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You searched for: Journal Journal of ethnopharmacology Remove constraint Journal: Journal of ethnopharmacology Subject Grewia mollis Remove constraint Subject: Grewia mollis Subject term Grewia mollis Remove constraint Subject term: Grewia mollis
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1. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites

Author:
Marianne Molander; Dan Staerk; Hanne Mørck Nielsen; Johanna M. Brandner; Drissa Diallo; Chifundera Kusamba Zacharie; Johannes van Staden; Anna K. Jäger
Source:
Journal of ethnopharmacology 2015 v.165 pp. 1-8
ISSN:
0378-8741
Subject:
Dichrostachys cinerea; Grewia mollis; Paullinia pinnata; Tamarindus indica; antiserum; cell movement; cytotoxicity; enzymes; ethanol; models; mortality; necrosis; plant extracts; snake bites; therapeutics; tissue repair; traditional medicine; venoms; Sub-Saharan Africa
Abstract:
... Snakebite envenomation causes 5000–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone every year. The inaccessibility of antiserum therapy is a vast problem, and only about 2.5% of the actual need for antiserum in Africa is covered. Numerous plants have shown in vitro inhibitory activity against one or more of the hydrolytic enzymes involved in snakebite-i ...
DOI:
10.1016/j.jep.2015.02.014

2. Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa

Author:
Marianne Molander; Line Nielsen; Søren Søgaard; Dan Staerk; Nina Rønsted; Drissa Diallo; Kusamba Zacharie Chifundera; Johannes van Staden; Anna K. Jäger
Source:
Journal of ethnopharmacology 2014 v.157 pp. 171-180
ISSN:
0378-8741
Subject:
Bauhinia thonningii; Bitis arietans; Combretum; Grewia mollis; Lannea; Naja; Strychnos; active ingredients; antiserum; bioassays; enzyme inhibition; enzyme inhibitors; ethanol; hyaluronoglucosaminidase; inhibitory concentration 50; mortality; necrosis; patients; phospholipase A2; plant anatomy; polyphenols; proteinases; snake bites; snakes; traditional medicine; Democratic Republic of the Congo; Mali; South Africa
Abstract:
... Snakebite envenomation, every year, causes estimated 5–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone. Antiserum is not easily accessible in these regions or doctors are simply not available, thus more than 80% of all patients seek traditional practitioners as first-choice. Therefore it is important to investigate whether the plants used in traditional ...
DOI:
10.1016/j.jep.2014.09.027