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1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

Author:
Jean Paul Dzoyem; Victor Kuete; Lyndy J. McGaw; Jacobus N. Eloff
Source:
Journal of ethnopharmacology 2014 v.156 pp. 1-8
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Adansonia digitata; Aframomum; Mycobacterium aurum; Mycobacterium fortuitum; Mycobacterium smegmatis; Tamarindus indica; antibacterial properties; antioxidant activity; antioxidants; bromides; cytotoxicity; enzyme inhibition; flavonoids; fruits; herbs; infectious diseases; inflammation; inhibitory concentration 50; kidneys; lethal concentration 50; medicinal properties; minimum inhibitory concentration; monkeys; pain; spices; tetrazolium; traditional medicine; Africa
Abstract:
... Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their traditional use and safety. In this study, the 15-lipoxygenase inhibitory, antioxidant, antim ...
DOI:
10.1016/j.jep.2014.08.007

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

Author:
Qinxiao Guan; Shengwang Liang; Zhanhong Wang; Yongxia Yang; Shumei Wang
Source:
Journal of ethnopharmacology 2014 v.154 no.1 pp. 65-75
ISSN:
0378-8741
Subject:
Oriental traditional medicine; amino acids; apoptosis; biochemical pathways; brain; cerebrovascular disorders; death; emodin; energy; histopathology; infarction; ingredients; ischemia; metabolomics; models; neurons; nuclear magnetic resonance spectroscopy; pharmacodynamics; principal component analysis; protective effect; rats; rhubarb; society; urine
Abstract:
... The ischemia cerebrovascular disease is one of leading causes of death and long-term disability in modern society. Rhubarb is one of the common traditional Chinese medicine with many effects, and the main pharmacodynamic ingredients are aloe-emodin, rhein, emodin, chrysophanol and physcion. The five components are also known as rhubarb aglycone. Rhubarb aglycone has been confirmed to play a remark ...
DOI:
10.1016/j.jep.2014.03.002

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

Author:
Jong Rhan Kim; Jinhwan Choi; Jiyoung Kim; Heejeung Kim; Heerim Kang; Eun Hye Kim; Jeong-Hwa Chang; Yeong-Eun Kim; Young Jin Choi; Ki Won Lee; Hyong Joo Lee
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 365-371
ISSN:
0378-8741
Subject:
ginsenosides; immunomodulators; plant extracts; oral administration; metabolites; Dermatophagoides farinae; chemokine CCL22; skin lesions; ears; monoclonal antibodies; splenocytes; traditional medicine; blood serum; histology; anti-allergic agents; mice; Panax; eosinophils; atopic dermatitis; mast cells
Abstract:
... Ginseng and ginsenosides are frequently used in the treatment of chronic inflammatory diseases. Recently, 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol (GPD), the main metabolite of ginsenosides, was reported to have both anti-allergic and anti-pruritic effects. The immunomodulatory effects of GPD-fortified ginseng extract (GFGE) on atopic dermatitis (AD)-like symptoms in mice were investigated. T ...
DOI:
10.1016/j.jep.2013.10.058

4. 4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities

Author:
Ki Hyun Kim; Eunjung Moon; Sun Yeou Kim; Sang Un Choi; Jei Hyun Lee; Kang Ro Lee
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 503-508
ISSN:
0378-8741
Subject:
Raphanus sativus; anti-inflammatory agents; antineoplastic activity; carbon; fractionation; human cell lines; inducible nitric oxide synthase; inhibitory concentration 50; mice; neoplasm cells; neuroglia; nitrites; nuclear magnetic resonance spectroscopy; protein synthesis; seed extracts; seeds; stable isotopes; sulforaphane; traditional medicine
Abstract:
... Raphanus sativus seeds (Brassicaceae) known as Raphani Semen have long been used as anti-cancer and/or anti-inflammatory agents in Korean traditional medicine. This study was designed to isolate the bioactive constituents from the seed extracts of Raphanus sativus and evaluate their anti-inflammatory and antitumor activities.Bioassay-guided fractionation and chemical investigation of a methanolic ...
DOI:
10.1016/j.jep.2013.11.003

5. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Author:
Yanyan Yang; Woo Seok Yang; Tao Yu; Gi-Ho Sung; Kye Won Park; Keejung Yoon; Young-Jin Son; Hyunsik Hwang; Yi-Seong Kwak; Chang-Muk Lee; Man Hee Rhee; Jong-Hoon Kim; Jae Youl Cho
Source:
Journal of ethnopharmacology 2014 v.154 no.1 pp. 218-228
ISSN:
0378-8741
Subject:
Panax ginseng; anti-inflammatory activity; apoptosis; cyclic AMP; gastritis; herbal medicines; inducible nitric oxide synthase; inflammation; interferon regulatory factor-3; interferons; lipopolysaccharides; luciferase; messenger RNA; mice; mitogen-activated protein kinase; models; nitric oxide; peritonitis; prostaglandin synthase; traditional medicine; Korean Peninsula
Abstract:
... Korean Red Ginseng (KRG) is one of the representative traditional herbal medicines prepared from Panax ginseng Meyer (Araliaceae) in Korea. It has been reported that KRG exhibits a lot of different biological actions such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, anti-cancer, and anti-inflammatory activities. Although systematic studies have investigated how KR ...
DOI:
10.1016/j.jep.2014.04.008

6. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative

Author:
Xian Yang; Liuliu Yuan; Chaomei Xiong; Chunping Yin; Jinlan Ruan
Source:
Journal of ethnopharmacology 2014 v.157 pp. 105-113
ISSN:
0378-8741
Subject:
Cyclosorus; Western blotting; antioxidants; blood circulation; blood serum; blood stasis; castration; catalase; edema; glutathione peroxidase; glycosides; histopathology; hydrolysates; hyperplasia; immunohistochemistry; inflammation; interleukin-17; interleukin-1beta; interleukin-6; interleukin-8; models; oral administration; oxidative stress; phosphatidylinositol 3-kinase; prostaglandin synthase; protective effect; rats; subcutaneous injection; superoxide dismutase; testosterone; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Abacopteris penangiana (Hook.) Ching (AP) is a member of parathelypteris glanduligera and used in folk medicine for the treatment of blood circulation and blood stasis, edema and inflammation as recorded in the ″Chinese Materia Medica″.The purpose of this study was to investigate the effects of total flavanol glycosides (TFA) from AP and its acid hydrolysate (AHT) on testosterone-induced benign pr ...
DOI:
10.1016/j.jep.2014.09.025

7. Absorption and metabolism of three monoester-diterpenoid alkaloids in Aconitum carmichaeli after oral administration to rats by HPLC–MS

Author:
Hai Zhang; Qiong Wu; Wuhong Li; Sen Sun; Wen Zhang; Zhenyu Zhu; Guoqing Zhang; Yifeng Chai
Source:
Journal of ethnopharmacology 2014 v.154 no.3 pp. 645-652
ISSN:
0378-8741
Subject:
Aconitum; P-glycoproteins; absorption; alkaloids; bacterial artificial chromosomes; bioavailability; chemical constituents of plants; herbal medicines; high performance liquid chromatography; liver microsomes; males; mass spectrometry; oral administration; pharmacokinetics; quality control; rats; toxicity; traditional medicine
Abstract:
... Ethnopharmacological relevance:Aconitum carmichaelii (AC) is a well-known herbal medicine for its excellent pharmacological effects and toxicity. The monoester-diterpenoid alkaloids (MDAs), including benzoylmesaconine (BMC), benzoylaconine (BAC) and benzoylhyaconine (BHC), are the main active components in AC. It was found that the diester alkaloids could be transformed into monoester-diterpenoid ...
DOI:
10.1016/j.jep.2014.04.039

8. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Author:
Lian-Wu Xie; Atanas G. Atanasov; De-An Guo; Clemens Malainer; Jing-Xian Zhang; Martin Zehl; Shu-Hong Guan; Elke H. Heiss; Ernst Urban; Verena M. Dirsch; Brigitte Kopp
Source:
Journal of ethnopharmacology 2014 v.152 no.3 pp. 470-477
ISSN:
0378-8741
Subject:
Lycium chinense; Oriental traditional medicine; active ingredients; agonists; amides; antagonists; bark; cortex; diabetes mellitus; ethyl acetate; fractionation; genes; inflammation; inhibitory concentration 50; mechanism of action; methanol; methylene chloride; moieties; nuclear magnetic resonance spectroscopy; palmitic acid; peroxisome proliferator-activated receptors; structure-activity relationships; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; tyramine
Abstract:
... The root bark of Lycium chinense Miller, Lycii Radicis Cortex, has been used in traditional Chinese medicine (TCM) to treat different inflammation-related symptoms, such as diabetes mellitus. The pro-inflammatory transcription factor nuclear factor kappa B (NF-κB) is a key regulator of inflammation, while the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is a key mo ...
DOI:
10.1016/j.jep.2014.01.029

9. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

Author:
Lili Wang; Zhiqiang Li; Lin Li; Yanlin Li; Meng Yu; Yunfeng Zhou; Xinyong Lv; Hiderori Arai; Yang Xu
Source:
Journal of ethnopharmacology 2014 v.158 pp. 207-215
ISSN:
0378-8741
Subject:
acute toxicity; adults; adverse effects; alanine transaminase; albumins; alkaline phosphatase; body weight; cholesterol; cortex; cough; glucose; hematopoiesis; histology; jaundice; kidneys; liver; liver function; lymphocytes; mice; mortality; oral administration; rats; rheumatoid arthritis; skin diseases; toxicity testing; traditional medicine; urea nitrogen
Abstract:
... Cortex Dictamni is used in Chinese folk medicine for the treatment of jaundice, cough, rheumatism and some skin diseases; however, its possible toxicity has not been rigorously studied. The present investigation was carried out to evaluate the safety of Cortex Dictamni aqueous extract (CDAE) by acute and sub-chronic toxicity studies.In acute toxicity tests, seven groups of mice (n=5/group/sex) wer ...
DOI:
10.1016/j.jep.2014.10.027

10. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

Author:
Maxwell I. Ezeja; Aruh O. Anaga; Isaac U. Asuzu
Source:
Journal of ethnopharmacology 2014 v.151 pp. 1155-1164
ISSN:
0378-8741
Subject:
Gouania; acute toxicity; antioxidant activity; blood sampling; blood serum; cholesterol; death; diabetes mellitus; dose response; edema; eyes; heart; heart diseases; hematologic tests; high density lipoprotein; histopathology; kidneys; leaf extracts; leaves; lipid peroxidation; liver; lungs; malaria; methanol; morbidity; oral administration; rats; superoxide dismutase; toxicity testing; traditional medicine; triacylglycerols; urea; very low density lipoprotein; Africa
Abstract:
... Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.Acute toxicity test of the plant lasted for 48 ...
DOI:
10.1016/j.jep.2013.12.034

11. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

Author:
Hwayong Park; Youn-Hwan Hwang; Hye Jin Yang; Hyun-Kyu Kim; Kyung Seuk Song; Jin Yeul Ma
Source:
Journal of ethnopharmacology 2014 v.156 pp. 182-189
ISSN:
0378-8741
Subject:
Chinese hamsters; Escherichia; Salmonella; acute toxicity; animal ovaries; bacteria; body weight changes; chromosome aberrations; dietary exposure; freeze drying; genotoxicity; glycyrrhizin; health services; herbs; ingredients; laboratory animals; liquid chromatography; mice; micronucleus tests; mutation; rats; signs and symptoms (animals and humans); therapeutics; traditional medicine; East Asia
Abstract:
... Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one.Guibi-tang, composed of 12 herbs, was fermented with bacteria and lyophilized. Single dos ...
DOI:
10.1016/j.jep.2014.09.004

12. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

Author:
J. Luka; S.J. Badau; A.W. Mbaya; J.J. Gadzama; H.A. Kumshe
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 268-273
ISSN:
0378-8741
Subject:
Diospyros mespiliformis; acute toxicity; antimalarials; blood serum; body weight changes; death; enzymes; erythrocytes; hematocrit; hematology; hemoglobin; lethal dose 50; leukocytes; local government; rats; roots; toxicity testing; traditional medicine; Nigeria
Abstract:
... Different parts of the plant Diospyros mespiliformis have been used traditionally for the treatment of ailments in Nigeria particularly among the Kamwe people of Michika local government area of Adamawa State where the root has been used as an anti-malarial for ages. Most of the uses have been without any scientific evidence and toxicological assessment. The present study aimed to determine acute ...
DOI:
10.1016/j.jep.2014.02.033

13. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

Author:
Jing Li; Guoyong Yu; Junfeng Fan
Source:
Journal of ethnopharmacology 2014 v.155 no.1 pp. 285-292
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Sorghum (Poaceae); active sites; adenosine diphosphate; arachidonic acid; aspirin; blood; cardiovascular diseases; collagen; glucosides; mandelic acid; metabolism; monosaccharides; platelet aggregation; prostaglandin synthase; sorbitol; thrombin; vinegars; xylitol
Abstract:
... Vinegar has been used as both a common seasoning and a traditional Chinese medicine. Sorghum vinegar is an excellent source of physiological substances with multiple health benefits.To evaluate the antiplatelet aggregation activity of alditols and monosaccharides extracted from sorghum vinegar and analysis its mechanism.Alditol and monosaccharide extract (AME) from sorghum vinegar was first evalua ...
DOI:
10.1016/j.jep.2014.05.018

14. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Author:
Boyang Hu; Hai Zhang; Xianli Meng; Fei Wang; Ping Wang
Source:
Journal of ethnopharmacology 2014 v.153 no.3 pp. 846-853
ISSN:
0378-8741
Subject:
IKappaB kinase; Rheum rhabarbarum; Western blotting; anthraquinones; anti-inflammatory activity; bioactive compounds; cytotoxicity; enzyme-linked immunosorbent assay; gene expression; genes; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; medicinal plants; messenger RNA; mitogen-activated protein kinase; nitric oxide; phosphatidylinositol 3-kinase; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rhubarb; traditional medicine; transcription factor NF-kappa B; China
Abstract:
... Rheum rhabarbarum (rhubarb) has long been used for the treatment of inflammation in China and other Asian countries. However, the mechanism underlying the anti-inflammatory activity of this medicinal plant is not fully understood. The present study was designed to investigate the anti-inflammatory effects of anthraquinones, the major constituents in rhubarb, and the molecular mechanism involved in ...
DOI:
10.1016/j.jep.2014.03.059

15. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

Author:
Mahendra S. Khyade; Deepak M. Kasote; Nityanand P. Vaikos
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 1-18
ISSN:
0378-8741
Subject:
Alstonia macrophylla; Alstonia scholaris; adulterated products; alkaloids; antineoplastic activity; aphrodisiacs; gastrointestinal system; jaundice; malaria; medicinal plants; metabolic studies; neoplasms; plant biochemistry; therapeutics; toxicity; traditional medicine; India; Malaysia; Philippines; Thailand
Abstract:
... Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been us ...
DOI:
10.1016/j.jep.2014.01.025

16. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

Author:
Edwin Ogechukwu Omeje; Mohd Parvez Khan; Patience Ogoamaka Osadebe; Deepshikha Tewari; Mohammad Faheem Khan; Kapil Dev; Rakesh Maurya; Naibedya Chattopadhyay
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 643-651
ISSN:
0378-8741
Subject:
Bombax; Citrus; Cola nitida; Garcinia kola; Loranthus; adults; alkaline phosphatase; antineoplastic activity; bark; bone formation; bone morphogenetic proteins; cytotoxicity; diabetes; disease control; females; gene expression; genes; hosts; hypoglycemic agents; leaves; lupeol; mineralization; models; neonates; osteoblasts; osteoporosis; pain; palmitates; postmenopause; quercetin; rats; skull; therapeutics; traditional medicine; transcription (genetics); transcription factors; viability; Nigeria
Abstract:
... Mistletoe extracts (decoctions) are used traditionally in eastern Nigeria for the management of bone pain, post menopausal syndrome and diabetes amongst several other ailments. While scientific evidence supporting its folkloric use as an antidiabetic agent has been documented, the age-long practice of its use in treatment of post menopausal syndrome has not been scientifically validated. Postmenop ...
DOI:
10.1016/j.jep.2013.11.029

17. Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats

Author:
Silici Sibel; Yonar M. Enis; Sahin Hüseyin; Atayoğlu A. Timucin; Ozkok Duran
Source:
Journal of ethnopharmacology 2014 v.156 pp. 155-161
ISSN:
0378-8741
Subject:
Rhododendron; antioxidant activity; blood plasma; blood sampling; brain; catalase; females; glutathione peroxidase; grayanotoxin; heart; honey; hypertension; intraperitoneal injection; kidneys; lipid peroxidation; liver; lungs; malondialdehyde; oxidants; rats; spleen; superoxide dismutase; testes; tissues; toxicity; traditional medicine
Abstract:
... Rhododendron honey, locally known as “mad honey”, contains gryanotoksin (GTX) and thus induces toxic effects when consumed in large amounts. But, it is still popularly used for treating medical conditions such as high blood pressure or gastro-intestinal disorders. The aim of this study was to evaluate the effect of GTX on antioxidant parameters measured from rats fed with Rhododendron honey.A tota ...
DOI:
10.1016/j.jep.2014.08.027

18. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Author:
Xiao-fen Zheng; Jun-sheng Tian; Peng Liu; Jie Xing; Xue-mei Qin
Source:
Journal of ethnopharmacology 2014 v.151 no.2 pp. 912-920
ISSN:
0378-8741
Subject:
Oriental traditional medicine; animal models; biochemical pathways; biomarkers; body weight; diarrhea; drugs; energy; feces; glycolysis; lactic acid; leucine; liver; males; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; oral administration; rats; spleen; starvation; swimming; uterine prolapse; valine
Abstract:
... Bu-zhong-yi-qi-tang (BT) is a classical formula for the treatment of spleen-qi descending, visceroptosis with hyposplenic qi, uterine prolapse, and rectal prolapse due to chronic diarrhea in traditional Chinese medicine (TCM) and has been identified as an effective drug for the treatment of TCM spleen-qi deficiency in clinical practice. The present study aimed to investigate the restorative effect ...
DOI:
10.1016/j.jep.2013.12.001

19. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

Author:
Hyun Kim; Mi-Jang Song
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 85-89
ISSN:
0378-8741
Subject:
Araliaceae; Asteraceae; Fabaceae; Pinaceae; Poaceae; Rosaceae; diabetes; indigenous knowledge; interviews; medicinal plants; national parks; nervous system diseases; pain; questionnaires; respiratory tract diseases; social networks; traditional medicine; Korean Peninsula
Abstract:
... The purpose of this study is to analyze and record traditional knowledge of medicinal plants utilized in communities of Jirisan National Park.Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and social network analysis (S ...
DOI:
10.1016/j.jep.2013.10.047

20. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

Author:
Hyun Kim; Mi-Jang Song
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 90-97
ISSN:
0378-8741
Subject:
Hymenochaetaceae; Pleurotaceae; Polyporaceae; Tricholomataceae; cardiovascular diseases; diabetes; indigenous knowledge; interviews; medicinal fungi; national parks; questionnaires; soups; traditional medicine; wild edible mushrooms; Korean Peninsula
Abstract:
... This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea).Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and inter-network ana ...
DOI:
10.1016/j.jep.2013.12.041

21. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate

Author:
A.B. Seres; E. Ducza; M. Báthori; A. Hunyadi; Z. Béni; M. Dékány; J. Hajagos-Tóth; J. Verli; Róbert Gáspár
Source:
Journal of ethnopharmacology 2014 v.153 no.2 pp. 446-453
ISSN:
0378-8741
Subject:
Apis mellifera; Western blotting; active ingredients; fractionation; gas chromatography-mass spectrometry; honey bees; male fertility; males; men; messenger RNA; milk; nuclear magnetic resonance spectroscopy; oleic acid; palmitates; protein content; protein synthesis; quantitative polymerase chain reaction; rats; spectral analysis; testosterone; therapeutics; tissues; traditional medicine; women
Abstract:
... Numerous honeybee (Apis mellifera) products have been used in traditional medicine to treat infertility and to increase vitality in both men and women. Drone milk (DM) is a relatively little-known honeybee product with a putative sexual hormone effect. The oestrogenic effect of a fraction of DM has recently been reported in rats. However, no information is available on the androgenic effects of DM ...
DOI:
10.1016/j.jep.2014.02.050

22. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

Author:
Soheil Zorofchian Moghadamtousi; Hamed Karimian; Elham Rouhollahi; Mohammadjavad Paydar; Mehran Fadaeinasab; Habsah Abdul Kadir
Source:
Journal of ethnopharmacology 2014 v.156 pp. 277-289
ISSN:
0378-8741
Subject:
Annona muricata; antineoplastic activity; apoptosis; caspases; cell cycle checkpoints; cell proliferation; colorectal neoplasms; cytochrome c; cytosol; cytotoxicity; ethyl acetate; flow cytometry; fluorescent antibody technique; in vivo studies; inhibitory concentration 50; interphase; lactate dehydrogenase; leaves; membrane permeability; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; phosphatidylserines; protein synthesis; reactive oxygen species; screening; traditional medicine
Abstract:
... Annona muricata known as “the cancer killer” has been widely used in the traditional medicine for the treatment of cancer and tumors. The purpose of this study is to investigate the anticancer properties of ethyl acetate extract of Annona muricata leaves (EEAM) on HT-29 and HCT-116 colon cancer cells and the underlying mechanisms.The effect of EEAM on the cell proliferation of HT-29 and HCT-116 ce ...
DOI:
10.1016/j.jep.2014.08.011

23. Anti-HBV activity of the different extracts from Phyllanthus rheedei Wight in cell culture based assay systems

Author:
V. Suresh; Jose Sojan; N. Krishna Radhika; V.V. Asha
Source:
Journal of ethnopharmacology 2014 v.156 pp. 309-315
ISSN:
0378-8741
Subject:
Phyllanthus; cell culture; cell lines; cytotoxicity; dose response; enzyme-linked immunosorbent assay; ethanol; hepatitis B antigens; liver; screening; traditional medicine; virion; India
Abstract:
... Phyllanthusrheedei Wight is a plant used by Muthuvan tribes of Kerala for treating liver related diseases.The different extracts of Phyllanthus rheedei were analysed on cell lines were viz, PLC/PRF, Hep3B, FLCII10 and HepG2215 for its anti-HBV property. The analysis was done through ELISA, SQRT-PCR and immuno blotting. The most active extract was then divided in to fractions using HPTLC and the mo ...
DOI:
10.1016/j.jep.2014.08.028

24. Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico

Author:
Wendy Itzel Escobedo Hinojosa; Macdiel Acevedo Quiróz; Irma Romero Álvarez; Patricia Escobar Castañeda; María Luisa Villarreal; Alexandre Cardoso Taketa
Source:
Journal of ethnopharmacology 2014 v.155 no.2 pp. 1156-1163
ISSN:
0378-8741
Subject:
Helicobacter pylori; bark; breasts; cell lines; colon; cytotoxicity; ears; edema; fibroblasts; gastritis; histology; indomethacin; inhibitory concentration 50; leaf extracts; leaves; mice; minimum inhibitory concentration; models; neoplasm cells; plant organs; quality control; stems; stomach ulcers; traditional medicine; wild plants; winter; Mexico
Abstract:
... The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts obtained from the leaves, stems, and root bark of Hippocratea celastroides collected in five different localities in Mexico, during the w ...
DOI:
10.1016/j.jep.2014.06.044

25. Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats

Author:
Bing Lin; Yong Zhao; Ping Han; Wei Yue; Xue-Qin Ma; Khalid Rahman; Cheng-Jian Zheng; Lu-Ping Qin; Ting Han
Source:
Journal of ethnopharmacology 2014 v.155 no.1 pp. 248-255
ISSN:
0378-8741
Subject:
Xanthium strumarium; adjuvants; blood serum; body weight changes; fruits; high performance liquid chromatography; histology; interleukin-10; interleukin-1beta; medicinal plants; methotrexate; rats; rheumatoid arthritis; spleen; therapeutics; thymus gland; traditional medicine; tumor necrosis factor-alpha; China
Abstract:
... Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete F ...
DOI:
10.1016/j.jep.2014.05.023

26. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

Author:
Hyun-Soo Shin; Jong-Min Han; Hyeong-Geug Kim; Min-Kyung Choi; Chang-Gue Son; Ho-Ryong Yoo; Hyun-Kyung Jo; In-Chan Seol
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 142-150
ISSN:
0378-8741
Subject:
Artemisia; Curcuma longa; Western diets; aorta; atherosclerosis; blood lipids; blood serum; cholesterol; curcumin; fatty liver; gene expression; glucose; high density lipoprotein; hyperlipidemia; interleukin-1beta; interleukin-6; lipid composition; low density lipoprotein; mice; reactive oxygen species; tissues; traditional medicine; triacylglycerols; tumor necrosis factor-alpha
Abstract:
... Artemisiaiwayomogi Kitamura and Curcuma longa Linne. (ACE) has been popularly used to treat atherosclerosis as well as hyperlipidemia in the Asian countries.Antiatherosclerotic and anti-hyperlipidemic effects of ACE were evaluated at protein and gene expression level by using apoE⁻/⁻ mice.Apoprotein E deficient (apoE⁻/⁻) mice were randomly divided into five groups and fed freely Western diet (WD) ...
DOI:
10.1016/j.jep.2014.01.039

27. Anti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway

Author:
Sun Haeng Park; Yoon-Young Sung; Kyoung Jin Nho; Ho Kyoung Kim
Source:
Journal of ethnopharmacology 2014 v.151 pp. 1109-1115
ISSN:
0378-8741
Subject:
Polygonum aviculare; Western diets; adhesion; adipocytes; adipose tissue; aorta; atherosclerosis; blood lipids; blood pressure; cell viability; dose response; ethanol; hypertension; intercellular adhesion molecule-1; mice; mitogen-activated protein kinase; obesity; phosphorylation; protective effect; staining; traditional medicine; transcription factor NF-kappa B
Abstract:
... Polygonum aviculare L. has been used in traditional Korean medicine to treat obesity and symptoms associated with hypertension. The effectiveness or mechanism of Polygonum aviculare L. ethanol extract (PAE) on atherosclerosis disease has not been examined experimentally. This study investigated the protective effect of PAE in atherosclerotic mice.ApoE KO mice were fed a Western diet (WD) alone or ...
DOI:
10.1016/j.jep.2013.12.021

28. Anti-biofilm activity of Marula – A study with the standardized bark extract

Author:
Ratul Sarkar; Sushil K. Chaudhary; Amrita Sharma; Kirendra K. Yadav; Neelesh K. Nema; Mamello Sekhoacha; Sanmoy Karmakar; Fernão C. Braga; Motlalepula Gilbert Matsabisa; Pulok K. Mukherjee; Tuhinadri Sen
Source:
Journal of ethnopharmacology 2014 v.154 no.1 pp. 170-175
ISSN:
0378-8741
Subject:
Pseudomonas aeruginosa; Sclerocarya birrea subsp. caffra; alcoholic beverages; antibiotic resistance; antimicrobial properties; bacterial motility; bark; biofilm; dysentery; ethnobotany; fruits; gentian violet; methanol; microbial growth; proteinases; pyoverdines; quorum sensing; secretion; socioeconomics; swarming; traditional medicine; virulence; Africa
Abstract:
... Marula (Sclerocarya birrea; family – Anacardiaceae) is an African plant, which enjoys wide socio-economic importance particularly in southern part of Africa. The fruits are consumed as food and also as alcoholic beverage (cream liquor). In different parts of Africa, the decoction of the bark is traditionally used for the treatment of dysentery, diarrhoea, and various other infectious conditions. T ...
DOI:
10.1016/j.jep.2014.03.067

29. Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

Author:
Muhammad Munawar Hayat; Sadia Sarwar; Shazia Anjum; Muhammad Uzair; Hafiz Muhammad Farhan Rasheed; Qaiser Jabeen; Bashir Ahmad Choudhary; Muhammad Ashraf
Source:
Journal of ethnopharmacology 2014 v.156 pp. 347-352
ISSN:
0378-8741
Subject:
rabbits; alloxan; Brassicaceae; median effective concentration; acetylcholinesterase; diarrhea; glibenclamide; jejunum; enzyme inhibition; tissues; animal disease models; traditional medicine; linoleate 13S-lipoxygenase; blood glucose; glycemic effect; potassium; phosphodiesterase I; diabetes; antioxidant activity; enzyme activity; rats; parasympatholytics; methanol; therapeutics; fever
Abstract:
... Folk herbal practitioners of the Cholistan desert claim Farsetia hamiltonii Royle (Brassicaceae) to treat diabetes, oxidative damages, diarrhea, fever, and abdominal cramps. The aim of this study was to scientifically find the potential of Farsetia hamiltonii in treating diabetes and gastrointestinal diseases.In vivo anti-diabetic activity of Farsetia hamiltonii was studied on alloxan induced diab ...
DOI:
10.1016/j.jep.2014.08.038

30. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model

Author:
Mohammed Auwal Ibrahim; M. Shahidul Islam
Source:
Journal of ethnopharmacology 2014 v.153 no.2 pp. 392-399
ISSN:
0378-8741
Subject:
acetone; alanine transaminase; alkaline phosphatase; alpha-amylase; alpha-glucosidase; animal disease models; bark; blood glucose; blood lipids; blood serum; body weight; enzyme inhibition; ethyl acetate; glucose tolerance; glycemic effect; glycogen; in vivo studies; insulin; insulin resistance; islets of Langerhans; liver; males; noninsulin-dependent diabetes mellitus; oral administration; rats; solvents; traditional medicine; urea; Nigeria
Abstract:
... Senna singueana is currently used in the traditional treatment of diabetes mellitus in Nigeria. The present study examined the anti-diabetic activity of the Senna singueana acetone fraction (SSAF) of stem bark in a type 2 diabetes (T2D) rat model.Crude ethyl acetate extract of the Senna singueana stem bark was fractionated with various solvents and the acetone fraction was selected for in vivo stu ...
DOI:
10.1016/j.jep.2014.02.042

31. Anti-diarrhoeal activity of methanol extract of Santalum album L. in mice and gastrointestinal effect on the contraction of isolated jejunum in rats

Author:
Huimin Guo; Jingze Zhang; Wenyuan Gao; Zhuo Qu; Changxiao Liu
Source:
Journal of ethnopharmacology 2014 v.154 no.3 pp. 704-710
ISSN:
0378-8741
Subject:
Santalum album; acetylcholine; antibacterial properties; calcium; diarrhea; dose response; gastric emptying; gastrointestinal transit; intragastric administration; jejunum; methanol; mice; muscarine receptors; neostigmine; parasympatholytics; potassium chloride; rats; serotonin; serotonin receptors; traditional medicine; verapamil
Abstract:
... Santalum album L., namely Sandalwood, honored as “Green Gold”, is a traditional Chinese herb which has the effects of anti-diarrhoeal and antibacterial activity. But there is limit scientific study on its activity and mechanism in gastrointestinal disorders.in vivo, after intragastric administration, the methanol extract of Sandalwood (SE) (200, 400 and 800mg/kg) were studied in castor oil-induced ...
DOI:
10.1016/j.jep.2014.04.043

32. Anti-fatigue effects of proteins isolated from Panax quinquefolium

Author:
Bin Qi; Li Liu; He Zhang; Guang-xin Zhou; Shan Wang; Xiao-zheng Duan; Xue-yuan Bai; Si-ming Wang; Da-qing Zhao
Source:
Journal of ethnopharmacology 2014 v.153 no.2 pp. 430-434
ISSN:
0378-8741
Subject:
Panax quinquefolius; amino acid composition; blood serum; body weight; forced swimming test; glutathione peroxidase; glycogen; high performance liquid chromatography; lactic acid; malondialdehyde; mice; molecular weight; perennials; polyacrylamide gel electrophoresis; protein content; proteins; superoxide dismutase; swimming; traditional medicine; urea nitrogen; Canada; Eastern United States
Abstract:
... American ginseng (Panax quinquefolium) is an obligate shade perennial plant that belongs to Araliaceae ginseng species, and is native to eastern USA and Canada. Ginseng proteins are reported to have several pharmaceutical properties. However, such properties of American ginseng proteins (AGP) have seldom been reported. Also, anti-fatigue properties of AGP have not been studied. Therefore, we exami ...
DOI:
10.1016/j.jep.2014.02.045

33. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

Author:
Shuli Man; Wei Fan; Wenyuan Gao; Yuanyuan Li; Yan Wang; Zhen Liu; Hongfa Li
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 407-412
ISSN:
0378-8741
Subject:
DNA fragmentation; Oriental traditional medicine; antioxidants; blood serum; diethylnitrosamine; lipid peroxidation; liver; liver diseases; metabolomics; nuclear magnetic resonance spectroscopy; oxidative stress; rats; saponins; tricarboxylic acid cycle; urine
Abstract:
... Paris polyphylla var. yunnanensis as a traditional Chinese medicine has been used in the treatment of liver disease for thousands of years. Rhizoma paridis saponins (RPS), as the main active components of Paris polyphylla, have been used to treat liver injury. Anti-cirrhosis effect of Rhizoma paridis saponins (RPS) has not been known.We analyzed diethylnitrosamine (DEN)-induced metabonomic changes ...
DOI:
10.1016/j.jep.2013.10.051

34. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model

Author:
Salman Khan; Omer Shehzad; Jaemoo Chun; Ran Joo Choi; Saitbyul Park; Md. Nurul Islam; Jae Sue Choi; Yeong Shik Kim
Source:
Journal of ethnopharmacology 2014 v.152 no.3 pp. 478-486
ISSN:
0378-8741
Subject:
Artemisia capillaris; adenosine; adenosine triphosphate; analgesic effect; analgesics; animal models; antineoplastic activity; carrageenan; edema; ethanol; genes; immunity; inducible nitric oxide synthase; mechanism of action; mice; nitrites; pain; signal transduction; somatosensory disorders; substance P; traditional medicine; transcription factor NF-kappa B
Abstract:
... Artemisia capillaris has widespread traditional and pharmacological applications such as analgesic, anti-inflammatory, anti-pyretic, enhance immunity and anti-tumor activity properties. To evaluate the pharmacological activities of this plant, capillarisin, one of the potent constituent of Artemisia capillaris was studied based on anti-hyperalgesic and anti-allodynic effects with detailed mechanis ...
DOI:
10.1016/j.jep.2014.01.028

35. Anti-hyperglycemic effect, inhibition of inflammatory cytokines expression, and histopathology profile in streptozotocin-induced diabetic rats treated with Arracacia tolucensis aerial-parts extracts

Author:
Mary Carmen García-Galicia; Eleuterio Burgueño-Tapia; Andrés Romero-Rojas; Julio César García-Zebadúa; Jorge Cornejo-Garrido; Cynthia Ordaz-Pichardo
Source:
Journal of ethnopharmacology 2014 v.152 no.1 pp. 91-98
ISSN:
0378-8741
Subject:
Arracacia; aerial parts; alanine transaminase; animal disease models; aspartate transaminase; biometry; blood glucose; body weight changes; cytokines; diabetes mellitus; drugs; ethanol; ethyl acetate; glibenclamide; glycemic effect; hexane; histopathology; intraperitoneal injection; kidneys; lipids; liver; males; medicinal plants; pancreas; rats; spleen; streptozotocin; therapeutics; traditional medicine; Mexico
Abstract:
... Arracacia tolucensis is a medicinal plant used in northeast of Mexico as a remedy to treat people with Diabetes mellitus (DM); however, there are no scientific studies that support this information. Thus, we evaluated the anti-hyperglycemic effect of the hexane, ethyl acetate and ethanol extracts from aerial parts in streptozotocin-induced diabetic rats.DM was induced in Wistar male rats by single ...
DOI:
10.1016/j.jep.2013.12.031

36. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice

Author:
Fabio R.M. Borges; Morgana D. Silva; Marina M. Córdova; Tiago R. Schambach; Moacir G. Pizzolatti; Adair R.S. Santos
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 144-150
ISSN:
0378-8741
Subject:
Polygala; aerial parts; anesthetics; anti-inflammatory activity; dexamethasone; inflammation; interleukin-10; interleukin-1beta; interleukin-6; intraperitoneal injection; kidneys; lipopolysaccharides; methylene chloride; mice; models; neutrophils; peritonitis; therapeutics; traditional medicine; tumor necrosis factor-alpha; Brazil
Abstract:
... Polygala sabulosa A. W. Bennett is a small herb popularly known as “timutu-pinheirinho” that is widely distributed in southern Brazil and that is used to treat disorders of the bowel and kidney and as a topical anesthetic and expectorant in folk medicine. This study was designed to investigate the anti-inflammatory properties of the hydroalcoholic extract (HEPs), CH2Cl2 fraction and the steroid α- ...
DOI:
10.1016/j.jep.2013.10.009

37. Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract

Author:
Deok Jeong; Young-Su Yi; Gi-Ho Sung; Woo Seok Yang; Jae Gwang Park; Keejung Yoon; Deok Hyo Yoon; Changsik Song; Yunmi Lee; Man Hee Rhee; Tae Woong Kim; Jong-Hoon Kim; Jae Youl Cho
Source:
Journal of ethnopharmacology 2014 v.152 no.3 pp. 487-496
ISSN:
0378-8741
Subject:
Artemisia; active ingredients; anti-inflammatory activity; ethanol; fractionation; heme oxygenase (biliverdin-producing); high performance liquid chromatography; hydrochloric acid; immunoblotting; lipopolysaccharides; luteolin; macrophages; mice; models; nitric oxide; prostaglandins; reporter genes; signal transduction; stomach ulcers; traditional medicine; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Artemisia asiatica Nakai (Compositae) is a representative herbal plant used to treat infection and inflammatory diseases. Although Artemisia asiatica is reported to have immunopharmacological activities, the mechanisms of these activities and the effectiveness of Artemisia asiatica preparations in use are not known.To evaluate the anti-inflammatory activities of Artemisia asiatica ethanol extract ...
DOI:
10.1016/j.jep.2014.01.030

38. Anti-inflammatory activity of animal oils from the Peruvian Amazon

Author:
Guillermo Schmeda-Hirschmann; Carla Delporte; Gabriela Valenzuela-Barra; Ximena Silva; Gabriel Vargas-Arana; Beatriz Lima; Gabriela E. Feresin
Source:
Journal of ethnopharmacology 2014 v.156 pp. 9-15
ISSN:
0378-8741
Subject:
Boa constrictor; Chelonoidis; Electrophorus electricus; Escherichia coli; Geochelone; Inia geoffrensis; Melanosuchus niger; Salmonella Enteritidis; Staphylococcus aureus; animal fats and oils; anti-inflammatory activity; anti-inflammatory agents; antimicrobial properties; arachidonic acid; conservation status; dolphins; ears; edema; esters; fish; gas chromatography-mass spectrometry; linoleic acid; markets; mice; minimum inhibitory concentration; oleic acid; palmitic acid; reptiles; traditional medicine; Amazonia; Peru
Abstract:
... Animal oils and fats from the fishes Electrophorus electricus and Potamotrygon motoro, the reptiles Boa constrictor, Chelonoidis denticulata (Geochelone denticulata) and Melanosuchus niger and the riverine dolphin Inia geoffrensis are used as anti-inflammatory agents in the Peruvian Amazon. The aim of the study was to assess the topic anti-inflammatory effect of the oils/fats as well as to evaluat ...
DOI:
10.1016/j.jep.2014.08.010

39. Anti-inflammatory activity of compounds from Boesenbergia longiflora rhizomes

Author:
Teeratad Sudsai; Samran Prabpai; Palangpon Kongsaeree; Chatchai Wattanapiromsakul; Supinya Tewtrakul
Source:
Journal of ethnopharmacology 2014 v.154 no.2 pp. 453-461
ISSN:
0378-8741
Subject:
abscess; anti-inflammatory activity; chloroform; chromatography; colitis; dose response; flavonoids; gene expression; inducible nitric oxide synthase; inhibitory concentration 50; macrophages; messenger RNA; mice; nitric oxide; rhizomes; sesquiterpenoids; sterols; traditional medicine; tumor necrosis factor-alpha
Abstract:
... The rhizomes of Boesenbergia longiflora (Wall.) Kuntze have been traditionally used in treatment of inflammatory bowel disease, ulcerative colitis, aphthous ulcer and abscess. Our previous study indicated that CHCl3 fractions of Boesenbergia longiflora had potential on anti-inflammatory properties. In the present study, we investigated the active constituents of this plant for anti-inflammatory ac ...
DOI:
10.1016/j.jep.2014.04.034

40. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats

Author:
K.D.K.P. Kumari; T.C.S. Weerakoon; S.M. Handunnetti; K. Samarasinghe; T.S. Suresh
Source:
Journal of ethnopharmacology 2014 v.151 pp. 1202-1208
ISSN:
0378-8741
Subject:
Aegle marmelos; anti-inflammatory activity; antioxidant activity; antioxidants; beverages; carrageenan; dose response; edema; erythrocytes; flowers; histamine; lipid peroxidation; nitric oxide; rats; rural areas; traditional medicine; trees; Asia
Abstract:
... Almost all part of the plant Aegle marmelos (Bael tree) has been used in the traditional medicine systems of Asian countries to treat various diseases over many centuries. The water extract of the dried flowers of Aegle marmelos is a commonly used beverage among Sri Lankan population in rural areas. Although extensive investigations done on many parts of the plant there are no experimental data av ...
DOI:
10.1016/j.jep.2013.12.043

41. Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

Author:
Ling Tong; Tu Chen; Zhenzhong Chen; Peng Zhang; Huifang Pi; Hanli Ruan; Jizhou Wu
Source:
Journal of ethnopharmacology 2014 v.155 no.3 pp. 1553-1560
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; anti-inflammatory activity; dose response; ears; edema; enzyme activity; ethanol; ethyl acetate; inducible nitric oxide synthase; inflammation; interleukin-6; lipopolysaccharides; macrophages; nitric oxide; prostaglandin synthase; rheumatoid arthritis; secretion; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; xylene
Abstract:
... Radix Toddaliae Asiaticae has long been used as a traditional ethnic Chinese medicine for the treatment of inflammation and rheumatism. In our earlier communication we have reported the anti-arthritic activity of the ethyl alcohol extract and ethyl acetate fraction from Radix Toddaliae Asiaticae. This study was to examine the anti-inflammatory activity of prenylcoumarin omphalocarpin isolated from ...
DOI:
10.1016/j.jep.2014.07.055

42. Anti-inflammatory and analgesic activity of aqueous extract of Flos populi

Author:
Qianqian Xu; Yubo Wang; Shijin Guo; Zhiqiang Shen; Yanping Wang; Limei Yang
Source:
Journal of ethnopharmacology 2014 v.152 no.3 pp. 540-545
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Populus canadensis; Populus tomentosa; analgesic effect; analgesics; anti-inflammatory activity; arachidonic acid; carrageenan; cotton; diarrhea; dose response; ears; edema; formalin; granuloma; hot plate test; males; pain; writhing test; East Asia
Abstract:
... Flos populi is an important traditional Chinese medicine prepared from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench (Salicaceae family). Flos populi is mainly used for the treatment of various inflammatory diseases and anti diarrhea in East Asian countries. The objective of this study was to investigate the anti-inflammatory and analgesic properties of the aqueous ...
DOI:
10.1016/j.jep.2014.01.037

43. Anti-inflammatory and anti-hypersensitive effects of the crude extract, fractions and triterpenes obtained from Chrysophyllum cainito leaves in mice

Author:
Nicole Anzanelo Meira; Luiz Carlos Klein Jr; Lilian W. Rocha; Zhelmy Martin Quintal; Franco Delle Monache; Valdir Cechinel Filho; Nara Lins Meira Quintão
Source:
Journal of ethnopharmacology 2014 v.151 no.2 pp. 975-983
ISSN:
0378-8741
Subject:
Chrysophyllum cainito; acetates; adverse effects; anti-inflammatory activity; chemical constituents of plants; chloroform; diabetes mellitus; edema; hypersensitivity; interleukin-1beta; leaves; locomotion; mice; myeloperoxidase; neutrophils; pain; thin layer chromatography; traditional medicine; trees; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Chrysophyllum cainito, popularly known as “star apple”, caimito, “abiu-roxo” or “abiu-do-Pará”, is a tree of about 25m in height. Besides its culinary use, it is also used in folk medicine for the treatment of diabetes mellitus and several inflammatory diseases.The crude methanolic extract (CME) was submitted to phytochemical studies for obtaining fractions and isolated compounds. They were monito ...
DOI:
10.1016/j.jep.2013.12.014

44. Anti-inflammatory and antioxidant activities of Costus afer Ker Gawl. hexane leaf fraction in arthritic rat models

Author:
Godswill Nduka Anyasor; Funmilayo Onajobi; Odutola Osilesi; Olugbenga Adebawo; Efere Martins Oboutor
Source:
Journal of ethnopharmacology 2014 v.155 no.1 pp. 543-551
ISSN:
0378-8741
Subject:
Costus; adjuvants; alanine transaminase; albumins; alkaline phosphatase; animal models; anti-inflammatory activity; antioxidant activity; antioxidants; arachidonic acid; aspartate transaminase; bilirubin; brain; carrageenan; catalase; diclofenac; edema; formaldehyde; globulins; glutathione; glutathione transferase; hexane; kidneys; leaves; liver; males; malondialdehyde; medicinal plants; nonsteroidal anti-inflammatory agents; prednisolone; protein content; rats; rheumatoid arthritis; superoxide dismutase; therapeutics; traditional medicine
Abstract:
... Costus afer Ker Gawl is an indigenous tropical African medicinal plant used as therapy in the treatment of inflammatory ailments such as rheumatoid arthritis. This study was designed to evaluate the anti-inflammatory and antioxidant activities of the hexane fraction of C. afer leaves (CAHLF).The anti-inflammatory effect of varying doses of CAHLF on carrageenan, arachidonic acid, and formaldehyde i ...
DOI:
10.1016/j.jep.2014.05.057

45. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

Author:
Minjung Song; Hye-Jin Park
Source:
Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
DOI:
10.1016/j.jep.2013.12.059

46. Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

Author:
Ji-Sun Shin; Eu-Jin Cho; Hye-Eun Choi; Ji-Hyung Seo; Hyo-Jin An; Hee-Juhn Park; Young-Wuk Cho; Kyung-Tae Lee
Source:
Journal of ethnopharmacology 2014 v.158 pp. 291-300
ISSN:
0378-8741
Subject:
Rubus coreanus; Rubus occidentalis; animal models; anti-inflammatory activity; asthma; body weight; colitis; colon; cytokines; dextran; diarrhea; epithelium; feces; hemorrhage; immunoassays; immunohistochemistry; lipopolysaccharides; luciferase; macrophage activation; macrophages; mechanism of action; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; sodium; stomach; therapeutics; traditional medicine; transcription factor NF-kappa B; triterpenoids
Abstract:
... Rubus coreanus Miquel (Rosaceae), the Korean black raspberry, has traditionally been used to treat inflammatory diseases including diarrhea, asthma, stomach ailment, and cancer. Although previous studies showed that the 19α-hydroxyursane-type triterpenoids isolated from Rubus coreanus exerted anti-inflammatory activities, their effects on ulcerative colitis and mode of action have not been explore ...
DOI:
10.1016/j.jep.2014.10.044

47. Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

Author:
Lucas A. Chibli; Kamilla C.M. Rodrigues; Carolina M. Gasparetto; Nícolas C.C. Pinto; Rodrigo L. Fabri; Elita Scio; Maria S. Alves; Glauciemar Del-Vechio-Vieira; Orlando V. Sousa
Source:
Journal of ethnopharmacology 2014 v.154 no.2 pp. 330-338
ISSN:
0378-8741
Subject:
Croton; Kalanchoe pinnata; anti-inflammatory activity; anti-inflammatory agents; arachidonic acid; capsaicin; ears; edema; ethanol; gastritis; high performance liquid chromatography; histopathology; hyperplasia; inflammation; leaves; luteolin; mice; models; oils; quercetin; rutin; skin diseases; topical application; traditional medicine; Brazil
Abstract:
... Bryophyllum pinnatum (Lam.) Oken (Crassulaceae), popularly known in Brazil as “folha-da-fortuna”, is a plant species used in folk medicine for the external and internal treatment of inflammation, infection, wound, burn, boil, ulcers and gastritis, and several other diseases. The present study aimed to perform the chemical characterization and the evaluation of the topical anti-inflammatory effect ...
DOI:
10.1016/j.jep.2014.03.035

48. Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis)

Author:
Kai Wang; Jianglin Zhang; Shun Ping; Quanxin Ma; Xuan Chen; Hongzhuan Xuan; Jinhu Shi; Cuiping Zhang; Fuliang Hu
Source:
Journal of ethnopharmacology 2014 v.155 no.1 pp. 300-311
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Populus canadensis; anti-inflammatory activity; antioxidant activity; buds; endotoxemia; ethanol; flavonoids; high performance liquid chromatography; histopathology; interleukin-10; interleukin-12; interleukin-1beta; interleukin-6; lungs; messenger RNA; propolis; protective effect; reporter genes; secretion; therapeutics; traditional medicine; tumor necrosis factor-alpha
Abstract:
... Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese ...
DOI:
10.1016/j.jep.2014.05.037

49. Anti-melanoma activity of Cynanchi atrati Radix is mediated by regulation of NF-kappa B activity and pro-apoptotic proteins

Author:
Seung-Wan Son; Hyeong-Geug Kim; Jong-Min Han; Jin-Seok Lee; Min-Kyung Choi; Jong-Seok Lee; Chang-Gue Son
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 250-257
ISSN:
0378-8741
Subject:
4',6-diamidino-2-phenylindole; apoptosis; cell proliferation; drugs; ethanol; fever; flow cytometry; gene expression; genes; immunoblotting; melanoma; mice; patients; pro-apoptotic proteins; staining; traditional medicine; transcription factor NF-kappa B
Abstract:
... Cynanchi atrati Radix has been traditionally prescribed for patients with inflammatory fever or chronic tumoral disorders. Melanoma is one of the most devastating cancer types, in which overexpression of nuclear factor kappa B (NF-κB) enables the cancer to survive without apoptosis. To identify a potential anti-melanoma candidate, we evaluated the apoptotic activity of an ethanol extract of Cynanc ...
DOI:
10.1016/j.jep.2014.02.037

50. Anti-stress effect of astragaloside IV in immobilized mice

Author:
Hyun-A. Oh; Hyuck Jai Choi; Nam Jae Kim; Dong-Hyun Kim
Source:
Journal of ethnopharmacology 2014 v.153 no.3 pp. 928-932
ISSN:
0378-8741
Subject:
Astragalus membranaceus; antagonists; anti-inflammatory activity; anxiety; astragalosides; blood serum; corticosterone; enzyme-linked immunosorbent assay; ethanol; immunomodulation; inflammation; interleukin-6; mice; oral administration; roots; traditional medicine; tranquilizers; tumor necrosis factor-alpha
Abstract:
... Astragaloside IV, a major component extracted from the roots of Astragalus membranaceus (AM), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. To clarify anti-stress effect of AM, anxiolytic and anti-inflammatory effects of 80% ethanol extract of AM and astragaloside IV were investigated in immobilization stress model.The mice were orally ad ...
DOI:
10.1016/j.jep.2014.03.068