Journal: Journal of ethnopharmacology / Journal name: Journal of ethnopharmacology / Publication Year: 2014 / Text Availability: Citation in PubAg

1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

Author:: Jean Paul Dzoyem; Victor Kuete; Lyndy J. McGaw; Jacobus N. Eloff
Source:: Journal of ethnopharmacology 2014 v.156 pp. 1-8
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Adansonia digitata; Aframomum; Mycobacterium aurum; Mycobacterium fortuitum; Mycobacterium smegmatis; Tamarindus indica; antibacterial properties; antioxidant activity; antioxidants; bromides; cytotoxicity; enzyme inhibition; flavonoids; fruits; herbs; infectious diseases; inflammation; inhibitory concentration 50; kidneys; lethal concentration 50; medicinal properties; minimum inhibitory concentration; monkeys; pain; spices; tetrazolium; traditional medicine; Africa
Abstract:: ... Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their traditional use and safety. In this study, the 15-lipoxygenase inhibitory, antioxidant, antim ...
DOI:: 10.1016/j.jep.2014.08.007
: https://doi.org/10.1016/j.jep.2014.08.007

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

Author:: Qinxiao Guan; Shengwang Liang; Zhanhong Wang; Yongxia Yang; Shumei Wang
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 65-75
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; amino acids; apoptosis; biochemical pathways; brain; cerebrovascular disorders; death; emodin; energy; histopathology; infarction; ingredients; ischemia; metabolomics; models; neurons; nuclear magnetic resonance spectroscopy; pharmacodynamics; principal component analysis; protective effect; rats; rhubarb; society; urine
Abstract:: ... The ischemia cerebrovascular disease is one of leading causes of death and long-term disability in modern society. Rhubarb is one of the common traditional Chinese medicine with many effects, and the main pharmacodynamic ingredients are aloe-emodin, rhein, emodin, chrysophanol and physcion. The five components are also known as rhubarb aglycone. Rhubarb aglycone has been confirmed to play a remark ...
DOI:: 10.1016/j.jep.2014.03.002
: https://doi.org/10.1016/j.jep.2014.03.002

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

Author:: Jong Rhan Kim; Jinhwan Choi; Jiyoung Kim; Heejeung Kim; Heerim Kang; Eun Hye Kim; Jeong-Hwa Chang; Yeong-Eun Kim; Young Jin Choi; Ki Won Lee; Hyong Joo Lee
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 365-371
ISSN:: 0378-8741
Subject:: ginsenosides; immunomodulators; plant extracts; oral administration; metabolites; Dermatophagoides farinae; chemokine CCL22; skin lesions; ears; monoclonal antibodies; splenocytes; traditional medicine; blood serum; histology; anti-allergic agents; mice; Panax; eosinophils; atopic dermatitis; mast cells
Abstract:: ... Ginseng and ginsenosides are frequently used in the treatment of chronic inflammatory diseases. Recently, 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol (GPD), the main metabolite of ginsenosides, was reported to have both anti-allergic and anti-pruritic effects. The immunomodulatory effects of GPD-fortified ginseng extract (GFGE) on atopic dermatitis (AD)-like symptoms in mice were investigated. T ...
DOI:: 10.1016/j.jep.2013.10.058
: https://doi.org/10.1016/j.jep.2013.10.058

4. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Author:: Yanyan Yang; Woo Seok Yang; Tao Yu; Gi-Ho Sung; Kye Won Park; Keejung Yoon; Young-Jin Son; Hyunsik Hwang; Yi-Seong Kwak; Chang-Muk Lee; Man Hee Rhee; Jong-Hoon Kim; Jae Youl Cho
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 218-228
ISSN:: 0378-8741
Subject:: Panax ginseng; anti-inflammatory activity; apoptosis; cyclic AMP; gastritis; herbal medicines; inducible nitric oxide synthase; inflammation; interferon regulatory factor-3; interferons; lipopolysaccharides; luciferase; messenger RNA; mice; mitogen-activated protein kinase; models; nitric oxide; peritonitis; prostaglandin synthase; traditional medicine; Korean Peninsula
Abstract:: ... Korean Red Ginseng (KRG) is one of the representative traditional herbal medicines prepared from Panax ginseng Meyer (Araliaceae) in Korea. It has been reported that KRG exhibits a lot of different biological actions such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, anti-cancer, and anti-inflammatory activities. Although systematic studies have investigated how KR ...
DOI:: 10.1016/j.jep.2014.04.008
: https://doi.org/10.1016/j.jep.2014.04.008

5. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Author:: Lian-Wu Xie; Atanas G. Atanasov; De-An Guo; Clemens Malainer; Jing-Xian Zhang; Martin Zehl; Shu-Hong Guan; Elke H. Heiss; Ernst Urban; Verena M. Dirsch; Brigitte Kopp
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 470-477
ISSN:: 0378-8741
Subject:: Lycium chinense; Oriental traditional medicine; active ingredients; agonists; amides; antagonists; bark; cortex; diabetes mellitus; ethyl acetate; fractionation; genes; inflammation; inhibitory concentration 50; mechanism of action; methanol; methylene chloride; moieties; nuclear magnetic resonance spectroscopy; palmitic acid; peroxisome proliferator-activated receptors; structure-activity relationships; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; tyramine
Abstract:: ... The root bark of Lycium chinense Miller, Lycii Radicis Cortex, has been used in traditional Chinese medicine (TCM) to treat different inflammation-related symptoms, such as diabetes mellitus. The pro-inflammatory transcription factor nuclear factor kappa B (NF-κB) is a key regulator of inflammation, while the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is a key mo ...
DOI:: 10.1016/j.jep.2014.01.029
: https://doi.org/10.1016/j.jep.2014.01.029

6. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

Author:: Lili Wang; Zhiqiang Li; Lin Li; Yanlin Li; Meng Yu; Yunfeng Zhou; Xinyong Lv; Hiderori Arai; Yang Xu
Source:: Journal of ethnopharmacology 2014 v.158 pp. 207-215
ISSN:: 0378-8741
Subject:: acute toxicity; adults; adverse effects; alanine transaminase; albumins; alkaline phosphatase; body weight; cholesterol; cortex; cough; glucose; hematopoiesis; histology; jaundice; kidneys; liver; liver function; lymphocytes; mice; mortality; oral administration; rats; rheumatoid arthritis; skin diseases; toxicity testing; traditional medicine; urea nitrogen
Abstract:: ... Cortex Dictamni is used in Chinese folk medicine for the treatment of jaundice, cough, rheumatism and some skin diseases; however, its possible toxicity has not been rigorously studied. The present investigation was carried out to evaluate the safety of Cortex Dictamni aqueous extract (CDAE) by acute and sub-chronic toxicity studies.In acute toxicity tests, seven groups of mice (n=5/group/sex) wer ...
DOI:: 10.1016/j.jep.2014.10.027
: https://doi.org/10.1016/j.jep.2014.10.027

7. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

Author:: Maxwell I. Ezeja; Aruh O. Anaga; Isaac U. Asuzu
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1155-1164
ISSN:: 0378-8741
Subject:: Gouania; acute toxicity; antioxidant activity; blood sampling; blood serum; cholesterol; death; diabetes mellitus; dose response; edema; eyes; heart; heart diseases; hematologic tests; high density lipoprotein; histopathology; kidneys; leaf extracts; leaves; lipid peroxidation; liver; lungs; malaria; methanol; morbidity; oral administration; rats; superoxide dismutase; toxicity testing; traditional medicine; triacylglycerols; urea; very low density lipoprotein; Africa
Abstract:: ... Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.Acute toxicity test of the plant lasted for 48 ...
DOI:: 10.1016/j.jep.2013.12.034
: https://doi.org/10.1016/j.jep.2013.12.034

8. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

Author:: Hwayong Park; Youn-Hwan Hwang; Hye Jin Yang; Hyun-Kyu Kim; Kyung Seuk Song; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2014 v.156 pp. 182-189
ISSN:: 0378-8741
Subject:: Chinese hamsters; Escherichia; Salmonella; acute toxicity; animal ovaries; bacteria; body weight changes; chromosome aberrations; dietary exposure; freeze drying; genotoxicity; glycyrrhizin; health services; herbs; ingredients; laboratory animals; liquid chromatography; mice; micronucleus tests; mutation; rats; signs and symptoms (animals and humans); therapeutics; traditional medicine; East Asia
Abstract:: ... Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one.Guibi-tang, composed of 12 herbs, was fermented with bacteria and lyophilized. Single dos ...
DOI:: 10.1016/j.jep.2014.09.004
: https://doi.org/10.1016/j.jep.2014.09.004

9. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

Author:: J. Luka; S.J. Badau; A.W. Mbaya; J.J. Gadzama; H.A. Kumshe
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 268-273
ISSN:: 0378-8741
Subject:: Diospyros mespiliformis; acute toxicity; antimalarials; blood serum; body weight changes; death; enzymes; erythrocytes; hematocrit; hematology; hemoglobin; lethal dose 50; leukocytes; local government; rats; roots; toxicity testing; traditional medicine; Nigeria
Abstract:: ... Different parts of the plant Diospyros mespiliformis have been used traditionally for the treatment of ailments in Nigeria particularly among the Kamwe people of Michika local government area of Adamawa State where the root has been used as an anti-malarial for ages. Most of the uses have been without any scientific evidence and toxicological assessment. The present study aimed to determine acute ...
DOI:: 10.1016/j.jep.2014.02.033
: https://doi.org/10.1016/j.jep.2014.02.033

10. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

Author:: Jing Li; Guoyong Yu; Junfeng Fan
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 285-292
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Sorghum (Poaceae); active sites; adenosine diphosphate; arachidonic acid; aspirin; blood; cardiovascular diseases; collagen; glucosides; mandelic acid; metabolism; monosaccharides; platelet aggregation; prostaglandin synthase; sorbitol; thrombin; vinegars; xylitol
Abstract:: ... Vinegar has been used as both a common seasoning and a traditional Chinese medicine. Sorghum vinegar is an excellent source of physiological substances with multiple health benefits.To evaluate the antiplatelet aggregation activity of alditols and monosaccharides extracted from sorghum vinegar and analysis its mechanism.Alditol and monosaccharide extract (AME) from sorghum vinegar was first evalua ...
DOI:: 10.1016/j.jep.2014.05.018
: https://doi.org/10.1016/j.jep.2014.05.018

11. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

Author:: Mahendra S. Khyade; Deepak M. Kasote; Nityanand P. Vaikos
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 1-18
ISSN:: 0378-8741
Subject:: Alstonia macrophylla; Alstonia scholaris; adulterated products; alkaloids; antineoplastic activity; aphrodisiacs; gastrointestinal system; jaundice; malaria; medicinal plants; metabolic studies; neoplasms; plant biochemistry; therapeutics; toxicity; traditional medicine; India; Malaysia; Philippines; Thailand
Abstract:: ... Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been us ...
DOI:: 10.1016/j.jep.2014.01.025
: https://doi.org/10.1016/j.jep.2014.01.025

12. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

Author:: Edwin Ogechukwu Omeje; Mohd Parvez Khan; Patience Ogoamaka Osadebe; Deepshikha Tewari; Mohammad Faheem Khan; Kapil Dev; Rakesh Maurya; Naibedya Chattopadhyay
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 643-651
ISSN:: 0378-8741
Subject:: Bombax; Citrus; Cola nitida; Garcinia kola; Loranthus; adults; alkaline phosphatase; antineoplastic activity; bark; bone formation; bone morphogenetic proteins; cytotoxicity; diabetes; disease control; females; gene expression; genes; hosts; hypoglycemic agents; leaves; lupeol; mineralization; models; neonates; osteoblasts; osteoporosis; pain; palmitates; postmenopause; quercetin; rats; skull; therapeutics; traditional medicine; transcription (genetics); transcription factors; viability; Nigeria
Abstract:: ... Mistletoe extracts (decoctions) are used traditionally in eastern Nigeria for the management of bone pain, post menopausal syndrome and diabetes amongst several other ailments. While scientific evidence supporting its folkloric use as an antidiabetic agent has been documented, the age-long practice of its use in treatment of post menopausal syndrome has not been scientifically validated. Postmenop ...
DOI:: 10.1016/j.jep.2013.11.029
: https://doi.org/10.1016/j.jep.2013.11.029

13. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Author:: Xiao-fen Zheng; Jun-sheng Tian; Peng Liu; Jie Xing; Xue-mei Qin
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 912-920
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; animal models; biochemical pathways; biomarkers; body weight; diarrhea; drugs; energy; feces; glycolysis; lactic acid; leucine; liver; males; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; oral administration; rats; spleen; starvation; swimming; uterine prolapse; valine
Abstract:: ... Bu-zhong-yi-qi-tang (BT) is a classical formula for the treatment of spleen-qi descending, visceroptosis with hyposplenic qi, uterine prolapse, and rectal prolapse due to chronic diarrhea in traditional Chinese medicine (TCM) and has been identified as an effective drug for the treatment of TCM spleen-qi deficiency in clinical practice. The present study aimed to investigate the restorative effect ...
DOI:: 10.1016/j.jep.2013.12.001
: https://doi.org/10.1016/j.jep.2013.12.001

14. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

Author:: Hyun Kim; Mi-Jang Song
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 85-89
ISSN:: 0378-8741
Subject:: Araliaceae; Asteraceae; Fabaceae; Pinaceae; Poaceae; Rosaceae; diabetes; indigenous knowledge; interviews; medicinal plants; national parks; nervous system diseases; pain; questionnaires; respiratory tract diseases; social networks; traditional medicine; Korean Peninsula
Abstract:: ... The purpose of this study is to analyze and record traditional knowledge of medicinal plants utilized in communities of Jirisan National Park.Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and social network analysis (S ...
DOI:: 10.1016/j.jep.2013.10.047
: https://doi.org/10.1016/j.jep.2013.10.047

15. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

Author:: Hyun Kim; Mi-Jang Song
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 90-97
ISSN:: 0378-8741
Subject:: Hymenochaetaceae; Pleurotaceae; Polyporaceae; Tricholomataceae; cardiovascular diseases; diabetes; indigenous knowledge; interviews; medicinal fungi; national parks; questionnaires; soups; traditional medicine; wild edible mushrooms; Korean Peninsula
Abstract:: ... This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea).Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and inter-network ana ...
DOI:: 10.1016/j.jep.2013.12.041
: https://doi.org/10.1016/j.jep.2013.12.041

16. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate

Author:: A.B. Seres; E. Ducza; M. Báthori; A. Hunyadi; Z. Béni; M. Dékány; J. Hajagos-Tóth; J. Verli; Róbert Gáspár
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 446-453
ISSN:: 0378-8741
Subject:: Apis mellifera; Western blotting; active ingredients; fractionation; gas chromatography-mass spectrometry; honey bees; male fertility; males; men; messenger RNA; milk; nuclear magnetic resonance spectroscopy; oleic acid; palmitates; protein content; protein synthesis; quantitative polymerase chain reaction; rats; spectral analysis; testosterone; therapeutics; tissues; traditional medicine; women
Abstract:: ... Numerous honeybee (Apis mellifera) products have been used in traditional medicine to treat infertility and to increase vitality in both men and women. Drone milk (DM) is a relatively little-known honeybee product with a putative sexual hormone effect. The oestrogenic effect of a fraction of DM has recently been reported in rats. However, no information is available on the androgenic effects of DM ...
DOI:: 10.1016/j.jep.2014.02.050
: https://doi.org/10.1016/j.jep.2014.02.050

17. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

Author:: Hyun-Soo Shin; Jong-Min Han; Hyeong-Geug Kim; Min-Kyung Choi; Chang-Gue Son; Ho-Ryong Yoo; Hyun-Kyung Jo; In-Chan Seol
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 142-150
ISSN:: 0378-8741
Subject:: Artemisia; Curcuma longa; Western diets; aorta; atherosclerosis; blood lipids; blood serum; cholesterol; curcumin; fatty liver; gene expression; glucose; high density lipoprotein; hyperlipidemia; interleukin-1beta; interleukin-6; lipid composition; low density lipoprotein; mice; reactive oxygen species; tissues; traditional medicine; triacylglycerols; tumor necrosis factor-alpha
Abstract:: ... Artemisiaiwayomogi Kitamura and Curcuma longa Linne. (ACE) has been popularly used to treat atherosclerosis as well as hyperlipidemia in the Asian countries.Antiatherosclerotic and anti-hyperlipidemic effects of ACE were evaluated at protein and gene expression level by using apoE⁻/⁻ mice.Apoprotein E deficient (apoE⁻/⁻) mice were randomly divided into five groups and fed freely Western diet (WD) ...
DOI:: 10.1016/j.jep.2014.01.039
: https://doi.org/10.1016/j.jep.2014.01.039

18. Anti-biofilm activity of Marula – A study with the standardized bark extract

Author:: Ratul Sarkar; Sushil K. Chaudhary; Amrita Sharma; Kirendra K. Yadav; Neelesh K. Nema; Mamello Sekhoacha; Sanmoy Karmakar; Fernão C. Braga; Motlalepula Gilbert Matsabisa; Pulok K. Mukherjee; Tuhinadri Sen
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 170-175
ISSN:: 0378-8741
Subject:: Pseudomonas aeruginosa; Sclerocarya birrea subsp. caffra; alcoholic beverages; antibiotic resistance; antimicrobial properties; bacterial motility; bark; biofilm; dysentery; ethnobotany; fruits; gentian violet; methanol; microbial growth; proteinases; pyoverdines; quorum sensing; secretion; socioeconomics; swarming; traditional medicine; virulence; Africa
Abstract:: ... Marula (Sclerocarya birrea; family – Anacardiaceae) is an African plant, which enjoys wide socio-economic importance particularly in southern part of Africa. The fruits are consumed as food and also as alcoholic beverage (cream liquor). In different parts of Africa, the decoction of the bark is traditionally used for the treatment of dysentery, diarrhoea, and various other infectious conditions. T ...
DOI:: 10.1016/j.jep.2014.03.067
: https://doi.org/10.1016/j.jep.2014.03.067

19. Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

Author:: Muhammad Munawar Hayat; Sadia Sarwar; Shazia Anjum; Muhammad Uzair; Hafiz Muhammad Farhan Rasheed; Qaiser Jabeen; Bashir Ahmad Choudhary; Muhammad Ashraf
Source:: Journal of ethnopharmacology 2014 v.156 pp. 347-352
ISSN:: 0378-8741
Subject:: rabbits; alloxan; Brassicaceae; median effective concentration; acetylcholinesterase; diarrhea; glibenclamide; jejunum; enzyme inhibition; tissues; animal disease models; traditional medicine; linoleate 13S-lipoxygenase; blood glucose; glycemic effect; potassium; phosphodiesterase I; diabetes; antioxidant activity; enzyme activity; rats; parasympatholytics; methanol; therapeutics; fever
Abstract:: ... Folk herbal practitioners of the Cholistan desert claim Farsetia hamiltonii Royle (Brassicaceae) to treat diabetes, oxidative damages, diarrhea, fever, and abdominal cramps. The aim of this study was to scientifically find the potential of Farsetia hamiltonii in treating diabetes and gastrointestinal diseases.In vivo anti-diabetic activity of Farsetia hamiltonii was studied on alloxan induced diab ...
DOI:: 10.1016/j.jep.2014.08.038
: https://doi.org/10.1016/j.jep.2014.08.038

20. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model

Author:: Mohammed Auwal Ibrahim; M. Shahidul Islam
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 392-399
ISSN:: 0378-8741
Subject:: acetone; alanine transaminase; alkaline phosphatase; alpha-amylase; alpha-glucosidase; animal disease models; bark; blood glucose; blood lipids; blood serum; body weight; enzyme inhibition; ethyl acetate; glucose tolerance; glycemic effect; glycogen; in vivo studies; insulin; insulin resistance; islets of Langerhans; liver; males; noninsulin-dependent diabetes mellitus; oral administration; rats; solvents; traditional medicine; urea; Nigeria
Abstract:: ... Senna singueana is currently used in the traditional treatment of diabetes mellitus in Nigeria. The present study examined the anti-diabetic activity of the Senna singueana acetone fraction (SSAF) of stem bark in a type 2 diabetes (T2D) rat model.Crude ethyl acetate extract of the Senna singueana stem bark was fractionated with various solvents and the acetone fraction was selected for in vivo stu ...
DOI:: 10.1016/j.jep.2014.02.042
: https://doi.org/10.1016/j.jep.2014.02.042

21. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

Author:: Shuli Man; Wei Fan; Wenyuan Gao; Yuanyuan Li; Yan Wang; Zhen Liu; Hongfa Li
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 407-412
ISSN:: 0378-8741
Subject:: DNA fragmentation; Oriental traditional medicine; antioxidants; blood serum; diethylnitrosamine; lipid peroxidation; liver; liver diseases; metabolomics; nuclear magnetic resonance spectroscopy; oxidative stress; rats; saponins; tricarboxylic acid cycle; urine
Abstract:: ... Paris polyphylla var. yunnanensis as a traditional Chinese medicine has been used in the treatment of liver disease for thousands of years. Rhizoma paridis saponins (RPS), as the main active components of Paris polyphylla, have been used to treat liver injury. Anti-cirrhosis effect of Rhizoma paridis saponins (RPS) has not been known.We analyzed diethylnitrosamine (DEN)-induced metabonomic changes ...
DOI:: 10.1016/j.jep.2013.10.051
: https://doi.org/10.1016/j.jep.2013.10.051

22. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice

Author:: Fabio R.M. Borges; Morgana D. Silva; Marina M. Córdova; Tiago R. Schambach; Moacir G. Pizzolatti; Adair R.S. Santos
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 144-150
ISSN:: 0378-8741
Subject:: Polygala; aerial parts; anesthetics; anti-inflammatory activity; dexamethasone; inflammation; interleukin-10; interleukin-1beta; interleukin-6; intraperitoneal injection; kidneys; lipopolysaccharides; methylene chloride; mice; models; neutrophils; peritonitis; therapeutics; traditional medicine; tumor necrosis factor-alpha; Brazil
Abstract:: ... Polygala sabulosa A. W. Bennett is a small herb popularly known as “timutu-pinheirinho” that is widely distributed in southern Brazil and that is used to treat disorders of the bowel and kidney and as a topical anesthetic and expectorant in folk medicine. This study was designed to investigate the anti-inflammatory properties of the hydroalcoholic extract (HEPs), CH2Cl2 fraction and the steroid α- ...
DOI:: 10.1016/j.jep.2013.10.009
: https://doi.org/10.1016/j.jep.2013.10.009

23. Anti-inflammatory activity of animal oils from the Peruvian Amazon

Author:: Guillermo Schmeda-Hirschmann; Carla Delporte; Gabriela Valenzuela-Barra; Ximena Silva; Gabriel Vargas-Arana; Beatriz Lima; Gabriela E. Feresin
Source:: Journal of ethnopharmacology 2014 v.156 pp. 9-15
ISSN:: 0378-8741
Subject:: Boa constrictor; Chelonoidis; Electrophorus electricus; Escherichia coli; Geochelone; Inia geoffrensis; Melanosuchus niger; Salmonella Enteritidis; Staphylococcus aureus; animal fats and oils; anti-inflammatory activity; anti-inflammatory agents; antimicrobial properties; arachidonic acid; conservation status; dolphins; ears; edema; esters; fish; gas chromatography-mass spectrometry; linoleic acid; markets; mice; minimum inhibitory concentration; oleic acid; palmitic acid; reptiles; traditional medicine; Amazonia; Peru
Abstract:: ... Animal oils and fats from the fishes Electrophorus electricus and Potamotrygon motoro, the reptiles Boa constrictor, Chelonoidis denticulata (Geochelone denticulata) and Melanosuchus niger and the riverine dolphin Inia geoffrensis are used as anti-inflammatory agents in the Peruvian Amazon. The aim of the study was to assess the topic anti-inflammatory effect of the oils/fats as well as to evaluat ...
DOI:: 10.1016/j.jep.2014.08.010
: https://doi.org/10.1016/j.jep.2014.08.010

24. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats

Author:: K.D.K.P. Kumari; T.C.S. Weerakoon; S.M. Handunnetti; K. Samarasinghe; T.S. Suresh
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1202-1208
ISSN:: 0378-8741
Subject:: Aegle marmelos; anti-inflammatory activity; antioxidant activity; antioxidants; beverages; carrageenan; dose response; edema; erythrocytes; flowers; histamine; lipid peroxidation; nitric oxide; rats; rural areas; traditional medicine; trees; Asia
Abstract:: ... Almost all part of the plant Aegle marmelos (Bael tree) has been used in the traditional medicine systems of Asian countries to treat various diseases over many centuries. The water extract of the dried flowers of Aegle marmelos is a commonly used beverage among Sri Lankan population in rural areas. Although extensive investigations done on many parts of the plant there are no experimental data av ...
DOI:: 10.1016/j.jep.2013.12.043
: https://doi.org/10.1016/j.jep.2013.12.043

25. Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

Author:: Ling Tong; Tu Chen; Zhenzhong Chen; Peng Zhang; Huifang Pi; Hanli Ruan; Jizhou Wu
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1553-1560
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; anti-inflammatory activity; dose response; ears; edema; enzyme activity; ethanol; ethyl acetate; inducible nitric oxide synthase; inflammation; interleukin-6; lipopolysaccharides; macrophages; nitric oxide; prostaglandin synthase; rheumatoid arthritis; secretion; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; xylene
Abstract:: ... Radix Toddaliae Asiaticae has long been used as a traditional ethnic Chinese medicine for the treatment of inflammation and rheumatism. In our earlier communication we have reported the anti-arthritic activity of the ethyl alcohol extract and ethyl acetate fraction from Radix Toddaliae Asiaticae. This study was to examine the anti-inflammatory activity of prenylcoumarin omphalocarpin isolated from ...
DOI:: 10.1016/j.jep.2014.07.055
: https://doi.org/10.1016/j.jep.2014.07.055

26. Anti-inflammatory and analgesic activity of aqueous extract of Flos populi

Author:: Qianqian Xu; Yubo Wang; Shijin Guo; Zhiqiang Shen; Yanping Wang; Limei Yang
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 540-545
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Populus canadensis; Populus tomentosa; analgesic effect; analgesics; anti-inflammatory activity; arachidonic acid; carrageenan; cotton; diarrhea; dose response; ears; edema; formalin; granuloma; hot plate test; males; pain; writhing test; East Asia
Abstract:: ... Flos populi is an important traditional Chinese medicine prepared from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench (Salicaceae family). Flos populi is mainly used for the treatment of various inflammatory diseases and anti diarrhea in East Asian countries. The objective of this study was to investigate the anti-inflammatory and analgesic properties of the aqueous ...
DOI:: 10.1016/j.jep.2014.01.037
: https://doi.org/10.1016/j.jep.2014.01.037

27. Anti-inflammatory and anti-hypersensitive effects of the crude extract, fractions and triterpenes obtained from Chrysophyllum cainito leaves in mice

Author:: Nicole Anzanelo Meira; Luiz Carlos Klein Jr; Lilian W. Rocha; Zhelmy Martin Quintal; Franco Delle Monache; Valdir Cechinel Filho; Nara Lins Meira Quintão
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 975-983
ISSN:: 0378-8741
Subject:: Chrysophyllum cainito; acetates; adverse effects; anti-inflammatory activity; chemical constituents of plants; chloroform; diabetes mellitus; edema; hypersensitivity; interleukin-1beta; leaves; locomotion; mice; myeloperoxidase; neutrophils; pain; thin layer chromatography; traditional medicine; trees; triterpenoids; tumor necrosis factor-alpha
Abstract:: ... Chrysophyllum cainito, popularly known as “star apple”, caimito, “abiu-roxo” or “abiu-do-Pará”, is a tree of about 25m in height. Besides its culinary use, it is also used in folk medicine for the treatment of diabetes mellitus and several inflammatory diseases.The crude methanolic extract (CME) was submitted to phytochemical studies for obtaining fractions and isolated compounds. They were monito ...
DOI:: 10.1016/j.jep.2013.12.014
: https://doi.org/10.1016/j.jep.2013.12.014

28. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

Author:: Minjung Song; Hye-Jin Park
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
DOI:: 10.1016/j.jep.2013.12.059
: https://doi.org/10.1016/j.jep.2013.12.059

29. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

Author:: Ji-Sun Shin; Eu-Jin Cho; Hye-Eun Choi; Ji-Hyung Seo; Hyo-Jin An; Hee-Juhn Park; Young-Wuk Cho; Kyung-Tae Lee
Source:: Journal of ethnopharmacology 2014 v.158 pp. 291-300
ISSN:: 0378-8741
Subject:: Rubus coreanus; Rubus occidentalis; animal models; anti-inflammatory activity; asthma; body weight; colitis; colon; cytokines; dextran; diarrhea; epithelium; feces; hemorrhage; immunoassays; immunohistochemistry; lipopolysaccharides; luciferase; macrophage activation; macrophages; mechanism of action; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; sodium; stomach; therapeutics; traditional medicine; transcription factor NF-kappa B; triterpenoids
Abstract:: ... Rubus coreanus Miquel (Rosaceae), the Korean black raspberry, has traditionally been used to treat inflammatory diseases including diarrhea, asthma, stomach ailment, and cancer. Although previous studies showed that the 19α-hydroxyursane-type triterpenoids isolated from Rubus coreanus exerted anti-inflammatory activities, their effects on ulcerative colitis and mode of action have not been explore ...
DOI:: 10.1016/j.jep.2014.10.044
: https://doi.org/10.1016/j.jep.2014.10.044

30. Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis)

Author:: Kai Wang; Jianglin Zhang; Shun Ping; Quanxin Ma; Xuan Chen; Hongzhuan Xuan; Jinhu Shi; Cuiping Zhang; Fuliang Hu
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 300-311
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Populus canadensis; anti-inflammatory activity; antioxidant activity; buds; endotoxemia; ethanol; flavonoids; high performance liquid chromatography; histopathology; interleukin-10; interleukin-12; interleukin-1beta; interleukin-6; lungs; messenger RNA; propolis; protective effect; reporter genes; secretion; therapeutics; traditional medicine; tumor necrosis factor-alpha
Abstract:: ... Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese ...
DOI:: 10.1016/j.jep.2014.05.037
: https://doi.org/10.1016/j.jep.2014.05.037

31. Anti-stress effect of astragaloside IV in immobilized mice

Author:: Hyun-A. Oh; Hyuck Jai Choi; Nam Jae Kim; Dong-Hyun Kim
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 928-932
ISSN:: 0378-8741
Subject:: Astragalus membranaceus; antagonists; anti-inflammatory activity; anxiety; astragalosides; blood serum; corticosterone; enzyme-linked immunosorbent assay; ethanol; immunomodulation; inflammation; interleukin-6; mice; oral administration; roots; traditional medicine; tranquilizers; tumor necrosis factor-alpha
Abstract:: ... Astragaloside IV, a major component extracted from the roots of Astragalus membranaceus (AM), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. To clarify anti-stress effect of AM, anxiolytic and anti-inflammatory effects of 80% ethanol extract of AM and astragaloside IV were investigated in immobilization stress model.The mice were orally ad ...
DOI:: 10.1016/j.jep.2014.03.068
: https://doi.org/10.1016/j.jep.2014.03.068

32. Anti-trypanosomal activity of African medicinal plants: A review update

Author:: Mohammed Auwal Ibrahim; Aminu Mohammed; Murtala Bindawa Isah; Abubakar Babando Aliyu
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 26-54
ISSN:: 0378-8741
Subject:: African trypanosomiasis; antitrypanosomal properties; clinical trials; in vivo studies; livestock; medicinal plants; traditional medicine; tropical diseases
Abstract:: ... African trypanosomiasis is one of the neglected tropical diseases caused by different species of trypanosomes that affect both human and livestock with devastating consequences in the continent. Most of the affected populations commonly use traditional medicinal plants for the treatment of the disease. Consequently, this prompted ethnopharmacological research activities on the anti-trypanosomal ac ...
DOI:: 10.1016/j.jep.2014.04.012
: https://doi.org/10.1016/j.jep.2014.04.012

33. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo

Author:: Bengui Ye; Jun Li; Zu Li; Jinrong Yang; Ting Niu; Shu Wang
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 258-267
ISSN:: 0378-8741
Subject:: Marsdenia tenacissima; Western blotting; antineoplastic activity; apoptosis; asthma; caspase-3; caspase-9; cell cycle; cough; cyclins; cytotoxicity; esophageal neoplasms; genes; hepatoma; immunohistochemistry; lung neoplasms; medicinal plants; models; mononuclear leukocytes; neoplasm cells; staining; stomach neoplasms; traditional medicine; China
Abstract:: ... Marsdenia tenacissima, a traditional Chinese medicinal herb, endemic to Yunnan Province is widely used to treat cough, asthma, expectorant, esophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. The aim of this study was to evaluate in vitro and in vivo anti-hematologic neoplasm potential of the ethanolic extract of this herb (crude ethanolic extract of Marsdenia tenacissima ...
DOI:: 10.1016/j.jep.2014.02.035
: https://doi.org/10.1016/j.jep.2014.02.035

34. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

Author:: Hong-Xiang Sun; Li-Qing Chen; Juan Zhang; Feng-Yang Chen
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 831-839
ISSN:: 0378-8741
Subject:: GATA transcription factors; Musca domestica; Oriental traditional medicine; antibodies; antineoplastic activity; antineoplastic agents; blood serum; cell-mediated immunity; coma; cytotoxic T-lymphocytes; gene expression; immunoglobulin G; immunomodulators; insects; interferon-gamma; interleukin-10; larvae; mechanism of action; messenger RNA; mice; natural killer cells; necrosis; oral administration; osteomyelitis; protein content; sarcoma; splenocytes; stomach neoplasms; transcription (genetics)
Abstract:: ... The larvae of Musca domestica (Diptera: Muscidae) have been used traditionally for malnutritional stagnation, decubital necrosis, osteomyelitis, ecthyma and lip scald and also to treat coma and gastric cancer in the traditional Chinese medicine. Its in vitro antitumor activity and immunomodulatory effect in naïve mice in relation to the traditional uses were also reported. However, the in vivo ant ...
DOI:: 10.1016/j.jep.2014.03.052
: https://doi.org/10.1016/j.jep.2014.03.052

35. Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves

Author:: Erdem Yesilada; İlhan Gürbüz; Gülnur Toker
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 478-483
ISSN:: 0378-8741
Subject:: Sambucus ebulus; abscess; anti-ulcer activity; bioassays; butanol; chromatography; flavonols; fractionation; glycosides; in vivo studies; ion exchange; leaves; methanol; models; nuclear magnetic resonance spectroscopy; pain; peptic ulcers; rats; separation; silica gel; solvents; tissue repair; traditional medicine
Abstract:: ... Sambucus ebulus L. has a very prominent place in Turkish folk medicine. Leaves of the plant are practiced externally to relieve rheumatic pain, to treat abscess, for wound healing and internally against hemorrhoids and stomachache. In a previous work, aqueous extract of the leaves was shown to possess potent antiulcerogenic activity on water immersion and immobilization-induced stress ulcer model ...
DOI:: 10.1016/j.jep.2014.03.004
: https://doi.org/10.1016/j.jep.2014.03.004

36. Antibacterial activity of the roots, stems and leaves of Alchornea floribunda

Author:: X. Siwe Noundou; R.W.M. Krause; S.F. van Vuuren; D. Tantoh Ndinteh; D.K. Olivier
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 1023-1027
ISSN:: 0378-8741
Subject:: Alchornea; Bacillus cereus; Enterococcus faecalis; Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; Moraxella catarrhalis; Proteus mirabilis; Staphylococcus aureus; Staphylococcus saprophyticus; antibacterial properties; chloroform; ethanol; ethyl acetate; fungi; gastrointestinal system; leaf extracts; leaves; methanol; pathogens; phytopharmaceuticals; roots; solvents; stems; traditional medicine; Africa
Abstract:: ... Alchornea floribunda Müll. Arg. is used in traditional medicine across Africa for the treatment of bacterial, fungal, parasitic and inflammatory disorders.To evaluate the antibacterial activity of the crude extracts of different plant parts in order to provide a scientific rationale for the proposed broad efficacy of Alchornea floribunda in the treatment of bacterial infections.Extracts of roots, ...
DOI:: 10.1016/j.jep.2013.12.002
: https://doi.org/10.1016/j.jep.2013.12.002

37. Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

Author:: Dandan Cheng; Yingying Zhang; Demin Gao; Hongmeng Zhang
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1300-1305
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Pseudomonas aeruginosa; Pyrrosia; aerial parts; agar; anthraquinones; anti-inflammatory activity; anti-inflammatory agents; antibacterial properties; asthma; bronchitis; butanol; cell lines; cytotoxicity; ears; ethanol; ethyl acetate; flavonoids; lung neoplasms; mice; microorganisms; minimum inhibitory concentration; neoplasm cells; petroleum; phenols; pyelonephritis; reducing sugars; saponins; screening; solvents; splenocytes; steroids; terpenoids; xylene
Abstract:: ... Pyrrosia petiolosa is commonly used as a traditional Chinese medicine for treatment of acute pyelonephritis, chronic bronchitis and bronchial asthma. This study aims to evaluate the antibacterial activity of the ethanol extract and its derived fractions of Pyrrosia petiolosa obtained with solvents of different polarities and to perform the anti-inflammatory screening.The powdered aerial parts of P ...
DOI:: 10.1016/j.jep.2014.07.029
: https://doi.org/10.1016/j.jep.2014.07.029

38. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action

Author:: Daishu Mizuki; Kinzo Matsumoto; Ken Tanaka; Xoan Thi Le; Hironori Fujiwara; Tsutomu Ishikawa; Yoshihiro Higuchi
Source:: Journal of ethnopharmacology 2014 v.156 pp. 16-25
ISSN:: 0378-8741
Subject:: Butea superba; animal models; binding proteins; blood serum; cognitive disorders; corticosterone; dementia; dried herbs; drugs; elderly; hippocampus; immunohistochemistry; males; mechanism of action; medicinal plants; messenger RNA; mice; neurogenesis; plant extracts; sucrose; tail suspension test; tissues; traditional medicine
Abstract:: ... Butea superba (BS) is a Thai medicinal plant that has been used as a folk medicine to improve physical and mental conditions and to prevent impaired sexual performance in middle-aged or elderly males. We have previously reported that this plant extract could improve cognitive deficits and depression-like behavior in olfactory bulbectomized mice, an animal model of dementia and depression.In this s ...
DOI:: 10.1016/j.jep.2014.08.014
: https://doi.org/10.1016/j.jep.2014.08.014

39. Antidepressant-like effect of the hydroethanolic leaf extract of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice: Involvement of monoaminergic system

Author:: Ismail O. Ishola; Esther O. Agbaje; Moshood O. Akinleye; Chris O. Ibeh; Olufunmilayo O. Adeyemi
Source:: Journal of ethnopharmacology 2014 v.158 pp. 364-372
ISSN:: 0378-8741
Subject:: traditional medicine; dopamine; antidepressants; leaf extracts; locomotion; dose response; serotonin; antagonists; dopamine receptors; yohimbine; forced swimming test; behavior disorders; Alchornea cordifolia; mice; intraperitoneal injection; alpha-1 adrenergic receptors; oral administration; leaves; alpha-2 adrenergic receptors
Abstract:: ... The leaf of Alchornea cordifolia (Euphorbiaceae) is used in traditional African medicine in the treatment of various neurological and psychiatric disorders including depression. Previous studies have shown its potent antidepressant-like effect in the forced swimming test (FST). Hence, this study sought to investigate the involvement of monoaminergic systems in the antidepressant-like effect elicit ...
DOI:: 10.1016/j.jep.2014.10.008
: https://doi.org/10.1016/j.jep.2014.10.008

40. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats

Author:: Dan Li; Cheng Peng; Xiaofang Xie; Yu Mao; Min Li; Zhixing Cao; Danqing Fan
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 561-567
ISSN:: 0378-8741
Subject:: Malus toringoides; alloxan; animal disease models; blood glucose; blood serum; body weight; c-peptide; diabetes; flavonoids; glycemic effect; glycogen; glycosylation; hemoglobin; hyperglycemia; hyperlipidemia; hypertension; indigestion; leaves; liver; malondialdehyde; mice; mountains; plant growth; rats; snow; streptozotocin; superoxide dismutase; traditional medicine; China
Abstract:: ... The leaf of Malus toringoides (Rehd.) Hughes is a traditional folk medicine in Tibet, China, which is called “E Se” in Tibetan language. This original plant grows on snow mountains at an attitude of 3000 to 3700m. It is primarily used to treat hypertension, hyperlipidemia, hyperglycemia, indigestion and other diseases. This study aimed to evaluate the antidiabetic effect of flavonoids extracted fr ...
DOI:: 10.1016/j.jep.2014.02.026
: https://doi.org/10.1016/j.jep.2014.02.026

41. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

Author:: Hichem Sebai; Mohamed-Amine Jabri; Abdelaziz Souli; Kais Rtibi; Slimen Selmi; Olfa Tebourbi; Jamel El-Benna; Mohsen Sakly
Source:: Journal of ethnopharmacology 2014 v.152 no.2 pp. 327-332
ISSN:: 0378-8741
Subject:: Matricaria chamomilla; antidiarrheal effect; antioxidant activity; castor oil; catalase; chamomile; diarrhea; dose response; glutathione peroxidase; hydrogen peroxide; intestinal mucosa; iron; malondialdehyde; oral administration; oxidative stress; protective effect; rats; superoxide dismutase; traditional medicine
Abstract:: ... Matricaria recutita L. (Chamomile) has been widely used in the Tunisian traditional medicine for the treatment of digestive system disorders. The present work aims to investigate the protective effects of chamomile decoction extract (CDE) against castor oil-induced diarrhea and oxidative stress in rats.The antidiarrheal activity was evaluated using castor oil-induced diarrhea method. In this respe ...
DOI:: 10.1016/j.jep.2014.01.015
: https://doi.org/10.1016/j.jep.2014.01.015

42. Antigenotoxic and antioxidant effects of the Mongolian medicinal plant Leptopyrum fumarioides (L): An in vitro study

Author:: Delgerbat Boldbaatar; Hesham R. El-Seedi; Meriana Findakly; Safa Jabri; Batkhuu Javzan; Battsetseg Choidash; Ulf Göransson; Björn Hellman
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 599-606
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; DNA damage; antioxidant activity; antioxidants; butanol; catechol; comet assay; drugs; flavones; in vitro studies; medicinal plants; methanol; methylene chloride; mice; mutagens; neoplasm cells; traditional medicine; Mongolia
Abstract:: ... Leptopyrum fumarioides has been used in the traditional medicine of Mongolia for the treatment of various diseases, including drug intoxications. However, since there is only sparse information about its chemistry, active components, and pharmacological and toxicological effects, the major aim of the present study employing mouse lymphoma cells was to evaluate the genotoxic and antigenotoxic/antio ...
DOI:: 10.1016/j.jep.2014.06.005
: https://doi.org/10.1016/j.jep.2014.06.005

43. Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases

Author:: Nadir Abuzeid; Sadaf Kalsum; Richin John Koshy; Marie Larsson; Mikaela Glader; Henrik Andersson; Johanna Raffetseder; Elsje Pienaar; Daniel Eklund; Muddathir S. Alhassan; Haidar A. AlGadir; Waleed S. Koko; Thomas Schön; M. Ahmed Mesaik; Omer M. Abdalla; Asaad Khalid; Maria Lerm
Source:: Journal of ethnopharmacology 2014 v.157 pp. 134-139
ISSN:: 0378-8741
Subject:: Khaya senegalensis; Mycobacterium tuberculosis; Rosmarinus officinalis; active ingredients; antibacterial properties; antibiotics; avirulent strains; bark; butanol; chloroform; culture media; cytotoxicity; ethanol; ethyl acetate; fractionation; hexane; hydrophilicity; hydrophobicity; infectious diseases; inhibitory concentration 50; leaf extracts; macrophages; medicinal plants; multiple drug resistance; new drugs; screening; solvents; traditional medicine; Sudan
Abstract:: ... The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important source of new drugs, and design and implementation of antimycobacterial susceptibil ...
DOI:: 10.1016/j.jep.2014.09.020
: https://doi.org/10.1016/j.jep.2014.09.020

44. Antimycobacterial, anti-inflammatory and genotoxicity evaluation of plants used for the treatment of tuberculosis and related symptoms in South Africa

Author:: B. Madikizela; A.R. Ndhlala; J.F. Finnie; J. Van Staden
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 386-391
ISSN:: 0378-8741
Subject:: Abrus precatorius; Ficus; Mycobacterium tuberculosis; Phanerophlebia; Salmonella Typhimurium; Terminalia; anti-inflammatory activity; antibacterial properties; bioactive compounds; drug resistance; ethanol; genotoxicity; methylene chloride; minimum inhibitory concentration; petroleum; prostaglandin synthase; screening; solvents; traditional medicine; tuberculosis; South Africa
Abstract:: ... Emergence of drug-resistant tuberculosis strains and long duration of treatment has established an urgent need to search for new effective agents. The great floral diversity of South Africa has potential for producing new bioactive compounds, therefore pharmacological screening of plant extracts within this region offers much potential. To assess the in vitro antimycobacterial, anti-inflammatory a ...
DOI:: 10.1016/j.jep.2014.02.034
: https://doi.org/10.1016/j.jep.2014.02.034

45. Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L

Author:: Yu Wang; Ping Chen; Changyun Tang; Yao Wang; Yazhen Li; Hao Zhang
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 944-950
ISSN:: 0378-8741
Subject:: Carthamus tinctorius; acetic acid; analgesic effect; animal models; anti-inflammatory activity; anti-inflammatory agents; aspirin; dose response; ears; edema; formalin; formalin test; glycosides; high performance liquid chromatography; inflammation; kaempferol; mice; nociception; oral administration; pain; traditional medicine; writhing test; China
Abstract:: ... Safflower (Carthamus tinctorius L.) has been long used both in the traditional system and folk medicine as an analgesic anti-inflammatory agent in China. The aim of the study was to evaluate the antinociceptive and anti-inflammatory activities of hydroalcoholic extract (HE) and two isolated kaempferol glycosides of Carthamus tinctorius L. to provide experimental evidence for its traditional use.An ...
DOI:: 10.1016/j.jep.2013.12.003
: https://doi.org/10.1016/j.jep.2013.12.003

46. Antinociceptive property of Olax subscorpioidea Oliv (Olacaceae) extract in mice

Author:: Olusegun Adebayo Adeoluwa; Adegbuyi Oladele Aderibigbe; Elizabeth Toyin Olonode
Source:: Journal of ethnopharmacology 2014 v.156 pp. 353-357
ISSN:: 0378-8741
Subject:: Erythropalaceae; acetic acid; analgesics; behavior disorders; dose response; formalin; hot plate test; latent period; leaves; mice; neoplasms; pain; shrubs; tail; traditional medicine; trees; Nigeria
Abstract:: ... Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is used in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer. However, there is dearth of information on scientific basis for its folkloric use in the management of pain. Therefore, the study was designed to investigate the antinociceptive property of the extract of Olax subsc ...
DOI:: 10.1016/j.jep.2014.08.040
: https://doi.org/10.1016/j.jep.2014.08.040

47. Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats

Author:: Chun-Feng Zhang; Su-Li Zhang; Xin He; Xiao-Lin Yang; Hai-Tao Wu; Bao-Qin Lin; Cui-Ping Jiang; Jun Wang; Chun-Hao Yu; Zhong-Lin Yang; Chong-Zhi Wang; Ping Li; Chun-Su Yuan
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 793-800
ISSN:: 0378-8741
Subject:: Daphne genkwa; adjuvants; animal models; antioxidant activity; antioxidants; apigenin; blood viscosity; edema; herbal medicines; high performance liquid chromatography; histopathology; inflammation; luteolin; mass spectrometry; oxidative stress; pain; rats; rheumatoid arthritis; traditional medicine; weight loss; China
Abstract:: ... Genkwa flos (Daphne genkwa Sieb. et Zucc.), a Chinese herbal medicine, has been traditionally used for over two thousand years in China for inflammation related symptoms, including joint pain. To evaluate the antioxidative effects of flavonoid aglycones (FA) isolated from Genkwa flos on adjuvant arthritis in rats and to identify the relationship between antioxidant potential and whole blood viscos ...
DOI:: 10.1016/j.jep.2014.03.046
: https://doi.org/10.1016/j.jep.2014.03.046

48. Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils

Author:: Maria do Rosário Martins; Silvia Arantes; Fátima Candeias; Maria Teresa Tinoco; Júlio Cruz-Morais
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 485-492
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Artemia salina; Schinus molle; acute toxicity; agar; alpha-phellandrene; alpha-pinene; analgesics; antimicrobial properties; antioxidant activity; antioxidants; antiseptics; bacteria; beta-phellandrene; chemical composition; essential oils; food industry; free radicals; fruits; gas chromatography-mass spectrometry; leaves; limonene; mice; minimum inhibitory concentration; myrcene; parasympatholytics; pharmaceutical industry; screening; spoilage fungi; traditional medicine
Abstract:: ... Schinus molle L. has been used in folk medicine as antibacterial, antiviral, topical antiseptic, antifungal, antioxidant, anti-inflammatory, anti-tumoural as well as antispasmodic and analgesic; however, there are few studies of pharmacological and toxicological properties of Schinus molle essential oils. The aim of this study was to evaluate the antioxidant and antimicrobial activities of Schinus ...
DOI:: 10.1016/j.jep.2013.10.063
: https://doi.org/10.1016/j.jep.2013.10.063

49. Antiproliferative activity and new argininyl bufadienolide esters from the “cururú” toad Rhinella (Bufo) schneideri

Author:: Guillermo Schmeda-Hirschmann; Cristina Quispe; Cristina Theoduloz; Paulo Teixeira de Sousa; Carlos Parizotto
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1076-1085
ISSN:: 0378-8741
Subject:: Bufo; pressing; leukemia; erysipelas; neoplasm cells; spectral analysis; lungs; epithelium; inhibitory concentration 50; bladder; etoposide; alkaloids; toad venoms; spectroscopy; traditional medicine; human cell lines; bufadienolides; lung neoplasms; adenocarcinoma; Rhinella; toads; wetlands; parotid gland; bioactive properties; fibroblasts; Pantanal
Abstract:: ... Toads known as “cururú” (Rhinella schneideri) have been used in the Brazilian Pantanal and Paraguayan Chaco wetlands to treat erysipelas and cancer. The aim of the study was to assess the antiproliferative effect of the venom obtained from Rhinella schneideri and to identify its constituents by spectroscopic and spectrometric methods.The venom was obtained by gentle pressing the parotid glands of ...
DOI:: 10.1016/j.jep.2014.06.025
: https://doi.org/10.1016/j.jep.2014.06.025

50. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents

Author:: Jinlian Zhao; Dimitrios Evangelopoulos; Sanjib Bhakta; Alexander I. Gray; Véronique Seidel
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 796-800
ISSN:: 0378-8741
Subject:: 4-hydroxybenzoic acid; Arctium lappa; Mycobacterium tuberculosis; Tussilago farfara; ethyl acetate; growth retardation; hexane; kaempferol; methanol; methylene chloride; nuclear magnetic resonance spectroscopy; p-coumaric acid; quercetin; sitosterols; spectral analysis; stigmasterol; traditional medicine
Abstract:: ... Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was (i) to screen Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis and (ii) to isolate and identify the compound(s) responsible for this reputed anti-TB effect.The activity of extracts and isolated compounds was dete ...
DOI:: 10.1016/j.jep.2014.06.034
: https://doi.org/10.1016/j.jep.2014.06.034

51. Antitubercular constituents from Premna odorata Blanco

Author:: Stephen B. Lirio; Allan Patrick G. Macabeo; Erickson M. Paragas; Matthias Knorn; Paul Kohls; Scott G. Franzblau; Yuehong Wang; Ma. Alicia M. Aguinaldo
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 471-474
ISSN:: 0378-8741
Subject:: Mycobacterium tuberculosis; Premna; antibacterial properties; beta-sitosterol; colorimetry; formates; fractionation; gas chromatography-mass spectrometry; gel chromatography; leaves; medicinal plants; nuclear magnetic resonance spectroscopy; silica gel; solvents; stigmasterol; traditional medicine; tuberculosis; Philippines
Abstract:: ... Premna odorata Blanco (Lamiaceae) is a medicinal plant traditionally used in Albay Province, in southeastern Luzon, Philippines to treat tuberculosis. This study aimed to determine the antitubercular property of the crude extract and sub-extracts of the leaves, and to isolate the bioactive principles from the active fractions.Through extraction, solvent polarity-based fractionation and silica gel ...
DOI:: 10.1016/j.jep.2014.04.015
: https://doi.org/10.1016/j.jep.2014.04.015

52. Antitussive, expectorant and anti-inflammatory activities of different extracts from Exocarpium Citri grandis

Author:: Kun Jiang; Qian Song; Lei Wang; Tianzhu Xie; Xi Wu; Ping Wang; Guo Yin; Wencai Ye; Tiejie Wang
Source:: Journal of ethnopharmacology 2014 v.156 pp. 97-101
ISSN:: 0378-8741
Subject:: ammonia; animal models; anti-inflammatory activity; anti-inflammatory agents; cough; ears; edema; ethanol; freeze drying; mice; phenolsulfonphthalein; secretion; solvents; traditional medicine; xylene; China
Abstract:: ... Exocarpium Citri grandis (C. grandis, Huajuhong in Chinese), the epicarp of C. grandis ‘Tomentosa’, is used as an antitussive, expectorant and anti-inflammatory drug for hundreds of years in China. The study was aimed at evaluating the antitussive, expectorant and anti-inflammatory effects of different extracts of C. grandis, providing experimental evidence for its traditional use, and laying a fo ...
DOI:: 10.1016/j.jep.2014.08.030
: https://doi.org/10.1016/j.jep.2014.08.030

53. Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sessé ex DC. (balsam)

Author:: Viviane Carrasco; Lorraine Aparecida Pinto; Kátia Wolff Cordeiro; Claudia Andrea Lima Cardoso; Karine de Cássia Freitas
Source:: Journal of ethnopharmacology 2014 v.158 pp. 345-351
ISSN:: 0378-8741
Subject:: Sedum dendroideum; acetic acid; acidity; animals; anti-ulcer activity; antioxidant activity; antioxidants; chemical constituents of plants; cimetidine; ethanol; indomethacin; leaf extracts; leaves; models; mucus; nitric oxide; oxidation; pH; screening; secretion; stomach ulcers; subacute toxicity; toxicity testing; traditional medicine
Abstract:: ... The leaves of Sedum dendroideum, commonly known as balsam, have long been employed for the treatment of gastric ulcers. The aim of study was to evaluate the antiulcer activity and toxicological properties of Sedum dendroideum using induced gastric ulcer models in Wistar rats.The hydroethanolic extract of Sedum dendroideum (ESD) was analyzed using an acute ulcer model using ethanol and indomethacin ...
DOI:: 10.1016/j.jep.2014.10.042
: https://doi.org/10.1016/j.jep.2014.10.042

54. Are plants used for skin care in South Africa fully explored?

Author:: Namrita Lall; Navneet Kishore
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 61-84
ISSN:: 0378-8741
Subject:: Aloe; Artemisia afra; Harpephyllum caffrum; Sclerocarya birrea; Sideroxylon; Ximenia americana; cosmetics; hyperpigmentation; ingredients; medicinal plants; medicinal properties; therapeutics; traditional medicine; South Africa
Abstract:: ... South Africa is an important focal point of botanical diversity, and although many plant species have been used since ancient times in ethnomedicine, only a few species have hitherto been fully investigated scientifically. A large proportion of the South African population use traditional medicines for their physical and psychological health needs. Many medicinal plants have recently gained popula ...
DOI:: 10.1016/j.jep.2014.02.021
: https://doi.org/10.1016/j.jep.2014.02.021

55. Assessment of Cuscuta chinensis seeds׳ effect on melanogenesis: Comparison of water and ethanol fractions in vitro and in vivo

Author:: Tian-Jing Wang; Jing An; Xiao-Hui Chen; Qiu-Di Deng; Liu Yang
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 240-248
ISSN:: 0378-8741
Subject:: Cuscuta; Danio rerio; Western blotting; dose response; enzyme activity; ethanol; herbs; larvae; melanin; melanocytes; melanogenesis; melanoma; melanosis; messenger RNA; mice; models; mushrooms; phenotype; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; seeds; traditional medicine; Asia
Abstract:: ... Cuscuta chinensis seeds have traditionally been used to treat freckles and melasma in Asia, although recent reports have revealed that Semen cuscutae is a promoter of melanogenesis. The present study aims to investigate the mechanism of this opposite effect of Semen cuscutae on melanogenesis.In accordance with traditional usage, the water fraction and the ethanol fraction from Semen cuscutae (WFSC ...
DOI:: 10.1016/j.jep.2014.04.016
: https://doi.org/10.1016/j.jep.2014.04.016

56. Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)

Author:: G. Picard; C. Valadeau; J. Albán–Castillo; R. Rojas; J.R. Starr; R. Callejas-Posada; S.A.L. Bennett; J.T. Arnason
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1500-1507
ISSN:: 0378-8741
Subject:: Drymaria; Piper; anxiety; benzodiazepines; bioassays; enzyme inhibition; ethnobotany; gamma-aminobutyric acid; mechanism of action; surveys; traditional medicine; Peru
Abstract:: ... A previous pilot ethnobotanical and ethnopharmacological study with the Q‘echi׳ Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including ...
DOI:: 10.1016/j.jep.2014.07.039
: https://doi.org/10.1016/j.jep.2014.07.039

57. Atractylodes macrocephala Koidz promotes intestinal epithelial restitution via the polyamine—Voltage-gated K+ channel pathway

Author:: Hou-Pan Song; Ru-Liu Li; Xu Chen; Yi-Yu Wang; Jia-Zhong Cai; Jia Liu; Wei-Wen Chen
Source:: Journal of ethnopharmacology 2014 v.152 no.1 pp. 163-172
ISSN:: 0378-8741
Subject:: Atractylodes macrocephala; Oriental traditional medicine; Western blotting; alpha-difluoromethylornithine; calcium; cell movement; computer software; digestive system diseases; drugs; flow cytometry; high performance liquid chromatography; intestinal mucosa; membrane potential; messenger RNA; models; polystyrenes; potassium channels; protein content; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; spermidine
Abstract:: ... Atractylodes macrocephala Koidz (AMK) has been used widely as a digestive and tonic in traditional Chinese medicine. AMK has shown noteworthy promoting effect on intestinal epithelial cell migration, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study was to investigate the efficacy of AMK on intestinal mucosal restitution and the underl ...
DOI:: 10.1016/j.jep.2013.12.049
: https://doi.org/10.1016/j.jep.2013.12.049

58. Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics

Author:: Haojun Zhang; Tingting Zhao; Yuewen Gong; Xi Dong; Weiku Zhang; Sifan Sun; Hua Wang; Yanting Gu; Xiaoguang Lu; Meihua Yan; Ping Li
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 556-564
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; animal disease models; blood glucose; blood serum; diabetic nephropathy; excretion; fibrosis; herbs; immunohistochemistry; intraperitoneal injection; kidneys; mechanism of action; messenger RNA; protein content; rats; transcription factor NF-kappa B; transforming growth factor beta 1; tumor necrosis factor-alpha; urine; China
Abstract:: ... Traditional Chinese medical herbs have been used in China for a long time to treat different diseases. Based on traditional Chinese medicine (TCM) principle, Chaihuang-Yishen granule (CHYS) was developed and has been employed clinically to treat chronic kidney disease including diabetic nephropathy (DN). The present study was designed to investigate its mechanism of action in treatment of DN.Diabe ...
DOI:: 10.1016/j.jep.2013.11.020
: https://doi.org/10.1016/j.jep.2013.11.020

59. Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats

Author:: Chen-Liang Tsai; Yu-Chieh Lin; Hui-Min Wang; Tz-Chong Chou
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 197-206
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Scutellaria baicalensis; antioxidant activity; body weight; catheters; edema; enzyme activity; flavonoids; heme oxygenase (biliverdin-producing); histopathology; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; models; myeloperoxidase; nitrates; nitrites; rats; superoxide anion; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Baicalein (BE), a phenolic flavonoid extracted mainly from the root of Scutellaria baicalensis Georgi, a Chinese herb, is traditionally used in oriental medicine. Several studies have demonstrated that BE exerts many beneficial effects including anti-inflammatory and antioxidant activities. However, its effect on acute lung injury (ALI) and the molecular mechanisms involved remain unclear and warr ...
DOI:: 10.1016/j.jep.2014.02.010
: https://doi.org/10.1016/j.jep.2014.02.010

60. Bidirectional effects of methanol extract of Wei-Chang-An pill on gastrointestinal transit and the spasmolytic activity on isolated rat jejunum

Author:: Zhuo Qu; Jingze Zhang; Wenyuan Gao; Huimin Guo; Changxiao Liu
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 203-212
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; acetylcholine; calcium; chlorides; digestive system diseases; dose response; gastric emptying; gastrointestinal transit; jejunum; methanol; mice; muscarine receptors; parasympatholytics; potassium; rats; verapamil
Abstract:: ... Wei-Chang-An pill (WCA pill), a traditional Chinese medicine, has been used for treating various gastrointestinal diseases for several decades. Despite the popular medicinal use of WCA pill, less data was available to its activity and mechanism in gastrointestinal disorders. To examine the effects of the methanol extract of WCA pill (ME) on gastrointestinal tract so as to assess some of the possib ...
DOI:: 10.1016/j.jep.2014.05.017
: https://doi.org/10.1016/j.jep.2014.05.017

61. Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation

Author:: Joana Liberal; Vera Francisco; Gustavo Costa; Artur Figueirinha; Maria Teresa Amaral; Carla Marques; Henrique Girão; Maria Celeste Lopes; Maria Teresa Cruz; Maria Teresa Batista
Source:: Journal of ethnopharmacology 2014 v.158 pp. 113-122
ISSN:: 0378-8741
Subject:: Fragaria vesca; anti-inflammatory activity; autophagy; gastrointestinal system; inflammation; kaempferol; leaf extracts; leaves; macrophages; neoplasms; nitric oxide; nitrites; proanthocyanidins; proteasome endopeptidase complex; proteins; proteolysis; quercetin; traditional medicine; ubiquitination
Abstract:: ... Fragaria vesca leaves have been used in folk medicine for the treatment of several diseases, namely gastrointestinal, cardiovascular and urinary disorders, which could be related with the potential anti-inflammatory properties of the extract. This work aims to disclose the bioactivity and the underlying action mechanism of an extract from Fragaria vesca leaves in order to support its traditional u ...
DOI:: 10.1016/j.jep.2014.09.043
: https://doi.org/10.1016/j.jep.2014.09.043

62. Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses

Author:: Lei Zhang; Rong Yan; Ruyu Su; Cong Yang; Sijun Liu; Xuhua Yu; Xiang Chang; Shijie Zhang; Changhui Liu; Meili Xu; Wu Zeng; Yunbo Chen; Qi Wang
Source:: Journal of ethnopharmacology 2014 v.152 no.2 pp. 266-271
ISSN:: 0378-8741
Subject:: Alzheimer disease; Cnidium monnieri; Oriental traditional medicine; active ingredients; bioavailability; fruits; high performance liquid chromatography; oral administration; pharmacokinetics; rats; synergism; China
Abstract:: ... Bushen Yizhi prescription (BSYZ) is a traditional Chinese compound prescription, which is commonly used in China for treating ShenXu and hypophrenia based on traditional Chinese medicine and Alzheimer's Disease according to modern Chinese medicine. Cnidium monnieri (L.) Cusson fruits (CM) is treated as the main herb of BSYZ, and its main active ingredient Osthole (OST) is considered as one of the ...
DOI:: 10.1016/j.jep.2013.09.045
: https://doi.org/10.1016/j.jep.2013.09.045

63. Biochemical and hematological effects of acute and sub-acute administration to ethyl acetate fraction from the stem bark Scutia buxifolia Reissek in mice

Author:: Andreia R.H. da Silva; Laís da R. Moreira; Evelyne da S. Brum; Mayara L. de Freitas; Aline A. Boligon; Margareth L. Athayde; Silvane S. Roman; Cinthia M. Mazzanti; Ricardo Brandão
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 908-916
ISSN:: 0378-8741
Subject:: Organization for Economic Cooperation and Development; Scutia buxifolia; aspartate transaminase; bark; behavior change; blood platelets; ethyl acetate; females; glucose; guidelines; hematocrit; hemoglobin; histology; histopathology; leukocytes; liver; males; mice; mortality; toxicity; toxicity testing; traditional medicine; Argentina; Brazil; Uruguay
Abstract:: ... Scutia buxifolia is a native tree of Southern Brazil, Uruguay, and Argentina, which is popularly known as “coronilha” and it is used as a cardiotonic, antihypertensive and diuretic substance. The aim of this study was to assess the acute and sub-acute toxicity of the ethyl acetate fraction from the stem bark Scutia buxifolia in male and female mice.The toxicity studies were based on the guidelines ...
DOI:: 10.1016/j.jep.2014.03.063
: https://doi.org/10.1016/j.jep.2014.03.063

64. Biodistribution evaluation of icaritin in rats by ultra-performance liquid chromatography–tandem mass spectrometry

Author:: Shuang-Qing Zhang
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1382-1387
ISSN:: 0378-8741
Subject:: Epimedium; acetonitrile; coumestrol; herbal medicines; ionization; liquid chromatography; rats; tandem mass spectrometry; tissue distribution; tissues; traditional medicine
Abstract:: ... Icaritin (ICT) is a major bioactive prenylflavonoid derivative contained in the Epimedium which is a widely used herbal medicine for the treatment of infertility, impotence, cardiovascular and skeletal diseases listed in the Chinese Pharmacopoeia. The aim of this study is to investigate the tissue distribution of ICT in rats by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC ...
DOI:: 10.1016/j.jep.2014.07.045
: https://doi.org/10.1016/j.jep.2014.07.045

65. Biomolecular evidence of anti-inflammatory effects by Clematis mandshurica Ruprecht root extract in rodent cells

Author:: Chul Won Lee; Sang Mi Park; Youn Sook Kim; Kyung Hwan Jegal; Jong Rok Lee; Il Je Cho; Sae Kwang Ku; Ji Yeon Lee; Yong-Tae Ahn; Yonghae Son; Seong A. Ju; Sang Chan Kim; Won G. An
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1141-1155
ISSN:: 0378-8741
Subject:: Clematis terniflora var. mandshurica; analgesics; anti-inflammatory activity; anti-inflammatory agents; arthritis; dose response; edema; gene expression; hepatitis; histopathology; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; macrophages; mast cells; messenger RNA; mitogen-activated protein kinase; nitric oxide; prostaglandin synthase; prostaglandins; protein synthesis; rats; therapeutics; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha; Asia
Abstract:: ... Clematis mandshurica Ruprecht root is widely used in Asia as an analgesic and anti-inflammatory agent. This research investigated the anti-inflammatory effects of Clematis mandshurica Ruprecht root extract (CRE) using RAW 264.7 macrophage cells and carrageenan- (CA-) induced rat paw edema.Production of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, nitric oxide (NO) and prostaglandin ...
DOI:: 10.1016/j.jep.2014.06.048
: https://doi.org/10.1016/j.jep.2014.06.048

66. Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats

Author:: O.B. Oloyede; T.O. Ajiboye; A.F. Abdussalam; A.O. Adeleye
Source:: Journal of ethnopharmacology 2014 v.157 pp. 309-319
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Blighia sapida; DNA; animal disease models; antioxidant activity; blood glucose; blood serum; catalase; diabetes; dose response; glibenclamide; glucose 6-phosphate; glutathione peroxidase; glutathione-disulfide reductase; glycemic effect; high density lipoprotein cholesterol; hydrogen peroxide; hydroxyl radicals; hyperlipidemia; iron; leaf extracts; leaves; lipid peroxides; liver; low density lipoprotein cholesterol; malondialdehyde; oral administration; oxidative stress; pancreas; rats; superoxide dismutase; traditional medicine; triacylglycerols; Nigeria
Abstract:: ... Blighia sapida leaves are used in the management of diabetes in Nigeria. Thus the antidiabetic activity of methanolic Blighia sapida leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats were investigated.In vitro antioxidant activity of the extract (0.2–1.0mg/mL) was investigated using 2,2-diphenyl-1-1picrylhydrazyl (DPPH) radical, superoxide i ...
DOI:: 10.1016/j.jep.2014.08.022
: https://doi.org/10.1016/j.jep.2014.08.022

67. Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

Author:: Shuping Fu; Yong Gu; Jian-Qin Jiang; Xi Chen; Mingjing Xu; Xingmiao Chen; Jiangang Shen
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 692-701
ISSN:: 0378-8741
Subject:: adults; animal models; blood-brain barrier; brain; cortex; endothelial cells; glycosides; histology; infarction; ischemia; isoflavones; metalloproteinases; neuroprotective effect; nitric oxide; permeability; proteins; rats; stroke; tight junctions; traditional medicine
Abstract:: ... Astragali Radix (AR) has been used for thousands years to treat ischemic stroke. Calycosin and its glycoside form calycosin-7-O-β-d-glucoside (CG) are two representative isoflavones in Astragali Radix. However, its neurological effects and related molecular mechanisms are largely unknown. The present study aims to evaluate the neuroprotective effects of CG on blood–brain barrier (BBB) integrity of ...
DOI:: 10.1016/j.jep.2014.06.015
: https://doi.org/10.1016/j.jep.2014.06.015

68. Cardiovascular protective effects of Casearia sylvestris Swartz in Swiss and C57BL/6 LDLr-null mice undergoing high fat diet

Author:: Nayara Mercedes Frediani Brant; Francielly Mourão Gasparotto; Valdinei de Oliveira Araújo; Jhonatan Christian Maraschin; Rita de Cassia Lima Ribeiro; Emerson Luiz Botelho Lourenço; Euclides Lara Cardozo Junior; Arquimedes Gasparotto Junior
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 419-427
ISSN:: 0378-8741
Subject:: Casearia; aldosterone; aorta; atherogenesis; atherosclerosis; blood lipids; blood serum; colorimetry; high density lipoprotein cholesterol; high fat diet; histopathology; hyperlipidemia; lipid peroxidation; low density lipoprotein cholesterol; mice; models; nitrites; obesity; oral administration; oxidative stress; peptidyl-dipeptidase A; platelet aggregation; protective effect; renal function; systolic blood pressure; traditional medicine; triacylglycerols; vasopressin
Abstract:: ... Although Casearia sylvestris Swartz is used in Brazilian folk medicine to treat obesity, no study has been conducted to evaluate the effects of this species in an experimental model of dyslipidemia and atherosclerosis. So, the aim of this study was to evaluate possible hypolipemiant and antiatherogenic activity of the methanolic extract obtained from Casearia sylvestris (MECS) using Swiss and C57B ...
DOI:: 10.1016/j.jep.2014.04.019
: https://doi.org/10.1016/j.jep.2014.04.019

69. Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages

Author:: Chian-Jiun Liou; Wen-Bin Len; Shu-Ju Wu; Chwan-Fwu Lin; Xin-Ling Wu; Wen-Chung Huang
Source:: Journal of ethnopharmacology 2014 v.158 pp. 310-316
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Vitex rotundifolia; Western blotting; anti-inflammatory activity; apoptosis; enzyme-linked immunosorbent assay; fruits; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasm cells; nitric oxide; prostaglandin synthase; prostaglandins; protein synthesis; signal transduction; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... The fruits of Vitex rotundifolia L. are widely used to treat inflammation of the airway in Traditional Chinese medicine. Previous studies found that casticin, isolated from Vitex rotundifolia, could induce apoptosis of tumor cells. In this study, we evaluated the anti-inflammatory effects of casticin and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophages.RAW264.7 ...
DOI:: 10.1016/j.jep.2014.10.046
: https://doi.org/10.1016/j.jep.2014.10.046

70. Cathinone, an active principle of Catha edulis, accelerates oxidative stress in the limbic area of swiss albino mice

Author:: Mohammed M. Safhi; Mohammad Firoz Alam; Sohail Hussain; Mohammed Abdul Hakeem Siddiqui; Gulrana Khuwaja; Ibrahim Abdu Jubran Khardali; Rashad Mohammed Al-Sanosi; Fakhrul Islam
Source:: Journal of ethnopharmacology 2014 v.156 pp. 102-106
ISSN:: 0378-8741
Subject:: Catha edulis; antioxidants; brain; catalase; enzyme activity; glutathione; lipid peroxidation; males; mice; oxidative stress; superoxide dismutase; traditional medicine
Abstract:: ... Cathinone hydrochloride is an active principle of the khat plant (Catha edulis) that produces pleasurable and stimulating effects in khat chewers. To the best of our knowledge no data of cathinone on oxidative stress in limbic areas of mice is available. This is the first study of cathinone on oxidative stress in limbic areas of the brain in Swiss albino male mice.The animals were divided into fou ...
DOI:: 10.1016/j.jep.2014.08.004
: https://doi.org/10.1016/j.jep.2014.08.004

71. Cecropia pachystachya extract attenuated the renal lesion in 5/6 nephrectomized rats by reducing inflammation and renal arginase activity

Author:: Claudia C. Maquiaveli; Edson R. da Silva; Lara C. Rosa; Heloísa D.C. Francescato; João Francisco Lucon Júnior; Cleonice G.A. Silva; Dulce E. Casarini; Fernanda A. Ronchi; Terezila M. Coimbra
Source:: Journal of ethnopharmacology 2014 v.158 pp. 49-57
ISSN:: 0378-8741
Subject:: Cecropia; albuminuria; arginase; bladder; chemokine CCL2; cortex; enzyme activity; excretion; glomerular filtration rate; histology; hypertension; inflammation; kidney diseases; kidneys; macrophages; males; mitogen-activated protein kinase; nitric oxide; peptidyl-dipeptidase A; rats; surgery; systolic blood pressure; traditional medicine; transforming growth factor beta
Abstract:: ... The plant Cecropia pachystachya Trécul has been used in Brazilian folk medicine to treat hypertension, bladder and kidney inflammation and renal diseases. The aim of this study was to evaluate the potential of the aqueous fraction from the ethanolic extract of Cecropia pachystachya (FCP) in the management of hypertension, inflammation and progressive renal disease in rats submitted to 5/6 nephrect ...
DOI:: 10.1016/j.jep.2014.09.042
: https://doi.org/10.1016/j.jep.2014.09.042

72. Challenges of safety evaluation

Author:: Jacqueline Wiesner
Source:: Journal of ethnopharmacology 2014 v.158 pp. 467-470
ISSN:: 0378-8741
Subject:: guidelines; marketing; mutagenicity; traditional medicine
Abstract:: ... Each application for authorisation of a medicinal product must be accompanied by the particulars and documents referred to in Directive 2001/83/EC on the Community code relating to medicinal products for human use. Details on the documentation needed for traditional herbal medicinal products (THMP) are given in article 16c of the above mentioned Directive. It is pointed out that a bibliographic re ...
DOI:: 10.1016/j.jep.2014.08.013
: https://doi.org/10.1016/j.jep.2014.08.013

73. Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin

Author:: Premrutai Thitilertdecha; Richard H. Guy; Michael G. Rowan
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 400-407
ISSN:: 0378-8741
Subject:: Clerodendrum; Petasites; absorption; aerial parts; antioxidant activity; apigenin; asthma; chrysin; clinical trials; cough; ferulic acid; fever; hesperetin; high performance liquid chromatography; luteolin; mammals; mass spectrometry; naringenin; nuclear magnetic resonance spectroscopy; permeability; plant extracts; polyphenols; prediction; skin diseases; topical application; traditional medicine; vanillic acid; verbascoside; vomiting; Thailand
Abstract:: ... Clerodendrum petasites S. Moore (CP) has been widely prescribed in Thailand and neighbouring countries for both oral and topical administration to treat asthma, fever, cough, vomiting and skin diseases, for at least 30 years. However, the nature of the active species remains poorly characterized and there have been no clinical trials concerning the topical delivery of this medicine. The study aims ...
DOI:: 10.1016/j.jep.2014.04.021
: https://doi.org/10.1016/j.jep.2014.04.021

74. Chemical characterization of Centaurium erythrea L. and its effects on carbohydrate and lipid metabolism in experimental diabetes

Author:: Gjoshe Stefkov; Biljana Miova; Suzana Dinevska-Kjovkarovska; Jasmina Petreska Stanoeva; Marina Stefova; Gordana Petrusevska; Svetlana Kulevanova
Source:: Journal of ethnopharmacology 2014 v.152 no.1 pp. 71-77
ISSN:: 0378-8741
Subject:: Centaurium; aerial parts; animal disease models; bitter-tasting compounds; blood; blood glucose; blood lipids; carbohydrate metabolism; chemical composition; cholesterol; diabetes; enzyme activity; flavonoids; formic acid; freeze drying; glibenclamide; glucose-6-phosphatase; glycemic effect; glycogen; high density lipoprotein; hyperglycemia; lipid metabolism; low density lipoprotein; maceration; mechanism of action; medicinal plants; methanol; phosphorylase; rats; secoiridoids; streptozotocin; traditional medicine; triacylglycerols; ultrasonics; xanthones; Balkans
Abstract:: ... Centaurium erythrea L. fam. Gentianaceae (CE) has been traditionally used for centuries in folk medicine of Balkans as a bitter medicinal herb for digestive complications and for treating febrile conditions and diabetes. The aim of this study was to gain insight into the chemical composition and underlying biochemical mechanism of action of the antihyperglycemic and antilipidemic activities of the ...
DOI:: 10.1016/j.jep.2013.11.047
: https://doi.org/10.1016/j.jep.2013.11.047

75. Chemical composition and antinociceptive effect of aqueous extract from Rourea induta Planch. leaves in acute and chronic pain models

Author:: Milena Kalegari; Murilo Luiz Cerutti; Sérgio José Macedo-Júnior; Franciane Bobinski; Marilis Dallarmi Miguel; Véronique Eparvier; Adair Roberto Soares Santos; Didier Stien; Obdulio Gomes Miguel
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 801-809
ISSN:: 0378-8741
Subject:: Chagas disease; Rourea; adjuvants; analgesic effect; chemical composition; chlorogenic acid; formalin; hypersensitivity; interleukin-1beta; leaves; locomotion; mice; models; oral administration; pain; procyanidins; quercetin; receptors; shrubs; spinal cord; temperature; titration; traditional medicine; trees; tumor necrosis factor-alpha; Brazil
Abstract:: ... Rourea induta Planch. is a small tree or shrub growing wild in Brazil and belonging to the Connaraceae family. It is used for the treatment of Chagas disease and as antirheumatic in folk medicine. This study was designed to investigate the antinociceptive activity of the aqueous extract (AERi) of Rourea induta leaves in rodents, as well as isolate and identify components that can be responsible fo ...
DOI:: 10.1016/j.jep.2014.03.045
: https://doi.org/10.1016/j.jep.2014.03.045

76. Chemical composition, potential toxicity, and quality control procedures of the crude drug of Cyrtopodium macrobulbon

Author:: Viridiana Morales-Sánchez; Isabel Rivero-Cruz; Guillermo Laguna-Hernández; Gerardo Salazar-Chávez; Rachel Mata
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 790-797
ISSN:: 0378-8741
Subject:: acute toxicity; alcohols; analgesic effect; chemical composition; chemical constituents of plants; cineole; drugs; formates; gas chromatography-mass spectrometry; guidelines; headspace analysis; high performance liquid chromatography; hydroxybenzaldehyde; lethal dose 50; men; mice; models; quality control; solid phase microextraction; traditional medicine; volatile compounds; Mexico
Abstract:: ... Cyrtopodium macrobulbon (“cañaveral”) has been long used in Mexican traditional medicine for the treatment of painful urinary ailments (“mal de orin”) in men. This study was conducted (i) to establish the potential acute toxicity and the antinociceptive activity of some preparations of Cyrtopodium macrobulbon, in order to demonstrate its preclinical efficacy for treating symptoms of “mal de orin”; ...
DOI:: 10.1016/j.jep.2014.05.006
: https://doi.org/10.1016/j.jep.2014.05.006

77. Chemical variability along the value chains of turmeric (Curcuma longa): A comparison of nuclear magnetic resonance spectroscopy and high performance thin layer chromatography

Author:: Anthony Booker; Debora Frommenwiler; Deborah Johnston; Chinenye Umealajekwu; Eike Reich; Michael Heinrich
Source:: Journal of ethnopharmacology 2014 v.152 no.2 pp. 292-301
ISSN:: 0378-8741
Subject:: Curcuma longa; case studies; computer software; farmers; herbal medicines; income; interviews; livelihood; medicinal plants; metabolomics; multivariate analysis; nuclear magnetic resonance spectroscopy; powders; supply chain; thin layer chromatography; traditional medicine; turmeric; Europe; India; United States
Abstract:: ... Herbal medicine value chains have generally been overlooked compared with food commodities. Not surprisingly, revenue generation tends to be weighted towards the end of the chain and consequently the farmers and producers are the lowest paid beneficiaries. Value chains have an impact both on the livelihood of producers and on the composition and quality of products commonly sold locally and global ...
DOI:: 10.1016/j.jep.2013.12.042
: https://doi.org/10.1016/j.jep.2013.12.042

78. A Chinese medicine preparation induces neuroprotection by regulating paracrine signaling of brain microvascular endothelial cells

Author:: Weihong Li; Pengtao Li; Ziwang Liu; Qinghong Du; Andre Steinmetz; Ning Wang; Huan Du; Jinghong Hu
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 686-693
ISSN:: 0378-8741
Subject:: Gardenia jasminoides; Oriental traditional medicine; Panax notoginseng; Western blotting; brain; calcium; cytochrome c; drugs; endothelial cells; fluorescent antibody technique; herbs; ischemia; membrane potential; mitochondrial membrane; models; neurons; neuroprotective effect; paracrine signaling; platelet-activating factor; staining; therapeutics; vascular endothelial growth factors
Abstract:: ... Tong Luo Jiu Nao injection (TLJN), a Chinese medicine preparation, was extracted from the Chinese herbs Panax notoginseng and Gardenia jasminoides. Its pharmacological effect on cerebral ischemia was observed in the study. We previously reported that paracrine signaling of brain microvascular endothelial cells (BMECs) had a direct impact on the survival of neurons in mimicked cerebral ischemia in ...
DOI:: 10.1016/j.jep.2013.11.035
: https://doi.org/10.1016/j.jep.2013.11.035

79. Chromatographic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang decoction and their characterization

Author:: Jianwu Zhou; Guanzhen Gao; Qiuping Chu; Huiqin Wang; Pingfan Rao; Lijing Ke
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1116-1123
ISSN:: 0378-8741
Subject:: Ephedra sinica; alkaloids; atomic force microscopy; cell proliferation; cell viability; emulsions; ephedrine; gel chromatography; light scattering; medicinal properties; metabolism; nanoparticles; phytopharmaceuticals; pseudoephedrine; reversed-phase liquid chromatography; scanning electron microscopy; solutes; traditional medicine
Abstract:: ... The herbal decoction is a complex dispersion system containing solutes, colloid, aggregates, emulsions and precipitates. In which phase bioactive phytochemicals are dispersed determines their delivery, action and metabolism. This study took ephedrine, a well-studied and widely used phytochemical, as an example to elucidate its exact distribution in the phases of Ma-Xing-Shi-Gan-Tang decoction (MXS ...
DOI:: 10.1016/j.jep.2013.12.029
: https://doi.org/10.1016/j.jep.2013.12.029

80. Citrullus colocynthis (L.) Schrad (bitter apple fruit): A review of its phytochemistry, pharmacology, traditional uses and nutritional potential

Author:: Abdullah I. Hussain; Hassaan A. Rathore; Munavvar Z.A. Sattar; Shahzad A.S. Chatha; Satyajit D. Sarker; Anwar H. Gilani
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 54-66
ISSN:: 0378-8741
Subject:: Citrullus colocynthis; adverse effects; alkaloids; anti-inflammatory activity; antioxidants; apples; asthma; bronchitis; cardiovascular diseases; colic; common cold; constipation; cough; cytotoxicity; databases; deserts; diabetes; digestive system; dysentery; essential oils; ethnobotany; fatty acids; flavonoids; fruits; functional foods; gastroenteritis; glycosides; indigestion; insecticides; jaundice; leprosy; mastitis; minerals; neoplasms; neutralization; nutrient content; nutritive value; protein content; surveys; therapeutics; traditional medicine
Abstract:: ... Citrullus colocynthis (L.) Schrad is a valuable cucurbit plant, widely distributed in the desert areas of the world. Citrullus colocynthis fruits are usually recognized for its wide range of medicinal uses as well as pharmaceutical and nutraceutical potential. This review aims to appraise the published information on the ethnobotanical knowledge, phytochemistry, ethnopharmacology, nutraceutical po ...
DOI:: 10.1016/j.jep.2014.06.011
: https://doi.org/10.1016/j.jep.2014.06.011

81. Clinical trials of traditional Chinese medicine in the treatment of diabetic nephropathy—A systematic review based on a subgroup analysis

Author:: Xiaoyu Liu; Ling Liu; Pinyi Chen; Liang Zhou; Yanqi Zhang; Yazhou Wu; Lei Jiang; Dixiang Cheng; Wenquan Huang; Dong Yi
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 810-819
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; confidence interval; databases; diabetic nephropathy; ingredients; randomized clinical trials; relative risk; renal function; systematic review
Abstract:: ... The purpose of this study is to systematically evaluate the efficacy of traditional Chinese medicine (TCM) decoctions with different ingredients in the treatment of diabetic nephropathy (DN).Papers obtained after the retrieval of randomized controlled clinical trials (RCTs) of TCM treatments of diabetic nephropathy through online database (e.g. Medline, CBM, CNKI, VIP, the online database of Chine ...
DOI:: 10.1016/j.jep.2013.11.028
: https://doi.org/10.1016/j.jep.2013.11.028

82. Cnidoscolus chayamansa Mc Vaugh, an important antioxidant, anti-inflammatory and cardioprotective plant used in Mexico

Author:: Rosa Virginia García-Rodríguez; Gabriel Alfonso Gutiérrez-Rebolledo; Enrique Méndez-Bolaina; Alberto Sánchez-Medina; Octavio Maldonado-Saavedra; Miguel Ángel Domínguez-Ortiz; Maribel Vázquez-Hernández; Omar David Muñoz-Muñiz; Jesús Samuel Cruz-Sánchez
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 937-943
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Cnidoscolus chayamansa; acute toxicity; animal models; anti-inflammatory activity; antioxidant activity; cardioprotective effect; diabetes; diet; digestive system diseases; ears; edema; ethanol; ethyl acetate; free radical scavengers; ischemia; leaves; lethal dose 50; maceration; medicinal plants; mice; nutritive value; rheumatoid arthritis; therapeutics; traditional medicine; Central America; Mexico
Abstract:: ... Cnidoscolus chayamansa Mc Vaugh (Euphorbiaceae) is commonly known as ‘chaya’ in Central America. In South East Mexico, because of its high nutritional values, is an important part of the diet of many indigenous communities. Chaya is also used as a traditional remedy for the treatment of diabetes, rheumatism, gastrointestinal disorders and inflammation-related diseases. Although Cnidoscolus chayama ...
DOI:: 10.1016/j.jep.2013.12.004
: https://doi.org/10.1016/j.jep.2013.12.004

83. Combination use of ferulic acid, ligustrazine and tetrahydropalmatine inhibits the growth of ectopic endometrial tissue: A multi-target therapy for endometriosis rats

Author:: Qing Tang; Fanghong Shang; Xiaocui Wang; Yang Yang; Gang Chen; Yi Chen; Jifen Zhang; Xiaoyu Xu
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1218-1225
ISSN:: 0378-8741
Subject:: Angelica; IKappaB kinase; Oriental traditional medicine; blood serum; endometrium; ferulic acid; follicle-stimulating hormone; gonadotropin-releasing hormone; interleukin-1beta; lovage; luteinizing hormone; macrophages; menstruation; phagocytosis; protein synthesis; rats; rhizomes; therapeutics; tumor necrosis factor-alpha
Abstract:: ... Ferulic acid (FA), ligustrazine (LZ) and tetrahydropalmatine (THP) are separately isolated from Chinese Angelica, Szechwan Lovage Rhizome and Rhizoma in the Jiawei-Foshou-San formula, a popular traditional Chinese medicine for irregular menses. It has been reported that the combination use of FA+LZ+THP has similar effect on endometriosis, but the underlying mechanisms are unclear. This study was t ...
DOI:: 10.1016/j.jep.2013.12.047
: https://doi.org/10.1016/j.jep.2013.12.047

84. Comparative metabolism of Radix scutellariae extract by intestinal bacteria from normal and type 2 diabetic mice in vitro

Author:: Jun Xu; Min Zhao; Dawei Qian; Er-xin Shang; Shu Jiang; Jianming Guo; Jin-ao Duan; Leyue Du
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 368-374
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; absorption; active ingredients; animal disease models; automation; baicalin; beta-glucuronidase; bioactive properties; blood flow; computer software; digestive system; intestinal microorganisms; liquids; mass spectrometry; medicinal plants; metabolism; metabolites; mice; noninsulin-dependent diabetes mellitus; pathological processes and conditions; ultra-performance liquid chromatography; China
Abstract:: ... Traditional Chinese medicine (TCM) has been used in clinical practice for several thousand years. TCM has played an indispensable role in the prevention and treatment of disease, especially the complicated and chronic ones. In TCMs, many ingredients which are known to have biological effects just pass through the gut, they do not get into the bloodstream. Study on interactions of these active ingr ...
DOI:: 10.1016/j.jep.2014.02.020
: https://doi.org/10.1016/j.jep.2014.02.020

85. Comparative pharmacokinetic investigation on baicalin and wogonoside in type 2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction

Author:: Meng-Yun He; Yuan-Xiong Deng; Qun-Zhi Shi; Xiao-Jie Zhang; Yuan Lv
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 334-342
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; animal disease models; baicalin; herbs; high fat diet; high performance liquid chromatography; intraperitoneal injection; noninsulin-dependent diabetes mellitus; oral administration; pharmacokinetics; rats; streptozotocin; China
Abstract:: ... Huanglian Jiedu decoction (HLJDD) is used traditionally in China for the treatment of diabetes mellitus in clinical practice, which has been proved to be effective. The purpose of this study was to investigate the pharmacokinetic characteristics (especially the area under the curve, AUC) of baicalin and wogonoside in type 2 diabetic rats after oral administration of HLJDD extract and to explore it ...
DOI:: 10.1016/j.jep.2014.05.033
: https://doi.org/10.1016/j.jep.2014.05.033

86. Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats

Author:: Xiu-Jun Wu; Meng-Liang Zhang; Xiang-Yong Cui; J. Paul Fawcett; Jing-Kai Gu
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 839-845
ISSN:: 0378-8741
Subject:: absorption; active ingredients; bioavailability; drugs; edema; half life; inflammation; intravenous injection; isomers; liquid chromatography; oral administration; pharmacokinetics; rats; sodium; tandem mass spectrometry; traditional medicine; triterpenoid saponins
Abstract:: ... Adequate pharmacokinetic data of escin, a natural mixture of triterpene saponins used for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema, is of special interest in view of the growing use of escin agent in clinical medicine. However, pharmacokinetic data are inadequate to support their clinical indication. Escin Ib and isoescin Ib are the chief active ingredient ...
DOI:: 10.1016/j.jep.2013.11.039
: https://doi.org/10.1016/j.jep.2013.11.039

87. Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes

Author:: Mei-Ling Hou; Li-Wen Chang; Chi-Hung Lin; Lie-Chwen Lin; Tung-Hu Tsai
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1291-1299
ISSN:: 0378-8741
Subject:: Rheum palmatum; absorption; constipation; electrospray ionization mass spectrometry; gene expression; gene expression regulation; genes; half life; liquid chromatography; microarray technology; pharmacokinetics; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; traditional medicine
Abstract:: ... Rhein is a pharmacological active component found in Rheum palmatum L. that is the major herb of the San-Huang-Xie-Xin-Tang (SHXXT), a medicinal herbal product used as a remedy for constipation. Here we have investigated the comparative pharmacokinetics of rhein in normal and constipated rats. Microarray analysis was used to explore whether drug-metabolizing genes will be altered after SHXXT treat ...
DOI:: 10.1016/j.jep.2014.07.022
: https://doi.org/10.1016/j.jep.2014.07.022

88. Comparison of chemical compositions and osteoprotective effects of different sections of velvet antler

Author:: Sung-Hui Tseng; Chun-Hsien Sung; Lih-Geeng Chen; Ying-Jang Lai; Wei-Shun Chang; Hsin-Ching Sung; Ching-Chiung Wang
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 352-360
ISSN:: 0378-8741
Subject:: Cervus nippon; alkaline phosphatase; amino acids; calcium; chemical composition; estradiol; femur; insulin-like growth factor I; mineralization; osteocalcin; osteoporosis; ovariectomy; testosterone; traditional medicine; velvet antlers; vertebrae; water solubility
Abstract:: ... Velvet antlers (VA) have been claimed for centuries to have numerous medical benefits including strengthen bones. To investigate and compare the anti-osteoporotic activities from different sections of VA.Fresh VA prepared from farmed sika deers (Cervus nippon) was divided into upper (VAU), middle (VAM), and basal (VAB) sections. The chemical constituents and anti-osteoporotic effect of different s ...
DOI:: 10.1016/j.jep.2013.10.060
: https://doi.org/10.1016/j.jep.2013.10.060

89. Comparisons of the chemical profiles, cytotoxicities and anti-inflammatory effects of raw and rice wine-processed Herba Siegesbeckiae

Author:: Tao Su; Hua Yu; Hiu-Yee Kwan; Xiao-Qing Ma; Hui-Hui Cao; Chi-Yan Cheng; Alexander Kai-Man Leung; Chi-Leung Chan; Wei-Dong Li; Hui Cao; Wang-Fun Fong; Zhi-Ling Yu
Source:: Journal of ethnopharmacology 2014 v.156 pp. 365-369
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; anti-inflammatory activity; bromides; cultured cells; cytotoxicity; herbs; inducible nitric oxide synthase; lipopolysaccharides; liquids; macrophages; mass spectrometry; medicinal plants; messenger RNA; models; nitric oxide; prostaglandin synthase; rice; rice wines; stigmasterol
Abstract:: ... Although slightly toxic, the Chinese medicinal herb Herba Siegesbeckiae (HS) has long been used as a remedy for traditional Chinese medicine symptoms that resemble inflammatory joint disorders, because it can eliminate the wind-dampness and soothe painful joints. Proper processing can reduce the toxicity and/or enhance the efficacy of raw herbs. In this study, we aim to examine if processing with ...
DOI:: 10.1016/j.jep.2014.09.038
: https://doi.org/10.1016/j.jep.2014.09.038

90. Complement activity of polysaccharides from three different plant parts of Terminalia macroptera extracted as healers do

Author:: Yuan-Feng Zou; Bing-Zhao Zhang; Kari Tvete Inngjerdingen; Hilde Barsett; Drissa Diallo; Terje Einar Michaelsen; Berit Smestad Paulsen
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 672-678
ISSN:: 0378-8741
Subject:: Terminalia; acetates; anion exchange chromatography; arabinogalactans; bark; bioactive properties; boiling; chemical composition; complement; cough; diarrhea; fever; gas chromatography-mass spectrometry; gel chromatography; hepatitis; immune system; leaves; malaria; physicochemical properties; traditional medicine; tuberculosis; Mali
Abstract:: ... Water decoctions of the root bark, stem bark and leaves of Terminalia macroptera are used by traditional healers in Mali to cure a wide range of illnesses, such as wounds, hepatitis, malaria, fever, cough and diarrhea as well as tuberculosis. Plant polysaccharides isolated from crude water extracts have previously shown effects related to the immune system. The aims of this study are comparing the ...
DOI:: 10.1016/j.jep.2014.06.017
: https://doi.org/10.1016/j.jep.2014.06.017

91. Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman – A case report with pharmaceutical analysis

Author:: Mike H. Pillukat; Carolin Bester; Andreas Hensel; Matthias Lechtenberg; Frank Petereit; Susanne Beckebaum; Klaus-Michael Müller; Hartmut H.J. Schmidt
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 165-170
ISSN:: 0378-8741
Subject:: adverse effects; albumins; case studies; dialysis; dietary supplements; drug therapy; drug toxicity; drugs; epicatechin; epigallocatechin gallate; green tea; health promotion; hepatitis; high performance liquid chromatography; histology; monitoring; neoplasms; risk; traditional medicine; women
Abstract:: ... Etnopharmacological Relevance: The popularity of concentrated green tea extracts as dietary supplements for a wide range of applications is increasing due to their health-promoting effects attributed to the high amounts of catechins they contain. The most important of the green tea catechins is (−)-epigallocatechin-3-O-gallate (EGCG). While their beneficiary effects have been studied extensively, ...
DOI:: 10.1016/j.jep.2014.05.015
: https://doi.org/10.1016/j.jep.2014.05.015

92. Confocal mirco-Raman spectroscopic analysis of the antioxidant protection mechanism of the oligosaccharides extracted from Morinda officinalis on human sperm DNA

Author:: Di-Ling Chen; Ning Li; Li Lin; He-ming Long; Hui Lin; Jun Chen; He-Ming Zhang; Chang-chun Zeng; Song-Hao Liu
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 119-124
ISSN:: 0378-8741
Subject:: DNA; Morinda; Oriental traditional medicine; Raman spectroscopy; coculture; herbal medicines; herbs; hydrogen peroxide; male fertility; models; oligosaccharides; principal component analysis; screening; society; spectral analysis; spermatozoa
Abstract:: ... Male infertility is a stressful and frustrating problem for the society, but a number of male infertility treatments are available as traditional Chinese medicine strategies which have been tried with variable success, while evidence is still limited on whether-or how much-herbs or supplements might help increase fertility, so the aim of this study was to investigate if the oligosaccharides extrac ...
DOI:: 10.1016/j.jep.2014.01.021
: https://doi.org/10.1016/j.jep.2014.01.021

93. Consensus analysis of sastric formulations used by non-institutionally trained siddha medical practitioners of Virudhunagar and Tirunelveli districts of Tamil Nadu, India

Author:: S. Mutheeswaran; P. Pandikumar; M. Chellappandian; S. Ignacimuthu; V. Duraipandiyan; M. Logamanian
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 290-296
ISSN:: 0378-8741
Subject:: animals; aphrodisiacs; data analysis; gastrointestinal system; health status; heart; ingredients; interviews; jaundice; physicians; quantitative analysis; traditional medicine; India
Abstract:: ... Siddha system of traditional medicine has been practiced in Tamil Nadu. This system of medicine has a high number of non-institutionally trained practitioners but studies on their traditional medicinal knowledge are not adequate. The present study is aimed to document and analyze the sastric (traditional) formulations used by the non-institutionally trained siddha medical practitioners in Virudhun ...
DOI:: 10.1016/j.jep.2014.02.043
: https://doi.org/10.1016/j.jep.2014.02.043

94. Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

Author:: Thomas Friedemann; Benjamin Otto; Kristin Klätschke; Udo Schumacher; Yi Tao; Alexander Kai-Man Leung; Thomas Efferth; Sven Schröder
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 607-615
ISSN:: 0378-8741
Subject:: Coptis chinensis; NAD (coenzyme); NADH dehydrogenase; Oriental traditional medicine; alkaloids; anti-inflammatory activity; apoptosis; cell viability; diabetic neuropathy; genes; membrane potential; mitochondrial membrane; neurodegenerative diseases; neuroprotective effect; oxidative stress; quantitative polymerase chain reaction; reactive oxygen species; reverse transcriptase polymerase chain reaction; rhizomes; therapeutics
Abstract:: ... The dried rhizome of Coptis chinensis Franch. (family Ranunculaceae) is traditionally used in Chinese medicine for the treatment of inflammatory diseases and diabetes. Recent studies showed a variety of activities of Coptis chinensis Franch. alkaloids, including neuroprotective, neuroregenerative, anti-diabetic, anti-oxidative and anti-inflammatory effects. However, there is no report on the neuro ...
DOI:: 10.1016/j.jep.2014.06.004
: https://doi.org/10.1016/j.jep.2014.06.004

95. Counteraction of Bothrops snake venoms by Combretum leprosum root extract and arjunolic acid

Author:: Fabrício F.A. Fernandes; Marcelo A. Tomaz; Camila Z. El-Kik; Marcos Monteiro-Machado; Marcelo A. Strauch; Bruno L. Cons; Matheus S. Tavares-Henriques; Adélia C.O. Cintra; Valdir A. Facundo; Paulo A. Melo
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 552-562
ISSN:: 0378-8741
Subject:: Bothrops jararaca; Combretum leprosum; accidents; collagenase; creatine kinase; death; edema; enzyme activity; hematocrit; hemorrhage; hyaluronoglucosaminidase; mice; mortality; phospholipase A2; phospholipases; proteolysis; protocols; snake bites; snake venoms; traditional medicine; Brazil
Abstract:: ... Serotherapy against snakebite is often unavailable in some regions over Brazil, where people make use of plants from folk medicine to deal with ophidic accidents. About 10% of Combretum species have some ethnopharmacological use, including treatment of snakebites.We evaluated the ability of the extract of Combretum leprosum and its component arjunolic acid to reduce some in vivo and in vitro effec ...
DOI:: 10.1016/j.jep.2014.05.056
: https://doi.org/10.1016/j.jep.2014.05.056

96. Cuscuta chinensis Lam.: A systematic review on ethnopharmacology, phytochemistry and pharmacology of an important traditional herbal medicine

Author:: Sineeporn Donnapee; Jin Li; Xi Yang; Ai-hua Ge; Paul Owusu Donkor; Xiu-mei Gao; Yan-xu Chang
Source:: Journal of ethnopharmacology 2014 v.157 pp. 292-308
ISSN:: 0378-8741
Subject:: Cuscuta; abortifacients; active ingredients; anti-inflammatory agents; antidepressants; antioxidant activity; antioxidants; aphrodisiacs; essential oils; fatty acids; flavonoids; glycosides; herbal medicines; hydroquinone; in vitro studies; lignans; medicinal properties; models; pain; pharmacokinetics; phenolic acids; phytopharmaceuticals; plant extracts; polysaccharides; renal failure; steroids; systematic review; traditional medicine; China; India; Korean Peninsula; Pakistan; Thailand; Vietnam
Abstract:: ... Cuscuta chinensis Lam. has found its use as a traditional medicine in China, Korea, Pakistan, Vietnam, India and Thailand. It is commonly used as an anti-aging agent, anti-inflammatory agent, pain reliever and aphrodisiac. To provide an overview of the ethnopharmacology, phytochemistry, pharmacokinetics, pharmacology and clinical applications of Cuscuta chinensis, as well as being an evidence base ...
DOI:: 10.1016/j.jep.2014.09.032
: https://doi.org/10.1016/j.jep.2014.09.032

97. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice

Author:: Cuihua Jiang; Nan Yao; Qingqing Wang; Jinghua Zhang; Yan Sun; Na Xiao; Kang Liu; Fang Huang; Shengzuo Fang; Xulan Shang; Baolin Liu; Yicheng Ni; Zhiqi Yin; Jian Zhang
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 344-351
ISSN:: 0378-8741
Subject:: Cyclocarya paliurus; adipocytes; adiponectin; adipose tissue; diabetes; glucose; glucose tolerance tests; glycogen; homeostasis; indigenous species; inflammation; insulin; insulin receptor substrate proteins; insulin resistance; interleukin-6; leaf extracts; leaves; liver; macrophages; metformin; mice; muscles; phosphorylation; plants (botany); quantitative polymerase chain reaction; resistin; reverse transcriptase polymerase chain reaction; serine; traditional medicine; tyrosine
Abstract:: ... Cyclocarya paliurus Batal., a Chinese native plant, is the sole species in its genus and its leaves have been widely used as a remedy for diabetes in traditional folk medicine. The study was undertaken to evaluate the effects of Cyclocarya paliurus leaves extracts (CPE) on adipokine expression and insulin sensitivity in mice.Mice were stimulated with conditioned medium (prepared from activated mac ...
DOI:: 10.1016/j.jep.2014.02.003
: https://doi.org/10.1016/j.jep.2014.02.003

98. Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu—A Rasayana from Indian Ayurveda

Author:: Ranjit K. Harwansh; Kakali Mukherjee; Santanu Bhadra; Amit Kar; Shiv Bahadur; Achintya Mitra; Pulok K. Mukherjee
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 674-681
ISSN:: 0378-8741
Subject:: Ayurvedic medicine; Piper longum; Piper nigrum; Zingiber officinale; asthma; cough; cytochrome P-450; digestive system diseases; drugs; enzymes; fever; fluorescence; ingredients; inhibitory concentration 50; isozymes; liver microsomes; rats; reversed-phase high performance liquid chromatography; screening; India
Abstract:: ... Trikatu is a very well known ‘Rasayana’ in Ayurveda and widely used as a polyherbal ayurvedic formulation in India. It consists of three well known plants, viz., Piper longum (PL), Piper nigrum (PN) and Zingiber officinale (ZO) in equal ratio. Trikatu has been prescribed for cough, cold, fever, asthma, respiratory problems and improvement of digestive disorders. The aim of the present study was to ...
DOI:: 10.1016/j.jep.2014.03.023
: https://doi.org/10.1016/j.jep.2014.03.023

99. Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy

Author:: Niko S. Radulović; Dragan B. Zlatković; Tatjana Ilić-Tomić; Lidija Senerović; Jasmina Nikodinovic-Runic
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 125-132
ISSN:: 0378-8741
Subject:: Reseda lutea; apoptosis; benzyl isothiocyanate; cell cycle; cell lines; cytotoxicity; fibroblasts; flowers; fruits; gas chromatography-mass spectrometry; melanoma; metabolites; nuclear magnetic resonance spectroscopy; traditional medicine
Abstract:: ... Reseda lutea L. (Resedaceae) or Wild Mignonette is a widely distributed plant species. Pliny the Elder (AD 23–AD 79), a Roman scholar and naturalist, reported the use of R. lutea for reducing tumors in his Historia naturalis. Accounts of the beneficial effects of R. lutea in tumor treatment could also be found in the works of later authors, such as Étienne François Geoffroy (1672–1731) and Samuel ...
DOI:: 10.1016/j.jep.2014.01.034
: https://doi.org/10.1016/j.jep.2014.01.034

100. Cytotoxicity and apoptogenic effects of Lafoensia pacari

Author:: Daniela Beck da Silva Marcondes; Cristiane Loiva Reichert; Lucas Ferrari de Andrade; Cid Aimbiré de Moraes Santos; Almeriane Maria Weffort-Santos
Source:: Journal of ethnopharmacology 2014 v.157 pp. 243-250
ISSN:: 0378-8741
Subject:: American Indians; Lafoensia; apoptosis; cell cycle checkpoints; cell proliferation; cytotoxicity; high performance liquid chromatography; human cell lines; in vitro studies; lactate dehydrogenase; methanol; neoplasm cells; traditional medicine
Abstract:: ... The stem barks of Lafoensia pacari have been traditionally used not only by South Amerindians but also by Brazilian and Paraguayan populations for treating a variety of unhealthy conditions to which their biological potential has been scientifically documented in several reports over the last decade. Although its anticancer usage is also popular, no scientific support for such activity has been fo ...
DOI:: 10.1016/j.jep.2014.09.018
: https://doi.org/10.1016/j.jep.2014.09.018

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1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

4. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

5. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

6. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

7. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

8. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

9. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

10. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

11. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

12. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

13. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

14. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

15. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

16. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate

17. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

18. Anti-biofilm activity of Marula – A study with the standardized bark extract

19. Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

20. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model

21. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

22. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice

23. Anti-inflammatory activity of animal oils from the Peruvian Amazon

24. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats

25. Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

26. Anti-inflammatory and analgesic activity of aqueous extract of Flos populi

27. Anti-inflammatory and anti-hypersensitive effects of the crude extract, fractions and triterpenes obtained from Chrysophyllum cainito leaves in mice

28. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

29. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

30. Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis)

31. Anti-stress effect of astragaloside IV in immobilized mice

32. Anti-trypanosomal activity of African medicinal plants: A review update

33. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo

34. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

35. Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves

36. Antibacterial activity of the roots, stems and leaves of Alchornea floribunda

37. Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

38. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action

39. Antidepressant-like effect of the hydroethanolic leaf extract of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice: Involvement of monoaminergic system

40. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats

41. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

42. Antigenotoxic and antioxidant effects of the Mongolian medicinal plant Leptopyrum fumarioides (L): An in vitro study

43. Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases

44. Antimycobacterial, anti-inflammatory and genotoxicity evaluation of plants used for the treatment of tuberculosis and related symptoms in South Africa

45. Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L

46. Antinociceptive property of Olax subscorpioidea Oliv (Olacaceae) extract in mice

47. Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats

48. Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils

49. Antiproliferative activity and new argininyl bufadienolide esters from the “cururú” toad Rhinella (Bufo) schneideri

50. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents

51. Antitubercular constituents from Premna odorata Blanco

52. Antitussive, expectorant and anti-inflammatory activities of different extracts from Exocarpium Citri grandis

53. Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sessé ex DC. (balsam)

54. Are plants used for skin care in South Africa fully explored?

55. Assessment of Cuscuta chinensis seeds׳ effect on melanogenesis: Comparison of water and ethanol fractions in vitro and in vivo

56. Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)

57. Atractylodes macrocephala Koidz promotes intestinal epithelial restitution via the polyamine—Voltage-gated K+ channel pathway

58. Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics

59. Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats

60. Bidirectional effects of methanol extract of Wei-Chang-An pill on gastrointestinal transit and the spasmolytic activity on isolated rat jejunum

61. Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation

62. Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses

63. Biochemical and hematological effects of acute and sub-acute administration to ethyl acetate fraction from the stem bark Scutia buxifolia Reissek in mice

64. Biodistribution evaluation of icaritin in rats by ultra-performance liquid chromatography–tandem mass spectrometry

65. Biomolecular evidence of anti-inflammatory effects by Clematis mandshurica Ruprecht root extract in rodent cells

66. Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats

67. Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

68. Cardiovascular protective effects of Casearia sylvestris Swartz in Swiss and C57BL/6 LDLr-null mice undergoing high fat diet

69. Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages

70. Cathinone, an active principle of Catha edulis, accelerates oxidative stress in the limbic area of swiss albino mice