U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Journal Journal of proteomics Remove constraint Journal: Journal of proteomics Journal name Journal of proteomics Remove constraint Journal name: Journal of proteomics Subject term blood platelets Remove constraint Subject term: blood platelets
Start Over

Search

7  Search Results

1 - 7 of 7
Number of results to display per page

Search Results

1. Defining the TLT-1 interactome from resting and activated human platelets

Author:
Anna M. Schmoker; Leishla M. Perez Pearson; Claudia Cruz; Luis G. Colon Flores; Siobhan Branfeild; Fabiola D. Pagán Torres; Karmen Fonseca; Yadira M. Cantres; Carla A. Salgado Ramirez; Loyda M. Melendez; Bryan A. Ballif; A. Valance Washington
Source:
Journal of proteomics 2020 v.215 pp. 103638
ISSN:
1874-3919
Subject:
adaptive immunity; blood platelets; cell adhesion; cell movement; coagulation; defense mechanisms; fibrinogen; granules; hemorrhage; humans; immunoblotting; megakaryocytes; pathogens; phosphorylation; plasma membrane; platelet aggregation; precipitin tests; proteomics; secretion; transmembrane proteins
Abstract:
... The triggering receptor expressed on myeloid cells (TREM) protein family forms a class of type I transmembrane proteins expressed in immune cells that play important roles in innate and adaptive immune responses. The TREM family member TREM-like transcript 1 (TLT-1, also TREML1) is expressed in megakaryocytes and packaged into platelet granules. TLT-1 binds fibrinogen and plays a role in bleeding ...
DOI:
10.1016/j.jprot.2020.103638
PubMed:
31923473
PubMed Central:
PMC7044047

2. Differential protein expression of blood platelet components associated with adverse transfusion reactions

Author:
Chaker Aloui; Céline Barlier; Stéphane Claverol; Jocelyne Fagan; Danielle Awounou; Emmanuelle Tavernier; Denis Guyotat; Hind Hamzeh-Cognasse; Fabrice Cognasse; Olivier Garraud; Sandrine Laradi
Source:
Journal of proteomics 2019 v.194 pp. 25-36
ISSN:
1874-3919
Subject:
adherens junctions; bags; bioinformatics; blood platelets; cytoskeleton; gene expression regulation; inflammation; integrins; liquid chromatography; patients; pellets; platelet activation; protein synthesis; proteome; proteomics; signal transduction; tandem mass spectrometry
Abstract:
... Platelets found within platelet components (PCs) intended for transfusion release inflammatory molecules. Despite the implementation of leukoreduction, some of these PCs are occasionally associated with adverse transfusion reactions (ATRs). The aim of this study was to decipher the platelet proteome in two types of PCs, buffy-coat-derived pooled PCs (PPCs) and single-donor apheresis PCs (SDA-PCs), ...
DOI:
10.1016/j.jprot.2018.12.019

3. Exploration of the platelet proteome in patients with early-stage cancer

Author:
Siamack Sabrkhany; Marijke J.E. Kuijpers; Jaco C. Knol; Steven W.M. Olde Damink; Anne-Marie C. Dingemans; Henk M. Verheul; Sander R. Piersma; Thang V. Pham; Arjan W. Griffioen; Mirjam G.A. oude Egbrink; Connie R. Jimenez
Source:
Journal of proteomics 2018 v.177 pp. 65-74
ISSN:
1874-3919
Subject:
biomarkers; blood platelets; blood sampling; blood serum; chemokines; data collection; diagnostic techniques; growth factors; head; lungs; neoplasms; patients; protein synthesis; proteins; proteome; proteomics; resection
Abstract:
... Platelets play an important role in tumor growth and, at the same time, platelet characteristics are affected by cancer presence. Therefore, we investigated whether the platelet proteome harbors differentially expressed proteins associated with early-stage cancer. For this proof-of-concept study, patients with early-stage lung (n = 8) or head of pancreas cancer (n = 4) were included, as were healt ...
DOI:
10.1016/j.jprot.2018.02.011

4. Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation

Author:
Irene Izquierdo; María N. Barrachina; Lidia Hermida-Nogueira; Vanessa Casas; Johannes A. Eble; Montserrat Carrascal; Joaquín Abián; Ángel García
Source:
Journal of proteomics 2019 v.195 pp. 88-97
ISSN:
1874-3919
Subject:
G-proteins; blood platelets; cyclic AMP; cytoskeletal proteins; glycoproteins; lectins; lipids; liquid chromatography; platelet activation; protein composition; protein kinases; protein transport; proteomics; receptors; tandem mass spectrometry; thrombosis
Abstract:
... Lipid rafts are membrane microdomains that have been proposed to play an important role in several platelet-signalling cascades, including those mediated by the receptors Glycoprotein VI (GPVI), and C-type lectin domain family 1 member B (CLEC-2), both involved in thrombus formation. We have performed a LC-MS/MS proteomic analysis of lipid rafts isolated from platelets activated through GPVI and C ...
DOI:
10.1016/j.jprot.2019.01.014

5. Proteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion

Author:
Lidia Hermida-Nogueira; María N. Barrachina; Irene Izquierdo; María García-Vence; Serena Lacerenza; Susana Bravo; Azucena Castrillo; Ángel García
Source:
Journal of proteomics 2019 pp. -
ISSN:
1874-3919
Subject:
adverse effects; biomarkers; blood banks; blood platelets; chemokine CCL5; chemokine CXCL4; glycolysis; glycoproteins; lactic acid; monocytes; neutrophils; pathogens; patients; platelet activation; proteome; proteomics; storage time; ultraviolet radiation; vitamin B12
Abstract:
... In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may have an impact on platelets and their releasate leading to potential adverse reactions following transfusion to patients. The aim of this study was to analyze the proteome of extracellular vesi ...
DOI:
10.1016/j.jprot.2019.103529

6. Secretome profiling of apheresis platelet supernatants during routine storage via antibody-based microarray

Author:
Julian Kamhieh-Milz; Shakhawan A. Mustafa; Viktor Sterzer; Hatice Celik; Sahime Keski; Omid Khorramshahi; Kamran Movassaghi; Jörg D. Hoheisel; Mohamed S.S. Alhamdani; Abdulgabar Salama
Source:
Journal of proteomics 2017 v.150 pp. 74-85
ISSN:
1874-3919
Subject:
proteins; antibody microarrays; hemostasis; blood platelets; exosomes; genes; proteomics; RNA
Abstract:
... Platelet storage lesions (PSLs) occur during platelet concentrate (PC) storage. Adverse transfusion reactions (ATRs) have been demonstrated to be more frequent in older PCs and removal of the supernatant prior to transfusion reduces their occurrence. Proteomic profiling of PC supernatants was thus performed to identify proteins associated with PSLs and ATRs. Twenty-four PCs were investigated daily ...
DOI:
10.1016/j.jprot.2016.07.028

7. A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

Author:
Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
Source:
Journal of proteomics 2019 v.192 pp. 258-266
ISSN:
1874-3919
Subject:
acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
Abstract:
... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
DOI:
10.1016/j.jprot.2018.09.007