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You searched for: Journal Journal of medicinal food Remove constraint Journal: Journal of medicinal food Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity
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1. Aloe arborescens Polysaccharides: In Vitro Immunomodulation and Potential Cytotoxic Activity

Author:
Nazeam Jilan A.; Gad Haidy A.; Esmat Ahmed; El-Hefnawy Hala M.; Singab Abdel-Naser B.
Source:
Journal of medicinal food 2017 v.20 no.5 pp. 491-501
ISSN:
1557-7600
Subject:
Aloe arborescens; adjuvants; antineoplastic activity; cytotoxicity; drug therapy; glucose; humans; hydrogen; immunosuppression; inhibitory concentration 50; leaves; liver neoplasms; lymphocyte proliferation; mannose; molecular weight; neoplasm cells; patients; phagocytosis; polysaccharides; spectrophotometers; uronic acids
Abstract:
... Different polysaccharides were isolated from the leaves of Aloe arborescens using the gradient power of hydrogen followed by antitumor and immunomodulatory assay. The total polysaccharide content of different fractions, water-soluble polysaccharide (WAP), acid-soluble polysaccharide (ACP), and alkaline-soluble polysaccharide (ALP), was estimated using a phenol-sulfuric acid spectrophotometric meth ...
DOI:
10.1089/jmf.2016.0148

2. Anticancer Activity of Protocatechualdehyde in Human Breast Cancer Cells

Author:
Choi Jieun; Jiang Xiaojing; Jeong Jin Boo; Lee Seong-Ho
Source:
Journal of medicinal food 2014 v.17 no.8 pp. 842-848
ISSN:
1557-7600
Subject:
antineoplastic activity; apoptosis; barley; breast neoplasms; cell cycle checkpoints; cell proliferation; colorectal neoplasms; cyclins; dose response; gene overexpression; half life; humans; messenger RNA; neoplasm cells; polyphenols; proto-oncogenes; tau-protein kinase; tea; transcription factor NF-kappa B
Abstract:
... Protocatechualdehyde (PCA) is a natural polyphenol compound isolated from the root of the herb S. miltiorrhiza and barley tea plants. PCA possesses antiproliferative and pro-apoptotic properties in human colorectal cancer cells. However, the cellular mechanism has not been fully understood. β-catenin and cyclin D1 are proto-oncogene that is overexpressed in many types of cancers and leads to cance ...
DOI:
10.1089/jmf.2013.0159

3. Anticancer Properties of Extracts from Opuntia humifusa Against Human Cervical Carcinoma Cells

Author:
Hahm Sahng-Wook; Park Jieun; Oh Se-Yeong; Lee Chul-Won; Park Kun-Young; Kim Hyunggee; Son Yong-Suk
Source:
Journal of medicinal food 2015 v.18 no.1 pp. 31-44
ISSN:
1557-7600
Subject:
Opuntia humifusa; antineoplastic activity; antioxidants; ascorbic acid; cyclin-dependent kinase; cyclins; ethyl acetate; fibroblasts; fruits; hexane; humans; interphase; neoplasm cells; polyphenols; seeds; stems; taxifolin; uterine cervical neoplasms
Abstract:
... In this study, we found that the total polyphenol and ascorbic acid levels in the fruit of Opuntia humifusa are higher than those in other parts of the plant. We further hypothesized that antioxidants in O. humifusa might affect the growth or survival of cancer cells. Hexane extracts of seeds and ethyl acetate extracts of fruits and stems significantly suppressed the proliferation of HeLa cervical ...
DOI:
10.1089/jmf.2013.3096

4. Antimutagenic, Antirecombinogenic, and Antitumor Effect of Amygdalin in a Yeast Cell–Based Test and Mammalian Cell Lines

Author:
Todorova Atanaska; Pesheva Margarita; Iliev Ivan; Bardarov Krum; Todorova Teodora
Source:
Journal of medicinal food 2017 v.20 no.4 pp. 360-366
ISSN:
1557-7600
Subject:
Rosaceae; Saccharomyces cerevisiae; almonds; alternative medicine; amygdalin; anticarcinogenic activity; antineoplastic activity; apples; apricots; biochemical pathways; carcinogenesis; cell viability; cherries; chromium; colorectal neoplasms; cough; crossing over; cytotoxicity; fever; gene conversion; mammals; methyl methanesulfonate; mitosis; mutagens; mutation; nectarines; neoplasm cells; peaches; plums; seeds; thirst; yeasts
Abstract:
... Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, cough suppression, and quenching thirst. The aim of the present study is to determine the mutagenic and recombinogenic effects of amygdalin in a test syst ...
DOI:
10.1089/jmf.2016.0108

5. Antioxidant Capacity of Food Mixtures Is Not Correlated with Their Antiproliferative Activity Against MCF-7 Breast Cancer Cells

Author:
Wang Sunan; Zhu Fan; Meckling Kelly A.; Marcone Massimo F.
Source:
Journal of medicinal food 2013 v.16 no.12 pp. 1138-1145
ISSN:
1557-7600
Subject:
2,2-diphenyl-1-picrylhydrazyl; Vigna angularis; antineoplastic activity; antioxidants; apples; black beans; blackberries; blended foods; breast neoplasms; broccoli; cauliflower; fruits; grapes; growth retardation; kidney beans; mushrooms; neoplasm cells; onions; oxygen radical absorbance capacity; raspberries; soybeans; tomatoes
Abstract:
... Combining different foods may produce additive, synergistic, or antagonistic interactions that may modify certain physiological effects (i.e., anticancer properties). For investigating these interactions and potential synergetic combinations, thirteen foods from three categories, including fruits (raspberries, blackberries, apples, grapes), vegetables (broccoli, tomatoes, mushrooms, purple caulifl ...
DOI:
10.1089/jmf.2013.0051

6. Antiproliferative Activities of Lesser Galangal (Alpinia officinarum Hance Jam1), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale Rosc.) Against Acute Monocytic Leukemia

Author:
Omoregie Samson N.; Omoruyi Felix O.; Wright Vincent F.; Jones Lemore; Zimba Paul V.
Source:
Journal of medicinal food 2013 v.16 no.7 pp. 647-655
ISSN:
1557-7600
Subject:
Alpinia officinarum; Curcuma longa; Zingiber officinale; antineoplastic activity; chloroform; drug therapy; ginger; leaf extracts; leaves; leukemia; methanol; methylene chloride; neoplasm cells; reversed-phase high performance liquid chromatography; rhizomes; solvents; turmeric
Abstract:
... Acute monocytic leukemia (AML M5 or AMoL) is one of the several types of leukemia that are still awaiting cures. The use of chemotherapy for cancer management can be harmful to normal cells in the vicinity of the target leukemia cells. This study assessed the potency of the extracts from lesser galangal, turmeric, and ginger against AML M5 to use the suitable fractions in neutraceuticals. Aqueous ...
DOI:
10.1089/jmf.2012.0254

7. Antiproliferative Activity of Extracts of Campomanesia adamantium (Cambess.) O. Berg and Isolated Compound Dimethylchalcone Against B16-F10 Murine Melanoma

Author:
Magalli C.B. Lima e Silva; Danielle Bogo; Caroline A.F. Alexandrino; Renata T. Perdomo; Patrícia de O. Figueiredo; Pamela R. do Prado; Fernanda R. Garcez; Monica C.T. Kadri; Thalita V.N. Ximenes; Rita de Cassia A. Guimarães; Ulana C. Sarmento; Maria Lígia R. Macedo
Source:
Journal of medicinal food 2018 v.21 no.10 pp. 1024-1034
ISSN:
1557-7600
Subject:
Campomanesia; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; caspase-3; cerrado; coculture; diodes; fruit pulp; fruits; high performance liquid chromatography; indigenous species; ionization; macrophages; melanoma; methylene chloride; mice; nitric oxide; phenolic compounds; spectrometers
Abstract:
... Campomanesia adamantium, a native species of the Brazilian Cerrado, is characterized as a natural source of phenolic compounds and has known potential anticancer activities. This study aimed to evaluate the chemical profile of dichloromethane extracts of pulp (DEGPU) and peel (DEGPE) from the fruits of C. adamantium and to identify compounds with antiproliferative effects in vitro against melanoma ...
DOI:
10.1089/jmf.2018.0001

8. Antitumor Activity of the Protein and Small Molecule Component Fractions from Agrocybe aegerita Through Enhancement of Cytokine Production

Author:
Liang Yi; Liu Hong-Hong; Chen Yi-Jie; Sun Hui
Source:
Journal of medicinal food 2014 v.17 no.4 pp. 439-446
ISSN:
1557-7600
Subject:
Agrocybe aegerita; alpha-bisabolol; animal models; antineoplastic activity; blood serum; cytotoxicity; enzyme-linked immunosorbent assay; gene expression; gene expression regulation; granulocyte-macrophage colony-stimulating factor; interleukin-10; lectins; medicinal fungi; messenger RNA; mice; quantitative polymerase chain reaction; serine proteinases; splenocytes; triethylene glycol
Abstract:
... A water soluble extract from the medicinal mushroom Agrocybe aegerita has been shown to stimulate splenocyte proliferation, cytotoxic activity, and tumor rejection effect in tumor-bearing mouse models. In the present study, the crude extract was separated into a protein component fraction (Yp), mainly containing lectins and serine proteinase, and a small molecule component fraction (Ys), mainly co ...
DOI:
10.1089/jmf.2013.2846

9. Antrodia camphorata Grown on Germinated Brown Rice Inhibits HT-29 Human Colon Carcinoma Proliferation Through Inducing G0/G1 Phase Arrest and Apoptosis by Targeting the β-Catenin Signaling

Author:
Park Dong Ki; Lim Yoong Ho; Park Hye-Jin
Source:
Journal of medicinal food 2013 v.16 no.8 pp. 681-691
ISSN:
1557-7600
Subject:
Taiwanofungus camphoratus; adenosine; antineoplastic activity; apoptosis; brown rice; butanol; cell cycle checkpoints; cell proliferation; chemoprevention; colorectal neoplasms; cyclins; data analysis; diarrhea; drugs; ethanol; ethyl acetate; hexane; high performance liquid chromatography; humans; hypertension; interphase; liver neoplasms; neoplasm cells; pain; poisoning; pruritus; signal transduction; traditional medicine; East Asia
Abstract:
... Antrodia camphorata (AC) has been used as a traditional medicine to treat food and drug intoxication, diarrhea, abdominal pain, hypertension, pruritis (skin itch), and liver cancer in East Asia. In this study, we investigated anticancer activities of AC grown on germinated brown rice (CBR) in HT-29 human colon cancer cells. We found that the inhibitory efficacy of CBR 80% ethanol (EtOH) extract on ...
DOI:
10.1089/jmf.2012.2605

10. Apium graveolens Extract Inhibits Cell Proliferation and Expression of Vascular Endothelial Growth Factor and Induces Apoptosis in the Human Prostatic Carcinoma Cell Line LNCaP

Author:
Köken Tülay; Koca Buğra; Özkurt Mete; Erkasap Nilüfer; Kuş Gökhan; Karalar Mustafa
Source:
Journal of medicinal food 2016 v.19 no.12 pp. 1166-1171
ISSN:
1557-7600
Subject:
Apium graveolens; NAD ADP-ribosyltransferase; angiogenesis; antineoplastic activity; apoptosis; biomarkers; cell proliferation; cell viability; dose response; gene expression; humans; neoplasm cells; neoplasms; reverse transcriptase polymerase chain reaction; tissues; vascular endothelial growth factors
Abstract:
... Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. In this study, we investigated the anticancer effect of A. graveolens on the human prostatic carcinoma cell line LNCaP. LNCaP cells were treated with increasing concentrations of an ethanolic extract of A. graveolens ranging from 1000 to 3000 μg/mL, and viability was determined after 24 and 48 h using the XTT cel ...
DOI:
10.1089/jmf.2016.0061

11. Artemisia dracunculus Extracts Obtained by Organic Solvents and Supercritical CO2 Produce Cytotoxic and Antitumor Effects in Mice with L5178Y Lymphoma

Author:
Navarro-Salcedo Martha Hilda; Delgado-Saucedo Jorge Ivan; Siordia-Sánchez Victor Hugo; González-Ortiz Luis J.; Castillo-Herrera Gustavo Adolfo; Puebla-Pérez Ana M.
Source:
Journal of medicinal food 2017 v.20 no.11 pp. 1076-1082
ISSN:
1557-7600
Subject:
Artemisia dracunculus; acetone; acetonitrile; amides; antineoplastic activity; antioxidant activity; ascites; carbon dioxide; cytotoxicity; ethanol; ethyl acetate; flavones; growth retardation; hexane; inhibitory concentration 50; leaf extracts; lymphoma; mice; neoplasm cells; polyphenols; solvents; supercritical fluid extraction; tarragon
Abstract:
... We investigated the cytotoxic and antitumor effects of nine leaf extracts from Artemisia dracunculus (Tarragon). Five extracts were obtained using different organic solvents and four by supercritical CO₂. The cytotoxic effects were expressed as IC₅₀ in 100, 80, 80, 100, and 80 μg/mL by respective solvents: hexane, ethyl acetate, acetone, ethanol, and acetonitrile in L5178Y lymphoma cells. For supe ...
DOI:
10.1089/jmf.2017.0044

12. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

13. Bamboo Salt Suppresses Colon Carcinogenesis in C57BL/6 Mice with Chemically Induced Colitis

Author:
Ju Jaehyun; Lee Ga-Young; Kim Yoon-Se; Chang Hee Kyung; Do Myoung-Sool; Park Kun-Young
Source:
Journal of medicinal food 2016 v.19 no.11 pp. 1015-1022
ISSN:
1557-7600
Subject:
antineoplastic activity; azoxymethane; baking; bamboos; blood serum; carcinogenesis; colitis; colon; colorectal neoplasms; gene expression; genes; immunohistochemistry; interleukin-1beta; interleukin-6; messenger RNA; mice; models; protective effect; sodium sulfate; staining; tumor necrosis factor-alpha
Abstract:
... The aim of our experiment was to evaluate the anticancer effect of bamboo salt (BS) on C57BL/6 mice in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer model. BS, solar salt, and purified salt were evaluated for their protective effects during AOM/DSS-induced colon carcinogenesis in C57BL/6 mice. BS, especially after baking for nine separate intervals (BS9x), suppressed colo ...
DOI:
10.1089/jmf.2016.3798

14. Beneficial Health Effects of Chios Gum Mastic and Peroxisome Proliferator-Activated Receptors: Indications of Common Mechanisms

Author:
Georgiadis Ioannis; Karatzas Theodore; Korou Laskarina-Maria; Katsilambros Nikolaos; Perrea Despina
Source:
Journal of medicinal food 2015 v.18 no.1 pp. 1-10
ISSN:
1557-7600
Subject:
agonists; antineoplastic activity; antioxidants; chemical composition; databases; diabetes mellitus; gallic acid; gene expression; glycemic effect; hyperlipidemia; inflammation; metabolic syndrome; oleanolic acid; receptors; surveys; synergism; traditional medicine; transcription factors; Mediterranean region
Abstract:
... For thousands of years, Chios Gum Mastic (CGM), the resin produced by the trunk of Pistachia lentiscus var Chia, has been used for culinary and medicinal purposes and several therapeutic properties have been attributed to it. CGM has been used in traditional medicine of various nations in the eastern Mediterranean area. This survey was carried out to identify biological mechanisms that could expla ...
DOI:
10.1089/jmf.2014.0021

15. Black Currant (Ribes nigrum L.) Extract Induces Apoptosis of MKN-45 and TE-1 Cells Through MAPK- and PI3K/Akt-Mediated Mitochondrial Pathways

Author:
Liu Bingshuo; Li Zhiwei
Source:
Journal of medicinal food 2016 v.19 no.4 pp. 365-373
ISSN:
1557-7600
Subject:
Ribes nigrum; Western blotting; antineoplastic activity; apoptosis; black currants; mitochondria; mitogen-activated protein kinase; neoplasm cells; neoplasms; polyphenols; shrinkage; signal transduction; viability
Abstract:
... Black currant extract (BCE) is rich in polyphenols and can induce apoptosis in various cancer cells, but the molecular mechanism by which BCE induces cancer cell apoptosis has not been reported. The aim of this work was to elucidate the antitumor effect of BCE and the signal transduction pathways involved. MTT test results revealed that the viability of MKN-45 and TE-1 cells treated with BCE gradu ...
DOI:
10.1089/jmf.2015.3521

16. Centella asiatica Fraction-3 Suppresses the Nuclear Factor Erythroid 2-Related Factor 2 Anti-Oxidant Pathway and Enhances Reactive Oxygen Species-Mediated Cell Death in Cancerous Lung A549 Cells

Author:
Naidoo Dhaneshree Bestinee; Phulukdaree Alisa; Anand Krishnan; Sewram Vikash; Chuturgoon Anil Amichund
Source:
Journal of medicinal food 2017 v.20 no.10 pp. 959-968
ISSN:
1557-7600
Subject:
Centella asiatica; DNA damage; Western blotting; adenosine triphosphate; antineoplastic activity; antioxidant genes; caspases; catalase; cell death; cell viability; comet assay; cytotoxicity; enzyme activity; flow cytometry; fractionation; gas chromatography-mass spectrometry; gene expression; glutathione; inhibitory concentration 50; lactate dehydrogenase; leaf extracts; malondialdehyde; medicinal plants; membrane potential; mitochondria; mitochondrial membrane; oxygen; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; silica; superoxide dismutase; thin layer chromatography; traditional medicine
Abstract:
... Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica c ...
DOI:
10.1089/jmf.2017.0005

17. Centella asiatica Modulates Nrf-2 Antioxidant Mechanisms and Enhances Reactive Oxygen Species-Mediated Apoptotic Cell Death in Leukemic (THP-1) Cells

Author:
Dhaneshree Bestinee Naidoo; Alisa Phulukdaree; Anand Krishnan; Anil Amichund Chuturgoon; Vikash Sewram
Source:
Journal of medicinal food 2022 v.25 no.7 pp. 760-769
ISSN:
1557-7600
Subject:
Centella asiatica; DNA damage; DNA fragmentation; adenosine triphosphate; antineoplastic activity; antioxidant genes; apoptosis; caspases; cell viability; comet assay; cytotoxicity; flow cytometry; functional foods; gene expression; glutathione; glutathione peroxidase; leaves; malondialdehyde; mitochondria; oxygen; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; spectroscopy; therapeutics; traditional medicine; viability assays
Abstract:
... Centella asiatica is commonly used in traditional medicine owing to its many therapeutic properties including but not limited to antioxidant and antitumor potential. This study examined the antioxidant and antiproliferative effects of its crude (C) and fractionated (C3) ethanolic leaf extracts in THP-1 cells. In THP-1 cells, C and C3 cytotoxicity was evaluated (WST-1 viability assay; 24 h; [0.2–3  ...
DOI:
10.1089/jmf.2021.0173

18. Chlorogenic Acid-Enriched Extract of Ilex kudingcha C.J. Tseng Inhibits Angiogenesis in Zebrafish

Author:
Zhong Tao; Piao Linghua; Kim Hyun Jung; Liu Xiande; Jiang Shengnan; Liu Guomin
Source:
Journal of medicinal food 2017 v.20 no.12 pp. 1160-1167
ISSN:
1557-7600
Subject:
Danio rerio; Ilex kaushue; angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; blood; chlorogenic acid; dose response; endothelial cells; eyes; fever; high performance liquid chromatography; ingredients; magnetism; nuclear magnetic resonance spectroscopy; pruritus; tea; toxins; China
Abstract:
... Kudingcha is a particularly bitter tasting tea that has been widely used in China to eliminate fever and itching eyes, and to clear blood toxins. Kudingcha is considered of value for its potential anticancer effects that are attributed to the presence of characteristic bioactive ingredients. The chlorogenic acid (CGA) derivatives 3-0-caffeoylquinic acid, 5-0-caffeoylquinic acid, 3,5-0-dicaffeoylqu ...
DOI:
10.1089/jmf.2017.3987

19. Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells

Author:
Ferguson Jeannette E.; Orlando Robert A.
Source:
Journal of medicinal food 2015 v.18 no.4 pp. 497-502
ISSN:
1557-7600
Subject:
DNA; adjuvants; adverse effects; antineoplastic activity; breast neoplasms; cell proliferation; cell viability; curcumin; cytotoxicity; drug therapy; fluorouracil; humans; lethal dose 50; neoplasm cells
Abstract:
... Antimetabolites have proven successful as therapeutics for advanced-stage breast cancers, but are often accompanied by severe side effects that can limit treatment regimens. 5-Fluorouracil (5-FU), an antimetabolite that inhibits cell proliferation, has served an important role in standard chemotherapy protocols for a variety of solid tumors. Although reasonable response rates have been reported fo ...
DOI:
10.1089/jmf.2013.0086

20. Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from Murraya koenigii Leaves in Breast Cancer Cells—Molecular Docking Studies

Author:
Ismail Ayesha; Noolu Bindu; Gogulothu Ramesh; Perugu Shyam; Rajanna Ajumeera; Babu Suresh K.
Source:
Journal of medicinal food 2016 v.19 no.12 pp. 1155-1165
ISSN:
1557-7600
Subject:
Bergera koenigii; alkaloids; antineoplastic activity; apoptosis; bioactive compounds; breast neoplasms; cell cycle; cell proliferation; cell viability; coumarins; cytotoxicity; flavonoids; growth models; inhibitory concentration 50; leaves; neoplasm cells; proteasome endopeptidase complex; protein subunits; proteinases; proteolysis
Abstract:
... Murraya koenigii (curry tree) leaves are rich in bioactive compounds such as flavonoids, alkaloids, and coumarins. Alkaloids from M. koenigii leaves have antianalgesic, antiulcerogenic, antiobesity, and antitumor activities. In this study, we tested the cytotoxic and proteasome-inhibitory potential of a total alkaloid extract (TAE) from M. koenigii leaves in the breast cancer cell line MDA-MB-231. ...
DOI:
10.1089/jmf.2016.3767