; liquids; oxidative stress; polyphenols; pyrazines; rhizomes; toxicology
Abstract:
... The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastr ...
DOI:
10.1016/j.fct.2017.12.035

29. Evaluation of the antioxidant and gastroprotective activity and HPLC analysis of the hydroalcoholic extract of Tocoyena formosa leaves (Cham. & Schlecht) K. Schum

Author:
Francisco Rafael Alves Santana Cesário; Thaís Rodrigues de Albuquerque; Bruno Anderson Fernandes da Silva; Giovana Mendes de Lacerda; Lindaiane Bezerra Rodrigues; Anita Oliveira Brito Pereira Bezerra Martins; Lucindo Jose Quintans-Júnior; Jackson Roberto Guedes da Silva Almeida; Mariana Lima Vale; Henrique Douglas Melo Coutinho; Irwin Rose Alencar de Menezes
Source:
Food and chemical toxicology 2018 v.112 pp. 355-362
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; adverse effects; antioxidant activity; antioxidants; ethanol; high performance liquid chromatography; indomethacin; inhibitory concentration 50; leaves; median effective concentration; models; mucus; peptic ulcers; traditional medicine
Abstract:
... The peptic ulcer is a gastric disorder that affects millions of people and yet they cause many side effects. In this sense, natural products represent an important alternative to the discovery of compounds with gastroprotective activity. The present work has as its objective to evaluate the antioxidant and gastroprotective activity of the Hydroalcoholic Extract of Leaves from Tocoyena formosa (Cha ...
DOI:
10.1016/j.fct.2017.12.058

30. Flavonoids as protective agents against oxidative stress induced by gentamicin in systemic circulation. Potent protective activity and microbial synergism of luteolin

Author:
Pamela Soledad Bustos; Romina Deza-Ponzio; Paulina Laura Páez; José Luis Cabrera; Miriam Beatriz Virgolini; María Gabriela Ortega
Source:
Food and chemical toxicology 2018 v.118 pp. 294-302
ISSN:
0278-6915
Subject:
Escherichia coli; Staphylococcus aureus; additive effect; antibacterial properties; antioxidant activity; ascorbic acid; catalase; gentamicin; humans; laboratory animals; leukocytes; lipid peroxidation; luteolin; oxidative stress; rats; reactive oxygen species; superoxide dismutase; synergism; therapeutics; toxicology
Abstract:
... The flavonoids effect on gentamicin (GEN)-induced oxidative stress (OS) in systemic circulation was evaluated in terms of reactive oxygen species (ROS) production, enzymatic antioxidant defenses superoxide dismutase (SOD) and catalase (CAT), and lipid peroxidation (LP) in vitro on human leukocytes and in vivo on rat whole blood. The inhibitory activity of ROS was ATS < QTS < isovitexin < vitexin < ...
DOI:
10.1016/j.fct.2018.05.030

31. Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response

Author:
Rui-Bing Feng; Yang Wang; Chengwei He; Yan Yang; Jian-Bo Wan
Source:
Food and chemical toxicology 2018 v.119 pp. 479-488
ISSN:
0278-6915
Subject:
antioxidant activity; cytotoxicity; gallic acid; glutamate-cysteine ligase; glutathione; heme oxygenase (biliverdin-producing); hepatoprotective effect; hepatotoxicity; mitogen-activated protein kinase; molecular models; polyphenols; protein-protein interactions; proteins; reactive oxygen species; signal transduction; thermal stability; toxicology
Abstract:
... Gallic acid (GA), a natural polyphenol, has been shown to exert a variety of heath promoting effects. We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells. Pretreatment of GA prevented the hepatocytotoxicity induced by t-BHP, a ...
DOI:
10.1016/j.fct.2017.10.033

32. Genotoxicity and antioxidant activity of five Agrimonia and Filipendula species plant extracts evaluated by comet and micronucleus assays in human lymphocytes and Ames Salmonella/microsome test

Author:
Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
Source:
Food and chemical toxicology 2018 v.113 pp. 303-313
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
Abstract:
... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
DOI:
10.1016/j.fct.2017.12.031

33. Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK/Nrf2/p62 signaling axis

Author:
Jingjing Lu; Huijie Jiang; Biying Liu; Ruiqi Baiyun; Siyu Li; Yueying Lv; Da Li; Senqiu Qiao; Xiao Tan; Zhigang Zhang
Source:
Food and chemical toxicology 2018 v.116 pp. 59-69
ISSN:
0278-6915
Subject:
AMP-activated protein kinase; antioxidant activity; apoptosis; grape seeds; heavy metals; heme oxygenase (biliverdin-producing); lead; lungs; oxidative stress; poisoning; procyanidins; protective effect; rats; signal transduction; stress response; toxicity
Abstract:
... Lead (Pb) is one of the most relevant heavy metals contaminants which cause oxidative stress and threaten human health. The lung is one of the organs most severely damaged by Pb. In this study, we investigated the protective effect of grape seed procyanidin extract (GSPE) on Pb-induced lung injury in rats. We found that GSPE alleviated Pb-induced lung injury by relieving oxidative stress, reducing ...
DOI:
10.1016/j.fct.2018.03.034

34. HPLC and in vitro evaluation of antioxidant properties of fruit from Malpighia glabra (Malpighiaceae) at different stages of maturation

Author:
Eidla M.M. Nascimento; Fábio F.G. Rodrigues; Wégila D. Costa; Raimundo N.P. Teixeira; Aline A. Boligon; Erlânio O. Sousa; Fabíola F.G. Rodrigues; Henrique D.M. Coutinho; José Galberto M. da Costa
Source:
Food and chemical toxicology 2018 v.119 pp. 457-463
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Malpighia emarginata; antioxidant activity; antioxidants; beta-carotene; chelation; freeze drying; fruits; high performance liquid chromatography; in vitro studies; inhibitory concentration 50; iron; maturity stage; medicinal properties; peroxidation; pulp; quercetin; rutin; thiobarbituric acid-reactive substances
Abstract:
... Malpighia glabra L. is indicated for the treatment of diseases due presenting several medicinal properties. The aim of the present study was quantify phenolic compounds and carotenoids, additionally, evaluate the antioxidant potential of different methanolic fractions (mature stage, intermediate stage and green maturity stage) of Malpighia glabra. Methanolic fractions of the three stages of matura ...
DOI:
10.1016/j.fct.2017.11.042

35. Hibiscus sabdariffa anthocyanins-rich extract: Chemical stability, in vitro antioxidant and antiproliferative activities

Author:
Laércio Galvão Maciel; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Heitor Daguer; Luciano Molognoni; Mereci Mendes de Almeida; Daniel Granato; Neiva Deliberali Rosso
Source:
Food and chemical toxicology 2018 v.113 pp. 187-197
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Hibiscus sabdariffa; antioxidant activity; ascorbic acid; bioactive compounds; calyx; cell lines; color; cytotoxicity; electrospray ionization mass spectrometry; inhibitory concentration 50; lethal concentration 50; liquid chromatography; myrtillin; neoplasm cells; pH; temperature
Abstract:
... Hibiscus sabdariffa calyx is a rich source of anthocyanins and other bioactive compounds but no study reported the effects of experimental conditions on the extraction of these chemical compounds. Therefore, the effects of time and extraction temperature on the bioactive compounds and antioxidant activity of Hibiscus sabdariffa calyx were evaluated. In addition, the effects of copigmentation and p ...
DOI:
10.1016/j.fct.2018.01.053

36. High resolution UPLC-MS/MS profiling of polyphenolics in the methanol extract of Syzygium samarangense leaves and its hepatoprotective activity in rats with CCl4-induced hepatic damage

Author:
Mansour Sobeh; Fadia S. Youssef; Ahmed Esmat; Ganna Petruk; Ahmed H. El-Khatib; Daria Maria Monti; Mohamed L. Ashour; Michael Wink
Source:
Food and chemical toxicology 2018 v.113 pp. 145-153
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Syzygium samarangense; acylglycerols; alanine transaminase; antioxidant activity; antioxidants; aspartate transaminase; bilirubin; cholesterol; drugs; flavonoids; gallic acid; glutathione; hepatoprotective effect; histopathology; iron; leaves; liver; liver diseases; median effective concentration; methanol; models; oxidative stress; phosphorylation; polyphenols; rats; superoxide dismutase; tannins; toxicology
Abstract:
... Oxidative stress plays a crucial role in the development of several liver diseases. Many natural polyphenols can attenuate oxidative stress and liver injury. In this study, a phytochemical profiling of a methanol extract from leaves of Syzygium samarangense revealed 92 compounds belonging to flavonoids, phenolic acids, condensed tannins, and ellagitannins. The S. samarangense extract exhibited a n ...
DOI:
10.1016/j.fct.2018.01.031

37. Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.)

Author:
Azzurra Stefanucci; Gokhan Zengin; Marcello Locatelli; Giorgia Macedonio; Chin-Kun Wang; Ettore Novellino; M.Fawzi Mahomoodally; Adriano Mollica
Source:
Food and chemical toxicology 2018 v.118 pp. 181-189
ISSN:
0278-6915
Subject:
Capparis spinosa; acetylcholinesterase; active ingredients; antioxidant activity; bioactive compounds; buds; cholinesterase; chromatography; enzyme inhibition; essential oils; fatty acids; free radical scavengers; medicinal plants; phenolic compounds; provenance; rutin; toxicology; Italy; Morocco; Turkey (country)
Abstract:
... Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of differen ...
DOI:
10.1016/j.fct.2018.05.003

38. In vitro antioxidant and antihypertensive compounds from camu-camu (Myrciaria dubia McVaugh, Myrtaceae) seed coat: A multivariate structure-activity study

Author:
Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
Source:
Food and chemical toxicology 2018 v.120 pp. 479-490
ISSN:
0278-6915
Subject:
lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
Abstract:
... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
DOI:
10.1016/j.fct.2018.07.043

39. In vitro mechanisms of Beauvericin toxicity: A review

Author:
Beatriz Mallebrera; Alessandra Prosperini; Guillermina Font; María José Ruiz
Source:
Food and chemical toxicology 2018 v.111 pp. 537-545
ISSN:
0278-6915
Subject:
Beauveria bassiana; DNA fragmentation; Fusarium; antioxidant activity; apoptosis; cell lines; chromosome aberrations; cytotoxicity; fungi; grains; mechanism of action; mitochondria; mutagens; mycotoxins; oxidative stress; permeability; risk assessment; toxicology
Abstract:
... Beauvericin (BEA) is a mycotoxin produced by many species of fungus Fusarium and by Beauveria bassiana; BEA is a natural contaminant of cereals and cereals based products and possesses a wide variety of biological properties. The mechanism of action seems to be related to its ionophoric activity, that increases ion permeability in biological membranes. As a consequence, BEA causes cytotoxicity in ...
DOI:
10.1016/j.fct.2017.11.019

40. In vivo evaluation of effect of anthocyanin-rich wheat on rat liver microsomal drug-metabolizing cytochromes P450 and on biochemical and antioxidant parameters in rats

Author:
Jiří Prokop; Pavel Anzenbacher; Eva Mrkvicová; Leoš Pavlata; Iveta Zapletalová; Ondřej Šťastník; Petr Martinek; Pavel Kosina; Eva Anzenbacherová
Source:
Food and chemical toxicology 2018 v.122 pp. 225-233
ISSN:
0278-6915
Subject:
antioxidant activity; antioxidants; cytochrome P-450; diet; drugs; gene expression; genotype; health status; humans; in vivo studies; liver; markets; messenger RNA; metabolism; rats; weight gain; wheat; xenobiotics
Abstract:
... Wheat is one of the most important agricultural crops worldwide. Recently, anthocyanin-rich wheat genotypes were introduced to the market as a food with added value. In the experiment described here, two different genotypes with blue grain were studied (UC66049 and Skorpion). The aim of the investigation was to determine whether a 72-day-long intake of anthocyanin-rich wheat can influence the drug ...
DOI:
10.1016/j.fct.2018.10.029

41. Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots

Author:
Adriana Trifan; Sebastian E.W. Opitz; Roland Josuran; Andreas Grubelnik; Nils Esslinger; Samuel Peter; Sarah Bräm; Nadja Meier; Evelyn Wolfram
Source:
Food and chemical toxicology 2018 v.112 pp. 178-187
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Symphytum officinale; analgesics; anti-inflammatory activity; antioxidant activity; antioxidants; caffeic acid; comfrey; enzyme inhibition; ethanol; free radicals; isomers; polyphenols; pyrrolizidine alkaloids; roots; rosmarinic acid; salvianolic acid; tandem mass spectrometry; toxicity; toxicology
Abstract:
... Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties. Up to date, key activity-determining constituents of comfrey root extracts have not been completely elucidated. Therefore, we applied different approaches to further characterize a comfrey root extract (65% ethanol). The phenolic profile of comfrey ...
DOI:
10.1016/j.fct.2017.12.051

42. Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro

Author:
Lada Živković; Vladan Bajić; Dragana Dekanski; Andrea Čabarkapa-Pirković; Francesca Giampieri; Massimiliano Gasparrini; Luca Mazzoni; Biljana Spremo Potparević
Source:
Food and chemical toxicology 2018 v.119 pp. 61-65
ISSN:
0278-6915
Subject:
DNA; DNA damage; antioxidant activity; blood cells; comet assay; genotoxicity; humans; hydrogen peroxide; manuka honey; mutagens
Abstract:
... Manuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from 25–1000 μg/mL, by performing an in vitro comet assay after exposure to human whole blood. No genotoxic effect on whole blood cells was observed within the tested concentration ran ...
DOI:
10.1016/j.fct.2018.05.034

43. Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. (Asteraceae) and Veronica persica Poiret (Plantaginaceae)

Author:
Radu Claudiu Fierascu; Milen I. Georgiev; Irina Fierascu; Camelia Ungureanu; Sorin Marius Avramescu; Alina Ortan; Mihaela Ioana Georgescu; Anca Nicoleta Sutan; Anca Zanfirescu; Cristina Elena Dinu-Pirvu; Bruno Stefan Velescu; Valentina Anuta
Source:
Food and chemical toxicology 2018 v.111 pp. 44-52
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Arctium lappa; Aspergillus niger; Penicillium; Veronica persica; aerial parts; anti-inflammatory activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; chromosome aberrations; fungi; high performance liquid chromatography; inflammation; meristems; models; roots; toxicology
Abstract:
... The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the ...
DOI:
10.1016/j.fct.2017.11.008

44. Molecular determinants of PPARγ partial agonism and related in silico/in vivo studies of natural saponins as potential type 2 diabetes modulators

Author:
Merilin Al Sharif; Petko Alov; Antonia Diukendjieva; Vessela Vitcheva; Rumyana Simeonova; Ilina Krasteva; Aleksandar Shkondrov; Ivanka Tsakovska; Ilza Pajeva
Source:
Food and chemical toxicology 2018 v.112 pp. 47-59
ISSN:
0278-6915
Subject:
Astragalus; agonists; animal disease models; antioxidant activity; biomarkers; crystal structure; glucose; glycemic effect; homeostasis; humans; hypertension; in vivo studies; metabolic syndrome; molecular models; noninsulin-dependent diabetes mellitus; obesity; pharmacology; rats; sapogenins; saponins; toxicology
Abstract:
... The metabolic syndrome, which includes hypertension, type 2 diabetes (T2D) and obesity, has reached an epidemic-like scale. Saponins and sapogenins are considered as valuable natural products for ameliorating this pathology, possibly through the nuclear receptor PPARγ activation. The aims of this study were: to look for in vivo antidiabetic effects of a purified saponins' mixture (PSM) from Astrag ...
DOI:
10.1016/j.fct.2017.12.009

45. NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice

Author:
Jing Sun; Jingqi Fu; Yang Zhong; Lu Li; Chengjie Chen; Xiaolei Wang; Linlin Wang; Yongyong Hou; Huihui Wang; Rui Zhao; Xixuan Zhang; Masayuki Yamamoto; Yuanyuan Xu; Jingbo Pi
Source:
Food and chemical toxicology 2018 v.121 pp. 495-503
ISSN:
0278-6915
Subject:
acetaldehyde; alcohol abuse; alcohol drinking; antioxidant activity; death; dimethyl fumarate; ethanol; glucose; hypoglycemia; hypothermia; insulin secretion; islets of Langerhans; liver; metabolism; mice; mortality; oxidative stress; pancreatitis; pathogenesis; phenotype; protective effect; risk factors; toxicology
Abstract:
... Binge alcohol drinking is an important health concern and well-known risk factor for the development of numerous disorders. Oxidative stress plays a critical role in the pathogenesis of acute alcoholism. Nuclear factor erythroid 2 like 2 (NRF2) is a master regulator of cellular adaptive response to oxidative insults. However, the role of NRF2 in acute alcoholism and associated pathologies remains ...
DOI:
10.1016/j.fct.2018.09.042

46. Nanoencapsulated Illicium verum Hook.f. essential oil as an effective novel plant-based preservative against aflatoxin B1 production and free radical generation

Author:
Abhishek Kumar Dwivedy; Vipin Kumar Singh; Bhanu Prakash; Nawal Kishore Dubey
Source:
Food and chemical toxicology 2018 v.111 pp. 102-113
ISSN:
0278-6915
Subject:
Aspergillus flavus; Illicium verum; Pistacia vera; aflatoxin B1; antifungal properties; antioxidant activity; calcium; cell membranes; containers; ergosterol; essential oils; free radical scavengers; free radicals; freeze drying; fungi; gels; ions; lethal dose 50; magnesium; methyl chavicol; mice; microbial contamination; minimum inhibitory concentration; nanocapsules; potassium; scanning electron microscopy; shelf life; toxicology; toxigenic strains; transmission electron microscopy
Abstract:
... The study reports efficacy of Illicium verum essential oil (IvEO) against food borne moudls and its nanoencapsulation for enhancing antifungal and antiaflatoxigenic potency. Chemical characterization of the IvEO showed anethole (89.12%) as major compound followed by estragole (4.859%). The IvEO showed broad fungitoxic spectrum against common food borne moulds. It's minimum inhibitory concentration ...
DOI:
10.1016/j.fct.2017.11.007

47. Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Author:
Sengul Uysal; Asli Ugurlu; Gokhan Zengin; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Adriano Mollica; Luisa Custodio; Nuno R. Neng; José M.F. Nogueira; M. Fawzi Mahomoodally
Source:
Food and chemical toxicology 2018 v.111 pp. 525-536
ISSN:
0278-6915
Subject:
Bidens tripartita; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cell lines; cell viability; chlorogenic acid; computer simulation; cytotoxicity; enzyme inhibition; epicatechin; ethyl acetate; high performance liquid chromatography; hydrogen bonding; methanol; neoplasm cells; neoplasms; plasmids; toxicology; viability assays
Abstract:
... Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Perform ...
DOI:
10.1016/j.fct.2017.11.058

48. Pancratium triflorum Roxb. (Amaryllidaceae) and Molineria trichocarpa (Wight) N.P. Balakr (Hypoxidaceae): Cytotoxic and antioxidant activities

Author:
M. Johnson; P. Maharaja; N. Janakiraman; G. Adaikala Raj; I.R.A. Menezes; J.G.M. da Costa; L.C.L. Verde; H.D.M. Coutinho
Source:
Food and chemical toxicology 2018 v.119 pp. 290-295
ISSN:
0278-6915
Subject:
Artemia; Hypoxidaceae; Pancratium; acetone; antioxidant activity; chloroform; cytotoxicity; inhibitory concentration 50; lethal concentration 50; medicinal properties; methanol; mortality; nauplii; petroleum; India
Abstract:
... The present investigation was carried out to evaluate the antioxidant and cytotoxic activities of Pancratium triflorum Roxb and Molineria trichocarpa were collected from South Vagaikulam, Tirunelveli district, Tamil Nadu, India. The antioxidant activities of P. triflorum extracts were as follows with the IC₅₀ values methanol (228.13 μg/mL) > chloroform (311.33 μg/mL) > acetone (398.08 μg/mL) > pet ...
DOI:
10.1016/j.fct.2018.02.055

49. Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice

Author:
Karma D. James; Mary J. Kennett; Joshua D. Lambert
Source:
Food and chemical toxicology 2018 v.111 pp. 302-309
ISSN:
0278-6915
Subject:
antioxidant activity; dietary supplements; epigallocatechin gallate; genetic markers; glutathione peroxidase; green tea; health effects assessments; hemorrhage; hepatotoxicity; inflammation; messenger RNA; mice; mitochondria; necrosis; oxidative stress; protein content; quantitative polymerase chain reaction; superoxide dismutase; tea (beverage); toxicology; transmission electron microscopy
Abstract:
... Green tea and (-)-epigallocatechin-3-gallate (EGCG) have been studied for their obesity-related health effects. Many green tea extract (GTE)-based dietary supplements are commercially-available. Although green tea beverage has a long history of safe use, a growing number of case-reports have linked GTE-based supplements to incidents of hepatotoxicity. Animal studies support the hepatotoxic potenti ...
DOI:
10.1016/j.fct.2017.11.029
PubMed:
29175576
PubMed Central:
PMC5756669
CHORUS:
10.1016/j.fct.2017.11.029

50. Procyanidin B2 protects against d-galactose-induced mimetic aging in mice: Metabolites and microbiome analysis

Author:
Ying Xiao; Jialin Dong; Zhiting Yin; Qiguo Wu; Yiming Zhou; Xiaoli Zhou
Source:
Food and chemical toxicology 2018 v.119 pp. 141-149
ISSN:
0278-6915
Subject:
Bacteroidetes; Bifidobacterium; Lachnospiraceae; Roseburia; antioxidant activity; carnitine; cholic acid; cognition; diet; galactose; hippuric acid; intestinal microorganisms; linoleic acid; memory; metabolites; metabolomics; mice; microbiome; oleic acid; pantothenic acid; phosphatidylcholines; procyanidins; pyruvic acid; taurocholic acid; toxicology; tricarboxylic acid cycle
Abstract:
... To elucidate the possible mechanisms for the preventive effect of procyanidin B2 on aging, a combined analysis of metabolic profile and gut microbiome was carried out in the present study. The mimetic aged mice induced by d-galactose injection (500 mg/kg, sc daily), and the preventive group was fed with the diet plus 0.2% procyanidin B2. After 7 weeks of treatment, the spatial memory was assayed u ...
DOI:
10.1016/j.fct.2018.05.017

51. Protective effect of flavonoids from Cyclocarya paliurus leaves against carbon tetrachloride-induced acute liver injury in mice

Author:
Jianhua Xie; Wenjie Wang; Caijun Dong; Lixin Huang; Hui Wang; Chang Li; Shaoping Nie; Mingyong Xie
Source:
Food and chemical toxicology 2018 v.119 pp. 392-399
ISSN:
0278-6915
Subject:
Cyclocarya paliurus; alanine transaminase; antioxidant activity; aspartate transaminase; carbon tetrachloride; chemical analysis; dietary supplements; flavonoids; glutathione peroxidase; hepatoprotective effect; leaves; liver diseases; malondialdehyde; mass spectrometry; mice; models; nuclear magnetic resonance spectroscopy; superoxide dismutase; toxicology; China
Abstract:
... Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus), known locally as ‘sweet tea tree’, is commonly cultivated in China. Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (FC) is reported to exhibit multiple biological effects, including anti-inflammatory, anti-oxidant and anti-diabetic activities. However, their influence on carbon tetrachloride (CCl₄)-induced acute liver injury remains u ...
DOI:
10.1016/j.fct.2018.01.016

52. Protective effects of Devosia sp. ANSB714 on growth performance, immunity function, antioxidant capacity and tissue residues in growing-finishing pigs fed with deoxynivalenol contaminated diets

Author:
Xiaoying Li; Yongpeng Guo; Lihong Zhao; Yu Fan; Cheng Ji; Jianyun Zhang; Qiugang Ma
Source:
Food and chemical toxicology 2018 v.121 pp. 246-251
ISSN:
0278-6915
Subject:
Devosia; adverse effects; antioxidant activity; average daily gain; blood serum; deoxynivalenol; diet; drinking water; fermentation; glutathione peroxidase; growth performance; immunity; immunoglobulin A; kidneys; liver; poisoning; protective effect; rice; swine; swine feeding; toxicity
Abstract:
... This study aimed to investigate the toxic effects of deoxynivalenol (DON) and the effectiveness of Devosia sp. ANSB714 for alleviation of DON toxicosis in growing-finishing pigs. A total of twenty pigs were allocated equally to four treatments for 18 days: CON (basal diet formulated with normal rice), Devosia sp. ANSB714 (CON + Devosia sp. ANSB714), DON (toxic diet formulated with DON-contaminated ...
DOI:
10.1016/j.fct.2018.09.007

53. Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 1: Enhancement of cellular viability, regulation of cellular apoptosis and improvement of mitochondrial functionality

Author:
Sadia Afrin; Massimiliano Gasparrini; Tamara Y. Forbes-Hernández; Danila Cianciosi; Patricia Reboredo-Rodriguez; Piera Pia Manna; Maurizio Battino; Francesca Giampieri
Source:
Food and chemical toxicology 2018 v.121 pp. 203-213
ISSN:
0278-6915
Subject:
antioxidant activity; apoptosis; biogenesis; caspase-3; dose response; gallic acid; glycolysis; inflammation; lipopolysaccharides; macrophages; manuka honey; mitochondria; protective effect; proteins; quercetin; tissue repair; toxicology; viability; Australia; New Zealand
Abstract:
... Manuka honey (MH) is a monofloral honey from Australia and New Zealand, well-known for its healthy properties, such as antioxidant, antimicrobial and wound healing capacities. The aim of this work was to assess the phenolic composition and the total antioxidant capacity (TAC) of MH, as well as its effects on cellular viability, proliferation, apoptosis and metabolism in lipopolysaccharide (LPS)-tr ...
DOI:
10.1016/j.fct.2018.09.001

54. Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice

Author:
Hanvit Cha; Seoyoon Lee; Jin Hyup Lee; Jeen-Woo Park
Source:
Food and chemical toxicology 2018 v.121 pp. 131-139
ISSN:
0278-6915
Subject:
DNA damage; acetaminophen; alanine transaminase; antioxidant activity; apoptosis; aspartate transaminase; blood serum; disease models; hepatotoxicity; inflammation; isomers; liver; liver failure; mice; mitogen-activated protein kinase; morbidity; mortality; overdose; p-coumaric acid; protective effect; reactive oxygen species; vegetables
Abstract:
... Acetaminophen (N-acetyl-p-aminophenol, AAP) is an effective analgesic and antipyretic drug with minimal toxicity when used at therapeutic doses. However, AAP overdose is the most common cause of drug-induced acute liver failure and one of the main causes of morbidity and mortality. p-Coumaric acid (PCA) is the most abundant isomer of hydroxycinnamic acid in nature, and it can be widely found in fr ...
DOI:
10.1016/j.fct.2018.08.060

55. Protective effects of rosuvastatin and vitamin E against fipronil-mediated oxidative damage and apoptosis in rat liver and kidney

Author:
Mohamed M. Abdel-Daim; Ahmed Abdeen
Source:
Food and chemical toxicology 2018 v.114 pp. 69-77
ISSN:
0278-6915
Subject:
alanine transaminase; albino; alkaline phosphatase; antioxidant activity; apoptosis; aspartate transaminase; blood serum; caspase-3; catalase; cholesterol; creatinine; fipronil; glutathione; glutathione peroxidase; histology; humans; insecticides; kidneys; lactate dehydrogenase; liver; malondialdehyde; nitric oxide; protective effect; rats; superoxide dismutase; toxicity; urea; vitamin E
Abstract:
... Fipronil (FPN) is a phenylpyrazole insecticide that is extensively used in agriculture and veterinary applications. However, FPN is also a potent environmental toxicant to animals and humans. Therefore, the current study aimed to investigate the protective role of rosuvastatin (ROSU) and vitamin E (Vit E) against FPN-induced hepatorenal toxicity in albino rats. Seven groups with eight rats each we ...
DOI:
10.1016/j.fct.2018.01.055

56. Proteomic approaches to investigate age related vulnerability to lindane induced neurodegenerative effects in rats

Author:
Anubha Mudawal; Ankita Srivastava; Anshuman Singh; Jai Shankar; Sanjay Yadav; Manisha Mishra; Pradhyumna K. Singh; Vinay K. Khanna; Devendra Parmar
Source:
Food and chemical toxicology 2018 v.115 pp. 499-510
ISSN:
0278-6915
Subject:
Western blotting; adults; antioxidant activity; apoptosis; autophagy; calcium; energy metabolism; enzyme activity; glutathione; hippocampus; homeostasis; lindane; lipid peroxidation; neurodegenerative diseases; proteasome endopeptidase complex; proteomics; rats; reactive oxygen species; toxicology; ubiquitin
Abstract:
... Proteomic studies were carried out in immature (3 week), adult (18 week) and aged (48 week) rats to understand the age dependent vulnerability to lindane induced neurodegeneration. 2-D and western blot analysis of protein extracts of hippocampus and substantia-nigra isolated from lindane treated rats (2.5 mg/kg; p.o. X 21 days) revealed marked dysregulation in the expression of proteins related to ...
DOI:
10.1016/j.fct.2018.03.049

57. Purple pitanga fruit (Eugenia uniflora L.) protects against oxidative stress and increase the lifespan in Caenorhabditis elegans via the DAF-16/FOXO pathway

Author:
Andréia Limana Tambara; Liliana de Los Santos Moraes; Ana Helena Dal Forno; Jean Ramos Boldori; Ana Thalita Gonçalves Soares; Cristiane de Freitas Rodrigues; Lilian Regina Barros Mariutti; Adriana Zerlotti Mercadante; Daiana Silva de Ávila; Cristiane Casagrande Denardin
Source:
Food and chemical toxicology 2018 v.120 pp. 639-650
ISSN:
0278-6915
Subject:
Caenorhabditis elegans; Eugenia uniflora; anthocyanins; antioxidant activity; chemical composition; fruits; heat shock proteins; hydrogen peroxide; juglone; longevity; metabolism; mutants; oxidative stress; reproduction; superoxide dismutase; toxicity; toxicology; trees; Brazil
Abstract:
... Pitanga, a fruit of the pitangueira tree (Eugenia uniflora L.), is native to Brazil and has a high antioxidant capacity due to the elevated amount of anthocyanins. The present study aimed to investigate the chemical composition of the purple pitanga fruit and to evaluate its antioxidant effect in the nematode Caenorhabditis elegans. We observed that the ethanolic extract of purple pitanga did not ...
DOI:
10.1016/j.fct.2018.07.057

58. Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD)

Author:
Paramahamsa Maturu; Yanhong Wei-Liang; Vasilis P. Androutsopoulos; Weiwu Jiang; Lihua Wang; Aristides M. Tsatsakis; Xanthi I. Couroucli
Source:
Food and chemical toxicology 2018 v.114 pp. 23-33
ISSN:
0278-6915
Subject:
NAD(P)H dehydrogenase (quinone); NADP (coenzyme); air; antioxidant activity; beverages; bronchopulmonary dysplasia; disease models; fruits; gene expression regulation; hyperoxia; infant diseases; inflammation; liver; lungs; macrophages; messenger RNA; mice; neonates; neutrophils; oxidative stress; oxygen; premature birth; quercetin; quinones; risk factors; steroids; therapeutics; toxicology; transcription factor NF-kappa B; vegetables
Abstract:
... Quercetin (QU) is one of the most common flavonoids that are present in a wide variety of fruits, vegetables, and beverages. This compound possesses potent anti-inflammatory and anti-oxidant properties. Supplemental oxygen is routinely administered to premature infants with pulmonary insufficiency. However, hyperoxia is one of the major risk factors for the development of bronchopulmonary dysplasi ...
DOI:
10.1016/j.fct.2018.02.026

59. Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vaccinium myrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin

Author:
Guillermo Cásedas; Elena González-Burgos; Carine Smith; Víctor López; María Pilar Gómez-Serranillos
Source:
Food and chemical toxicology 2018 v.118 pp. 572-580
ISSN:
0278-6915
Subject:
Vaccinium macrocarpon; Vaccinium myrtillus; anthocyanins; antioxidant activity; blueberries; catalase; cranberries; cyanidin; freeze drying; fruit juices; fruits; hydrogen peroxide; lipid peroxidation; mitochondria; neurons; neuroprotective effect; oxidative stress; polyphenols; superoxide dismutase; thiobarbituric acid-reactive substances
Abstract:
... Blueberry and cranberry are fruits with high polyphenol content, particularly anthocyanins. As cyanidin derivatives have been identified as one of the most representative polyphenols in berry juices, cyanidin has been designated for a better comparison and understanding of the potential neuroprotection of juices obtained from two Vaccinium species. Neuroblastoma SH-SY5Y cells were previously treat ...
DOI:
10.1016/j.fct.2018.05.066

60. Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats

Author:
Anca Oana Docea; Eliza Gofita; Marina Goumenou; Daniela Calina; Otilia Rogoveanu; Marius Varut; Cristian Olaru; Efthalia Kerasioti; Polyxeni Fountoucidou; Ioannis Taitzoglou; Ovidiu Zlatian; Valerii N. Rakitskii; Antonio F. Hernandez; Dimitrios Kouretas; Aristidis Tsatsakis
Source:
Food and chemical toxicology 2018 v.115 pp. 470-481
ISSN:
0278-6915
Subject:
acceptable daily intake; adverse effects; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartame; bilirubin; bisphenol A; blood; body weight changes; calcium; carbaryl; catalase; dimethoate; enzyme activity; ethylene; females; glyphosate; gum arabic; hepatotoxicity; humans; liver function tests; males; methomyl; no observed adverse effect level; normal values; parathion-methyl; rats; sodium benzoate; toxicology; triadimefon
Abstract:
... This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylp ...
DOI:
10.1016/j.fct.2018.03.052

61. Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast

Author:
Massimiliano Gasparrini; Francesca Giampieri; Tamara Y. Forbes-Hernandez; Sadia Afrin; Danila Cianciosi; Patricia Reboredo-Rodriguez; Alfonso Varela-Lopez; JiaoJiao Zhang; Josè L. Quiles; Bruno Mezzetti; Stefano Bompadre; Maurizio Battino
Source:
Food and chemical toxicology 2018 v.114 pp. 128-140
ISSN:
0278-6915
Subject:
Escherichia coli; antioxidant activity; apoptosis; chronic diseases; endotoxins; fibroblasts; humans; inflammation; lipopolysaccharides; mitochondria; oxidative stress; reactive oxygen species; signal transduction; strawberries; toxicology; transcription factor NF-kappa B
Abstract:
... A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measur ...
DOI:
10.1016/j.fct.2018.02.038

62. Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes

Author:
Guoyuan Qi; Wanqiang Wu; Yashi Mi; Renjie Shi; Keyu Sun; Runnan Li; Xiao Liu; Xuebo Liu
Source:
Food and chemical toxicology 2018 v.122 pp. 181-193
ISSN:
0278-6915
Subject:
antioxidant activity; antioxidants; circadian clocks; circadian rhythm; enzymes; functional foods; hepatocytes; homeostasis; mitochondria; models; oxidative stress; polyphenols; protein synthesis; secretion; tea; transcription (genetics)
Abstract:
... Circadian rhythms are intimately linked to cellular redox status homeostasis via the regulation of mitochondrial function. Tea polyphenols (TP) are nutraceuticals that possess powerful antioxidant properties, especially ameliorating oxidative stress. The objective of this study was to investigate whether circadian clock is involved in the protection effect of TP on oxidative stress cell models. TP ...
DOI:
10.1016/j.fct.2018.10.031

63. Topiramate mitigates 3-nitropropionic acid-induced striatal neurotoxicity via modulation of AMPA receptors

Author:
Heba N. Shalaby; Dalia M. El-Tanbouly; Hala F. Zaki
Source:
Food and chemical toxicology 2018 v.118 pp. 227-234
ISSN:
0278-6915
Subject:
3-nitropropionic acid; anticonvulsants; antioxidant activity; binding proteins; caspase-3; gene expression; glutamate receptors; glycogen (starch) synthase; histopathology; messenger RNA; neurodegenerative diseases; neuroprotective effect; neurotoxicity; neurotransmitters; non-specific serine/threonine protein kinase; phosphorylation; propionic acid; rats; regulatory proteins; toxicology
Abstract:
... Prevalence of glutamate receptor subunit 2 (GluR2)-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is a hallmark of excitotoxicity-related neurodegenerative diseases. Topiramate (TPM) is a structurally novel anticonvulsant with a well-known modulatory effects on AMPA/kainate subtypes of glutamate receptors. The present study aimed at investigating the neuroprotec ...
DOI:
10.1016/j.fct.2018.05.022

64. Toxic effects of zearalenone on gametogenesis and embryonic development: A molecular point of review

Author:
Dacheng Yang; Xinwei Jiang; Jianxia Sun; Xia Li; Xusheng Li; Rui Jiao; Ziyao Peng; Yuqi Li; Weibin Bai
Source:
Food and chemical toxicology 2018 v.119 pp. 24-30
ISSN:
0278-6915
Subject:
DNA damage; antioxidant activity; apoptosis; embryogenesis; estrogen receptors; gametogenesis; germ cells; hormones; humans; lipid peroxides; molds (fungi); oxidative stress; testes; toxicity; toxicology; zearalenone
Abstract:
... Zearalenone is commonly generated from moldy cereal grain, which is toxic to the development of gametogenesis and embryo in human and animals. The zearalenone-induced reproductive damage is mainly attributed to four mechanisms. Firstly, zearalenone as an oestrogen-like compound binds to estrogen receptor and causes damage to germ cells and testicular structure. Secondly, zearalenone disrupts the b ...
DOI:
10.1016/j.fct.2018.06.003

65. UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation

Author:
Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
Source:
Food and chemical toxicology 2018 v.115 pp. 414-424
ISSN:
0278-6915
Subject:
foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
Abstract:
... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
DOI:
10.1016/j.fct.2018.01.054

66. Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities

Author:
Arti Nile; Shivraj Hariram Nile; Doo Hwan Kim; Young Soo Keum; Park Gyun Seok; Kavita Sharma
Source:
Food and chemical toxicology 2018 v.119 pp. 281-289
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Alzheimer disease; antioxidant activity; cell lines; cytotoxicity; diabetes; enzymes; ethanol; glycemic effect; glycosides; high performance liquid chromatography; human health; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; onions; quercetin; sedatives; solid wastes; solvents; toxicity testing
Abstract:
... Onion (Allium cepa L.) is rich with flavonols which perceived benefits to human health. Flavonols like quercetin and quercetin glycosides from onion solid waste (OSW) have been extracted and tested against enzymes of clinical importance in Alzheimer's disease and diabetes and be shown to have cytotoxic and antioxidant effects. A simple high-performance liquid chromatography-diode array detector me ...
DOI:
10.1016/j.fct.2018.02.056

67. The antioxidant activity of a prenyl flavonoid alters its antifungal toxicity on Candida albicans biofilms

Author:
Mariana Andrea Peralta; María Gabriela Ortega; José Luis Cabrera; María Gabriela Paraje
Source:
Food and chemical toxicology 2018 v.114 pp. 285-291
ISSN:
0278-6915
Subject:
Candida albicans; Dalea; antifungal properties; antioxidant activity; biofilm; confocal laser scanning microscopy; flavonoids; gentian violet; metabolites; nitrogen; oxidants; superoxide dismutase; topography; toxicity; toxicology
Abstract:
... The antioxidant effect of 8PP, a prenylflavonoid from Dalea elegans on Candida albicans biofilms, was investigated. We previously reported that sensitive (SCa) and resistant C. albicans (RCa) biofilms were strongly inhibited by this compound, in a dose-depending manner (50 μM-100 μM), with a prooxidant effect leading to accumulation of endogenous oxidative metabolites and increased antioxidant def ...
DOI:
10.1016/j.fct.2018.02.042

68. The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

Author:
Milad Iranshahy; Mehrdad Iranshahi; Seyed Reza Abtahi; Gholamreza Karimi
Source:
Food and chemical toxicology 2018 v.120 pp. 261-276
ISSN:
0278-6915
Subject:
alkaloids; antioxidant activity; drugs; genes; hepatocytes; hepatoprotective effect; hepatotoxicity; humans; knockout mutants; leucine zipper; liver; metabolism; organelles; oxidants; oxidative stress; polyphenols; reactive oxygen species; terpenoids; toxicology; transcription factors; xenobiotics
Abstract:
... Internal metabolism and environmental toxicant exposure can be caused to generate reactive oxygen species in human organelles which lead to oxidative stress. The nuclear factor erythroid 2–related factor 2 (Nrf2), a basic leucine zipper (bZip) transcription factor, controls the expression of antioxidant response element (ARE)–dependent genes to regulate cellular resistance to oxidants. Nrf2 is an ...
DOI:
10.1016/j.fct.2018.07.024