Journal: Journal of ethnopharmacology / Journal name: Journal of ethnopharmacology / Publication Year: 2014

1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

Author:: Jean Paul Dzoyem; Victor Kuete; Lyndy J. McGaw; Jacobus N. Eloff
Source:: Journal of ethnopharmacology 2014 v.156 pp. 1-8
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Adansonia digitata; Aframomum; Mycobacterium aurum; Mycobacterium fortuitum; Mycobacterium smegmatis; Tamarindus indica; antibacterial properties; antioxidant activity; antioxidants; bromides; cytotoxicity; enzyme inhibition; flavonoids; fruits; herbs; infectious diseases; inflammation; inhibitory concentration 50; kidneys; lethal concentration 50; medicinal properties; minimum inhibitory concentration; monkeys; pain; spices; tetrazolium; traditional medicine; Africa
Abstract:: ... Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their traditional use and safety. In this study, the 15-lipoxygenase inhibitory, antioxidant, antim ...
DOI:: 10.1016/j.jep.2014.08.007
: https://doi.org/10.1016/j.jep.2014.08.007

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

Author:: Qinxiao Guan; Shengwang Liang; Zhanhong Wang; Yongxia Yang; Shumei Wang
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 65-75
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; amino acids; apoptosis; biochemical pathways; brain; cerebrovascular disorders; death; emodin; energy; histopathology; infarction; ingredients; ischemia; metabolomics; models; neurons; nuclear magnetic resonance spectroscopy; pharmacodynamics; principal component analysis; protective effect; rats; rhubarb; society; urine
Abstract:: ... The ischemia cerebrovascular disease is one of leading causes of death and long-term disability in modern society. Rhubarb is one of the common traditional Chinese medicine with many effects, and the main pharmacodynamic ingredients are aloe-emodin, rhein, emodin, chrysophanol and physcion. The five components are also known as rhubarb aglycone. Rhubarb aglycone has been confirmed to play a remark ...
DOI:: 10.1016/j.jep.2014.03.002
: https://doi.org/10.1016/j.jep.2014.03.002

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

Author:: Jong Rhan Kim; Jinhwan Choi; Jiyoung Kim; Heejeung Kim; Heerim Kang; Eun Hye Kim; Jeong-Hwa Chang; Yeong-Eun Kim; Young Jin Choi; Ki Won Lee; Hyong Joo Lee
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 365-371
ISSN:: 0378-8741
Subject:: ginsenosides; immunomodulators; plant extracts; oral administration; metabolites; Dermatophagoides farinae; chemokine CCL22; skin lesions; ears; monoclonal antibodies; splenocytes; traditional medicine; blood serum; histology; anti-allergic agents; mice; Panax; eosinophils; atopic dermatitis; mast cells
Abstract:: ... Ginseng and ginsenosides are frequently used in the treatment of chronic inflammatory diseases. Recently, 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol (GPD), the main metabolite of ginsenosides, was reported to have both anti-allergic and anti-pruritic effects. The immunomodulatory effects of GPD-fortified ginseng extract (GFGE) on atopic dermatitis (AD)-like symptoms in mice were investigated. T ...
DOI:: 10.1016/j.jep.2013.10.058
: https://doi.org/10.1016/j.jep.2013.10.058

4. 4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities

Author:: Ki Hyun Kim; Eunjung Moon; Sun Yeou Kim; Sang Un Choi; Jei Hyun Lee; Kang Ro Lee
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 503-508
ISSN:: 0378-8741
Subject:: Raphanus sativus; anti-inflammatory agents; antineoplastic activity; carbon; fractionation; human cell lines; inducible nitric oxide synthase; inhibitory concentration 50; mice; neoplasm cells; neuroglia; nitrites; nuclear magnetic resonance spectroscopy; protein synthesis; seed extracts; seeds; stable isotopes; sulforaphane; traditional medicine
Abstract:: ... Raphanus sativus seeds (Brassicaceae) known as Raphani Semen have long been used as anti-cancer and/or anti-inflammatory agents in Korean traditional medicine. This study was designed to isolate the bioactive constituents from the seed extracts of Raphanus sativus and evaluate their anti-inflammatory and antitumor activities.Bioassay-guided fractionation and chemical investigation of a methanolic ...
DOI:: 10.1016/j.jep.2013.11.003
: https://doi.org/10.1016/j.jep.2013.11.003

5. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Author:: Yanyan Yang; Woo Seok Yang; Tao Yu; Gi-Ho Sung; Kye Won Park; Keejung Yoon; Young-Jin Son; Hyunsik Hwang; Yi-Seong Kwak; Chang-Muk Lee; Man Hee Rhee; Jong-Hoon Kim; Jae Youl Cho
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 218-228
ISSN:: 0378-8741
Subject:: Panax ginseng; anti-inflammatory activity; apoptosis; cyclic AMP; gastritis; herbal medicines; inducible nitric oxide synthase; inflammation; interferon regulatory factor-3; interferons; lipopolysaccharides; luciferase; messenger RNA; mice; mitogen-activated protein kinase; models; nitric oxide; peritonitis; prostaglandin synthase; traditional medicine; Korean Peninsula
Abstract:: ... Korean Red Ginseng (KRG) is one of the representative traditional herbal medicines prepared from Panax ginseng Meyer (Araliaceae) in Korea. It has been reported that KRG exhibits a lot of different biological actions such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, anti-cancer, and anti-inflammatory activities. Although systematic studies have investigated how KR ...
DOI:: 10.1016/j.jep.2014.04.008
: https://doi.org/10.1016/j.jep.2014.04.008

6. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative

Author:: Xian Yang; Liuliu Yuan; Chaomei Xiong; Chunping Yin; Jinlan Ruan
Source:: Journal of ethnopharmacology 2014 v.157 pp. 105-113
ISSN:: 0378-8741
Subject:: Cyclosorus; Western blotting; antioxidants; blood circulation; blood serum; blood stasis; castration; catalase; edema; glutathione peroxidase; glycosides; histopathology; hydrolysates; hyperplasia; immunohistochemistry; inflammation; interleukin-17; interleukin-1beta; interleukin-6; interleukin-8; models; oral administration; oxidative stress; phosphatidylinositol 3-kinase; prostaglandin synthase; protective effect; rats; subcutaneous injection; superoxide dismutase; testosterone; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Abacopteris penangiana (Hook.) Ching (AP) is a member of parathelypteris glanduligera and used in folk medicine for the treatment of blood circulation and blood stasis, edema and inflammation as recorded in the ″Chinese Materia Medica″.The purpose of this study was to investigate the effects of total flavanol glycosides (TFA) from AP and its acid hydrolysate (AHT) on testosterone-induced benign pr ...
DOI:: 10.1016/j.jep.2014.09.025
: https://doi.org/10.1016/j.jep.2014.09.025

7. Absorption and metabolism of three monoester-diterpenoid alkaloids in Aconitum carmichaeli after oral administration to rats by HPLC–MS

Author:: Hai Zhang; Qiong Wu; Wuhong Li; Sen Sun; Wen Zhang; Zhenyu Zhu; Guoqing Zhang; Yifeng Chai
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 645-652
ISSN:: 0378-8741
Subject:: Aconitum; P-glycoproteins; absorption; alkaloids; bacterial artificial chromosomes; bioavailability; chemical constituents of plants; herbal medicines; high performance liquid chromatography; liver microsomes; males; mass spectrometry; oral administration; pharmacokinetics; quality control; rats; toxicity; traditional medicine
Abstract:: ... Ethnopharmacological relevance:Aconitum carmichaelii (AC) is a well-known herbal medicine for its excellent pharmacological effects and toxicity. The monoester-diterpenoid alkaloids (MDAs), including benzoylmesaconine (BMC), benzoylaconine (BAC) and benzoylhyaconine (BHC), are the main active components in AC. It was found that the diester alkaloids could be transformed into monoester-diterpenoid ...
DOI:: 10.1016/j.jep.2014.04.039
: https://doi.org/10.1016/j.jep.2014.04.039

8. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Author:: Lian-Wu Xie; Atanas G. Atanasov; De-An Guo; Clemens Malainer; Jing-Xian Zhang; Martin Zehl; Shu-Hong Guan; Elke H. Heiss; Ernst Urban; Verena M. Dirsch; Brigitte Kopp
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 470-477
ISSN:: 0378-8741
Subject:: Lycium chinense; Oriental traditional medicine; active ingredients; agonists; amides; antagonists; bark; cortex; diabetes mellitus; ethyl acetate; fractionation; genes; inflammation; inhibitory concentration 50; mechanism of action; methanol; methylene chloride; moieties; nuclear magnetic resonance spectroscopy; palmitic acid; peroxisome proliferator-activated receptors; structure-activity relationships; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; tyramine
Abstract:: ... The root bark of Lycium chinense Miller, Lycii Radicis Cortex, has been used in traditional Chinese medicine (TCM) to treat different inflammation-related symptoms, such as diabetes mellitus. The pro-inflammatory transcription factor nuclear factor kappa B (NF-κB) is a key regulator of inflammation, while the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is a key mo ...
DOI:: 10.1016/j.jep.2014.01.029
: https://doi.org/10.1016/j.jep.2014.01.029

9. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

Author:: Lili Wang; Zhiqiang Li; Lin Li; Yanlin Li; Meng Yu; Yunfeng Zhou; Xinyong Lv; Hiderori Arai; Yang Xu
Source:: Journal of ethnopharmacology 2014 v.158 pp. 207-215
ISSN:: 0378-8741
Subject:: acute toxicity; adults; adverse effects; alanine transaminase; albumins; alkaline phosphatase; body weight; cholesterol; cortex; cough; glucose; hematopoiesis; histology; jaundice; kidneys; liver; liver function; lymphocytes; mice; mortality; oral administration; rats; rheumatoid arthritis; skin diseases; toxicity testing; traditional medicine; urea nitrogen
Abstract:: ... Cortex Dictamni is used in Chinese folk medicine for the treatment of jaundice, cough, rheumatism and some skin diseases; however, its possible toxicity has not been rigorously studied. The present investigation was carried out to evaluate the safety of Cortex Dictamni aqueous extract (CDAE) by acute and sub-chronic toxicity studies.In acute toxicity tests, seven groups of mice (n=5/group/sex) wer ...
DOI:: 10.1016/j.jep.2014.10.027
: https://doi.org/10.1016/j.jep.2014.10.027

10. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

Author:: Maxwell I. Ezeja; Aruh O. Anaga; Isaac U. Asuzu
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1155-1164
ISSN:: 0378-8741
Subject:: Gouania; acute toxicity; antioxidant activity; blood sampling; blood serum; cholesterol; death; diabetes mellitus; dose response; edema; eyes; heart; heart diseases; hematologic tests; high density lipoprotein; histopathology; kidneys; leaf extracts; leaves; lipid peroxidation; liver; lungs; malaria; methanol; morbidity; oral administration; rats; superoxide dismutase; toxicity testing; traditional medicine; triacylglycerols; urea; very low density lipoprotein; Africa
Abstract:: ... Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.Acute toxicity test of the plant lasted for 48 ...
DOI:: 10.1016/j.jep.2013.12.034
: https://doi.org/10.1016/j.jep.2013.12.034

11. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

Author:: Hwayong Park; Youn-Hwan Hwang; Hye Jin Yang; Hyun-Kyu Kim; Kyung Seuk Song; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2014 v.156 pp. 182-189
ISSN:: 0378-8741
Subject:: Chinese hamsters; Escherichia; Salmonella; acute toxicity; animal ovaries; bacteria; body weight changes; chromosome aberrations; dietary exposure; freeze drying; genotoxicity; glycyrrhizin; health services; herbs; ingredients; laboratory animals; liquid chromatography; mice; micronucleus tests; mutation; rats; signs and symptoms (animals and humans); therapeutics; traditional medicine; East Asia
Abstract:: ... Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one.Guibi-tang, composed of 12 herbs, was fermented with bacteria and lyophilized. Single dos ...
DOI:: 10.1016/j.jep.2014.09.004
: https://doi.org/10.1016/j.jep.2014.09.004

12. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

Author:: J. Luka; S.J. Badau; A.W. Mbaya; J.J. Gadzama; H.A. Kumshe
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 268-273
ISSN:: 0378-8741
Subject:: Diospyros mespiliformis; acute toxicity; antimalarials; blood serum; body weight changes; death; enzymes; erythrocytes; hematocrit; hematology; hemoglobin; lethal dose 50; leukocytes; local government; rats; roots; toxicity testing; traditional medicine; Nigeria
Abstract:: ... Different parts of the plant Diospyros mespiliformis have been used traditionally for the treatment of ailments in Nigeria particularly among the Kamwe people of Michika local government area of Adamawa State where the root has been used as an anti-malarial for ages. Most of the uses have been without any scientific evidence and toxicological assessment. The present study aimed to determine acute ...
DOI:: 10.1016/j.jep.2014.02.033
: https://doi.org/10.1016/j.jep.2014.02.033

13. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

Author:: Jing Li; Guoyong Yu; Junfeng Fan
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 285-292
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Sorghum (Poaceae); active sites; adenosine diphosphate; arachidonic acid; aspirin; blood; cardiovascular diseases; collagen; glucosides; mandelic acid; metabolism; monosaccharides; platelet aggregation; prostaglandin synthase; sorbitol; thrombin; vinegars; xylitol
Abstract:: ... Vinegar has been used as both a common seasoning and a traditional Chinese medicine. Sorghum vinegar is an excellent source of physiological substances with multiple health benefits.To evaluate the antiplatelet aggregation activity of alditols and monosaccharides extracted from sorghum vinegar and analysis its mechanism.Alditol and monosaccharide extract (AME) from sorghum vinegar was first evalua ...
DOI:: 10.1016/j.jep.2014.05.018
: https://doi.org/10.1016/j.jep.2014.05.018

14. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Author:: Boyang Hu; Hai Zhang; Xianli Meng; Fei Wang; Ping Wang
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 846-853
ISSN:: 0378-8741
Subject:: IKappaB kinase; Rheum rhabarbarum; Western blotting; anthraquinones; anti-inflammatory activity; bioactive compounds; cytotoxicity; enzyme-linked immunosorbent assay; gene expression; genes; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; medicinal plants; messenger RNA; mitogen-activated protein kinase; nitric oxide; phosphatidylinositol 3-kinase; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rhubarb; traditional medicine; transcription factor NF-kappa B; China
Abstract:: ... Rheum rhabarbarum (rhubarb) has long been used for the treatment of inflammation in China and other Asian countries. However, the mechanism underlying the anti-inflammatory activity of this medicinal plant is not fully understood. The present study was designed to investigate the anti-inflammatory effects of anthraquinones, the major constituents in rhubarb, and the molecular mechanism involved in ...
DOI:: 10.1016/j.jep.2014.03.059
: https://doi.org/10.1016/j.jep.2014.03.059

15. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

Author:: Mahendra S. Khyade; Deepak M. Kasote; Nityanand P. Vaikos
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 1-18
ISSN:: 0378-8741
Subject:: Alstonia macrophylla; Alstonia scholaris; adulterated products; alkaloids; antineoplastic activity; aphrodisiacs; gastrointestinal system; jaundice; malaria; medicinal plants; metabolic studies; neoplasms; plant biochemistry; therapeutics; toxicity; traditional medicine; India; Malaysia; Philippines; Thailand
Abstract:: ... Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been us ...
DOI:: 10.1016/j.jep.2014.01.025
: https://doi.org/10.1016/j.jep.2014.01.025

16. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

Author:: Edwin Ogechukwu Omeje; Mohd Parvez Khan; Patience Ogoamaka Osadebe; Deepshikha Tewari; Mohammad Faheem Khan; Kapil Dev; Rakesh Maurya; Naibedya Chattopadhyay
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 643-651
ISSN:: 0378-8741
Subject:: Bombax; Citrus; Cola nitida; Garcinia kola; Loranthus; adults; alkaline phosphatase; antineoplastic activity; bark; bone formation; bone morphogenetic proteins; cytotoxicity; diabetes; disease control; females; gene expression; genes; hosts; hypoglycemic agents; leaves; lupeol; mineralization; models; neonates; osteoblasts; osteoporosis; pain; palmitates; postmenopause; quercetin; rats; skull; therapeutics; traditional medicine; transcription (genetics); transcription factors; viability; Nigeria
Abstract:: ... Mistletoe extracts (decoctions) are used traditionally in eastern Nigeria for the management of bone pain, post menopausal syndrome and diabetes amongst several other ailments. While scientific evidence supporting its folkloric use as an antidiabetic agent has been documented, the age-long practice of its use in treatment of post menopausal syndrome has not been scientifically validated. Postmenop ...
DOI:: 10.1016/j.jep.2013.11.029
: https://doi.org/10.1016/j.jep.2013.11.029

17. Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats

Author:: Silici Sibel; Yonar M. Enis; Sahin Hüseyin; Atayoğlu A. Timucin; Ozkok Duran
Source:: Journal of ethnopharmacology 2014 v.156 pp. 155-161
ISSN:: 0378-8741
Subject:: Rhododendron; antioxidant activity; blood plasma; blood sampling; brain; catalase; females; glutathione peroxidase; grayanotoxin; heart; honey; hypertension; intraperitoneal injection; kidneys; lipid peroxidation; liver; lungs; malondialdehyde; oxidants; rats; spleen; superoxide dismutase; testes; tissues; toxicity; traditional medicine
Abstract:: ... Rhododendron honey, locally known as “mad honey”, contains gryanotoksin (GTX) and thus induces toxic effects when consumed in large amounts. But, it is still popularly used for treating medical conditions such as high blood pressure or gastro-intestinal disorders. The aim of this study was to evaluate the effect of GTX on antioxidant parameters measured from rats fed with Rhododendron honey.A tota ...
DOI:: 10.1016/j.jep.2014.08.027
: https://doi.org/10.1016/j.jep.2014.08.027

18. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Author:: Xiao-fen Zheng; Jun-sheng Tian; Peng Liu; Jie Xing; Xue-mei Qin
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 912-920
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; animal models; biochemical pathways; biomarkers; body weight; diarrhea; drugs; energy; feces; glycolysis; lactic acid; leucine; liver; males; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; oral administration; rats; spleen; starvation; swimming; uterine prolapse; valine
Abstract:: ... Bu-zhong-yi-qi-tang (BT) is a classical formula for the treatment of spleen-qi descending, visceroptosis with hyposplenic qi, uterine prolapse, and rectal prolapse due to chronic diarrhea in traditional Chinese medicine (TCM) and has been identified as an effective drug for the treatment of TCM spleen-qi deficiency in clinical practice. The present study aimed to investigate the restorative effect ...
DOI:: 10.1016/j.jep.2013.12.001
: https://doi.org/10.1016/j.jep.2013.12.001

19. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

Author:: Hyun Kim; Mi-Jang Song
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 85-89
ISSN:: 0378-8741
Subject:: Araliaceae; Asteraceae; Fabaceae; Pinaceae; Poaceae; Rosaceae; diabetes; indigenous knowledge; interviews; medicinal plants; national parks; nervous system diseases; pain; questionnaires; respiratory tract diseases; social networks; traditional medicine; Korean Peninsula
Abstract:: ... The purpose of this study is to analyze and record traditional knowledge of medicinal plants utilized in communities of Jirisan National Park.Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and social network analysis (S ...
DOI:: 10.1016/j.jep.2013.10.047
: https://doi.org/10.1016/j.jep.2013.10.047

20. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

Author:: Hyun Kim; Mi-Jang Song
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 90-97
ISSN:: 0378-8741
Subject:: Hymenochaetaceae; Pleurotaceae; Polyporaceae; Tricholomataceae; cardiovascular diseases; diabetes; indigenous knowledge; interviews; medicinal fungi; national parks; questionnaires; soups; traditional medicine; wild edible mushrooms; Korean Peninsula
Abstract:: ... This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea).Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and inter-network ana ...
DOI:: 10.1016/j.jep.2013.12.041
: https://doi.org/10.1016/j.jep.2013.12.041

21. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate

Author:: A.B. Seres; E. Ducza; M. Báthori; A. Hunyadi; Z. Béni; M. Dékány; J. Hajagos-Tóth; J. Verli; Róbert Gáspár
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 446-453
ISSN:: 0378-8741
Subject:: Apis mellifera; Western blotting; active ingredients; fractionation; gas chromatography-mass spectrometry; honey bees; male fertility; males; men; messenger RNA; milk; nuclear magnetic resonance spectroscopy; oleic acid; palmitates; protein content; protein synthesis; quantitative polymerase chain reaction; rats; spectral analysis; testosterone; therapeutics; tissues; traditional medicine; women
Abstract:: ... Numerous honeybee (Apis mellifera) products have been used in traditional medicine to treat infertility and to increase vitality in both men and women. Drone milk (DM) is a relatively little-known honeybee product with a putative sexual hormone effect. The oestrogenic effect of a fraction of DM has recently been reported in rats. However, no information is available on the androgenic effects of DM ...
DOI:: 10.1016/j.jep.2014.02.050
: https://doi.org/10.1016/j.jep.2014.02.050

22. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

Author:: Soheil Zorofchian Moghadamtousi; Hamed Karimian; Elham Rouhollahi; Mohammadjavad Paydar; Mehran Fadaeinasab; Habsah Abdul Kadir
Source:: Journal of ethnopharmacology 2014 v.156 pp. 277-289
ISSN:: 0378-8741
Subject:: Annona muricata; antineoplastic activity; apoptosis; caspases; cell cycle checkpoints; cell proliferation; colorectal neoplasms; cytochrome c; cytosol; cytotoxicity; ethyl acetate; flow cytometry; fluorescent antibody technique; in vivo studies; inhibitory concentration 50; interphase; lactate dehydrogenase; leaves; membrane permeability; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; phosphatidylserines; protein synthesis; reactive oxygen species; screening; traditional medicine
Abstract:: ... Annona muricata known as “the cancer killer” has been widely used in the traditional medicine for the treatment of cancer and tumors. The purpose of this study is to investigate the anticancer properties of ethyl acetate extract of Annona muricata leaves (EEAM) on HT-29 and HCT-116 colon cancer cells and the underlying mechanisms.The effect of EEAM on the cell proliferation of HT-29 and HCT-116 ce ...
DOI:: 10.1016/j.jep.2014.08.011
: https://doi.org/10.1016/j.jep.2014.08.011

23. Anti-HBV activity of the different extracts from Phyllanthus rheedei Wight in cell culture based assay systems

Author:: V. Suresh; Jose Sojan; N. Krishna Radhika; V.V. Asha
Source:: Journal of ethnopharmacology 2014 v.156 pp. 309-315
ISSN:: 0378-8741
Subject:: Phyllanthus; cell culture; cell lines; cytotoxicity; dose response; enzyme-linked immunosorbent assay; ethanol; hepatitis B antigens; liver; screening; traditional medicine; virion; India
Abstract:: ... Phyllanthusrheedei Wight is a plant used by Muthuvan tribes of Kerala for treating liver related diseases.The different extracts of Phyllanthus rheedei were analysed on cell lines were viz, PLC/PRF, Hep3B, FLCII10 and HepG2215 for its anti-HBV property. The analysis was done through ELISA, SQRT-PCR and immuno blotting. The most active extract was then divided in to fractions using HPTLC and the mo ...
DOI:: 10.1016/j.jep.2014.08.028
: https://doi.org/10.1016/j.jep.2014.08.028

24. Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico

Author:: Wendy Itzel Escobedo Hinojosa; Macdiel Acevedo Quiróz; Irma Romero Álvarez; Patricia Escobar Castañeda; María Luisa Villarreal; Alexandre Cardoso Taketa
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1156-1163
ISSN:: 0378-8741
Subject:: Helicobacter pylori; bark; breasts; cell lines; colon; cytotoxicity; ears; edema; fibroblasts; gastritis; histology; indomethacin; inhibitory concentration 50; leaf extracts; leaves; mice; minimum inhibitory concentration; models; neoplasm cells; plant organs; quality control; stems; stomach ulcers; traditional medicine; wild plants; winter; Mexico
Abstract:: ... The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts obtained from the leaves, stems, and root bark of Hippocratea celastroides collected in five different localities in Mexico, during the w ...
DOI:: 10.1016/j.jep.2014.06.044
: https://doi.org/10.1016/j.jep.2014.06.044

25. Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats

Author:: Bing Lin; Yong Zhao; Ping Han; Wei Yue; Xue-Qin Ma; Khalid Rahman; Cheng-Jian Zheng; Lu-Ping Qin; Ting Han
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 248-255
ISSN:: 0378-8741
Subject:: Xanthium strumarium; adjuvants; blood serum; body weight changes; fruits; high performance liquid chromatography; histology; interleukin-10; interleukin-1beta; medicinal plants; methotrexate; rats; rheumatoid arthritis; spleen; therapeutics; thymus gland; traditional medicine; tumor necrosis factor-alpha; China
Abstract:: ... Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete F ...
DOI:: 10.1016/j.jep.2014.05.023
: https://doi.org/10.1016/j.jep.2014.05.023

26. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

Author:: Hyun-Soo Shin; Jong-Min Han; Hyeong-Geug Kim; Min-Kyung Choi; Chang-Gue Son; Ho-Ryong Yoo; Hyun-Kyung Jo; In-Chan Seol
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 142-150
ISSN:: 0378-8741
Subject:: Artemisia; Curcuma longa; Western diets; aorta; atherosclerosis; blood lipids; blood serum; cholesterol; curcumin; fatty liver; gene expression; glucose; high density lipoprotein; hyperlipidemia; interleukin-1beta; interleukin-6; lipid composition; low density lipoprotein; mice; reactive oxygen species; tissues; traditional medicine; triacylglycerols; tumor necrosis factor-alpha
Abstract:: ... Artemisiaiwayomogi Kitamura and Curcuma longa Linne. (ACE) has been popularly used to treat atherosclerosis as well as hyperlipidemia in the Asian countries.Antiatherosclerotic and anti-hyperlipidemic effects of ACE were evaluated at protein and gene expression level by using apoE⁻/⁻ mice.Apoprotein E deficient (apoE⁻/⁻) mice were randomly divided into five groups and fed freely Western diet (WD) ...
DOI:: 10.1016/j.jep.2014.01.039
: https://doi.org/10.1016/j.jep.2014.01.039

27. Anti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway

Author:: Sun Haeng Park; Yoon-Young Sung; Kyoung Jin Nho; Ho Kyoung Kim
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1109-1115
ISSN:: 0378-8741
Subject:: Polygonum aviculare; Western diets; adhesion; adipocytes; adipose tissue; aorta; atherosclerosis; blood lipids; blood pressure; cell viability; dose response; ethanol; hypertension; intercellular adhesion molecule-1; mice; mitogen-activated protein kinase; obesity; phosphorylation; protective effect; staining; traditional medicine; transcription factor NF-kappa B
Abstract:: ... Polygonum aviculare L. has been used in traditional Korean medicine to treat obesity and symptoms associated with hypertension. The effectiveness or mechanism of Polygonum aviculare L. ethanol extract (PAE) on atherosclerosis disease has not been examined experimentally. This study investigated the protective effect of PAE in atherosclerotic mice.ApoE KO mice were fed a Western diet (WD) alone or ...
DOI:: 10.1016/j.jep.2013.12.021
: https://doi.org/10.1016/j.jep.2013.12.021

28. Anti-biofilm activity of Marula – A study with the standardized bark extract

Author:: Ratul Sarkar; Sushil K. Chaudhary; Amrita Sharma; Kirendra K. Yadav; Neelesh K. Nema; Mamello Sekhoacha; Sanmoy Karmakar; Fernão C. Braga; Motlalepula Gilbert Matsabisa; Pulok K. Mukherjee; Tuhinadri Sen
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 170-175
ISSN:: 0378-8741
Subject:: Pseudomonas aeruginosa; Sclerocarya birrea subsp. caffra; alcoholic beverages; antibiotic resistance; antimicrobial properties; bacterial motility; bark; biofilm; dysentery; ethnobotany; fruits; gentian violet; methanol; microbial growth; proteinases; pyoverdines; quorum sensing; secretion; socioeconomics; swarming; traditional medicine; virulence; Africa
Abstract:: ... Marula (Sclerocarya birrea; family – Anacardiaceae) is an African plant, which enjoys wide socio-economic importance particularly in southern part of Africa. The fruits are consumed as food and also as alcoholic beverage (cream liquor). In different parts of Africa, the decoction of the bark is traditionally used for the treatment of dysentery, diarrhoea, and various other infectious conditions. T ...
DOI:: 10.1016/j.jep.2014.03.067
: https://doi.org/10.1016/j.jep.2014.03.067

29. Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

Author:: Muhammad Munawar Hayat; Sadia Sarwar; Shazia Anjum; Muhammad Uzair; Hafiz Muhammad Farhan Rasheed; Qaiser Jabeen; Bashir Ahmad Choudhary; Muhammad Ashraf
Source:: Journal of ethnopharmacology 2014 v.156 pp. 347-352
ISSN:: 0378-8741
Subject:: rabbits; alloxan; Brassicaceae; median effective concentration; acetylcholinesterase; diarrhea; glibenclamide; jejunum; enzyme inhibition; tissues; animal disease models; traditional medicine; linoleate 13S-lipoxygenase; blood glucose; glycemic effect; potassium; phosphodiesterase I; diabetes; antioxidant activity; enzyme activity; rats; parasympatholytics; methanol; therapeutics; fever
Abstract:: ... Folk herbal practitioners of the Cholistan desert claim Farsetia hamiltonii Royle (Brassicaceae) to treat diabetes, oxidative damages, diarrhea, fever, and abdominal cramps. The aim of this study was to scientifically find the potential of Farsetia hamiltonii in treating diabetes and gastrointestinal diseases.In vivo anti-diabetic activity of Farsetia hamiltonii was studied on alloxan induced diab ...
DOI:: 10.1016/j.jep.2014.08.038
: https://doi.org/10.1016/j.jep.2014.08.038

30. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model

Author:: Mohammed Auwal Ibrahim; M. Shahidul Islam
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 392-399
ISSN:: 0378-8741
Subject:: acetone; alanine transaminase; alkaline phosphatase; alpha-amylase; alpha-glucosidase; animal disease models; bark; blood glucose; blood lipids; blood serum; body weight; enzyme inhibition; ethyl acetate; glucose tolerance; glycemic effect; glycogen; in vivo studies; insulin; insulin resistance; islets of Langerhans; liver; males; noninsulin-dependent diabetes mellitus; oral administration; rats; solvents; traditional medicine; urea; Nigeria
Abstract:: ... Senna singueana is currently used in the traditional treatment of diabetes mellitus in Nigeria. The present study examined the anti-diabetic activity of the Senna singueana acetone fraction (SSAF) of stem bark in a type 2 diabetes (T2D) rat model.Crude ethyl acetate extract of the Senna singueana stem bark was fractionated with various solvents and the acetone fraction was selected for in vivo stu ...
DOI:: 10.1016/j.jep.2014.02.042
: https://doi.org/10.1016/j.jep.2014.02.042

31. Anti-diarrhoeal activity of methanol extract of Santalum album L. in mice and gastrointestinal effect on the contraction of isolated jejunum in rats

Author:: Huimin Guo; Jingze Zhang; Wenyuan Gao; Zhuo Qu; Changxiao Liu
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 704-710
ISSN:: 0378-8741
Subject:: Santalum album; acetylcholine; antibacterial properties; calcium; diarrhea; dose response; gastric emptying; gastrointestinal transit; intragastric administration; jejunum; methanol; mice; muscarine receptors; neostigmine; parasympatholytics; potassium chloride; rats; serotonin; serotonin receptors; traditional medicine; verapamil
Abstract:: ... Santalum album L., namely Sandalwood, honored as “Green Gold”, is a traditional Chinese herb which has the effects of anti-diarrhoeal and antibacterial activity. But there is limit scientific study on its activity and mechanism in gastrointestinal disorders.in vivo, after intragastric administration, the methanol extract of Sandalwood (SE) (200, 400 and 800mg/kg) were studied in castor oil-induced ...
DOI:: 10.1016/j.jep.2014.04.043
: https://doi.org/10.1016/j.jep.2014.04.043

32. Anti-fatigue effects of proteins isolated from Panax quinquefolium

Author:: Bin Qi; Li Liu; He Zhang; Guang-xin Zhou; Shan Wang; Xiao-zheng Duan; Xue-yuan Bai; Si-ming Wang; Da-qing Zhao
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 430-434
ISSN:: 0378-8741
Subject:: Panax quinquefolius; amino acid composition; blood serum; body weight; forced swimming test; glutathione peroxidase; glycogen; high performance liquid chromatography; lactic acid; malondialdehyde; mice; molecular weight; perennials; polyacrylamide gel electrophoresis; protein content; proteins; superoxide dismutase; swimming; traditional medicine; urea nitrogen; Canada; Eastern United States
Abstract:: ... American ginseng (Panax quinquefolium) is an obligate shade perennial plant that belongs to Araliaceae ginseng species, and is native to eastern USA and Canada. Ginseng proteins are reported to have several pharmaceutical properties. However, such properties of American ginseng proteins (AGP) have seldom been reported. Also, anti-fatigue properties of AGP have not been studied. Therefore, we exami ...
DOI:: 10.1016/j.jep.2014.02.045
: https://doi.org/10.1016/j.jep.2014.02.045

33. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

Author:: Shuli Man; Wei Fan; Wenyuan Gao; Yuanyuan Li; Yan Wang; Zhen Liu; Hongfa Li
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 407-412
ISSN:: 0378-8741
Subject:: DNA fragmentation; Oriental traditional medicine; antioxidants; blood serum; diethylnitrosamine; lipid peroxidation; liver; liver diseases; metabolomics; nuclear magnetic resonance spectroscopy; oxidative stress; rats; saponins; tricarboxylic acid cycle; urine
Abstract:: ... Paris polyphylla var. yunnanensis as a traditional Chinese medicine has been used in the treatment of liver disease for thousands of years. Rhizoma paridis saponins (RPS), as the main active components of Paris polyphylla, have been used to treat liver injury. Anti-cirrhosis effect of Rhizoma paridis saponins (RPS) has not been known.We analyzed diethylnitrosamine (DEN)-induced metabonomic changes ...
DOI:: 10.1016/j.jep.2013.10.051
: https://doi.org/10.1016/j.jep.2013.10.051

34. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model

Author:: Salman Khan; Omer Shehzad; Jaemoo Chun; Ran Joo Choi; Saitbyul Park; Md. Nurul Islam; Jae Sue Choi; Yeong Shik Kim
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 478-486
ISSN:: 0378-8741
Subject:: Artemisia capillaris; adenosine; adenosine triphosphate; analgesic effect; analgesics; animal models; antineoplastic activity; carrageenan; edema; ethanol; genes; immunity; inducible nitric oxide synthase; mechanism of action; mice; nitrites; pain; signal transduction; somatosensory disorders; substance P; traditional medicine; transcription factor NF-kappa B
Abstract:: ... Artemisia capillaris has widespread traditional and pharmacological applications such as analgesic, anti-inflammatory, anti-pyretic, enhance immunity and anti-tumor activity properties. To evaluate the pharmacological activities of this plant, capillarisin, one of the potent constituent of Artemisia capillaris was studied based on anti-hyperalgesic and anti-allodynic effects with detailed mechanis ...
DOI:: 10.1016/j.jep.2014.01.028
: https://doi.org/10.1016/j.jep.2014.01.028

35. Anti-hyperglycemic effect, inhibition of inflammatory cytokines expression, and histopathology profile in streptozotocin-induced diabetic rats treated with Arracacia tolucensis aerial-parts extracts

Author:: Mary Carmen García-Galicia; Eleuterio Burgueño-Tapia; Andrés Romero-Rojas; Julio César García-Zebadúa; Jorge Cornejo-Garrido; Cynthia Ordaz-Pichardo
Source:: Journal of ethnopharmacology 2014 v.152 no.1 pp. 91-98
ISSN:: 0378-8741
Subject:: Arracacia; aerial parts; alanine transaminase; animal disease models; aspartate transaminase; biometry; blood glucose; body weight changes; cytokines; diabetes mellitus; drugs; ethanol; ethyl acetate; glibenclamide; glycemic effect; hexane; histopathology; intraperitoneal injection; kidneys; lipids; liver; males; medicinal plants; pancreas; rats; spleen; streptozotocin; therapeutics; traditional medicine; Mexico
Abstract:: ... Arracacia tolucensis is a medicinal plant used in northeast of Mexico as a remedy to treat people with Diabetes mellitus (DM); however, there are no scientific studies that support this information. Thus, we evaluated the anti-hyperglycemic effect of the hexane, ethyl acetate and ethanol extracts from aerial parts in streptozotocin-induced diabetic rats.DM was induced in Wistar male rats by single ...
DOI:: 10.1016/j.jep.2013.12.031
: https://doi.org/10.1016/j.jep.2013.12.031

36. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice

Author:: Fabio R.M. Borges; Morgana D. Silva; Marina M. Córdova; Tiago R. Schambach; Moacir G. Pizzolatti; Adair R.S. Santos
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 144-150
ISSN:: 0378-8741
Subject:: Polygala; aerial parts; anesthetics; anti-inflammatory activity; dexamethasone; inflammation; interleukin-10; interleukin-1beta; interleukin-6; intraperitoneal injection; kidneys; lipopolysaccharides; methylene chloride; mice; models; neutrophils; peritonitis; therapeutics; traditional medicine; tumor necrosis factor-alpha; Brazil
Abstract:: ... Polygala sabulosa A. W. Bennett is a small herb popularly known as “timutu-pinheirinho” that is widely distributed in southern Brazil and that is used to treat disorders of the bowel and kidney and as a topical anesthetic and expectorant in folk medicine. This study was designed to investigate the anti-inflammatory properties of the hydroalcoholic extract (HEPs), CH2Cl2 fraction and the steroid α- ...
DOI:: 10.1016/j.jep.2013.10.009
: https://doi.org/10.1016/j.jep.2013.10.009

37. Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract

Author:: Deok Jeong; Young-Su Yi; Gi-Ho Sung; Woo Seok Yang; Jae Gwang Park; Keejung Yoon; Deok Hyo Yoon; Changsik Song; Yunmi Lee; Man Hee Rhee; Tae Woong Kim; Jong-Hoon Kim; Jae Youl Cho
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 487-496
ISSN:: 0378-8741
Subject:: Artemisia; active ingredients; anti-inflammatory activity; ethanol; fractionation; heme oxygenase (biliverdin-producing); high performance liquid chromatography; hydrochloric acid; immunoblotting; lipopolysaccharides; luteolin; macrophages; mice; models; nitric oxide; prostaglandins; reporter genes; signal transduction; stomach ulcers; traditional medicine; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Artemisia asiatica Nakai (Compositae) is a representative herbal plant used to treat infection and inflammatory diseases. Although Artemisia asiatica is reported to have immunopharmacological activities, the mechanisms of these activities and the effectiveness of Artemisia asiatica preparations in use are not known.To evaluate the anti-inflammatory activities of Artemisia asiatica ethanol extract ...
DOI:: 10.1016/j.jep.2014.01.030
: https://doi.org/10.1016/j.jep.2014.01.030

38. Anti-inflammatory activity of animal oils from the Peruvian Amazon

Author:: Guillermo Schmeda-Hirschmann; Carla Delporte; Gabriela Valenzuela-Barra; Ximena Silva; Gabriel Vargas-Arana; Beatriz Lima; Gabriela E. Feresin
Source:: Journal of ethnopharmacology 2014 v.156 pp. 9-15
ISSN:: 0378-8741
Subject:: Boa constrictor; Chelonoidis; Electrophorus electricus; Escherichia coli; Geochelone; Inia geoffrensis; Melanosuchus niger; Salmonella Enteritidis; Staphylococcus aureus; animal fats and oils; anti-inflammatory activity; anti-inflammatory agents; antimicrobial properties; arachidonic acid; conservation status; dolphins; ears; edema; esters; fish; gas chromatography-mass spectrometry; linoleic acid; markets; mice; minimum inhibitory concentration; oleic acid; palmitic acid; reptiles; traditional medicine; Amazonia; Peru
Abstract:: ... Animal oils and fats from the fishes Electrophorus electricus and Potamotrygon motoro, the reptiles Boa constrictor, Chelonoidis denticulata (Geochelone denticulata) and Melanosuchus niger and the riverine dolphin Inia geoffrensis are used as anti-inflammatory agents in the Peruvian Amazon. The aim of the study was to assess the topic anti-inflammatory effect of the oils/fats as well as to evaluat ...
DOI:: 10.1016/j.jep.2014.08.010
: https://doi.org/10.1016/j.jep.2014.08.010

39. Anti-inflammatory activity of compounds from Boesenbergia longiflora rhizomes

Author:: Teeratad Sudsai; Samran Prabpai; Palangpon Kongsaeree; Chatchai Wattanapiromsakul; Supinya Tewtrakul
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 453-461
ISSN:: 0378-8741
Subject:: abscess; anti-inflammatory activity; chloroform; chromatography; colitis; dose response; flavonoids; gene expression; inducible nitric oxide synthase; inhibitory concentration 50; macrophages; messenger RNA; mice; nitric oxide; rhizomes; sesquiterpenoids; sterols; traditional medicine; tumor necrosis factor-alpha
Abstract:: ... The rhizomes of Boesenbergia longiflora (Wall.) Kuntze have been traditionally used in treatment of inflammatory bowel disease, ulcerative colitis, aphthous ulcer and abscess. Our previous study indicated that CHCl3 fractions of Boesenbergia longiflora had potential on anti-inflammatory properties. In the present study, we investigated the active constituents of this plant for anti-inflammatory ac ...
DOI:: 10.1016/j.jep.2014.04.034
: https://doi.org/10.1016/j.jep.2014.04.034

40. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats

Author:: K.D.K.P. Kumari; T.C.S. Weerakoon; S.M. Handunnetti; K. Samarasinghe; T.S. Suresh
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1202-1208
ISSN:: 0378-8741
Subject:: Aegle marmelos; anti-inflammatory activity; antioxidant activity; antioxidants; beverages; carrageenan; dose response; edema; erythrocytes; flowers; histamine; lipid peroxidation; nitric oxide; rats; rural areas; traditional medicine; trees; Asia
Abstract:: ... Almost all part of the plant Aegle marmelos (Bael tree) has been used in the traditional medicine systems of Asian countries to treat various diseases over many centuries. The water extract of the dried flowers of Aegle marmelos is a commonly used beverage among Sri Lankan population in rural areas. Although extensive investigations done on many parts of the plant there are no experimental data av ...
DOI:: 10.1016/j.jep.2013.12.043
: https://doi.org/10.1016/j.jep.2013.12.043

41. Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

Author:: Ling Tong; Tu Chen; Zhenzhong Chen; Peng Zhang; Huifang Pi; Hanli Ruan; Jizhou Wu
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1553-1560
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; anti-inflammatory activity; dose response; ears; edema; enzyme activity; ethanol; ethyl acetate; inducible nitric oxide synthase; inflammation; interleukin-6; lipopolysaccharides; macrophages; nitric oxide; prostaglandin synthase; rheumatoid arthritis; secretion; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; xylene
Abstract:: ... Radix Toddaliae Asiaticae has long been used as a traditional ethnic Chinese medicine for the treatment of inflammation and rheumatism. In our earlier communication we have reported the anti-arthritic activity of the ethyl alcohol extract and ethyl acetate fraction from Radix Toddaliae Asiaticae. This study was to examine the anti-inflammatory activity of prenylcoumarin omphalocarpin isolated from ...
DOI:: 10.1016/j.jep.2014.07.055
: https://doi.org/10.1016/j.jep.2014.07.055

42. Anti-inflammatory and analgesic activity of aqueous extract of Flos populi

Author:: Qianqian Xu; Yubo Wang; Shijin Guo; Zhiqiang Shen; Yanping Wang; Limei Yang
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 540-545
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Populus canadensis; Populus tomentosa; analgesic effect; analgesics; anti-inflammatory activity; arachidonic acid; carrageenan; cotton; diarrhea; dose response; ears; edema; formalin; granuloma; hot plate test; males; pain; writhing test; East Asia
Abstract:: ... Flos populi is an important traditional Chinese medicine prepared from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench (Salicaceae family). Flos populi is mainly used for the treatment of various inflammatory diseases and anti diarrhea in East Asian countries. The objective of this study was to investigate the anti-inflammatory and analgesic properties of the aqueous ...
DOI:: 10.1016/j.jep.2014.01.037
: https://doi.org/10.1016/j.jep.2014.01.037

43. Anti-inflammatory and anti-hypersensitive effects of the crude extract, fractions and triterpenes obtained from Chrysophyllum cainito leaves in mice

Author:: Nicole Anzanelo Meira; Luiz Carlos Klein Jr; Lilian W. Rocha; Zhelmy Martin Quintal; Franco Delle Monache; Valdir Cechinel Filho; Nara Lins Meira Quintão
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 975-983
ISSN:: 0378-8741
Subject:: Chrysophyllum cainito; acetates; adverse effects; anti-inflammatory activity; chemical constituents of plants; chloroform; diabetes mellitus; edema; hypersensitivity; interleukin-1beta; leaves; locomotion; mice; myeloperoxidase; neutrophils; pain; thin layer chromatography; traditional medicine; trees; triterpenoids; tumor necrosis factor-alpha
Abstract:: ... Chrysophyllum cainito, popularly known as “star apple”, caimito, “abiu-roxo” or “abiu-do-Pará”, is a tree of about 25m in height. Besides its culinary use, it is also used in folk medicine for the treatment of diabetes mellitus and several inflammatory diseases.The crude methanolic extract (CME) was submitted to phytochemical studies for obtaining fractions and isolated compounds. They were monito ...
DOI:: 10.1016/j.jep.2013.12.014
: https://doi.org/10.1016/j.jep.2013.12.014

44. Anti-inflammatory and antioxidant activities of Costus afer Ker Gawl. hexane leaf fraction in arthritic rat models

Author:: Godswill Nduka Anyasor; Funmilayo Onajobi; Odutola Osilesi; Olugbenga Adebawo; Efere Martins Oboutor
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 543-551
ISSN:: 0378-8741
Subject:: Costus; adjuvants; alanine transaminase; albumins; alkaline phosphatase; animal models; anti-inflammatory activity; antioxidant activity; antioxidants; arachidonic acid; aspartate transaminase; bilirubin; brain; carrageenan; catalase; diclofenac; edema; formaldehyde; globulins; glutathione; glutathione transferase; hexane; kidneys; leaves; liver; males; malondialdehyde; medicinal plants; nonsteroidal anti-inflammatory agents; prednisolone; protein content; rats; rheumatoid arthritis; superoxide dismutase; therapeutics; traditional medicine
Abstract:: ... Costus afer Ker Gawl is an indigenous tropical African medicinal plant used as therapy in the treatment of inflammatory ailments such as rheumatoid arthritis. This study was designed to evaluate the anti-inflammatory and antioxidant activities of the hexane fraction of C. afer leaves (CAHLF).The anti-inflammatory effect of varying doses of CAHLF on carrageenan, arachidonic acid, and formaldehyde i ...
DOI:: 10.1016/j.jep.2014.05.057
: https://doi.org/10.1016/j.jep.2014.05.057

45. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

Author:: Minjung Song; Hye-Jin Park
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
DOI:: 10.1016/j.jep.2013.12.059
: https://doi.org/10.1016/j.jep.2013.12.059

46. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

Author:: Ji-Sun Shin; Eu-Jin Cho; Hye-Eun Choi; Ji-Hyung Seo; Hyo-Jin An; Hee-Juhn Park; Young-Wuk Cho; Kyung-Tae Lee
Source:: Journal of ethnopharmacology 2014 v.158 pp. 291-300
ISSN:: 0378-8741
Subject:: Rubus coreanus; Rubus occidentalis; animal models; anti-inflammatory activity; asthma; body weight; colitis; colon; cytokines; dextran; diarrhea; epithelium; feces; hemorrhage; immunoassays; immunohistochemistry; lipopolysaccharides; luciferase; macrophage activation; macrophages; mechanism of action; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; sodium; stomach; therapeutics; traditional medicine; transcription factor NF-kappa B; triterpenoids
Abstract:: ... Rubus coreanus Miquel (Rosaceae), the Korean black raspberry, has traditionally been used to treat inflammatory diseases including diarrhea, asthma, stomach ailment, and cancer. Although previous studies showed that the 19α-hydroxyursane-type triterpenoids isolated from Rubus coreanus exerted anti-inflammatory activities, their effects on ulcerative colitis and mode of action have not been explore ...
DOI:: 10.1016/j.jep.2014.10.044
: https://doi.org/10.1016/j.jep.2014.10.044

47. Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

Author:: Lucas A. Chibli; Kamilla C.M. Rodrigues; Carolina M. Gasparetto; Nícolas C.C. Pinto; Rodrigo L. Fabri; Elita Scio; Maria S. Alves; Glauciemar Del-Vechio-Vieira; Orlando V. Sousa
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 330-338
ISSN:: 0378-8741
Subject:: Croton; Kalanchoe pinnata; anti-inflammatory activity; anti-inflammatory agents; arachidonic acid; capsaicin; ears; edema; ethanol; gastritis; high performance liquid chromatography; histopathology; hyperplasia; inflammation; leaves; luteolin; mice; models; oils; quercetin; rutin; skin diseases; topical application; traditional medicine; Brazil
Abstract:: ... Bryophyllum pinnatum (Lam.) Oken (Crassulaceae), popularly known in Brazil as “folha-da-fortuna”, is a plant species used in folk medicine for the external and internal treatment of inflammation, infection, wound, burn, boil, ulcers and gastritis, and several other diseases. The present study aimed to perform the chemical characterization and the evaluation of the topical anti-inflammatory effect ...
DOI:: 10.1016/j.jep.2014.03.035
: https://doi.org/10.1016/j.jep.2014.03.035

48. Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis)

Author:: Kai Wang; Jianglin Zhang; Shun Ping; Quanxin Ma; Xuan Chen; Hongzhuan Xuan; Jinhu Shi; Cuiping Zhang; Fuliang Hu
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 300-311
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Populus canadensis; anti-inflammatory activity; antioxidant activity; buds; endotoxemia; ethanol; flavonoids; high performance liquid chromatography; histopathology; interleukin-10; interleukin-12; interleukin-1beta; interleukin-6; lungs; messenger RNA; propolis; protective effect; reporter genes; secretion; therapeutics; traditional medicine; tumor necrosis factor-alpha
Abstract:: ... Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese ...
DOI:: 10.1016/j.jep.2014.05.037
: https://doi.org/10.1016/j.jep.2014.05.037

49. Anti-influenza virus activity of the ethanolic extract from Peperomia sui

Author:: Chih-Hsueh Yang; Duen-Huey Tan; Wei-Li Hsu; Ting-Ting Jong; Chi-Luan Wen; Shih-Lan Hsu; Poa-Chun Chang
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 320-325
ISSN:: 0378-8741
Subject:: Orthomyxoviridae; Peperomia; avian influenza; bioactive properties; cell viability; chickens; enzyme activity; enzyme inhibition; fibroblasts; fluorescent antibody technique; hemagglutination; nucleoproteins; reverse transcriptase polymerase chain reaction; sialidase; traditional medicine; viability assays; viruses
Abstract:: ... Peperomia sui Lin and Lu (Peperomia sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explored the activity of Peperomia sui against influenza virus infections. This study was carried out to evaluate the anti-influenza virus activity and the potential virucidal effect of t ...
DOI:: 10.1016/j.jep.2014.05.035
PubMed:: 24882727
PubMed Central:: PMC7127046
: https://doi.org/10.1016/j.jep.2014.05.035

50. Anti-melanoma activity of Cynanchi atrati Radix is mediated by regulation of NF-kappa B activity and pro-apoptotic proteins

Author:: Seung-Wan Son; Hyeong-Geug Kim; Jong-Min Han; Jin-Seok Lee; Min-Kyung Choi; Jong-Seok Lee; Chang-Gue Son
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 250-257
ISSN:: 0378-8741
Subject:: 4',6-diamidino-2-phenylindole; apoptosis; cell proliferation; drugs; ethanol; fever; flow cytometry; gene expression; genes; immunoblotting; melanoma; mice; patients; pro-apoptotic proteins; staining; traditional medicine; transcription factor NF-kappa B
Abstract:: ... Cynanchi atrati Radix has been traditionally prescribed for patients with inflammatory fever or chronic tumoral disorders. Melanoma is one of the most devastating cancer types, in which overexpression of nuclear factor kappa B (NF-κB) enables the cancer to survive without apoptosis. To identify a potential anti-melanoma candidate, we evaluated the apoptotic activity of an ethanol extract of Cynanc ...
DOI:: 10.1016/j.jep.2014.02.037
: https://doi.org/10.1016/j.jep.2014.02.037

51. Anti-stress effect of astragaloside IV in immobilized mice

Author:: Hyun-A. Oh; Hyuck Jai Choi; Nam Jae Kim; Dong-Hyun Kim
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 928-932
ISSN:: 0378-8741
Subject:: Astragalus membranaceus; antagonists; anti-inflammatory activity; anxiety; astragalosides; blood serum; corticosterone; enzyme-linked immunosorbent assay; ethanol; immunomodulation; inflammation; interleukin-6; mice; oral administration; roots; traditional medicine; tranquilizers; tumor necrosis factor-alpha
Abstract:: ... Astragaloside IV, a major component extracted from the roots of Astragalus membranaceus (AM), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. To clarify anti-stress effect of AM, anxiolytic and anti-inflammatory effects of 80% ethanol extract of AM and astragaloside IV were investigated in immobilization stress model.The mice were orally ad ...
DOI:: 10.1016/j.jep.2014.03.068
: https://doi.org/10.1016/j.jep.2014.03.068

52. Anti-trypanosomal activity of African medicinal plants: A review update

Author:: Mohammed Auwal Ibrahim; Aminu Mohammed; Murtala Bindawa Isah; Abubakar Babando Aliyu
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 26-54
ISSN:: 0378-8741
Subject:: African trypanosomiasis; antitrypanosomal properties; clinical trials; in vivo studies; livestock; medicinal plants; traditional medicine; tropical diseases
Abstract:: ... African trypanosomiasis is one of the neglected tropical diseases caused by different species of trypanosomes that affect both human and livestock with devastating consequences in the continent. Most of the affected populations commonly use traditional medicinal plants for the treatment of the disease. Consequently, this prompted ethnopharmacological research activities on the anti-trypanosomal ac ...
DOI:: 10.1016/j.jep.2014.04.012
: https://doi.org/10.1016/j.jep.2014.04.012

53. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo

Author:: Bengui Ye; Jun Li; Zu Li; Jinrong Yang; Ting Niu; Shu Wang
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 258-267
ISSN:: 0378-8741
Subject:: Marsdenia tenacissima; Western blotting; antineoplastic activity; apoptosis; asthma; caspase-3; caspase-9; cell cycle; cough; cyclins; cytotoxicity; esophageal neoplasms; genes; hepatoma; immunohistochemistry; lung neoplasms; medicinal plants; models; mononuclear leukocytes; neoplasm cells; staining; stomach neoplasms; traditional medicine; China
Abstract:: ... Marsdenia tenacissima, a traditional Chinese medicinal herb, endemic to Yunnan Province is widely used to treat cough, asthma, expectorant, esophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. The aim of this study was to evaluate in vitro and in vivo anti-hematologic neoplasm potential of the ethanolic extract of this herb (crude ethanolic extract of Marsdenia tenacissima ...
DOI:: 10.1016/j.jep.2014.02.035
: https://doi.org/10.1016/j.jep.2014.02.035

54. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

Author:: Hong-Xiang Sun; Li-Qing Chen; Juan Zhang; Feng-Yang Chen
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 831-839
ISSN:: 0378-8741
Subject:: GATA transcription factors; Musca domestica; Oriental traditional medicine; antibodies; antineoplastic activity; antineoplastic agents; blood serum; cell-mediated immunity; coma; cytotoxic T-lymphocytes; gene expression; immunoglobulin G; immunomodulators; insects; interferon-gamma; interleukin-10; larvae; mechanism of action; messenger RNA; mice; natural killer cells; necrosis; oral administration; osteomyelitis; protein content; sarcoma; splenocytes; stomach neoplasms; transcription (genetics)
Abstract:: ... The larvae of Musca domestica (Diptera: Muscidae) have been used traditionally for malnutritional stagnation, decubital necrosis, osteomyelitis, ecthyma and lip scald and also to treat coma and gastric cancer in the traditional Chinese medicine. Its in vitro antitumor activity and immunomodulatory effect in naïve mice in relation to the traditional uses were also reported. However, the in vivo ant ...
DOI:: 10.1016/j.jep.2014.03.052
: https://doi.org/10.1016/j.jep.2014.03.052

55. Anti-tumor effect of Shu-gan-Liang-Xue decoction in breast cancer is related to the inhibition of aromatase and steroid sulfatase expression

Author:: Ning Zhou; Shu-Yan Han; Fei Zhou; Ping-ping Li
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 687-695
ISSN:: 0378-8741
Subject:: Western blotting; antineoplastic activity; aromatase; arylsulfatase; bioluminescence; breast neoplasms; cell lines; cell proliferation; dose response; enzyme activity; enzyme inhibition; estrogen receptors; estrogens; inhibitory concentration 50; mice; neoplasm cells; oral administration; ovariectomy; patients; protein content; sulfates; testosterone; traditional medicine
Abstract:: ... Shu-Gan-Liang-Xue Decoction (SGLXD), a traditional Chinese herbal formula used to ameliorate the hot flushes in breast cancer patients, was reported to have anti-tumor effect on breast cancer. Estrogen plays a critical role in the genesis and evolution of breast cancer. Aromatase and steroid sulfatase (STS) are key estrogen synthesis enzymes that predominantly contribute to the high local hormone ...
DOI:: 10.1016/j.jep.2014.04.045
: https://doi.org/10.1016/j.jep.2014.04.045

56. Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves

Author:: Erdem Yesilada; İlhan Gürbüz; Gülnur Toker
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 478-483
ISSN:: 0378-8741
Subject:: Sambucus ebulus; abscess; anti-ulcer activity; bioassays; butanol; chromatography; flavonols; fractionation; glycosides; in vivo studies; ion exchange; leaves; methanol; models; nuclear magnetic resonance spectroscopy; pain; peptic ulcers; rats; separation; silica gel; solvents; tissue repair; traditional medicine
Abstract:: ... Sambucus ebulus L. has a very prominent place in Turkish folk medicine. Leaves of the plant are practiced externally to relieve rheumatic pain, to treat abscess, for wound healing and internally against hemorrhoids and stomachache. In a previous work, aqueous extract of the leaves was shown to possess potent antiulcerogenic activity on water immersion and immobilization-induced stress ulcer model ...
DOI:: 10.1016/j.jep.2014.03.004
: https://doi.org/10.1016/j.jep.2014.03.004

57. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes

Author:: Shih-Hurng Loh; Yi-Ting Tsai; Chung-Yi Lee; Chung-Yi Chang; Chien-Sung Tsai; Tzu-Hurng Cheng; Cheng-I Lin
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 753-762
ISSN:: 0378-8741
Subject:: action potentials; alkaloids; arrhythmia; bioactive compounds; calcium; cardiomyocytes; cardioprotective agents; epinephrine; guinea pigs; herbal medicines; pH; patch-clamp technique; patients; sodium; surgery; traditional medicine
Abstract:: ... Dehydroevodiamine alkaloid (DeHE), a bioactive component of the Chinese herbal medicine Wu-Chu-Yu (Evodiae frutus), exerted antiarrhythmic effect in guinea-pig ventricular myocytes. We further characterize the electromechanical effects of DeHE in the human atrial and ventricular tissues obtained from hearts of patients undergoing corrective cardiac surgery or heart transplantation.The transmembran ...
DOI:: 10.1016/j.jep.2014.03.043
: https://doi.org/10.1016/j.jep.2014.03.043

58. Antibacterial activities of extracts from Ugandan medicinal plants used for oral care

Author:: Francis Ocheng; Freddie Bwanga; Moses Joloba; Ann-Karin Borg-Karlson; Anders Gustafsson; Celestino Obua
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 852-855
ISSN:: 0378-8741
Subject:: Actinobacillus actinomycetemcomitans; Bacteroides forsythus; Euclea; Helichrysum; Lactobacillus acidophilus; Lantana trifolia; Porphyromonas gingivalis; Streptococcus mutans; Streptococcus sobrinus; Zanthoxylum; aerial parts; agar; antibacterial properties; bacteria; dental caries; hexane; juices; leaf extracts; medicinal plants; methanol; periodontal diseases; pulp; solvents; traditional medicine
Abstract:: ... Medicinal plants are widely used for treatment of oral/dental diseases in Uganda.To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC).Pulp juice and solvent extracts (hexane, methanol and water) from the plants were tested against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivali ...
DOI:: 10.1016/j.jep.2014.06.027
: https://doi.org/10.1016/j.jep.2014.06.027

59. Antibacterial activities of plants from Central Africa used traditionally by the Bakola pygmies for treating respiratory and tuberculosis-related symptoms

Author:: M.C.Y. Fomogne-Fodjo; S. Van Vuuren; D.T. Ndinteh; R.W.M. Krause; D.K. Olivier
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 123-131
ISSN:: 0378-8741
Subject:: Alchornea; Klebsiella pneumoniae; Musanga cecropioides; Mycobacterium aurum; Mycobacterium smegmatis; Staphylococcus aureus; Xylopia aethiopica; antibacterial properties; bark; leaves; methanol; minimum inhibitory concentration; pathogens; respiratory system; respiratory tract diseases; traditional medicine; tuberculosis; virulent strains; Cameroon
Abstract:: ... The antibacterial activities of 18 plants from 10 different families were investigated for their antimicrobial efficacy, based on the traditional uses of these species by Bakola pygmies living in Central Africa, especially along the Ngoyang area in Cameroon for the treatment of respiratory and tuberculosis-related symptoms. The aim of the study is to test the antimicrobial efficacy of these plants ...
DOI:: 10.1016/j.jep.2014.04.032
: https://doi.org/10.1016/j.jep.2014.04.032

60. Antibacterial activity of the roots, stems and leaves of Alchornea floribunda

Author:: X. Siwe Noundou; R.W.M. Krause; S.F. van Vuuren; D. Tantoh Ndinteh; D.K. Olivier
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 1023-1027
ISSN:: 0378-8741
Subject:: Alchornea; Bacillus cereus; Enterococcus faecalis; Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; Moraxella catarrhalis; Proteus mirabilis; Staphylococcus aureus; Staphylococcus saprophyticus; antibacterial properties; chloroform; ethanol; ethyl acetate; fungi; gastrointestinal system; leaf extracts; leaves; methanol; pathogens; phytopharmaceuticals; roots; solvents; stems; traditional medicine; Africa
Abstract:: ... Alchornea floribunda Müll. Arg. is used in traditional medicine across Africa for the treatment of bacterial, fungal, parasitic and inflammatory disorders.To evaluate the antibacterial activity of the crude extracts of different plant parts in order to provide a scientific rationale for the proposed broad efficacy of Alchornea floribunda in the treatment of bacterial infections.Extracts of roots, ...
DOI:: 10.1016/j.jep.2013.12.002
: https://doi.org/10.1016/j.jep.2013.12.002

61. Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

Author:: Dandan Cheng; Yingying Zhang; Demin Gao; Hongmeng Zhang
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1300-1305
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Pseudomonas aeruginosa; Pyrrosia; aerial parts; agar; anthraquinones; anti-inflammatory activity; anti-inflammatory agents; antibacterial properties; asthma; bronchitis; butanol; cell lines; cytotoxicity; ears; ethanol; ethyl acetate; flavonoids; lung neoplasms; mice; microorganisms; minimum inhibitory concentration; neoplasm cells; petroleum; phenols; pyelonephritis; reducing sugars; saponins; screening; solvents; splenocytes; steroids; terpenoids; xylene
Abstract:: ... Pyrrosia petiolosa is commonly used as a traditional Chinese medicine for treatment of acute pyelonephritis, chronic bronchitis and bronchial asthma. This study aims to evaluate the antibacterial activity of the ethanol extract and its derived fractions of Pyrrosia petiolosa obtained with solvents of different polarities and to perform the anti-inflammatory screening.The powdered aerial parts of P ...
DOI:: 10.1016/j.jep.2014.07.029
: https://doi.org/10.1016/j.jep.2014.07.029

62. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers

Author:: Guang Li; Kai Yu; Fushuang Li; Kangping Xu; Jing Li; Shujin He; Shousong Cao; Guishan Tan
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 521-530
ISSN:: 0378-8741
Subject:: Hericium; amino acids; animal models; anthraquinones; antimicrobial properties; body weight; cell lines; chemical composition; cisplatin; colon; colorectal neoplasms; culture media; cytotoxicity; dipeptides; drug therapy; flavones; fluorouracil; growth retardation; high performance liquid chromatography; immunomodulation; inhibitory concentration 50; liver; liver neoplasms; maximum tolerated dose; mechanism of action; mice; mushrooms; neoplasm cells; nuclear magnetic resonance spectroscopy; porous media; pyrimidines; severe combined immunodeficiency; silica gel; stomach neoplasms; traditional medicine; China
Abstract:: ... Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China. HE possesses many beneficial functions such as anticancer, antiulcer, antiinflammation and antimicrobial effects, immunomodulation and other activities. The aim of the studies was to evaluate the anticancer efficacy of two ...
DOI:: 10.1016/j.jep.2014.03.003
: https://doi.org/10.1016/j.jep.2014.03.003

63. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action

Author:: Daishu Mizuki; Kinzo Matsumoto; Ken Tanaka; Xoan Thi Le; Hironori Fujiwara; Tsutomu Ishikawa; Yoshihiro Higuchi
Source:: Journal of ethnopharmacology 2014 v.156 pp. 16-25
ISSN:: 0378-8741
Subject:: Butea superba; animal models; binding proteins; blood serum; cognitive disorders; corticosterone; dementia; dried herbs; drugs; elderly; hippocampus; immunohistochemistry; males; mechanism of action; medicinal plants; messenger RNA; mice; neurogenesis; plant extracts; sucrose; tail suspension test; tissues; traditional medicine
Abstract:: ... Butea superba (BS) is a Thai medicinal plant that has been used as a folk medicine to improve physical and mental conditions and to prevent impaired sexual performance in middle-aged or elderly males. We have previously reported that this plant extract could improve cognitive deficits and depression-like behavior in olfactory bulbectomized mice, an animal model of dementia and depression.In this s ...
DOI:: 10.1016/j.jep.2014.08.014
: https://doi.org/10.1016/j.jep.2014.08.014

64. Antidepressant-like effect of the hydroethanolic leaf extract of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice: Involvement of monoaminergic system

Author:: Ismail O. Ishola; Esther O. Agbaje; Moshood O. Akinleye; Chris O. Ibeh; Olufunmilayo O. Adeyemi
Source:: Journal of ethnopharmacology 2014 v.158 pp. 364-372
ISSN:: 0378-8741
Subject:: traditional medicine; dopamine; antidepressants; leaf extracts; locomotion; dose response; serotonin; antagonists; dopamine receptors; yohimbine; forced swimming test; behavior disorders; Alchornea cordifolia; mice; intraperitoneal injection; alpha-1 adrenergic receptors; oral administration; leaves; alpha-2 adrenergic receptors
Abstract:: ... The leaf of Alchornea cordifolia (Euphorbiaceae) is used in traditional African medicine in the treatment of various neurological and psychiatric disorders including depression. Previous studies have shown its potent antidepressant-like effect in the forced swimming test (FST). Hence, this study sought to investigate the involvement of monoaminergic systems in the antidepressant-like effect elicit ...
DOI:: 10.1016/j.jep.2014.10.008
: https://doi.org/10.1016/j.jep.2014.10.008

65. Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

Author:: Guang Yue Su; Jing Yu Yang; Fang Wang; Jie Ma; Kuo Zhang; Ying Xu Dong; Shao Jiang Song; Xiu Mei Lu; Chun Fu Wu
Source:: Journal of ethnopharmacology 2014 v.152 no.1 pp. 217-226
ISSN:: 0378-8741
Subject:: animal models; antidepressants; dopamine; electrochemistry; food consumption; high performance liquid chromatography; hippocampus; immunohistochemistry; mechanism of action; nerve growth factor; neurotransmitters; rats; receptors; serotonin; staining; sucrose; therapeutics; traditional medicine; China
Abstract:: ... Xiaochaihutang (XCHT) has been used in China for thousands of years to treat “Shaoyang syndrome”, which involves depressive-like symptoms. However, few studies have investigated its antidepressant effects and pharmacological mechanism of action. The present study was designed to confirm the antidepressant effect of XCHT using a chronic unpredictable mild stress (CUMS) model and explore its potenti ...
DOI:: 10.1016/j.jep.2014.01.006
: https://doi.org/10.1016/j.jep.2014.01.006

66. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats

Author:: Ngueguim Tsofack Florence; Massa Zibi Benoit; Kouamouo Jonas; Tchuidjang Alexandra; Dzeufiet Djomeni Paul Désiré; Kamtchouing Pierre; Dimo Théophile
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 784-790
ISSN:: 0378-8741
Subject:: Annona muricata; alanine transaminase; animal disease models; antioxidant activity; antioxidants; aspartate transaminase; blood glucose; blood serum; catalase; creatinine; diabetes; glucose; glycemic effect; immunohistochemistry; islets of Langerhans; leaves; lipemic effect; low density lipoprotein cholesterol; metabolism; nitrites; plant extracts; protective effect; rats; staining; streptozotocin; superoxide dismutase; toxicity; traditional medicine; triacylglycerols; Cameroon
Abstract:: ... The leaves of Annona muricata are used in Cameroon to manage diabetes and its complications. The aim of this study was to evaluate the antidiabetic, antioxidant activities and the potential toxicity of aqueous extract of Annona muricata in streptozotocin-induced diabetic rats.Oral administration of Annona muricata aqueous extract (100mg/kg or 200mg/kg) was studied in normal and streptozotocin-indu ...
DOI:: 10.1016/j.jep.2013.09.021
: https://doi.org/10.1016/j.jep.2013.09.021

67. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats

Author:: Dan Li; Cheng Peng; Xiaofang Xie; Yu Mao; Min Li; Zhixing Cao; Danqing Fan
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 561-567
ISSN:: 0378-8741
Subject:: Malus toringoides; alloxan; animal disease models; blood glucose; blood serum; body weight; c-peptide; diabetes; flavonoids; glycemic effect; glycogen; glycosylation; hemoglobin; hyperglycemia; hyperlipidemia; hypertension; indigestion; leaves; liver; malondialdehyde; mice; mountains; plant growth; rats; snow; streptozotocin; superoxide dismutase; traditional medicine; China
Abstract:: ... The leaf of Malus toringoides (Rehd.) Hughes is a traditional folk medicine in Tibet, China, which is called “E Se” in Tibetan language. This original plant grows on snow mountains at an attitude of 3000 to 3700m. It is primarily used to treat hypertension, hyperlipidemia, hyperglycemia, indigestion and other diseases. This study aimed to evaluate the antidiabetic effect of flavonoids extracted fr ...
DOI:: 10.1016/j.jep.2014.02.026
: https://doi.org/10.1016/j.jep.2014.02.026

68. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

Author:: Hichem Sebai; Mohamed-Amine Jabri; Abdelaziz Souli; Kais Rtibi; Slimen Selmi; Olfa Tebourbi; Jamel El-Benna; Mohsen Sakly
Source:: Journal of ethnopharmacology 2014 v.152 no.2 pp. 327-332
ISSN:: 0378-8741
Subject:: Matricaria chamomilla; antidiarrheal effect; antioxidant activity; castor oil; catalase; chamomile; diarrhea; dose response; glutathione peroxidase; hydrogen peroxide; intestinal mucosa; iron; malondialdehyde; oral administration; oxidative stress; protective effect; rats; superoxide dismutase; traditional medicine
Abstract:: ... Matricaria recutita L. (Chamomile) has been widely used in the Tunisian traditional medicine for the treatment of digestive system disorders. The present work aims to investigate the protective effects of chamomile decoction extract (CDE) against castor oil-induced diarrhea and oxidative stress in rats.The antidiarrheal activity was evaluated using castor oil-induced diarrhea method. In this respe ...
DOI:: 10.1016/j.jep.2014.01.015
: https://doi.org/10.1016/j.jep.2014.01.015

69. Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats

Author:: Banani Das; Amitabha Dey; Anupam Das Talukdar; Kh. Nongalleima; Manabendra Dutta Choudhury; Lokesh Deb
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 424-429
ISSN:: 0378-8741
Subject:: Drynaria; abortifacients; acute toxicity; contraception; females; hormones; methanol; plant extracts; rats; rhizomes; toxicity testing; traditional medicine; uterine tissue; India
Abstract:: ... Plant based traditional medicines for birth control has been in practice in rural populations of North-East India, since time immemorial. Fresh rhizome of Drynaria quercifolia (L.) J. Smith is one of the plant parts used traditionally by different ethnic communities in Tripura, India for birth control. The present investigation is aimed to justify the scientific basis in traditional use of Drynari ...
DOI:: 10.1016/j.jep.2014.02.047
: https://doi.org/10.1016/j.jep.2014.02.047

70. Antigenotoxic and antioxidant effects of the Mongolian medicinal plant Leptopyrum fumarioides (L): An in vitro study

Author:: Delgerbat Boldbaatar; Hesham R. El-Seedi; Meriana Findakly; Safa Jabri; Batkhuu Javzan; Battsetseg Choidash; Ulf Göransson; Björn Hellman
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 599-606
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; DNA damage; antioxidant activity; antioxidants; butanol; catechol; comet assay; drugs; flavones; in vitro studies; medicinal plants; methanol; methylene chloride; mice; mutagens; neoplasm cells; traditional medicine; Mongolia
Abstract:: ... Leptopyrum fumarioides has been used in the traditional medicine of Mongolia for the treatment of various diseases, including drug intoxications. However, since there is only sparse information about its chemistry, active components, and pharmacological and toxicological effects, the major aim of the present study employing mouse lymphoma cells was to evaluate the genotoxic and antigenotoxic/antio ...
DOI:: 10.1016/j.jep.2014.06.005
: https://doi.org/10.1016/j.jep.2014.06.005

71. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats

Author:: Yan Weng; Lu Yu; Jia Cui; Yan-Rong Zhu; Chao Guo; Guo Wei; Jia-Lin Duan; Ying Yin; Yue Guan; Yan-Hua Wang; Zhi-Fu Yang; Miao-Miao Xi; Ai-Dong Wen
Source:: Journal of ethnopharmacology 2014 v.152 no.3 pp. 553-560
ISSN:: 0378-8741
Subject:: aspartate transaminase; hepatitis; low density lipoprotein cholesterol; noninsulin-dependent diabetes mellitus; creatinine; oral administration; glutathione; malondialdehyde; alanine; glibenclamide; saponins; medicinal properties; animal disease models; blood serum; superoxide dismutase; blood glucose; glycemic effect; triacylglycerols; insulin; rats; toxicity; antioxidant activity; weight loss; diuresis; antioxidants; rheumatoid arthritis; hypoglycemic agents; pain; glycosylation; hemoglobin; Aralia; urea; nephritis; edema; blood circulation; death; bark; Oriental traditional medicine
Abstract:: ... As a well-known traditional Chinese medicine the root bark of Aralia taibaiensis has multiple pharmacological activities, including relieving rheumatism, promoting blood circulation to arrest pain, inducing diuresis to reduce edema, and antidiabetic action. It has long been used as a folk medicine for the treatment of traumatic injury, rheumatic arthralgia, nephritis, edema, hepatitis and diabetes ...
DOI:: 10.1016/j.jep.2014.02.001
: https://doi.org/10.1016/j.jep.2014.02.001

72. Antihypertensive activities of the aqueous extract of Kalanchoe pinnata (Crassulaceae) in high salt-loaded rats

Author:: Orelien Sylvain Mtopi Bopda; Frida Longo; Thierry Ndzana Bella; Protais Marcellin Ohandja Edzah; Germain Sotoing Taïwe; Danielle Claude Bilanda; Esther Ngo Lemba Tom; Pierre Kamtchouing; Theophile Dimo
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 400-407
ISSN:: 0378-8741
Subject:: Kalanchoe pinnata; animal disease models; antihypertensive effect; antioxidants; aorta; biomarkers; diastolic blood pressure; glutathione; heart; heart rate; hypertension; kidneys; leaf extracts; leaves; liver; nitric oxide; nitrites; oral administration; oxidative stress; rats; sodium chloride; spironolactone; superoxide dismutase; systolic blood pressure; traditional medicine; Cameroon
Abstract:: ... The leaves of Kalanchoe pinnata (Crassulaceae) are used in Cameroon folk medicine to manage many diseases such as cardiovascular dysfunctions. In this work, we aimed to evaluate the activities of aqueous leaf extract of Kalanchoe pinnata on the blood pressure of normotensive rat (NTR) and salt hypertensive rats (SHR), as well as its antioxidant properties.Hypertension was induced in rats by oral a ...
DOI:: 10.1016/j.jep.2014.02.041
: https://doi.org/10.1016/j.jep.2014.02.041

73. Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum)

Author:: Petra Krejčová; Petra Kučerová; Gary I. Stafford; Anna K. Jäger; Roman Kubec
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 176-182
ISSN:: 0378-8741
Subject:: Allium; acetylcholinesterase; amine oxidase (flavin-containing); anti-inflammatory activity; drugs; enzyme inhibition; inflammation; inhibitory concentration 50; prostaglandin synthase; pyridines; serotonin; traditional medicine; transport proteins; Central Asia; Iran
Abstract:: ... Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione and four related sulfur-containing pyridine N-oxides which are prominent constituents of Allium stipitatum were tested.The ant ...
DOI:: 10.1016/j.jep.2014.03.066
: https://doi.org/10.1016/j.jep.2014.03.066

74. Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases

Author:: Nadir Abuzeid; Sadaf Kalsum; Richin John Koshy; Marie Larsson; Mikaela Glader; Henrik Andersson; Johanna Raffetseder; Elsje Pienaar; Daniel Eklund; Muddathir S. Alhassan; Haidar A. AlGadir; Waleed S. Koko; Thomas Schön; M. Ahmed Mesaik; Omer M. Abdalla; Asaad Khalid; Maria Lerm
Source:: Journal of ethnopharmacology 2014 v.157 pp. 134-139
ISSN:: 0378-8741
Subject:: Khaya senegalensis; Mycobacterium tuberculosis; Rosmarinus officinalis; active ingredients; antibacterial properties; antibiotics; avirulent strains; bark; butanol; chloroform; culture media; cytotoxicity; ethanol; ethyl acetate; fractionation; hexane; hydrophilicity; hydrophobicity; infectious diseases; inhibitory concentration 50; leaf extracts; macrophages; medicinal plants; multiple drug resistance; new drugs; screening; solvents; traditional medicine; Sudan
Abstract:: ... The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important source of new drugs, and design and implementation of antimycobacterial susceptibil ...
DOI:: 10.1016/j.jep.2014.09.020
: https://doi.org/10.1016/j.jep.2014.09.020

75. Antimycobacterial, anti-inflammatory and genotoxicity evaluation of plants used for the treatment of tuberculosis and related symptoms in South Africa

Author:: B. Madikizela; A.R. Ndhlala; J.F. Finnie; J. Van Staden
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 386-391
ISSN:: 0378-8741
Subject:: Abrus precatorius; Ficus; Mycobacterium tuberculosis; Phanerophlebia; Salmonella Typhimurium; Terminalia; anti-inflammatory activity; antibacterial properties; bioactive compounds; drug resistance; ethanol; genotoxicity; methylene chloride; minimum inhibitory concentration; petroleum; prostaglandin synthase; screening; solvents; traditional medicine; tuberculosis; South Africa
Abstract:: ... Emergence of drug-resistant tuberculosis strains and long duration of treatment has established an urgent need to search for new effective agents. The great floral diversity of South Africa has potential for producing new bioactive compounds, therefore pharmacological screening of plant extracts within this region offers much potential. To assess the in vitro antimycobacterial, anti-inflammatory a ...
DOI:: 10.1016/j.jep.2014.02.034
: https://doi.org/10.1016/j.jep.2014.02.034

76. Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L

Author:: Yu Wang; Ping Chen; Changyun Tang; Yao Wang; Yazhen Li; Hao Zhang
Source:: Journal of ethnopharmacology 2014 v.151 no.2 pp. 944-950
ISSN:: 0378-8741
Subject:: Carthamus tinctorius; acetic acid; analgesic effect; animal models; anti-inflammatory activity; anti-inflammatory agents; aspirin; dose response; ears; edema; formalin; formalin test; glycosides; high performance liquid chromatography; inflammation; kaempferol; mice; nociception; oral administration; pain; traditional medicine; writhing test; China
Abstract:: ... Safflower (Carthamus tinctorius L.) has been long used both in the traditional system and folk medicine as an analgesic anti-inflammatory agent in China. The aim of the study was to evaluate the antinociceptive and anti-inflammatory activities of hydroalcoholic extract (HE) and two isolated kaempferol glycosides of Carthamus tinctorius L. to provide experimental evidence for its traditional use.An ...
DOI:: 10.1016/j.jep.2013.12.003
: https://doi.org/10.1016/j.jep.2013.12.003

77. Antinociceptive and anti-inflammatory activity of Sambucus palmensis link, an endemic Canary Island species

Author:: Susana Abdala; Sandra Dévora; Domingo Martín-Herrera; Pedro Pérez-Paz
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 626-632
ISSN:: 0378-8741
Subject:: Sambucus; analgesic effect; analgesics; anti-inflammatory activity; carrageenan; edema; formalin; formalin test; indigenous species; inflammation; islands; mice; models; oral administration; pain; tail flick test; traditional medicine; Canary Islands
Abstract:: ... Sambucus palmensis Link is an endemic species of the Canary Islands, popularly known as “Saúco canario”. This species has wide use in folk medicine practice on the islands, especially as analgesic and anti-inflammatory. So the aim of our study is to evaluate the antinociceptive and anti-inflammatory activity of an aqueous extract of this species.Three aqueous extract doses (35, 52.5 and 70mg/kg) w ...
DOI:: 10.1016/j.jep.2014.06.002
: https://doi.org/10.1016/j.jep.2014.06.002

78. Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica

Author:: Mohammad Zafar Imam; Md. Moniruzzaman
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 109-115
ISSN:: 0378-8741
Subject:: Lannea coromandelica; analgesic effect; animal models; cyclic GMP; dose response; ethanol; formalin; leaves; naloxone; nociception; pain; potassium channels; receptors; traditional medicine; Bangladesh
Abstract:: ... Lannea coromandelica (Houtt.) Merr. is a plant locally called “Jiga”, found all over Bangladesh. Leaf of the plant is traditionally used in the treatment of local swellings, pains of body, toothache etc. This study evaluated the antinociceptive effect of the ethanol extract of L. coromandelica leaves (EELC).The antinociceptive activity of the extract (at the doses of 50, 100, and 200mg/kg) was eva ...
DOI:: 10.1016/j.jep.2014.03.032
: https://doi.org/10.1016/j.jep.2014.03.032

79. Antinociceptive property of Olax subscorpioidea Oliv (Olacaceae) extract in mice

Author:: Olusegun Adebayo Adeoluwa; Adegbuyi Oladele Aderibigbe; Elizabeth Toyin Olonode
Source:: Journal of ethnopharmacology 2014 v.156 pp. 353-357
ISSN:: 0378-8741
Subject:: Erythropalaceae; acetic acid; analgesics; behavior disorders; dose response; formalin; hot plate test; latent period; leaves; mice; neoplasms; pain; shrubs; tail; traditional medicine; trees; Nigeria
Abstract:: ... Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is used in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer. However, there is dearth of information on scientific basis for its folkloric use in the management of pain. Therefore, the study was designed to investigate the antinociceptive property of the extract of Olax subsc ...
DOI:: 10.1016/j.jep.2014.08.040
: https://doi.org/10.1016/j.jep.2014.08.040

80. Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents

Author:: Rosanna T. Basting; Catarine M. Nishijima; Juliana A. Lopes; Raquel C. Santos; Larissa Lucena Périco; Stefan Laufer; Silke Bauer; Miriam F. Costa; Lourdes C. Santos; Lúcia R.M. Rocha; Wagner Vilegas; Adair R.S. Santos; Catarina dos Santos; Clélia A. Hiruma-Lima
Source:: Journal of ethnopharmacology 2014 v.157 pp. 257-267
ISSN:: 0378-8741
Subject:: anti-inflammatory activity; xylene; carrageenan; flavonoids; phosphorylation; oral administration; mitogen-activated protein kinase; ears; indomethacin; secondary metabolites; formalin; nociception; phytopharmaceuticals; leaves; traditional medicine; naloxone; arginine; models; mice; rats; hot plate test; ethanol; pain; formalin test; nitric oxide; gastric mucosa; surveys; edema; mucus; Eugenia; glutamic acid; analgesic effect
Abstract:: ... An ethnopharmacological survey indicated that leaves from Eugenia punicifolia (Kunth) DC. (Myrtaceae) are popularly used as a natural therapeutic agent to treat pain and inflammation.The overall objective of the present study was to evaluate the antinociceptive, anti-inflammatory and gastroprotective activities of a hydroalcoholic extract of leaves from Eugenia punicifolia (HEEP) in rodents.The an ...
DOI:: 10.1016/j.jep.2014.09.041
: https://doi.org/10.1016/j.jep.2014.09.041

81. Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats

Author:: Chun-Feng Zhang; Su-Li Zhang; Xin He; Xiao-Lin Yang; Hai-Tao Wu; Bao-Qin Lin; Cui-Ping Jiang; Jun Wang; Chun-Hao Yu; Zhong-Lin Yang; Chong-Zhi Wang; Ping Li; Chun-Su Yuan
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 793-800
ISSN:: 0378-8741
Subject:: Daphne genkwa; adjuvants; animal models; antioxidant activity; antioxidants; apigenin; blood viscosity; edema; herbal medicines; high performance liquid chromatography; histopathology; inflammation; luteolin; mass spectrometry; oxidative stress; pain; rats; rheumatoid arthritis; traditional medicine; weight loss; China
Abstract:: ... Genkwa flos (Daphne genkwa Sieb. et Zucc.), a Chinese herbal medicine, has been traditionally used for over two thousand years in China for inflammation related symptoms, including joint pain. To evaluate the antioxidative effects of flavonoid aglycones (FA) isolated from Genkwa flos on adjuvant arthritis in rats and to identify the relationship between antioxidant potential and whole blood viscos ...
DOI:: 10.1016/j.jep.2014.03.046
: https://doi.org/10.1016/j.jep.2014.03.046

82. Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils

Author:: Maria do Rosário Martins; Silvia Arantes; Fátima Candeias; Maria Teresa Tinoco; Júlio Cruz-Morais
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 485-492
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Artemia salina; Schinus molle; acute toxicity; agar; alpha-phellandrene; alpha-pinene; analgesics; antimicrobial properties; antioxidant activity; antioxidants; antiseptics; bacteria; beta-phellandrene; chemical composition; essential oils; food industry; free radicals; fruits; gas chromatography-mass spectrometry; leaves; limonene; mice; minimum inhibitory concentration; myrcene; parasympatholytics; pharmaceutical industry; screening; spoilage fungi; traditional medicine
Abstract:: ... Schinus molle L. has been used in folk medicine as antibacterial, antiviral, topical antiseptic, antifungal, antioxidant, anti-inflammatory, anti-tumoural as well as antispasmodic and analgesic; however, there are few studies of pharmacological and toxicological properties of Schinus molle essential oils. The aim of this study was to evaluate the antioxidant and antimicrobial activities of Schinus ...
DOI:: 10.1016/j.jep.2013.10.063
: https://doi.org/10.1016/j.jep.2013.10.063

83. Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial

Author:: Seok Kyo Seo; Yeon Hong; Bo Hyon Yun; Seung Joo Chon; Yeon Soo Jung; Joo Hyun Park; SiHyun Cho; Young Sik Choi; Byung Seok Lee
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 753-757
ISSN:: 0378-8741
Subject:: Panax; antioxidant activity; antioxidants; blood serum; enzyme activity; glucose; glutathione peroxidase; glycemic effect; insulin; insulin resistance; malondialdehyde; models; oxidative stress; postmenopause; randomized clinical trials; superoxide dismutase; traditional medicine; women; East Asia
Abstract:: ... Red ginseng (RG) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the anti-oxidative and anti-diabetic effects of RG. This study aimed to investigate the effects of RG on oxidative stress and insulin resistance in postmenopausal women.We performed a randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45–60years. Part ...
DOI:: 10.1016/j.jep.2014.04.051
: https://doi.org/10.1016/j.jep.2014.04.051

84. Antiproliferative activity and new argininyl bufadienolide esters from the “cururú” toad Rhinella (Bufo) schneideri

Author:: Guillermo Schmeda-Hirschmann; Cristina Quispe; Cristina Theoduloz; Paulo Teixeira de Sousa; Carlos Parizotto
Source:: Journal of ethnopharmacology 2014 v.155 no.2 pp. 1076-1085
ISSN:: 0378-8741
Subject:: Bufo; pressing; leukemia; erysipelas; neoplasm cells; spectral analysis; lungs; epithelium; inhibitory concentration 50; bladder; etoposide; alkaloids; toad venoms; spectroscopy; traditional medicine; human cell lines; bufadienolides; lung neoplasms; adenocarcinoma; Rhinella; toads; wetlands; parotid gland; bioactive properties; fibroblasts; Pantanal
Abstract:: ... Toads known as “cururú” (Rhinella schneideri) have been used in the Brazilian Pantanal and Paraguayan Chaco wetlands to treat erysipelas and cancer. The aim of the study was to assess the antiproliferative effect of the venom obtained from Rhinella schneideri and to identify its constituents by spectroscopic and spectrometric methods.The venom was obtained by gentle pressing the parotid glands of ...
DOI:: 10.1016/j.jep.2014.06.025
: https://doi.org/10.1016/j.jep.2014.06.025

85. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents

Author:: Jinlian Zhao; Dimitrios Evangelopoulos; Sanjib Bhakta; Alexander I. Gray; Véronique Seidel
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 796-800
ISSN:: 0378-8741
Subject:: 4-hydroxybenzoic acid; Arctium lappa; Mycobacterium tuberculosis; Tussilago farfara; ethyl acetate; growth retardation; hexane; kaempferol; methanol; methylene chloride; nuclear magnetic resonance spectroscopy; p-coumaric acid; quercetin; sitosterols; spectral analysis; stigmasterol; traditional medicine
Abstract:: ... Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was (i) to screen Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis and (ii) to isolate and identify the compound(s) responsible for this reputed anti-TB effect.The activity of extracts and isolated compounds was dete ...
DOI:: 10.1016/j.jep.2014.06.034
: https://doi.org/10.1016/j.jep.2014.06.034

86. Antitubercular constituents from Premna odorata Blanco

Author:: Stephen B. Lirio; Allan Patrick G. Macabeo; Erickson M. Paragas; Matthias Knorn; Paul Kohls; Scott G. Franzblau; Yuehong Wang; Ma. Alicia M. Aguinaldo
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 471-474
ISSN:: 0378-8741
Subject:: Mycobacterium tuberculosis; Premna; antibacterial properties; beta-sitosterol; colorimetry; formates; fractionation; gas chromatography-mass spectrometry; gel chromatography; leaves; medicinal plants; nuclear magnetic resonance spectroscopy; silica gel; solvents; stigmasterol; traditional medicine; tuberculosis; Philippines
Abstract:: ... Premna odorata Blanco (Lamiaceae) is a medicinal plant traditionally used in Albay Province, in southeastern Luzon, Philippines to treat tuberculosis. This study aimed to determine the antitubercular property of the crude extract and sub-extracts of the leaves, and to isolate the bioactive principles from the active fractions.Through extraction, solvent polarity-based fractionation and silica gel ...
DOI:: 10.1016/j.jep.2014.04.015
: https://doi.org/10.1016/j.jep.2014.04.015

87. Antitussive, expectorant and anti-inflammatory activities of different extracts from Exocarpium Citri grandis

Author:: Kun Jiang; Qian Song; Lei Wang; Tianzhu Xie; Xi Wu; Ping Wang; Guo Yin; Wencai Ye; Tiejie Wang
Source:: Journal of ethnopharmacology 2014 v.156 pp. 97-101
ISSN:: 0378-8741
Subject:: ammonia; animal models; anti-inflammatory activity; anti-inflammatory agents; cough; ears; edema; ethanol; freeze drying; mice; phenolsulfonphthalein; secretion; solvents; traditional medicine; xylene; China
Abstract:: ... Exocarpium Citri grandis (C. grandis, Huajuhong in Chinese), the epicarp of C. grandis ‘Tomentosa’, is used as an antitussive, expectorant and anti-inflammatory drug for hundreds of years in China. The study was aimed at evaluating the antitussive, expectorant and anti-inflammatory effects of different extracts of C. grandis, providing experimental evidence for its traditional use, and laying a fo ...
DOI:: 10.1016/j.jep.2014.08.030
: https://doi.org/10.1016/j.jep.2014.08.030

88. Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sessé ex DC. (balsam)

Author:: Viviane Carrasco; Lorraine Aparecida Pinto; Kátia Wolff Cordeiro; Claudia Andrea Lima Cardoso; Karine de Cássia Freitas
Source:: Journal of ethnopharmacology 2014 v.158 pp. 345-351
ISSN:: 0378-8741
Subject:: Sedum dendroideum; acetic acid; acidity; animals; anti-ulcer activity; antioxidant activity; antioxidants; chemical constituents of plants; cimetidine; ethanol; indomethacin; leaf extracts; leaves; models; mucus; nitric oxide; oxidation; pH; screening; secretion; stomach ulcers; subacute toxicity; toxicity testing; traditional medicine
Abstract:: ... The leaves of Sedum dendroideum, commonly known as balsam, have long been employed for the treatment of gastric ulcers. The aim of study was to evaluate the antiulcer activity and toxicological properties of Sedum dendroideum using induced gastric ulcer models in Wistar rats.The hydroethanolic extract of Sedum dendroideum (ESD) was analyzed using an acute ulcer model using ethanol and indomethacin ...
DOI:: 10.1016/j.jep.2014.10.042
: https://doi.org/10.1016/j.jep.2014.10.042

89. Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats

Author:: Margaret O. Sofidiya; Foluso O. Agunbiade; Neil A. Koorbanally; Abimbola Sowemimo; Dapo Soesan; Titi Familusi
Source:: Journal of ethnopharmacology 2014 v.157 pp. 1-6
ISSN:: 0378-8741
Subject:: Bignoniaceae; acidity; anti-ulcer activity; chemical composition; dose response; electrospray ionization mass spectrometry; ethanol; ethyl acetate; indomethacin; inflammation; leaves; liquid chromatography; luteolin; models; pH; pylorus; rats; solvents; traditional medicine
Abstract:: ... The leaves of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. (Bignoniaceae) are used traditionally in the treatment of skin afflictions, sores, ulcers and inflammation. The aim of the study was to investigate the antiulcer activity of the crude ethanolic extract from the leaves of Markhamia tomentosa, determine the active fraction(s) of the extract and identify the chemical constituents in the ac ...
DOI:: 10.1016/j.jep.2014.09.012
: https://doi.org/10.1016/j.jep.2014.09.012

90. Antrodia salmonea inhibits TNF-α-induced angiogenesis and atherogenesis in human endothelial cells through the down-regulation of NF-κB and up-regulation of Nrf2 signaling pathways

Author:: Hsin-Ling Yang; Hebron C. Chang; Shu-Wei Lin; K.J. Senthil Kumar; Chun-Huei Liao; Hui-Min Wang; Kai-Yuan Lin; You-Cheng Hseu
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 394-406
ISSN:: 0378-8741
Subject:: Antrodia; Oriental traditional medicine; adhesion; angiogenesis; atherogenesis; atherosclerosis; culture media; endothelial cells; gelatinase B; glutamate-cysteine ligase; intercellular adhesion molecule-1; leukocytes; phosphorylation; protective effect; signal transduction; transcription factor NF-kappa B; transcriptional activation; tumor necrosis factor-alpha
Abstract:: ... Antrodia salmonea (AS) is known as a traditional Chinese medicine, but very few biological activities have been reported.The present study was aimed to investigate the anti-angiogenic and anti-atherosclerotic potential of the fermented culture broth of AS against tumor necrosis factor-α (TNF-α)-stimulated human endothelial (EA.hy 926) cells.The non-cytotoxic concentrations of AS significantly inhi ...
DOI:: 10.1016/j.jep.2013.10.052
: https://doi.org/10.1016/j.jep.2013.10.052

91. Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils

Author:: Chao-Hung Kuo; Bi-Chuang Weng; Chun-Chieh Wu; Sheau-Fang Yang; Deng-Chang Wu; Yuan-Chuen Wang
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1031-1039
ISSN:: 0378-8741
Subject:: Helicobacter pylori; apigenin; asphyxia; blood lipids; blood pressure; carbon dioxide; celery; chamomile; disease course; drinking water; fruits; gastritis; immunohistochemistry; inflammation; monocytes; neutrophils; parsley; stomach neoplasms; traditional medicine
Abstract:: ... Apigenin, one of the most common flavonoids, is abundant in celery, parsley, chamomile, passionflower, and other vegetables and fruits. Celery is recognized as a medicinal vegetable in Oriental countries to traditionally treat inflammation, swelling, blood pressure, serum lipid, and toothache. In this study, we investigated apigenin treatment effects on Helicobacter pylori-induced atrophic gastrit ...
DOI:: 10.1016/j.jep.2013.11.040
: https://doi.org/10.1016/j.jep.2013.11.040

92. Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies

Author:: Yuanzhi Lao; Xiaoyu Wang; Naihan Xu; Hongmei Zhang; Hongxi Xu
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 1-8
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; active ingredients; animals; cardiovascular diseases; diabetes; mechanism of action; neoplasms; neurons; patients; protein-protein interactions; proteomics; signal transduction; surveys; systematic review; tissues
Abstract:: ... The rationale for using traditional Chinese medicine (TCM) is based on the experience that has been gained from its wide use over thousands of years. However, the mechanisms of action of many TCM are still unclear. Proteomics, which mainly characterizes protein functions, protein–protein interactions, and protein modification in tissues or animals, can be used to investigate signaling pathway pert ...
DOI:: 10.1016/j.jep.2014.05.022
: https://doi.org/10.1016/j.jep.2014.05.022

93. Are plants used for skin care in South Africa fully explored?

Author:: Namrita Lall; Navneet Kishore
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 61-84
ISSN:: 0378-8741
Subject:: Aloe; Artemisia afra; Harpephyllum caffrum; Sclerocarya birrea; Sideroxylon; Ximenia americana; cosmetics; hyperpigmentation; ingredients; medicinal plants; medicinal properties; therapeutics; traditional medicine; South Africa
Abstract:: ... South Africa is an important focal point of botanical diversity, and although many plant species have been used since ancient times in ethnomedicine, only a few species have hitherto been fully investigated scientifically. A large proportion of the South African population use traditional medicines for their physical and psychological health needs. Many medicinal plants have recently gained popula ...
DOI:: 10.1016/j.jep.2014.02.021
: https://doi.org/10.1016/j.jep.2014.02.021

94. Arnebin-1 promotes the angiogenesis of human umbilical vein endothelial cells and accelerates the wound healing process in diabetic rats

Author:: Zhi Zeng; Bang-Hao Zhu
Source:: Journal of ethnopharmacology 2014 v.154 no.3 pp. 653-662
ISSN:: 0378-8741
Subject:: alloxan; angiogenesis; animal disease models; cell movement; diabetes; fibroblasts; herbal medicines; histology; human umbilical vein endothelial cells; macrophages; males; ointments; rats; surveys; synergism; tissue repair; topical application; traditional medicine; vascular endothelial growth factors; China
Abstract:: ... Zicao is a traditional wound healing herbal medicine that has been used for several hundred years in China. A survey of the published literatures revealed that arnebin-1, one of the naphthoquinone derivatives, played the most important role in wound healing property of this plant. However, whether arnebin-1 affects angiogenesis in vitro and has an effect on wound healing process in diabetic rats r ...
DOI:: 10.1016/j.jep.2014.04.038
: https://doi.org/10.1016/j.jep.2014.04.038

95. Assessment of Cuscuta chinensis seeds׳ effect on melanogenesis: Comparison of water and ethanol fractions in vitro and in vivo

Author:: Tian-Jing Wang; Jing An; Xiao-Hui Chen; Qiu-Di Deng; Liu Yang
Source:: Journal of ethnopharmacology 2014 v.154 no.1 pp. 240-248
ISSN:: 0378-8741
Subject:: Cuscuta; Danio rerio; Western blotting; dose response; enzyme activity; ethanol; herbs; larvae; melanin; melanocytes; melanogenesis; melanoma; melanosis; messenger RNA; mice; models; mushrooms; phenotype; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; seeds; traditional medicine; Asia
Abstract:: ... Cuscuta chinensis seeds have traditionally been used to treat freckles and melasma in Asia, although recent reports have revealed that Semen cuscutae is a promoter of melanogenesis. The present study aims to investigate the mechanism of this opposite effect of Semen cuscutae on melanogenesis.In accordance with traditional usage, the water fraction and the ethanol fraction from Semen cuscutae (WFSC ...
DOI:: 10.1016/j.jep.2014.04.016
: https://doi.org/10.1016/j.jep.2014.04.016

96. Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)

Author:: G. Picard; C. Valadeau; J. Albán–Castillo; R. Rojas; J.R. Starr; R. Callejas-Posada; S.A.L. Bennett; J.T. Arnason
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1500-1507
ISSN:: 0378-8741
Subject:: Drymaria; Piper; anxiety; benzodiazepines; bioassays; enzyme inhibition; ethnobotany; gamma-aminobutyric acid; mechanism of action; surveys; traditional medicine; Peru
Abstract:: ... A previous pilot ethnobotanical and ethnopharmacological study with the Q‘echi׳ Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including ...
DOI:: 10.1016/j.jep.2014.07.039
: https://doi.org/10.1016/j.jep.2014.07.039

97. Atractylodes macrocephala Koidz promotes intestinal epithelial restitution via the polyamine—Voltage-gated K+ channel pathway

Author:: Hou-Pan Song; Ru-Liu Li; Xu Chen; Yi-Yu Wang; Jia-Zhong Cai; Jia Liu; Wei-Wen Chen
Source:: Journal of ethnopharmacology 2014 v.152 no.1 pp. 163-172
ISSN:: 0378-8741
Subject:: Atractylodes macrocephala; Oriental traditional medicine; Western blotting; alpha-difluoromethylornithine; calcium; cell movement; computer software; digestive system diseases; drugs; flow cytometry; high performance liquid chromatography; intestinal mucosa; membrane potential; messenger RNA; models; polystyrenes; potassium channels; protein content; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; spermidine
Abstract:: ... Atractylodes macrocephala Koidz (AMK) has been used widely as a digestive and tonic in traditional Chinese medicine. AMK has shown noteworthy promoting effect on intestinal epithelial cell migration, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study was to investigate the efficacy of AMK on intestinal mucosal restitution and the underl ...
DOI:: 10.1016/j.jep.2013.12.049
: https://doi.org/10.1016/j.jep.2013.12.049

98. Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics

Author:: Haojun Zhang; Tingting Zhao; Yuewen Gong; Xi Dong; Weiku Zhang; Sifan Sun; Hua Wang; Yanting Gu; Xiaoguang Lu; Meihua Yan; Ping Li
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 556-564
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; animal disease models; blood glucose; blood serum; diabetic nephropathy; excretion; fibrosis; herbs; immunohistochemistry; intraperitoneal injection; kidneys; mechanism of action; messenger RNA; protein content; rats; transcription factor NF-kappa B; transforming growth factor beta 1; tumor necrosis factor-alpha; urine; China
Abstract:: ... Traditional Chinese medical herbs have been used in China for a long time to treat different diseases. Based on traditional Chinese medicine (TCM) principle, Chaihuang-Yishen granule (CHYS) was developed and has been employed clinically to treat chronic kidney disease including diabetic nephropathy (DN). The present study was designed to investigate its mechanism of action in treatment of DN.Diabe ...
DOI:: 10.1016/j.jep.2013.11.020
: https://doi.org/10.1016/j.jep.2013.11.020

99. Attenuation of inflammatory mediators, oxidative stress and toxic risk evaluation of Aporosa lindleyana Baill bark extract

Author:: Yakub Ali; Mohammad Sarwar Alam; Hinna Hamid; Asif Husain; Chetna Kharbanda; Sameena Bano; Syed Nazreen; Saqlain Haider
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1513-1521
ISSN:: 0378-8741
Subject:: anti-inflammatory activity; antioxidant activity; antioxidants; bark; carrageenan; catalase; edema; enzyme activity; enzyme-linked immunosorbent assay; fever; headache; hepatotoxicity; histology; indomethacin; inflammation; jaundice; lipid peroxidation; liver; mechanism of action; nitric oxide; oxidative stress; peptic ulcers; risk assessment; stomach; superoxide dismutase; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Traditionally, Aporosa lindleyana Baill. has been used against various ailments viz. jaundice, fever, headache, seminal loss and insanity. The present study aims to evaluate the anti-inflammatory and anti-oxidant activity of the ethanolic extract of Aporosa lindleyana Baill. bark and its fractions.The anti-inflammatory activity of ethanolic extract of Aporosa lindleyana Baill. bark and its various ...
DOI:: 10.1016/j.jep.2014.07.035
: https://doi.org/10.1016/j.jep.2014.07.035

100. Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats

Author:: Chen-Liang Tsai; Yu-Chieh Lin; Hui-Min Wang; Tz-Chong Chou
Source:: Journal of ethnopharmacology 2014 v.153 no.1 pp. 197-206
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Scutellaria baicalensis; antioxidant activity; body weight; catheters; edema; enzyme activity; flavonoids; heme oxygenase (biliverdin-producing); histopathology; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; models; myeloperoxidase; nitrates; nitrites; rats; superoxide anion; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Baicalein (BE), a phenolic flavonoid extracted mainly from the root of Scutellaria baicalensis Georgi, a Chinese herb, is traditionally used in oriental medicine. Several studies have demonstrated that BE exerts many beneficial effects including anti-inflammatory and antioxidant activities. However, its effect on acute lung injury (ALI) and the molecular mechanisms involved remain unclear and warr ...
DOI:: 10.1016/j.jep.2014.02.010
: https://doi.org/10.1016/j.jep.2014.02.010

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1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

4. 4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities

5. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

6. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative

7. Absorption and metabolism of three monoester-diterpenoid alkaloids in Aconitum carmichaeli after oral administration to rats by HPLC–MS

8. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

9. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

10. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

11. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

12. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

13. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

14. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

15. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

16. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

17. Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats

18. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

19. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

20. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

21. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate

22. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

23. Anti-HBV activity of the different extracts from Phyllanthus rheedei Wight in cell culture based assay systems

24. Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico

25. Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats

26. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

27. Anti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway

28. Anti-biofilm activity of Marula – A study with the standardized bark extract

29. Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

30. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model

31. Anti-diarrhoeal activity of methanol extract of Santalum album L. in mice and gastrointestinal effect on the contraction of isolated jejunum in rats

32. Anti-fatigue effects of proteins isolated from Panax quinquefolium

33. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

34. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model

35. Anti-hyperglycemic effect, inhibition of inflammatory cytokines expression, and histopathology profile in streptozotocin-induced diabetic rats treated with Arracacia tolucensis aerial-parts extracts

36. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice

37. Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract

38. Anti-inflammatory activity of animal oils from the Peruvian Amazon

39. Anti-inflammatory activity of compounds from Boesenbergia longiflora rhizomes

40. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats

41. Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

42. Anti-inflammatory and analgesic activity of aqueous extract of Flos populi

43. Anti-inflammatory and anti-hypersensitive effects of the crude extract, fractions and triterpenes obtained from Chrysophyllum cainito leaves in mice

44. Anti-inflammatory and antioxidant activities of Costus afer Ker Gawl. hexane leaf fraction in arthritic rat models

45. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

46. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

47. Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

48. Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis)

49. Anti-influenza virus activity of the ethanolic extract from Peperomia sui

50. Anti-melanoma activity of Cynanchi atrati Radix is mediated by regulation of NF-kappa B activity and pro-apoptotic proteins

51. Anti-stress effect of astragaloside IV in immobilized mice

52. Anti-trypanosomal activity of African medicinal plants: A review update

53. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo

54. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

55. Anti-tumor effect of Shu-gan-Liang-Xue decoction in breast cancer is related to the inhibition of aromatase and steroid sulfatase expression

56. Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves

57. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes

58. Antibacterial activities of extracts from Ugandan medicinal plants used for oral care

59. Antibacterial activities of plants from Central Africa used traditionally by the Bakola pygmies for treating respiratory and tuberculosis-related symptoms

60. Antibacterial activity of the roots, stems and leaves of Alchornea floribunda

61. Antibacterial and anti-inflammatory activities of extract and fractions from Pyrrosia petiolosa (Christ et Bar.) Ching

62. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers

63. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action

64. Antidepressant-like effect of the hydroethanolic leaf extract of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice: Involvement of monoaminergic system

65. Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

66. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats

67. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats

68. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

69. Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats

70. Antigenotoxic and antioxidant effects of the Mongolian medicinal plant Leptopyrum fumarioides (L): An in vitro study