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You searched for: Journal Journal of medicinal food Remove constraint Journal: Journal of medicinal food Subject antineoplastic activity Remove constraint Subject: antineoplastic activity
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1. Centella asiatica Modulates Nrf-2 Antioxidant Mechanisms and Enhances Reactive Oxygen Species-Mediated Apoptotic Cell Death in Leukemic (THP-1) Cells

Author:
Dhaneshree Bestinee Naidoo; Alisa Phulukdaree; Anand Krishnan; Anil Amichund Chuturgoon; Vikash Sewram
Source:
Journal of medicinal food 2022 v.25 no.7 pp. 760-769
ISSN:
1557-7600
Subject:
Centella asiatica; DNA damage; DNA fragmentation; adenosine triphosphate; antineoplastic activity; antioxidant genes; apoptosis; caspases; cell viability; comet assay; cytotoxicity; flow cytometry; functional foods; gene expression; glutathione; glutathione peroxidase; leaves; malondialdehyde; mitochondria; oxygen; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; spectroscopy; therapeutics; traditional medicine; viability assays
Abstract:
... Centella asiatica is commonly used in traditional medicine owing to its many therapeutic properties including but not limited to antioxidant and antitumor potential. This study examined the antioxidant and antiproliferative effects of its crude (C) and fractionated (C3) ethanolic leaf extracts in THP-1 cells. In THP-1 cells, C and C3 cytotoxicity was evaluated (WST-1 viability assay; 24 h; [0.2–3  ...
DOI:
10.1089/jmf.2021.0173

2. Myricitrin from Combretum lanceolatum Exhibits Inhibitory Effect on DNA-Topoisomerase Type IIα and Protective Effect Against In Vivo Doxorubicin-Induced Mutagenicity

Author:
Renata Trentin Perdomo; Camila Pineze Defende; Patrick da Silva Mirowski; Talita Vilalva Freire; Simone Schneider Weber; Walmir Silva Garcez; Zaira da Rosa Guterres; Maria de Fátima Cepa Matos; Fernanda Rodrigues Garcez
Source:
Journal of medicinal food 2021 v.24 no.3 pp. 273-281
ISSN:
1557-7600
Subject:
Combretum; DNA damage; DNA topoisomerase; Drosophila melanogaster; antimutagenic activity; antineoplastic activity; breasts; cell lines; chemoprevention; colon; crossing; cytotoxicity; doxorubicin; enzyme inhibition; food plants; fruits; kidneys; leukemia; mechanism of action; mutagenicity; myricetin; neoplasm cells; progeny; protective effect; somatic mutation; tetrazolium
Abstract:
... Flavonoids—compounds abundant in balanced daily diets—have been extensively investigated for biological activity. The pronounced antiproliferative effects of flavonoids have prompted studies to elucidate their mode of action against tumor cells. The anticancer properties of myricetin, a 3′,4′,5′-tri-hydroxylated flavonol, have been confirmed for a number of neoplasms, but myricitrin, its 3-O-rhamn ...
DOI:
10.1089/jmf.2020.0033

3. In Vitro Biological Properties of Solanum sessiliflorum (Dunal), an Amazonian Fruit

Author:
Greice Franciele Feyh dos Santos Montagner; Fernanda Barbisan; Pauline Christ Ledur; Aline Bolignon; Jéssica de Rosso Motta; Euler Esteves Ribeiro; Raquel de Souza Praia; Verônica Farina Azzolin; Francine Carla Cadoná; Alencar Kolinski Machado; Rômulo Pillon Barcelos; Ivana Beatrice Mânica da Cruz
Source:
Journal of medicinal food 2020 v.23 no.9 pp. 978-987
ISSN:
1557-7600
Subject:
Solanum sessiliflorum; antineoplastic activity; antioxidant activity; beta-carotene; breasts; catechin; colorectal neoplasms; cytotoxicity; diodes; flow cytometry; fluorouracil; fruits; functional foods; high performance liquid chromatography; human health; humans; low density lipoprotein; mitosis; mortality; mutagens; neoplasm cells; oxidation; pulp; quercetin; rutin; traditional medicine; viability
Abstract:
... Solanum sessiliflorum is an Amazonian fruit (cubiu) that has been domesticated since pre-Colombian era. It is also used in folk medicine to treat some clinical conditions. This investigation chemically characterized and analyzed the in vitro antioxidant and antitumoral effect of a cubiu pulp/seed hydroalcoholic extract. Cubiu extract was chemically characterized by high-performance liquid chromato ...
DOI:
10.1089/jmf.2019.0193

4. PTEN/Akt Signaling-Mediated Activation of the Mitochondrial Pathway Contributes to the 3,3′-Diindolylmethane-Mediated Antitumor Effect in Malignant Melanoma Cells

Author:
Xiaoli Wang; Yueqiang Zhao; Mosheng Yu; Yu Xu
Source:
Journal of medicinal food 2020 v.23 no.12 pp. 1248-1258
ISSN:
1557-7600
Subject:
antineoplastic activity; apoptosis; caspase-3; caspase-9; cell proliferation; chromosomes; functional foods; humans; melanoma; mitochondria
Abstract:
... 3,3′-diindolylmethane (DIM) has an anticancer activity, but the role DIM plays on malignant melanoma cells and its specific mechanism is unclear. We studied the biological effects of DIM on malignant melanoma cells and the related mechanism and the results showed that DIM significantly suppressed cell proliferation and induced apoptosis in malignant melanoma cells. In addition, the expression leve ...
DOI:
10.1089/jmf.2020.4704

5. Phenethyl Isothiocyanate Improves Lipid Metabolism and Inflammation via mTOR/PPARγ/AMPK Signaling in the Adipose Tissue of Obese Mice

Author:
Min-Hee Gwon; Jung-Mi Yun
Source:
Journal of medicinal food 2021 v.24 no.6 pp. 666-669
ISSN:
1557-7600
Subject:
adipogenesis; adipose tissue; antineoplastic activity; cholesterol; diet; functional foods; gallic acid; inflammation; isothiocyanates; lipid metabolism; low density lipoprotein; obesity; oxidation; peroxisome proliferator-activated receptor gamma; prostaglandin synthase; protein kinases; quantitative polymerase chain reaction; rapamycin
Abstract:
... Obesity is defined as excess adipose mass that causes serious health problems. Phenethyl isothiocyanate (PEITC) is a major and relatively nontoxic compound of the isothiocyanates. Although many studies have demonstrated that PEITC is a potent substance with physiological activities, such as anticancer activity, the precise mechanism for the effects of PEITC on inflammation and lipid metabolism in ...
DOI:
10.1089/jmf.2020.4881

6. Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera

Author:
Akiko Kojima-Yuasa; Isao Matsui-Yuasa
Source:
Journal of medicinal food 2020 v.23 no.5 pp. 465-475
ISSN:
1557-7600
Subject:
AMP-activated protein kinase; Alpinia conchigera; Alpinia galanga; acetates; anti-inflammatory activity; antineoplastic activity; chemical bonding; cooking; diabetes; disease prevention; hyperlipidemia; moieties; neoplasms; neurodegenerative diseases; obesity; rhizomes; seeds; signal transduction; spices; traditional medicine; South East Asia
Abstract:
... 1′-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of Alpinia galanga and Alpinia conchigera, which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, antiobesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observe ...
DOI:
10.1089/jmf.2019.4490

7. Sulforaphane Decrease of SERTAD1 Expression Triggers G1/S Arrest in Breast Cancer Cells

Author:
An-Chin Cheng; Ching-Ju Shen; Chao-Ming Hung; Yi-Chiang Hsu
Source:
Journal of medicinal food 2019 v.22 no.5 pp. 444-450
ISSN:
1557-7600
Subject:
DNA; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell cycle checkpoints; cell proliferation; chemoprevention; cyclins; flow cytometry; histone deacetylase; interphase; neoplasm cells; sulforaphane
Abstract:
... Studies have identified the potential of chemopreventive effects of sulforaphane (SFN); however, the underlying mechanisms of its effect on breast cancer require further elucidation. This study investigated the anticancer effects of SFN that specifically induces G1/S arrest in breast ductal carcinoma (ZR-75-1) cells. The proliferation of the cancer cells after treatment with SFN was detected by 3- ...
DOI:
10.1089/jmf.2018.4195
PubMed:
31084542
PubMed Central:
PMC6534085

8. Antiproliferative Activity of Extracts of Campomanesia adamantium (Cambess.) O. Berg and Isolated Compound Dimethylchalcone Against B16-F10 Murine Melanoma

Author:
Magalli C.B. Lima e Silva; Danielle Bogo; Caroline A.F. Alexandrino; Renata T. Perdomo; Patrícia de O. Figueiredo; Pamela R. do Prado; Fernanda R. Garcez; Monica C.T. Kadri; Thalita V.N. Ximenes; Rita de Cassia A. Guimarães; Ulana C. Sarmento; Maria Lígia R. Macedo
Source:
Journal of medicinal food 2018 v.21 no.10 pp. 1024-1034
ISSN:
1557-7600
Subject:
Campomanesia; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; caspase-3; cerrado; coculture; diodes; fruit pulp; fruits; high performance liquid chromatography; indigenous species; ionization; macrophages; melanoma; methylene chloride; mice; nitric oxide; phenolic compounds; spectrometers
Abstract:
... Campomanesia adamantium, a native species of the Brazilian Cerrado, is characterized as a natural source of phenolic compounds and has known potential anticancer activities. This study aimed to evaluate the chemical profile of dichloromethane extracts of pulp (DEGPU) and peel (DEGPE) from the fruits of C. adamantium and to identify compounds with antiproliferative effects in vitro against melanoma ...
DOI:
10.1089/jmf.2018.0001

9. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

10. The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras

Author:
Mi-Kyung Jeong; Hwa-Seung Yoo; In-Cheol Kang
Source:
Journal of medicinal food 2019 v.22 no.8 pp. 823-832
ISSN:
1557-7600
Subject:
Cordyceps militaris; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; lung neoplasms; neoplasm cells; proteomics
Abstract:
... We investigated the antitumor effect of Cordyceps militaris extract (CME) on A549 cisplatin-resistant (CR) lung cancer cells. The proliferation of A549/CR cells was suppressed by CME. Apoptosis of the cells was induced by CME. The cell cycle arrest was observed in the sub-G1 phase in the cells treated with CME. Proteomic profile analysis showed that H-Ras was downregulated in CME-treated cells and ...
DOI:
10.1089/jmf.2018.4232

11. Fermented Extraction of Citrus unshiu Peel Inhibits Viability and Migration of Human Pancreatic Cancers

Author:
Jungwhoi Lee; Jungsul Lee; Myungseung Kim; Jae Hoon Kim
Source:
Journal of medicinal food 2018 v.21 no.1 pp. 5-12
ISSN:
1557-7600
Subject:
Citrus unshiu; adverse effects; antineoplastic activity; antineoplastic agents; byproducts; caspase-3; computer simulation; hesperetin; hesperidin; human diseases; human umbilical vein endothelial cells; juices; models; mortality; naringenin; neoplasm cells; pancreatic neoplasms; prognosis; signal transduction; viability
Abstract:
... Pancreatic cancer is one of the most dangerous cancers with high mortality rates. Despite continuous efforts, there has been limited improvement in its prognosis. In this study, we prepared fermented extract of Citrus unshiu peel (fCUP) from the by-product after juice processing and then examined the anticancer effects of fCUP on human pancreatic cancer cells. Treatment with fCUP inhibited the gro ...
DOI:
10.1089/jmf.2017.3984

12. Fermented Ganjangs (Soy Sauce and Sesame Sauce) Attenuates Colonic Carcinogenesis in Azoxymethane/Dextran Sodium Sulfate-Treated C57BL/6J Mice

Author:
Jia-Le Song; Jung-Ho Choi; Jae-Hoon Seo; Kun-Young Park
Source:
Journal of medicinal food 2018 v.21 no.9 pp. 905-914
ISSN:
1557-7600
Subject:
antineoplastic activity; azoxymethane; blood serum; carcinogenesis; colon; dextran sulfate; fermentation; inducible nitric oxide synthase; interferon-gamma; interleukin-6; messenger RNA; mice; microorganisms; mucosa; neoplasms; prostaglandin synthase; raw materials; sodium; soy sauce; tumor necrosis factor-alpha
Abstract:
... The effects of different ganjangs (also designated as kanjang), including acid-hydrolyzed soy sauce (AHSS), fermented soy sauce (FSS), and fermented sesame sauce (FSeS), on azoxymethane (AOM, 10 mg/kg)/dextran sulfate sodium (DSS, 2%)-induced colorectal carcinogenesis in C57BL/6J mice were studied. Low doses (4 mL/kg) of both FSeS and FSS significantly increased colon length, suppressed AOM/DSS-in ...
DOI:
10.1089/jmf.2017.4111

13. Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway

Author:
Ha-Yeon Song; Hye-Min Kim; Sajid Mushtaq; Woo Sik Kim; Young Jun Kim; Seung-Taik Lim; Eui-Baek Byun
Source:
Journal of medicinal food 2019 v.22 no.7 pp. 713-721
ISSN:
1557-7600
Subject:
B-lymphocytes; NAD ADP-ribosyltransferase; adenosine; antineoplastic activity; apoptosis; caspase-9; chrysin; colorectal neoplasms; cytotoxicity; gamma radiation; human cell lines; irradiation; membrane potential; mitochondrial membrane; neoplasm cells; reactive oxygen species; signal transduction
Abstract:
... Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultaneously with the decrease of the chrysin peak, which increases the cytotoxicity in ...
DOI:
10.1089/jmf.2018.4320

14. High-Polyphenol Sorghum Bran Extract Inhibits Cancer Cell Growth Through ROS Induction, Cell Cycle Arrest, and Apoptosis

Author:
Dmitriy Smolensky; Davina Rhodes; D. Scott McVey; Zachary Fawver; Ramasamy Perumal; Thomas Herald; Leela Noronha
Source:
Journal of medicinal food 2018 v.21 no.10 pp. 990-998
ISSN:
1557-7600
Subject:
DNA damage; Sorghum bicolor; antineoplastic activity; apoptosis; bran; carcinogenesis; cell cycle checkpoints; cell growth; cell viability; chemoprevention; diet; foods; germplasm; mechanism of action; neoplasm cells; neoplasms; polyphenols; protein synthesis; public health; reactive oxygen species
Abstract:
... As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are of significant interest to public health. One such food is sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations of polyphenols. In a panel of 15 sorghum germplasm, we identified strains with higher polyphenol content than previously reported for this grain. Bran e ...
DOI:
10.1089/jmf.2018.0008

15. Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend

Author:
Eric D. Tague; Allen K. Bourdon; Amber MacDonald; Maggie S. Lookadoo; Edward D. Kim; Wesley M. White; Paul D. Terry; Shawn R. Campagna; Brynn H. Voy; Jay Whelan
Source:
Journal of medicinal food 2018 v.21 no.3 pp. 306-316
ISSN:
1557-7600
Subject:
acetyl-CoA carboxylase; adipose tissue; adiposity; animal disease models; anti-inflammatory activity; antineoplastic activity; beta oxidation; body weight; diet; enzyme inhibition; humans; lipogenesis; liver; metabolome; metabolomics; signal transduction; skeletal muscle; weight gain; United States
Abstract:
... Zyflamend is a highly controlled blend of 10 herbal extracts that synergistically impact multiple cell signaling pathways with anticancer and anti-inflammatory properties. More recently, its effects were shown to also modify cellular energetics, for example, activation of fatty acid oxidation and inhibition of lipogenesis. However, its general metabolic effects in vivo have yet to be explored. The ...
DOI:
10.1089/jmf.2017.0062

16. Propolis Protects Endotoxin Induced Acute Lung and Liver Inflammation Through Attenuating Inflammatory Responses and Oxidative Stress

Author:
Berat Yangi; Mehmet Cengiz Ustuner; Murat Dincer; Cansu Ozbayer; Neslihan Tekin; Derya Ustuner; Emine Colak; Umut Kerem Kolac; Emre Entok
Source:
Journal of medicinal food 2018 v.21 no.11 pp. 1096-1105
ISSN:
1557-7600
Subject:
DNA fragmentation; antineoplastic activity; catalase; endotoxins; inflammation; laboratory animals; lipopolysaccharides; liver; lungs; males; malondialdehyde; nitric oxide; oxidative stress; propolis; rats; reactive oxygen species; superoxide dismutase; tissues; tomography
Abstract:
... Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced inflammation in rats. Forty-two, 3- to 4-month-old male Sprague Dawley rats were u ...
DOI:
10.1089/jmf.2017.0151

17. Saccharina japonica Extract Suppresses Stemness of Glioma Stem Cells by Degrading Epidermal Growth Factor Receptor/Epidermal Growth Factor Receptor Variant III

Author:
So Yeon Kim; Jeong-Yub Kim; Woon-Seob Shin; Seok Joon Lee; Sung-Gil Chi; Ji-Yun Lee; Myung-Jin Park
Source:
Journal of medicinal food 2018 v.21 no.5 pp. 496-505
ISSN:
1557-7600
Subject:
Saccharina japonica; adjuvants; antineoplastic activity; apoptosis; epidermal growth factor receptors; glioblastoma; ionizing radiation; neoplasm cells; relapse; stem cells; therapeutics
Abstract:
... Cancer stem cells, a small subpopulation of cells with stem cell-like characteristics found within most solid tumors, are widely reported to be responsible for the malignancy of aggressive cancer cells, and targeting these cells presents a sound therapeutic strategy for reducing the risk of tumor relapse. In the present study, we examined the effects of an extract of Saccharina japonica (ESJ) on g ...
DOI:
10.1089/jmf.2017.3992

18. Aloe arborescens Polysaccharides: In Vitro Immunomodulation and Potential Cytotoxic Activity

Author:
Nazeam Jilan A.; Gad Haidy A.; Esmat Ahmed; El-Hefnawy Hala M.; Singab Abdel-Naser B.
Source:
Journal of medicinal food 2017 v.20 no.5 pp. 491-501
ISSN:
1557-7600
Subject:
Aloe arborescens; adjuvants; antineoplastic activity; cytotoxicity; drug therapy; glucose; humans; hydrogen; immunosuppression; inhibitory concentration 50; leaves; liver neoplasms; lymphocyte proliferation; mannose; molecular weight; neoplasm cells; patients; phagocytosis; polysaccharides; spectrophotometers; uronic acids
Abstract:
... Different polysaccharides were isolated from the leaves of Aloe arborescens using the gradient power of hydrogen followed by antitumor and immunomodulatory assay. The total polysaccharide content of different fractions, water-soluble polysaccharide (WAP), acid-soluble polysaccharide (ACP), and alkaline-soluble polysaccharide (ALP), was estimated using a phenol-sulfuric acid spectrophotometric meth ...
DOI:
10.1089/jmf.2016.0148

19. Antimutagenic, Antirecombinogenic, and Antitumor Effect of Amygdalin in a Yeast Cell–Based Test and Mammalian Cell Lines

Author:
Todorova Atanaska; Pesheva Margarita; Iliev Ivan; Bardarov Krum; Todorova Teodora
Source:
Journal of medicinal food 2017 v.20 no.4 pp. 360-366
ISSN:
1557-7600
Subject:
Rosaceae; Saccharomyces cerevisiae; almonds; alternative medicine; amygdalin; anticarcinogenic activity; antineoplastic activity; apples; apricots; biochemical pathways; carcinogenesis; cell viability; cherries; chromium; colorectal neoplasms; cough; crossing over; cytotoxicity; fever; gene conversion; mammals; methyl methanesulfonate; mitosis; mutagens; mutation; nectarines; neoplasm cells; peaches; plums; seeds; thirst; yeasts
Abstract:
... Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, cough suppression, and quenching thirst. The aim of the present study is to determine the mutagenic and recombinogenic effects of amygdalin in a test syst ...
DOI:
10.1089/jmf.2016.0108

20. Artemisia dracunculus Extracts Obtained by Organic Solvents and Supercritical CO2 Produce Cytotoxic and Antitumor Effects in Mice with L5178Y Lymphoma

Author:
Navarro-Salcedo Martha Hilda; Delgado-Saucedo Jorge Ivan; Siordia-Sánchez Victor Hugo; González-Ortiz Luis J.; Castillo-Herrera Gustavo Adolfo; Puebla-Pérez Ana M.
Source:
Journal of medicinal food 2017 v.20 no.11 pp. 1076-1082
ISSN:
1557-7600
Subject:
Artemisia dracunculus; acetone; acetonitrile; amides; antineoplastic activity; antioxidant activity; ascites; carbon dioxide; cytotoxicity; ethanol; ethyl acetate; flavones; growth retardation; hexane; inhibitory concentration 50; leaf extracts; lymphoma; mice; neoplasm cells; polyphenols; solvents; supercritical fluid extraction; tarragon
Abstract:
... We investigated the cytotoxic and antitumor effects of nine leaf extracts from Artemisia dracunculus (Tarragon). Five extracts were obtained using different organic solvents and four by supercritical CO₂. The cytotoxic effects were expressed as IC₅₀ in 100, 80, 80, 100, and 80 μg/mL by respective solvents: hexane, ethyl acetate, acetone, ethanol, and acetonitrile in L5178Y lymphoma cells. For supe ...
DOI:
10.1089/jmf.2017.0044

21. Centella asiatica Fraction-3 Suppresses the Nuclear Factor Erythroid 2-Related Factor 2 Anti-Oxidant Pathway and Enhances Reactive Oxygen Species-Mediated Cell Death in Cancerous Lung A549 Cells

Author:
Naidoo Dhaneshree Bestinee; Phulukdaree Alisa; Anand Krishnan; Sewram Vikash; Chuturgoon Anil Amichund
Source:
Journal of medicinal food 2017 v.20 no.10 pp. 959-968
ISSN:
1557-7600
Subject:
Centella asiatica; DNA damage; Western blotting; adenosine triphosphate; antineoplastic activity; antioxidant genes; caspases; catalase; cell death; cell viability; comet assay; cytotoxicity; enzyme activity; flow cytometry; fractionation; gas chromatography-mass spectrometry; gene expression; glutathione; inhibitory concentration 50; lactate dehydrogenase; leaf extracts; malondialdehyde; medicinal plants; membrane potential; mitochondria; mitochondrial membrane; oxygen; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; silica; superoxide dismutase; thin layer chromatography; traditional medicine
Abstract:
... Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica c ...
DOI:
10.1089/jmf.2017.0005

22. Chlorogenic Acid-Enriched Extract of Ilex kudingcha C.J. Tseng Inhibits Angiogenesis in Zebrafish

Author:
Zhong Tao; Piao Linghua; Kim Hyun Jung; Liu Xiande; Jiang Shengnan; Liu Guomin
Source:
Journal of medicinal food 2017 v.20 no.12 pp. 1160-1167
ISSN:
1557-7600
Subject:
Danio rerio; Ilex kaushue; angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; blood; chlorogenic acid; dose response; endothelial cells; eyes; fever; high performance liquid chromatography; ingredients; magnetism; nuclear magnetic resonance spectroscopy; pruritus; tea; toxins; China
Abstract:
... Kudingcha is a particularly bitter tasting tea that has been widely used in China to eliminate fever and itching eyes, and to clear blood toxins. Kudingcha is considered of value for its potential anticancer effects that are attributed to the presence of characteristic bioactive ingredients. The chlorogenic acid (CGA) derivatives 3-0-caffeoylquinic acid, 5-0-caffeoylquinic acid, 3,5-0-dicaffeoylqu ...
DOI:
10.1089/jmf.2017.3987

23. Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice

Author:
Joung Hyunchae; Kim Bobae; Park Hyunjoon; Lee Kyuyeon; Kim Hee-Hoon; Sim Ho-Cheol; Do Hyun-Jin; Hyun Chang-Kee; Do Myoung-Sool
Source:
Journal of medicinal food 2017 v.20 no.5 pp. 439-447
ISSN:
1557-7600
Subject:
Moringa oleifera; adipose tissue; adiposity; animal disease models; antineoplastic activity; antioxidants; cytokines; diabetes; endoplasmic reticulum; epididymis; fatty liver; fermentation; foods; gene expression; gene expression regulation; genes; glucose; glucose tolerance tests; high fat diet; inflammation; lipid metabolism; lipids; lipotoxicity; liver; liver neoplasms; messenger RNA; mice; muscles; myocardial infarction; nutritive value; obesity; oxidative stress; proteins; risk factors; stroke; trees
Abstract:
... Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anticancer effects. Fermentation can further improve the safety and nutritional value ...
DOI:
10.1089/jmf.2016.3860

24. Ginsenoside Rg3 Inhibition of Thyroid Cancer Metastasis Is Associated with Alternation of Actin Skeleton

Author:
Wenshuang Wu; Qian Zhou; Wanjun Zhao; Yanping Gong; Anping Su; Feng Liu; Yang Liu; Zhihui Li; Jingqiang Zhu
Source:
Journal of medicinal food 2018 v.21 no.9 pp. 849-857
ISSN:
1557-7600
Subject:
Oriental traditional medicine; Panax ginseng; actin; angiogenesis; antineoplastic activity; gelatinase A; ginsenosides; guanosinetriphosphatase; lungs; lymph nodes; metastasis; mice; models; neoplasm cells; pseudopodia; skeleton; staining; thyroid neoplasms; vascular endothelial growth factor A; vascular endothelial growth factor C
Abstract:
... Ginsenoside Rg3, a bioactive constituent from Panax ginseng, is a worldwide well-known traditional Chinese medicine used as a tonic. It also has good antitumor activity by inhibiting tumors metastasis. Tumor metastasis is a high risk in thyroid cancer. However, the effect and molecular mechanism underlying the antimetastatic activity of Rg3 in thyroid cancer have not been reported. In our study, w ...
DOI:
10.1089/jmf.2017.4144

25. Bamboo Salt Suppresses Colon Carcinogenesis in C57BL/6 Mice with Chemically Induced Colitis

Author:
Ju Jaehyun; Lee Ga-Young; Kim Yoon-Se; Chang Hee Kyung; Do Myoung-Sool; Park Kun-Young
Source:
Journal of medicinal food 2016 v.19 no.11 pp. 1015-1022
ISSN:
1557-7600
Subject:
antineoplastic activity; azoxymethane; baking; bamboos; blood serum; carcinogenesis; colitis; colon; colorectal neoplasms; gene expression; genes; immunohistochemistry; interleukin-1beta; interleukin-6; messenger RNA; mice; models; protective effect; sodium sulfate; staining; tumor necrosis factor-alpha
Abstract:
... The aim of our experiment was to evaluate the anticancer effect of bamboo salt (BS) on C57BL/6 mice in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer model. BS, solar salt, and purified salt were evaluated for their protective effects during AOM/DSS-induced colon carcinogenesis in C57BL/6 mice. BS, especially after baking for nine separate intervals (BS9x), suppressed colo ...
DOI:
10.1089/jmf.2016.3798

26. Black Currant (Ribes nigrum L.) Extract Induces Apoptosis of MKN-45 and TE-1 Cells Through MAPK- and PI3K/Akt-Mediated Mitochondrial Pathways

Author:
Liu Bingshuo; Li Zhiwei
Source:
Journal of medicinal food 2016 v.19 no.4 pp. 365-373
ISSN:
1557-7600
Subject:
Ribes nigrum; Western blotting; antineoplastic activity; apoptosis; black currants; mitochondria; mitogen-activated protein kinase; neoplasm cells; neoplasms; polyphenols; shrinkage; signal transduction; viability
Abstract:
... Black currant extract (BCE) is rich in polyphenols and can induce apoptosis in various cancer cells, but the molecular mechanism by which BCE induces cancer cell apoptosis has not been reported. The aim of this work was to elucidate the antitumor effect of BCE and the signal transduction pathways involved. MTT test results revealed that the viability of MKN-45 and TE-1 cells treated with BCE gradu ...
DOI:
10.1089/jmf.2015.3521

27. Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways

Author:
Dhillon Harsharan; Mamidi Sujan; McClean Phillip; Reindl Katie M.
Source:
Journal of medicinal food 2016 v.19 no.6 pp. 578-585
ISSN:
1557-7600
Subject:
Western blotting; alkaloids; antineoplastic activity; cell physiology; cytochrome c; endoplasmic reticulum; gene expression regulation; gene overexpression; humans; messenger RNA; models; neoplasm cells; oxidative stress; pancreatic neoplasms; peppers; reverse transcriptase polymerase chain reaction; sequence analysis; transcriptome; transcriptomics; unfolded protein response
Abstract:
... Piperlongumine (PL), an alkaloid obtained from long peppers, displays antitumorigenic properties for a variety of human cell- and animal-based models. The aim of this study was to identify the underlying molecular mechanisms for PL anticancer effects on human pancreatic cancer cells. RNA sequencing (RNA-seq) was used to identify the effects of PL on the transcriptome of MIA PaCa-2 human pancreatic ...
DOI:
10.1089/jmf.2015.0152
PubMed:
27119744
PubMed Central:
PMC4904158

28. Apium graveolens Extract Inhibits Cell Proliferation and Expression of Vascular Endothelial Growth Factor and Induces Apoptosis in the Human Prostatic Carcinoma Cell Line LNCaP

Author:
Köken Tülay; Koca Buğra; Özkurt Mete; Erkasap Nilüfer; Kuş Gökhan; Karalar Mustafa
Source:
Journal of medicinal food 2016 v.19 no.12 pp. 1166-1171
ISSN:
1557-7600
Subject:
Apium graveolens; NAD ADP-ribosyltransferase; angiogenesis; antineoplastic activity; apoptosis; biomarkers; cell proliferation; cell viability; dose response; gene expression; humans; neoplasm cells; neoplasms; reverse transcriptase polymerase chain reaction; tissues; vascular endothelial growth factors
Abstract:
... Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. In this study, we investigated the anticancer effect of A. graveolens on the human prostatic carcinoma cell line LNCaP. LNCaP cells were treated with increasing concentrations of an ethanolic extract of A. graveolens ranging from 1000 to 3000 μg/mL, and viability was determined after 24 and 48 h using the XTT cel ...
DOI:
10.1089/jmf.2016.0061

29. Beneficial Health Effects of Chios Gum Mastic and Peroxisome Proliferator-Activated Receptors: Indications of Common Mechanisms

Author:
Georgiadis Ioannis; Karatzas Theodore; Korou Laskarina-Maria; Katsilambros Nikolaos; Perrea Despina
Source:
Journal of medicinal food 2015 v.18 no.1 pp. 1-10
ISSN:
1557-7600
Subject:
agonists; antineoplastic activity; antioxidants; chemical composition; databases; diabetes mellitus; gallic acid; gene expression; glycemic effect; hyperlipidemia; inflammation; metabolic syndrome; oleanolic acid; receptors; surveys; synergism; traditional medicine; transcription factors; Mediterranean region
Abstract:
... For thousands of years, Chios Gum Mastic (CGM), the resin produced by the trunk of Pistachia lentiscus var Chia, has been used for culinary and medicinal purposes and several therapeutic properties have been attributed to it. CGM has been used in traditional medicine of various nations in the eastern Mediterranean area. This survey was carried out to identify biological mechanisms that could expla ...
DOI:
10.1089/jmf.2014.0021

30. Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells

Author:
Ferguson Jeannette E.; Orlando Robert A.
Source:
Journal of medicinal food 2015 v.18 no.4 pp. 497-502
ISSN:
1557-7600
Subject:
DNA; adjuvants; adverse effects; antineoplastic activity; breast neoplasms; cell proliferation; cell viability; curcumin; cytotoxicity; drug therapy; fluorouracil; humans; lethal dose 50; neoplasm cells
Abstract:
... Antimetabolites have proven successful as therapeutics for advanced-stage breast cancers, but are often accompanied by severe side effects that can limit treatment regimens. 5-Fluorouracil (5-FU), an antimetabolite that inhibits cell proliferation, has served an important role in standard chemotherapy protocols for a variety of solid tumors. Although reasonable response rates have been reported fo ...
DOI:
10.1089/jmf.2013.0086

31. Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from Murraya koenigii Leaves in Breast Cancer Cells—Molecular Docking Studies

Author:
Ismail Ayesha; Noolu Bindu; Gogulothu Ramesh; Perugu Shyam; Rajanna Ajumeera; Babu Suresh K.
Source:
Journal of medicinal food 2016 v.19 no.12 pp. 1155-1165
ISSN:
1557-7600
Subject:
Bergera koenigii; alkaloids; antineoplastic activity; apoptosis; bioactive compounds; breast neoplasms; cell cycle; cell proliferation; cell viability; coumarins; cytotoxicity; flavonoids; growth models; inhibitory concentration 50; leaves; neoplasm cells; proteasome endopeptidase complex; protein subunits; proteinases; proteolysis
Abstract:
... Murraya koenigii (curry tree) leaves are rich in bioactive compounds such as flavonoids, alkaloids, and coumarins. Alkaloids from M. koenigii leaves have antianalgesic, antiulcerogenic, antiobesity, and antitumor activities. In this study, we tested the cytotoxic and proteasome-inhibitory potential of a total alkaloid extract (TAE) from M. koenigii leaves in the breast cancer cell line MDA-MB-231. ...
DOI:
10.1089/jmf.2016.3767

32. Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways

Author:
Shebaby Wassim N.; Bodman-Smith K.B.; Mansour Anthony; Mroueh Mohamad; Taleb Robin I.; El-Sibai Mirvat; Daher Costantine F.
Source:
Journal of medicinal food 2015 v.18 no.7 pp. 745-752
ISSN:
1557-7600
Subject:
Daucus carota; Western blotting; adenocarcinoma; antineoplastic activity; antioxidant activity; apoptosis; carrots; caspase-3; cell cycle checkpoints; cell proliferation; cell viability; colon; dose response; flow cytometry; humans; inositols; mitogen-activated protein kinase; oils; pentane; phosphatidylinositol 3-kinase; traditional medicine
Abstract:
... Daucus carota L. ssp. carota (Apiacea, wild carrot, Queen Anne's lace) has been used in folk medicine throughout the world and recently was shown to possess anticancer and antioxidant activities. This study aims to determine the anticancer activity of the pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) of the Daucus Carota oil extract (DCOE) against human colon adenocarcinoma ...
DOI:
10.1089/jmf.2014.3225

33. Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis

Author:
Kim Byung Soo; Seo Hyobin; Kim Ha-Jeong; Bae Sang Mun; Son Hye-Nam; Lee Yoon Jeong; Ryu Sungpil; Park Rang-Woon; Nam Ju-Ock
Source:
Journal of medicinal food 2015 v.18 no.10 pp. 1121-1127
ISSN:
1557-7600
Subject:
Angelica gigas; antineoplastic activity; apoptosis; caspase-3; cell proliferation; dose response; melanoma; mitogen-activated protein kinase; models; phosphorylation
Abstract:
... Decursin, a bioactive phytochemical isolated from Angelica gigas Nakai (danggwi), has shown preclinical anticancer efficacy in various cancer models. However, the antitumor effect of decursin in melanoma models remains undefined. The antitumor activities of decursin were investigated in B16F10 cells in vitro and in vivo. In this study, we show that treatment with decursin inhibited cell proliferat ...
DOI:
10.1089/jmf.2014.3397
PubMed:
26336081
PubMed Central:
PMC4593895

34. Thymus vulgaris (Thyme) Inhibits Proliferation, Adhesion, Migration, and Invasion of Human Colorectal Cancer Cells

Author:
Al-Menhali Afnan; Al-Rumaihi Aisha; Al-Mohammed Hana; Al-Mazrooey Hana; Al-Shamlan Maryam; AlJassim Meaad; Al-Korbi Noof; Eid Ali Hussein
Source:
Journal of medicinal food 2015 v.18 no.1 pp. 54-59
ISSN:
1557-7600
Subject:
Thymus vulgaris; adhesion; antineoplastic activity; apoptosis; colorectal neoplasms; fibronectins; herbal medicines; humans; neoplasm cells; patients; phenotype; prognosis; thyme
Abstract:
... Colorectal cancer (CRC) remains one of the most common malignancies and a leading cause of cancer-related deaths. Its prognosis remains poor for patients with several grades of this disease. This underscores the need for alternative modalities, such as herbal medicines, to treat this disease. A commonly used plant that appears to be of high medicinal value is Thymus vulgaris L. However, the effect ...
DOI:
10.1089/jmf.2013.3121

35. Anticancer Activity of Protocatechualdehyde in Human Breast Cancer Cells

Author:
Choi Jieun; Jiang Xiaojing; Jeong Jin Boo; Lee Seong-Ho
Source:
Journal of medicinal food 2014 v.17 no.8 pp. 842-848
ISSN:
1557-7600
Subject:
antineoplastic activity; apoptosis; barley; breast neoplasms; cell cycle checkpoints; cell proliferation; colorectal neoplasms; cyclins; dose response; gene overexpression; half life; humans; messenger RNA; neoplasm cells; polyphenols; proto-oncogenes; tau-protein kinase; tea; transcription factor NF-kappa B
Abstract:
... Protocatechualdehyde (PCA) is a natural polyphenol compound isolated from the root of the herb S. miltiorrhiza and barley tea plants. PCA possesses antiproliferative and pro-apoptotic properties in human colorectal cancer cells. However, the cellular mechanism has not been fully understood. β-catenin and cyclin D1 are proto-oncogene that is overexpressed in many types of cancers and leads to cance ...
DOI:
10.1089/jmf.2013.0159

36. Anticancer Properties of Extracts from Opuntia humifusa Against Human Cervical Carcinoma Cells

Author:
Hahm Sahng-Wook; Park Jieun; Oh Se-Yeong; Lee Chul-Won; Park Kun-Young; Kim Hyunggee; Son Yong-Suk
Source:
Journal of medicinal food 2015 v.18 no.1 pp. 31-44
ISSN:
1557-7600
Subject:
Opuntia humifusa; antineoplastic activity; antioxidants; ascorbic acid; cyclin-dependent kinase; cyclins; ethyl acetate; fibroblasts; fruits; hexane; humans; interphase; neoplasm cells; polyphenols; seeds; stems; taxifolin; uterine cervical neoplasms
Abstract:
... In this study, we found that the total polyphenol and ascorbic acid levels in the fruit of Opuntia humifusa are higher than those in other parts of the plant. We further hypothesized that antioxidants in O. humifusa might affect the growth or survival of cancer cells. Hexane extracts of seeds and ethyl acetate extracts of fruits and stems significantly suppressed the proliferation of HeLa cervical ...
DOI:
10.1089/jmf.2013.3096

37. Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability

Author:
Oh Jisun; Jeon Seong Bin; Lee Yuri; Lee Hyeji; Kim Ju; Kwon Bo Ra; Yu Kang-Yeol; Cha Jeong-Dan; Hwang Seung-Mi; Choi Kyung-Min; Jeong Yong-Seob
Source:
Journal of medicinal food 2015 v.18 no.4 pp. 421-428
ISSN:
1557-7600
Subject:
Panax ginseng; antineoplastic activity; apoptosis; biocompatible materials; breast neoplasms; carcinogens; cell differentiation; cell proliferation; cell viability; diabetes; heart; hepatoma; human cell lines; medicinal plants; neoplasm cells; paclitaxel; stem cells; South Korea
Abstract:
... Red ginseng (Panax ginseng C.A. Meyer) is the most widely recognized medicinal herb due to its remedial effects in various disorders, such as cancers, diabetes, and heart problems. In this study, we investigated the anticancer effect of fermented red ginseng extract (f-RGE; provided by Jeonju Biomaterials Institute, Jeonju, South Korea) in a parallel comparison with the effect of nonfermented red ...
DOI:
10.1089/jmf.2014.3248

38. Kimchi Protects Against Azoxymethane/Dextran Sulfate Sodium–Induced Colorectal Carcinogenesis in Mice

Author:
Kim Hee-Young; Song Jia-Le; Chang Hee-Kyung; Kang Soon-Ah; Park Kun-Young
Source:
Journal of medicinal food 2014 v.17 no.8 pp. 833-841
ISSN:
1557-7600
Subject:
antineoplastic activity; azoxymethane; body weight; carcinogenesis; chemoprevention; colon; colorectal neoplasms; dextran; drinking water; health promotion; humans; inducible nitric oxide synthase; interferon-gamma; interleukin-6; intraperitoneal injection; kimchi; males; messenger RNA; mice; prostaglandin synthase; protein synthesis; sodium sulfate; tissues; tumor necrosis factor-alpha
Abstract:
... The chemopreventive effects of different types and quantities of kimchi prepared with different subingredients, including commercial kimchi (CK), standardized kimchi (SK), cancer-preventive kimchi (CPK), and anticancer kimchi (ACK), on colorectal carcinogenesis in mice were evaluated. The development of colon cancer was induced in male BALB/c mice with a single intraperitoneal injection of azoxyme ...
DOI:
10.1089/jmf.2013.2986
PubMed:
25029638
PubMed Central:
PMC4126272

39. The Polar High Molecular Weight Fraction of the Agaricus blazei Murill Extract, AndoSan™, Reduces the Activity of the Tumor-Associated Protease, Legumain, in RAW 264.7 Cells

Author:
Berven Lise; Karppinen Pernille; Hetland Geir; Samuelsen Anne Berit C.
Source:
Journal of medicinal food 2015 v.18 no.4 pp. 429-438
ISSN:
1557-7600
Subject:
Agaricus subrufescens; Grifola frondosa; Hericium; antineoplastic activity; beta-glucans; carbohydrate content; chemokines; ethanol; fractionation; glucose; growth factors; high performance liquid chromatography; immunomodulation; ingredients; legumain; leukocytes; molecular weight; pH
Abstract:
... AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans. Since these exhibit potent antitumor activity and have immunomodulatory effects, the stimulatory effect of AndoSan on the production of different cytokines, chemokines, and leukocyte growth factors has ...
DOI:
10.1089/jmf.2014.0018

40. Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803

Author:
Zhang Xiu-Zhen; Wang Ling; Liu Dong-Wu; Tang Guang-Yan; Zhang Hong-Yu
Source:
Journal of medicinal food 2014 v.17 no.9 pp. 955-962
ISSN:
1557-7600
Subject:
antineoplastic activity; apoptosis; berberine; caspase-3; cell cycle; confocal laser scanning microscopy; drugs; flow cytometry; humans; limonene; membrane potential; mitochondrial membrane; neoplasm cells; reactive oxygen species; synergism
Abstract:
... This study aims at evaluating the anticancer effects of berberine hydrochloride (berberine) and d-limonene, alone and in combination, on human gastric carcinoma cell line MGC803 to determine whether berberine and d-limonene work synergistically and elucidate their mechanisms. MGC803 cells were treated with berberine and d-limonene, alone and in combination, for 24–48 h. The inhibitory effects of t ...
DOI:
10.1089/jmf.2013.2967
PubMed:
25045784
PubMed Central:
PMC4152785

41. Antiproliferative Activities of Lesser Galangal (Alpinia officinarum Hance Jam1), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale Rosc.) Against Acute Monocytic Leukemia

Author:
Omoregie Samson N.; Omoruyi Felix O.; Wright Vincent F.; Jones Lemore; Zimba Paul V.
Source:
Journal of medicinal food 2013 v.16 no.7 pp. 647-655
ISSN:
1557-7600
Subject:
Alpinia officinarum; Curcuma longa; Zingiber officinale; antineoplastic activity; chloroform; drug therapy; ginger; leaf extracts; leaves; leukemia; methanol; methylene chloride; neoplasm cells; reversed-phase high performance liquid chromatography; rhizomes; solvents; turmeric
Abstract:
... Acute monocytic leukemia (AML M5 or AMoL) is one of the several types of leukemia that are still awaiting cures. The use of chemotherapy for cancer management can be harmful to normal cells in the vicinity of the target leukemia cells. This study assessed the potency of the extracts from lesser galangal, turmeric, and ginger against AML M5 to use the suitable fractions in neutraceuticals. Aqueous ...
DOI:
10.1089/jmf.2012.0254

42. Antitumor Activity of the Protein and Small Molecule Component Fractions from Agrocybe aegerita Through Enhancement of Cytokine Production

Author:
Liang Yi; Liu Hong-Hong; Chen Yi-Jie; Sun Hui
Source:
Journal of medicinal food 2014 v.17 no.4 pp. 439-446
ISSN:
1557-7600
Subject:
Agrocybe aegerita; alpha-bisabolol; animal models; antineoplastic activity; blood serum; cytotoxicity; enzyme-linked immunosorbent assay; gene expression; gene expression regulation; granulocyte-macrophage colony-stimulating factor; interleukin-10; lectins; medicinal fungi; messenger RNA; mice; quantitative polymerase chain reaction; serine proteinases; splenocytes; triethylene glycol
Abstract:
... A water soluble extract from the medicinal mushroom Agrocybe aegerita has been shown to stimulate splenocyte proliferation, cytotoxic activity, and tumor rejection effect in tumor-bearing mouse models. In the present study, the crude extract was separated into a protein component fraction (Yp), mainly containing lectins and serine proteinase, and a small molecule component fraction (Ys), mainly co ...
DOI:
10.1089/jmf.2013.2846

43. Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells

Author:
Chen Chien-An; Chen Chien-Chih; Shen Chien-Chang; Chang Hen-Hong; Chen Yu-Jen
Source:
Journal of medicinal food 2013 v.16 no.10 pp. 869-877
ISSN:
1557-7600
Subject:
Dendrobium loddigesii; Western blotting; adenocarcinoma; antineoplastic activity; apoptosis; cyclins; esophageal neoplasms; fluorescent antibody technique; humans; mitosis; neoplasm cells; polyploidy; squamous cell carcinoma
Abstract:
... Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. Moscatilin suppressed the growth of both the histological cell lines in a dose- and time-dependent manner. Mo ...
DOI:
10.1089/jmf.2012.2617
PubMed:
24074296
PubMed Central:
PMC3806377

44. Polyphyllin D Induces Apoptosis in U87 Human Glioma Cells Through the c-Jun NH2-Terminal Kinase Pathway

Author:
Yu Qiang; Li Qiaoyu; Lu Peisong; Chen Qianxue
Source:
Journal of medicinal food 2014 v.17 no.9 pp. 1036-1042
ISSN:
1557-7600
Subject:
B-lymphocytes; Western blotting; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cultured cells; flow cytometry; humans; leukemia; lymphoma; medicinal plants; mitogen-activated protein kinase; protein synthesis; Asia
Abstract:
... Polyphyllin D (PD), an active component from a traditional medicinal herb Paris polyphylla, which has long been used for the treatment of cancer in Asian countries, has been found to hold significant antitumor activity in vivo or in vitro. However, there were few reports on the effects and underlying mechanism of PD on apoptosis in U87 human glioma cells. The present study was conducted to evaluat ...
DOI:
10.1089/jmf.2013.2957

45. Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells

Author:
Baharetha Hussein M.; Nassar Zeyad D.; Aisha Abdalrahim F.; Ahamed Mohamed B. Khadeer; Al-Suede Foaud Saleih R.; Kadir Mohd Omar Abd; Ismail Zhari; Majid Amin Malik Shah Abdul
Source:
Journal of medicinal food 2013 v.16 no.12 pp. 1121-1130
ISSN:
1557-7600
Subject:
inhibitory concentration 50; carbon dioxide; cell movement; fever; caspases; humans; seeds; cytotoxicity; ultraviolet-visible spectroscopy; antineoplastic activity; scanning electron microscopes; neoplasm cells; Fourier transform infrared spectroscopy; Nigella sativa; spices; apoptosis; breast neoplasms
Abstract:
... Nigella sativa, commonly referred as black cumin, is a popular spice that has been used since the ancient Egyptians. It has traditionally been used for treatment of various human ailments ranging from fever to intestinal disturbances to cancer. This study investigated the apoptotic, antimetastatic, and anticancer activities of supercritical carbon dioxide (SC-CO₂) extracts of the seeds of N. sativ ...
DOI:
10.1089/jmf.2012.2624
PubMed:
24328702
PubMed Central:
PMC3868399

46. Xanthoceraside Induces Apoptosis in Melanoma Cells Through the Activation of Caspases and the Suppression of the IGF-1R/Raf/MEK/ERK Signaling Pathway

Author:
Jiao Qing; Zou Libo; Liu Peng; Xu Qian; Zhang Yifei; Yu Ying; Zou Lu; Chi Tianyan; Ji Xuefei
Source:
Journal of medicinal food 2014 v.17 no.10 pp. 1070-1078
ISSN:
1557-7600
Subject:
Western blotting; Xanthoceras sorbifolium; antineoplastic activity; apoptosis; caspase-3; caspase-8; caspase-9; cell cycle; cell viability; flow cytometry; hulls; humans; inflammation; insulin-like growth factor I receptor; mechanism of action; melanoma; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; mononuclear leukocytes; neoplasm cells; oxidative stress; saponins; signal transduction
Abstract:
... Xanthoceraside, a saponin extracted from the husks of Xanthoceras sorbifolia Bunge, suppresses inflammation and oxidative stress. However, the antitumor properties of xanthoceraside as well as its mechanism of action remain unclear. Therefore, we proposed to investigate its potential anticancer property. In this study, the viability of cells was measured by the MTT assay. Cell cycle and mitochondr ...
DOI:
10.1089/jmf.2013.3035

47. Antioxidant Capacity of Food Mixtures Is Not Correlated with Their Antiproliferative Activity Against MCF-7 Breast Cancer Cells

Author:
Wang Sunan; Zhu Fan; Meckling Kelly A.; Marcone Massimo F.
Source:
Journal of medicinal food 2013 v.16 no.12 pp. 1138-1145
ISSN:
1557-7600
Subject:
2,2-diphenyl-1-picrylhydrazyl; Vigna angularis; antineoplastic activity; antioxidants; apples; black beans; blackberries; blended foods; breast neoplasms; broccoli; cauliflower; fruits; grapes; growth retardation; kidney beans; mushrooms; neoplasm cells; onions; oxygen radical absorbance capacity; raspberries; soybeans; tomatoes
Abstract:
... Combining different foods may produce additive, synergistic, or antagonistic interactions that may modify certain physiological effects (i.e., anticancer properties). For investigating these interactions and potential synergetic combinations, thirteen foods from three categories, including fruits (raspberries, blackberries, apples, grapes), vegetables (broccoli, tomatoes, mushrooms, purple caulifl ...
DOI:
10.1089/jmf.2013.0051

48. Antrodia camphorata Grown on Germinated Brown Rice Inhibits HT-29 Human Colon Carcinoma Proliferation Through Inducing G0/G1 Phase Arrest and Apoptosis by Targeting the β-Catenin Signaling

Author:
Park Dong Ki; Lim Yoong Ho; Park Hye-Jin
Source:
Journal of medicinal food 2013 v.16 no.8 pp. 681-691
ISSN:
1557-7600
Subject:
Taiwanofungus camphoratus; adenosine; antineoplastic activity; apoptosis; brown rice; butanol; cell cycle checkpoints; cell proliferation; chemoprevention; colorectal neoplasms; cyclins; data analysis; diarrhea; drugs; ethanol; ethyl acetate; hexane; high performance liquid chromatography; humans; hypertension; interphase; liver neoplasms; neoplasm cells; pain; poisoning; pruritus; signal transduction; traditional medicine; East Asia
Abstract:
... Antrodia camphorata (AC) has been used as a traditional medicine to treat food and drug intoxication, diarrhea, abdominal pain, hypertension, pruritis (skin itch), and liver cancer in East Asia. In this study, we investigated anticancer activities of AC grown on germinated brown rice (CBR) in HT-29 human colon cancer cells. We found that the inhibitory efficacy of CBR 80% ethanol (EtOH) extract on ...
DOI:
10.1089/jmf.2012.2605

49. Genes Related to Suppression of Malignant Phenotype Induced by Maitake D-Fraction in Breast Cancer Cells

Author:
Alonso Eliana Noelia; Orozco Manuela; Nieto Alvaro Eloy; Balogh Gabriela Andrea
Source:
Journal of medicinal food 2013 v.16 no.7 pp. 602-617
ISSN:
1557-7600
Subject:
RNA; T-lymphocytes; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell growth; chemoprevention; complementary DNA; dose response; gene expression; genes; humans; macrophages; metastasis; microarray technology; mushrooms; natural killer cells; neoplasm cells; phenotype; polysaccharides; United States
Abstract:
... It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. However, the exact molecular mechanism ...
DOI:
10.1089/jmf.2012.0222
PubMed:
23875900
PubMed Central:
PMC3719462

50. Production of Bioactive Compounds with Antitumor Activity Against Sarcoma 180 by Pleurotus sajor-caju

Author:
Assis Ivaneliza Simionato; Chaves Mariane Bonatti; Silveira Marcia Luciane Lange; Gern Regina Maria Miranda; Wisbeck Elisabeth; Júnior Agenor Furigo; Furlan Sandra Aparecida
Source:
Journal of medicinal food 2013 v.16 no.11 pp. 1004-1012
ISSN:
1557-7600
Subject:
Pleurotus sajor-caju; ammonium sulfate; antineoplastic activity; antineoplastic agents; biomass; bioreactors; calcium carbonate; containers; culture media; exopolysaccharides; glucose; growth retardation; mice; mycelium; pH; peptones; sarcoma; yeast extract
Abstract:
... This work studied the influence of culture medium composition and pH on exopolysaccharide (EPS) production by Pleurotus sajor-caju and validates the antitumor activity of the produced EPSs and of the mycelial biomass (intracellular polysaccharides [IPSs]) against Sarcoma 180 (S180) cells. The effect of the initial concentrations of (NH₄)₂SO₄, yeast extract and soy peptone on EPS production by P. s ...
DOI:
10.1089/jmf.2012.0267