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You searched for: Journal Veterinary immunology and immunopathology Remove constraint Journal: Veterinary immunology and immunopathology
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1. Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells

Author:
Yuri Onizawa; Taiga Katoh; Ryotaro Miura; Kunitoshi Konda; Tatsuo Noguchi; Hisataka Iwata; Takehito Kuwayama; Seizo Hamano; Koumei Shirasuna
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110370
ISSN:
0165-2427
Subject:
acetoacetic acid; blood plasma; caspase-1; estrous cycle; gene expression; immunopathology; inflammasomes; inflammation; ketone bodies; metabolomics; repeat breeder; reproductive disorders; secretion
Abstract:
... Repeat breeding, which is non-pregnancy following three or more breeding attempts, is a serious reproductive disorder in cattle. In the present study, metabolomic profiling was used to identify metabolites in the blood plasma of repeat breeder cows (RBCs) and non-RBCs. Metabolomic analysis showed that acetoacetate (AcAc), a ketone body, was detected in RBCs, but not in non-RBCs. In contrast, β-hyd ...
DOI:
10.1016/j.vetimm.2021.110370

2. Antibodies from healthy or paratuberculosis infected cows have different effects on Mycobacterium avium subspecies paratuberculosis invasion in a calf ileal loop model

Author:
Ana Jolly; Bárbara Fernández; Ana Stempler; Giselle Ingratta; Gabriela Postma; Juan Boviez; Daniel Lombardo; Silvia Hajos; Silvia L. Mundo
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110381
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; calves; histology; histopathology; ileum; immunopathology; microbial load; models; paratuberculosis; protective effect; viability
Abstract:
... In this work, we used a calf ileal loop model to evaluate whether the preincubation of Mycobacterium avium subspecies paratuberculosis (MAP) with antibodies from healthy, MAP-positive or Lipoarabinomannan (LAM) immunized cows could affect the results of infection after 3.5 h. Bacterial load in tissue was assessed by Ziehl-Neelsen and by culture for each loop. MAP was detectable in all infected loo ...
DOI:
10.1016/j.vetimm.2022.110381

3. Antibodies that react with bovine T lymphocytes expressing the T cell receptor β chain subgroup BV20 inhibit antigen recognition

Author:
W. Ivan Morrison; Tara Sheldrake; Timothy Connelley
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110392
ISSN:
0165-2427
Subject:
antigens; cattle; cytotoxicity; gene duplication; genes; immunopathology
Abstract:
... In recent years, molecular studies have provided detailed information on the bovine T cell receptor (TCR) variable gene repertoire, both in resting T cells and during T cell responses. However, studies of the biological function of the receptor have been hampered by a lack of reagents that recognise the protein. Herein, we describe the characterisation of two antibodies (IL-A47 and IL-A98) that re ...
DOI:
10.1016/j.vetimm.2022.110392

4. Assessment of heterologous lumpy skin disease vaccine-induced immunity in pregnant cattle vaccinated at different times of gestation period and their influence on maternally derived antibodies

Author:
Ahmed Gaber; Sherin Rouby; Amera Elsaied; Ahmed El-Sherif
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110380
ISSN:
0165-2427
Subject:
cell-mediated immunity; gestation period; humoral immunity; immunopathology; longevity; lumpy skin disease; maternal immunity; parturition; pregnancy; sheep pox; vaccination; vaccines
Abstract:
... The present study aimed to evaluate the cell-mediated and the humoral immune response to Romanian sheep pox vaccine in pregnant cows (n = 12) vaccinated at different times of gestation period and the duration of maternal immunity in calves born to these cows. Evaluation of cellular immunity revealed an increase in lymphocytic proliferation that peaked at 10th day post vaccination (dpv) then gradua ...
DOI:
10.1016/j.vetimm.2021.110380

5. B cell memory responses induced by foot-and-mouth disease virus-like particles in BALB/c mice

Author:
Jia-huan Liu; Jun-juan Zhang; Wei-jian Han; Chuan Cui; Ming-zhu Li; Zhan-yun Tian; Ruo-man Bai; Li-min Li
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110458
ISSN:
0165-2427
Subject:
antibodies; blood serum; bone marrow; foot-and-mouth disease; immunization; immunoglobulin G; immunopathology; interleukin-6; memory; spleen; vaccine development
Abstract:
... A challenging but critical question is that new foot-and-mouth disease (FMD) vaccines should be to induce B cell memory to provide antibodies for long-term protection. The maintenance of B cell memory is dependent on long-lived plasma cells (LLPCs) and memory B cells. We developed a chimeric FMDV virus-like particles (FMDV-VLPs), fusing VP1-VP4 into HBcAg. In our study, we investigated if or how l ...
DOI:
10.1016/j.vetimm.2022.110458

6. CD4 bovine gene: Differential polymorphisms among cattle breeds and a new tool for rapid identification

Author:
Cintia Hiromi Okino; Wilson Malagó Junior; Cintia Righetti Marcondes; Rodrigo Giglioti; Hélio José Montassier; Henrique Nunes de Oliveira; Márcia Cristina de Sena Oliveira
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110462
ISSN:
0165-2427
Subject:
genes; genotyping; heterozygosity; homozygosity; hybrids; immunopathology; immunophenotyping; taurine; zebu
Abstract:
... Two mutations in the CD4 bovine gene (G>T/Q306H; A>C/K310N) were identified as causative for altered staining with anti-CD4 mAb #CC8. We developed a HRM qPCR for genotyping these mutations and compare with immunophenotyping in different cattle breeds. The assay distinguished five genotypes, B (homozygous, G/A) and C (heterozygous, G/A and T/C), found in taurine, A (homozygous, G/C) and D (heterozy ...
DOI:
10.1016/j.vetimm.2022.110462

7. Canine memory T-cell subsets in health and disease

Author:
Annie B. Bauman; Cambri E. Moeller; Aimee M. Soileau; Christine E. Goodermuth; Victoria R. Costa; Jessica C. Schaumburg; Cherie M. Pucheu-Haston; Nancy D. Welborn; Shannon D. Dehghanpir; Mark A. Mitchell; Sita S. Withers
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110401
ISSN:
0165-2427
Subject:
T-lymphocytes; antigens; atopic dermatitis; dogs; drug therapy; flow cytometry; immunopathology; immunotherapy; inflammation; lymph nodes; lymphoma; memory; prednisone
Abstract:
... A more complete understanding of canine T-lymphocyte immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. The aim of this study was to utilize CD45RA (indicating antigen inexperience) and CD62L (indicating lymph node homing capabi ...
DOI:
10.1016/j.vetimm.2022.110401

8. Changes in rabbit lymphocyte subpopulations and activation following long-term administration of meloxicam

Author:
Pavla Hamouzová; Šárka Stehlíková; Kristína Řeháková; Vladimír Jekl; Jan Chloupek; Jaroslav Doubek
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110496
ISSN:
0165-2427
Subject:
B-lymphocytes; analgesics; flow cytometry; hematology; immunology; immunopathology; meloxicam; rabbits
Abstract:
... Meloxicam is a commonly used analgesic in rabbits. However, its possible impact on lymphocyte subpopulations remained unknown. The aim of the study was to investigate a possible effect of long-term administration of meloxicam on rabbit lymphocyte subpopulations. The study included 8 rabbits given meloxicam orally once daily (1 mg/kg BW) for 14 days and 8 rabbits as a control group. Peripheral bloo ...
DOI:
10.1016/j.vetimm.2022.110496

9. Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression

Author:
Sara Marzo; Mark Gray; Waywen Loh; Lindsey A. Waddell; C. Irene McGuinnes; Jayne C. Hope; Heather A. Mathie
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110363
ISSN:
0165-2427
Subject:
T-lymphocytes; adaptive immunity; cattle; dendritic cells; flow cytometry; immunopathology; lymph; models; phenotype
Abstract:
... The bovine afferent lymphatic cannulation model allows collection of large volumes of afferent lymph and provides an opportunity to study lymphatic cells trafficking from the periphery directly ex-vivo. The technique requires surgical intervention, but influence of the procedure or time post-surgery on cells trafficking in the lymph has not been well documented. Here, we measured the volume of lym ...
DOI:
10.1016/j.vetimm.2021.110363

10. Chitosan-based formulation of hemagglutinin antigens for oculo-nasal booster vaccination of chickens against influenza viruses

Author:
Violetta Sączyńska; Agnieszka Romanik-Chruścielewska; Katarzyna Florys-Jankowska; Violetta Cecuda-Adamczewska; Małgorzata Kęsik-Brodacka
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110406
ISSN:
0165-2427
Subject:
Escherichia coli; aluminum hydroxide; avian influenza; chitosan; glutamic acid; hemagglutination; hemagglutinins; immunopathology; pH; public health; recombinant proteins; secondary immunization; viral antigens
Abstract:
... Avian influenza viruses (AIVs) and especially highly pathogenic (HP) AIVs of the H5 and H7 subtypes are of both veterinary and public health concern worldwide. In response to the demand for effective vaccines against H5N1 HPAIVs, we produced recombinant protein based on hemagglutinin (HA), a protective viral antigen. A fragment of the HA ectodomain, with a multibasic cleavage site deletion, was ex ...
DOI:
10.1016/j.vetimm.2022.110406

11. Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-α, IL1-β, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-γ bovine IL-17A and IL-1β revealed they recognize epitopes conserved on dolphin and bovine orthologues

Author:
Mahmoud M. Elnaggar; Gaber S. Abdellrazeq; Randy E. Sacco; Trevor R. Harsla; Mallory L. Mucci; Lindsay M. Fry; Victoria Hulubei; William C. Davis
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110456
ISSN:
0165-2427
Subject:
Tursiops truncatus; cattle; dolphins; epitopes; evolution; immunization; immunopathology; indicator species; interleukin-10; interleukin-17; interleukin-6; interleukin-8; leukocytes; sheep
Abstract:
... Opportunities to include Cetancodontamorpha in the study of the evolution of the immune system in the clades of Artiodactylamorpha, Ruminantiamorpha, Suinamorpha, and Camelidamorpha have increased with the use of the bottlenose dolphin, Tursiops truncatus, as a sentinel species to study the effects of environmental pollutants on the health of marine mammals. Efforts are currently underway to incre ...
Handle:
10113/7803613
DOI:
10.1016/j.vetimm.2022.110456

12. Controlled release vaccine implants for delivery of booster immunisations

Author:
Freya A. Russell; Logan K. Trim; Flavia Medeiros Savi; Craig Simon; Tim R. Dargaville; Dietmar W. Hutmacher; Kenneth W. Beagley
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110484
ISSN:
0165-2427
Subject:
T-lymphocytes; antibodies; antigens; blood serum; cell proliferation; immune response; immunopathology; livestock; polymers; secondary immunization; subcutaneous injection; tetanus; vaccination; vaccines; weight gain
Abstract:
... Most current animal vaccine regimes involve a primary vaccination followed sometime later by a booster vaccination. This presents challenges when vaccinating difficult to access animals such as livestock. Mustering livestock to deliver a vaccine boost is costly and stressful for animals. Thus, we have produced a platform system that can be administered at the same time as the priming immunisation ...
DOI:
10.1016/j.vetimm.2022.110484

13. Detection of PRRSV-2 alone and co-localized with CD163 positive macrophages in porcine placental areolae

Author:
Javier Barrera-Zarate; Susan E. Detmer; J. Alex Pasternak; Glenn Hamonic; Daniel J. MacPhee; John C.S. Harding
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110457
ISSN:
0165-2427
Subject:
Betaarterivirus suid 2; embryogenesis; endometrium; fetus; fluorescent antibody technique; immunopathology; inflammation; macrophages; phenotype; placenta; pregnancy; transplacental transmission; viral load; viruses
Abstract:
... The porcine epitheliochorial placenta creates a barrier for the transplacental transfer of some nutrients from the dam to the fetus, as well as feto-lethal viruses such as porcine reproductive and respiratory syndrome virus 2 (PRRSV-2). Areolae are specialized structures within the porcine placenta with a high absorptive and substance transport capacity that facilitate embryonic development. The o ...
DOI:
10.1016/j.vetimm.2022.110457

14. Development of low-cost cage-like particles to formulate veterinary vaccines

Author:
Giuliana A. Lupi; Florencia X. Santiago Valtierra; Gabriel Cabrera; Roque Spinelli; Álvaro S. Siano; Verónica González; Antonio Osuna; Gerardo M. Oresti; Iván Marcipar
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110460
ISSN:
0165-2427
Subject:
adjuvants; alum; cholesterol; delayed hypersensitivity; egg yolk; gas chromatography; immunoglobulin G; immunopathology; lysophospholipids; ovalbumin; saponins; thin layer chromatography
Abstract:
... Low-cost adjuvants are urgently needed for the development of veterinary vaccines able to trigger strong immune responses. In this work, we describe a method to obtain a low-cost cage-like particles (ISCOMATRIX-like) adjuvant useful to formulate veterinary vaccines candidates. The main components to form the particles are lipids and saponins, which were obtained from egg yolk by ethanolic extracti ...
DOI:
10.1016/j.vetimm.2022.110460

15. Diagnostic accuracy of digital Brix and serum total protein refractometers in estimating different passive immunity levels in dairy calves

Author:
Mehmet Akköse; Hüseyin Gökhan Kutsal; Mert Kurban; Elif Merve Çinar; Yadigar Polat; Murat Cengiz
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110442
ISSN:
0165-2427
Subject:
Holstein; blood serum; brix; immunopathology; passive immunity; refractive index
Abstract:
... The aim of this study was to determine the diagnostic accuracy of digital serum total protein (TP) and digital Brix refractometers in estimating different passive immunity levels (<10, <18, <25 mg/mL) in dairy calves. Blood samples were collected from 260 apparently healthy Holstein calves, aged 2–7 days. Serum IgG concentrations were measured using digital Brix and TP refractometers and the radia ...
DOI:
10.1016/j.vetimm.2022.110442

16. Differential detection of IgM and IgG antibodies to chimeric antigens in bovine tuberculosis

Author:
Archana A. Sridhara; Ashley Johnathan-Lee; Rubyat Elahi; Paul Lambotte; Javan Esfandiari; Maria Laura Boschiroli; Tanya J. Kerr; Michele A. Miller; Thomas Holder; Gareth Jones; H. Martin Vordermeier; Breanne N. Marpe; Tyler C. Thacker; Mitchell V. Palmer; W. Ray Waters; Konstantin P. Lyashchenko
Source:
Veterinary immunology and immunopathology 2022 pp. 110499
ISSN:
0165-2427
Subject:
Mycobacterium bovis; antibodies; blood serum; bovine tuberculosis; cattle; cross reaction; hosts; immunopathology; monitoring; rapid methods; risk; wildlife; France; Great Britain; South Africa
Abstract:
... Recent studies have suggested the potential of innovative serologic tests for accurate and rapid detection of bovine tuberculosis (bTB). Dual Path Platform (DPP) technology has been used to develop rapid animal-side antibody tests for Mycobacterium bovis infection in a range of livestock and wildlife host species. The present study evaluated diagnostic performance of DPP BovidTB IgM/IgG assay desi ...
DOI:
10.1016/j.vetimm.2022.110499

17. Distribution of M1 and M2 macrophages in cerebral granulomas caused by Encephalitozoon cuniculi

Author:
Adolfo Soto-Domínguez; Jennifer A. González-Castillo; Uziel Castillo-Velázquez; Luis E. Rodriguez-Tovar; Gerardo Méndez-Zamora; Diana E. Zamora-Avila; Alicia M. Nevárez-Garza
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110481
ISSN:
0165-2427
Subject:
Encephalitozoon cuniculi; brain; granuloma; immunology; immunopathology; inflammation; macrophages; phenotype
Abstract:
... Encephalitozoon cuniculi spores cause severe granulomatous inflammation in the brain where mononuclear cells and macrophages infiltrate. Here, we orally infected New Zealand white rabbits with 1 × 10⁶E. cuniculi viable spores to study the recruitment and localization of macrophages in brain granulomas. At day 30 post-infection, the positive phenotype markers iNOS (M1) and Arg-1 (M2) were located i ...
DOI:
10.1016/j.vetimm.2022.110481

18. Dynamic changes in Holstein heifer circulatory stress biomarkers in response to lipopolysaccharide immune challenge

Author:
T. Sullivan; A. Sharma; K. Lamers; C. White; B.A. Mallard; A. Cánovas; N.A. Karrow
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110426
ISSN:
0165-2427
Subject:
Holstein; acidosis; biomarkers; blood flow; blood serum; body temperature; climate change; cortisol; heat stress; immunopathology; inflammation; interleukin-10; intestinal mucosa; leukopenia; lipopolysaccharides; microRNA; septicemia; stress response; thrombocytopenia
Abstract:
... Dairy cattle routinely face a variety of stressors. For example, climate change has resulted in more frequent heat stress events that increase the incidence of bacterial infections by inducing conditions like leaky gut syndrome, whereby the integrity of the intestinal epithelium is compromised allowing for luminal bacteria and their membrane components to infiltrate the host’s bloodstream resultin ...
DOI:
10.1016/j.vetimm.2022.110426

19. Effect of Holstein genotype on ex-vivo cytokine response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) during the periparturient period

Author:
Amber A. Brink; Wanda J. Weber; John D. Lippolis; John B. Cole; Sandra M. Godden; Anthony Seykora; Brian A. Crooker
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110463
ISSN:
0165-2427
Subject:
Holstein; energy balance; genotype; immunopathology; innate immunity; interleukin-6; lactation; lipopolysaccharides; lipoteichoic acids; milk; pathogen-associated molecular patterns
Abstract:
... Effects of Holstein genotype on innate immune response were assessed with ex-vivo lipopolysaccharide (LPS) and lipoteichoic acid (LTA) stimulation of whole blood from unselected (UH, n = 10) and contemporary (CH, n = 11) Holsteins that differ in production by more than 4,500 kg/lactation. Blood was collected at −14, 7, 28, and 49 days in milk (DIM), mixed with a pathogen-associated molecular patte ...
Handle:
10113/7837475
DOI:
10.1016/j.vetimm.2022.110463

20. Effect of In-vivo heat challenge on physiological parameters and function of peripheral blood mononuclear cells in immune phenotyped dairy cattle

Author:
S.L. Cartwright; J. Schmied; A. Livernois; B.A. Mallard
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110405
ISSN:
0165-2427
Subject:
barns; body temperature; cell proliferation; cell respiration; climate change; dairy cattle; disease incidence; heat; heat stress; heat tolerance; heat-shock protein 70; humidity; immunology; immunopathology; vaccines
Abstract:
... The frequency of heat waves and hot days are increasing due to climate change, which leads to an increase in the occurrence of heat stress in dairy cattle. Previous studies have shown that dairy cattle identified as high immune responders have a reduced incidence of disease and improved vaccine response compared to average and low responders. Additionally, it has been observed that when cells from ...
DOI:
10.1016/j.vetimm.2022.110405

21. Effect of aging on monocyte phagocytic and inflammatory functions, and on the ex vivo inflammatory responses to lipopolysaccharide, in horses

Author:
A.C. Herbst; S.E. Reedy; A.E. Page; D.W. Horohov; A.A. Adams
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110459
ISSN:
0165-2427
Subject:
Escherichia coli; adiposity; body condition; ex vivo studies; flow cytometry; gene expression; genes; immunopathology; interleukin-18; interleukin-6; interleukin-8; lipopolysaccharides; monocytes; phagocytosis; young adults
Abstract:
... Studies investigating age-related changes in the function of monocytes are currently limited for horses. Thus, the main goal of this study was to determine the effect of aging on monocyte phagocytic capacity and pro-inflammatory cytokine responses to bacterial lipopolysaccharide (LPS). A second goal of this work was to examine the effect of aging on the inflammatory cytokine responses to LPS in a ...
DOI:
10.1016/j.vetimm.2022.110459

22. Effect of major versus minor mastectomy on host immunity in canine mammary cancer

Author:
Maria Karayannopoulou; Tilemachos Anagnostou; Apostolia Margariti; Maria Kritsepi-Konstantinou; Dimitra Psalla; Angelos-Lauris Thomas; Ioannis Savvas
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110403
ISSN:
0165-2427
Subject:
T-lymphocytes; anesthesia; cell-mediated immunity; immunopathology; immunosuppression; innate immunity; mammary neoplasms (animal); metastasis; neutrophils; surgery
Abstract:
... Surgical procedures can affect host immunity proportionally to the extent of surgical trauma. In cancer cases, surgery-induced immunosuppression can potentially promote tumour metastasis. The aim of this study was to investigate, in bitches with malignant mammary tumours, whether major surgery (total unilateral mastectomy or bilateral regional mastectomy) has a more negative effect than minor surg ...
DOI:
10.1016/j.vetimm.2022.110403

23. Effects of frequent teat stimulation on antimicrobial component production in mammary glands of lactating goats

Author:
Yusaku Tsugami; Rika Harada; Takahiro Nii; Naoki Suzuki; Naoki Isobe
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110431
ISSN:
0165-2427
Subject:
Japan; calcium-binding proteins; epithelium; humans; immunopathology; keratinocytes; lactoferrin; milk; milk yield
Abstract:
... Various antimicrobial components, such as lactoferrin, S100 calcium-binding protein A7 (S100A7), and IgA, produced by epithelial cells and leukocytes in lactating mammary glands are important for host defense against invading pathogens. Increase in milking frequency enhances milk yield in ruminants and implies an increase in frequency of teat stimulation. However, the influence of frequent teat st ...
DOI:
10.1016/j.vetimm.2022.110431

24. Effects of immunostimulators of microbial origin on T cells of pigs vaccinated with attenuated vaccine against Aujeszkyʼs disease

Author:
Miroslav Andrišić; Irena Žarković; Ksenija Šandor; Anja Vujnović; Eleonora Perak Junaković; Krešo Bendelja; Ana Savić Mlakar; Nada Oršolić; Lidija Šver; Miroslav Benić; Svjetlana Terzić
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110365
ISSN:
0165-2427
Subject:
Escherichia coli; Parapoxvirus; Propionibacterium granulosum; Suid alphaherpesvirus 1; T-lymphocytes; cell-mediated immunity; immunopathology; live vaccines; vaccination
Abstract:
... Aujeszky’s disease (AD) is a viral infectious disease caused by Suid herpesvirus 1 (SuHV-1). Vaccination and eradication of AD in domestic pigs is possible using marker vaccines with attenuated or inactivated SuHV-1, or subunit vaccines. However, vaccines with attenuated SuHV-1 have shown to be more potent in inducing strong cell-mediated immune response. The studies have shown that Parapoxvirus o ...
DOI:
10.1016/j.vetimm.2021.110365

25. Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints

Author:
Koji Nishi; Yuki Hirano; Ayano Sato; Ayako Eguchi; Kazuya Matsuda; Miyuki Toda; Takafumi Watanabe; Tomohito Iwasaki; Naoki Takahashi; Marina Hosotani; Reina Watanabe; Toshihide Kato; Hiromichi Ohtsuka; Satoshi Gondaira; Hidetoshi Higuchi
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110364
ISSN:
0165-2427
Subject:
Mycoplasma bovis; arthritis; calves; cartilage; fibrin; immunohistochemistry; immunopathology; inflammation; interleukin-12; interleukin-17; interleukin-6; interleukin-8; lameness; messenger RNA; monitoring; phosphates; stifle; synovial fluid; transmission electron microscopy
Abstract:
... Mycoplasma arthritis that caused by Mycoplasma bovis exhibit severe lameness. This disease is difficult to cure with antibiotics, but the detailed pathological mechanisms have not been fully clarified. In this study, we examined the effects of intra-articular inoculation with M. bovis on immunological responses in calf joints. We inoculated three calves each with M. bovis or phosphate buffer salin ...
DOI:
10.1016/j.vetimm.2021.110364

26. Evaluating the Immunogenicity of Recombinant VP1 Protein from the Foot-and-Mouth Disease Virus Encapsulated in Nanoliposome in Guinea Pig Animal Model

Author:
Marjan Kazemi; Mahmoud Reza Aghamaali; Rasool Madani; Tara Emami; Fariba Golchinfar
Source:
Veterinary immunology and immunopathology 2022 pp. 110497
ISSN:
0165-2427
Subject:
Foot-and-mouth disease virus; adjuvants; animal models; blood serum; cholesterol; foot-and-mouth disease; genes; guinea pigs; immune response; immunogenicity; immunopathology; livestock; neutralization; viruses
Abstract:
... Foot-and-mouth disease (FMD) is considered as contagious in livestock, which is caused by the Picornavridae virus family known as FMD virus (FMDV). In the present study, the VP1 gene from FMDV (O strain) was expressed and purified. In addition, nanoliposomes were utilized as an adjuvant. After formulating the nanoliposomes with DMPC, DMPG, and cholesterol, the recombinant VP1 protein was encapsula ...
DOI:
10.1016/j.vetimm.2022.110497

27. Evaluation of PD-1 and PD-L1 expression in canine urothelial carcinoma cell lines

Author:
Christopher J. Pinard; Samuel E. Hocker; Andrew C. Poon; Jordon M. Inkol; Arata Matsuyama; R. Darren Wood; Geoffrey A. Wood; J. Paul Woods; Anthony J. Mutsaers
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110367
ISSN:
0165-2427
Subject:
Western blotting; carcinoma; cell lines; dogs; flow cytometry; fluorescence microscopy; gene expression; humans; immunopathology; immunotherapy; neoplasm cells; reverse transcriptase polymerase chain reaction
Abstract:
... Urothelial carcinoma (UC) is the most common urinary tumor in dogs and despite combinational therapies, only modest improvements in survival have been achieved in recent years. Given the utility of monoclonal antibodies against PD-1 and PD-L1 in human UC, we evaluated the protein and mRNA expression in three established canine urothelial carcinoma cell lines. Flow cytometry and western blot analys ...
DOI:
10.1016/j.vetimm.2021.110367

28. Evaluation of equine xenogeneic mixed lymphocyte reactions using 5-ethynyl-2’-deoxyuridine (EdU)

Author:
Kate E. Birdwhistell; David J. Hurley; Bradley Heins; John F. Peroni
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110430
ISSN:
0165-2427
Subject:
T-lymphocytes; cell proliferation; cytokines; flow cytometry; horses; immunopathology; nucleobases; organ transplantation; swine; thymidine
Abstract:
... Allogeneic solid organ transplantation is currently the only treatment option for end stage organ disease. The shortage of available donor organs has driven efforts to utilize xenogeneic organs for transplantation. In vitro methods for evaluating immune-compatibility are a quick and low cost means of screening novel tissue products prior to more involved, expensive, and invasive live animal studie ...
DOI:
10.1016/j.vetimm.2022.110430

29. Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses

Author:
Constanza Salinas; Gabriel Espinosa; Natalia Morales; Claudio Henríquez; Gabriel Morán; Gonzalo Gajardo; Rafael A. Burgos; Benjamin Uberti
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110455
ISSN:
0165-2427
Subject:
adults; apoptosis; blood; blood glucose; body condition; glucose; hyperglycemia; immunopathology; insulin; insulin resistance; obesity; phagocytosis; reactive oxygen species; statistical models
Abstract:
... Obesity and insulin dysregulation (ID) are increasingly prevalent conditions in equid populations worldwide. Immune impairment is well described in humans with metabolic dysfunction and is reported but still incompletely understood in horses. This study evaluated the effect of acute induced transient hyperglycemia on apoptosis, phagocytosis and oxidative burst activity of peripheral blood polymorp ...
DOI:
10.1016/j.vetimm.2022.110455

30. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis

Author:
Yiğit KAÇAR; Ahmet Tarık BAYKAL; Levent AYDIN; Hasan BATMAZ
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110429
ISSN:
0165-2427
Subject:
Cryptosporidium; Holstein; amyloid; blood serum; calves; cow colostrum; cryptosporidiosis; gamma-glutamyltransferase; immunoglobulin G; immunopathology; oocysts; protein content; proteome; proteomics; sodium bicarbonate; zinc
Abstract:
... This study aimed to investigate the effect of using high-quality colostrum in addition to paromomycin on the treatment outcomes and serum proteomes of calves naturally affected by cryptosporidiosis. Thirty Holstein calves infected with only Cryptosporidium spp. were divided into three equal groups. Calves in the PC group received paromomycin orally at a dose of 100 mg/kg once daily for 5 days. Cal ...
DOI:
10.1016/j.vetimm.2022.110429

31. Evidence for transfer of maternal antigen specific cellular immunity against Mycobacterium avium ssp. paratuberculosis via colostrum in a goat twin model

Author:
L. Robbers; R. van de Mheen; L. Benedictus; R. Jorritsma; M. Nielen; H.J.C. Bijkerk; S.G. van der Grein; L. Ravesloot; A.P. Koets
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110402
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; blood serum; cell-mediated immunity; cow colostrum; epithelium; histology; immune response; immunopathology; injection site; intestines; models; tuberculin; vaccines
Abstract:
... Colostrum intake is one of the most important factors in neonatal health in ruminants, mainly because of its unique immunological properties. Both in practice as well as in research, the attention of lactogenic immunity is focused on the importance of colostral antibodies and less attention is given to the functional role of maternal cells in colostrum. Here we study the transfer of maternal leuko ...
DOI:
10.1016/j.vetimm.2022.110402

32. Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows

Author:
Jordan M. Eder; Randy E. Sacco
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110418
ISSN:
0165-2427
Subject:
acidification; adults; gene expression; glycolysis; immunopathology; interleukin-4; mitochondria; oxygen consumption; passive immunity; phenotype
Abstract:
... As maternal passive immunity wanes at 6–8 weeks, young calves must rely on their own naïve and developing immune system for protection against pathogens. Typically, an infection in the young induces a T cell-mediated response, which skews towards a Th2 phenotype and results in a reduced effector response. Our study examines the implications this transitional period of immunocompetency has on cellu ...
DOI:
10.1016/j.vetimm.2022.110418

33. Field evaluation of the tuberculin skin test for the detection of Mycobacterium tuberculosis complex infection in communal goats (Capra hircus) in KwaZulu-Natal, South Africa

Author:
Deborah M. Cooke; Wynand J. Goosen; Carmel Witte; Michele A. Miller
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110486
ISSN:
0165-2427
Subject:
Capra hircus; Mycobacterium tuberculosis complex; Saanen; Syncerus caffer; cattle; dairy herds; goats; immunopathology; land reform; pathogens; risk; rural development; tuberculin; tuberculosis; South Africa
Abstract:
... In South Africa, animal tuberculosis (TB) control programs predominantly focus on domestic cattle and African buffaloes (Syncerus caffer) despite increasing global reports of tuberculosis in goats (Capra hircus). Left undetected, Mycobacterium tuberculosis complex (MTBC) infected goats may hinder TB eradication efforts in cattle and increase zoonotic risk to humans. Since the publication of animal ...
DOI:
10.1016/j.vetimm.2022.110486

34. Flow cytometry panels for immunophenotyping dairy cattle peripheral blood leukocytes

Author:
S. Casaro; M.G. Marrero; D.M.C. Madrid; J.G. Prim; C.D. Nelson; K.N. Galvão; J. Laporta; J.P. Driver
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110417
ISSN:
0165-2427
Subject:
Holstein; calves; dairy cows; flow cytometry; immunopathology; immunophenotyping; monocytes; phenotype; pregnancy
Abstract:
... Many aspects of the bovine immune system remain poorly characterized, which poses an obstacle to improving dairy cow health. Herein, we describe two flow cytometry panels that included antibodies against CD8α, CD4, TCR-δ, CD172α, CD14, MHCII, CD21, CD62L, and CD11b. These panels were used to characterize the phenotype of leukocyte subpopulations from the peripheral blood of 30-day old Holstein cal ...
DOI:
10.1016/j.vetimm.2022.110417
CHORUS:
10.1016/j.vetimm.2022.110417

35. H3N2 canine influenza virus NS1 protein inhibits canine NLRP3 inflammasome activation

Author:
Pan Tao; Zhangyong Ning; Pei Zhou; Weiqi Xiao; Guiping Wang; Shoujun Li; Guihong Zhang
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110483
ISSN:
0165-2427
Subject:
Influenza A virus; canine influenza; caspase-1; dogs; immunopathology; inflammasomes; inflammation; innate immunity; interleukin-18; oligomerization; transcription (genetics)
Abstract:
... Inflammation is an innate immune response of the body against pathogens and other irritants. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is a major player in the inflammatory response against pathogenic microorganisms. In this study, we analyzed the relationship between the NLRP3 inflammasome and the influenza virus NS1 protein, which is involved in host immune escape. ...
DOI:
10.1016/j.vetimm.2022.110483

36. Identification of EDIL3 biomarkers as a biomarker and potential therapeutic target of canine mammary carcinomas based on integrated bioinformatics analysis

Author:
Zixiang Lin; Ce Jiang; Di Lv; Degui Lin
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110432
ISSN:
0165-2427
Subject:
bioinformatics; biomarkers; carcinogenesis; data collection; dogs; genes; immunity; immunopathology; mammary neoplasms (animal); therapeutics
Abstract:
... As the fierce battle with cancer is now expanding to companion animals, effective treatment of canine mammary carcinomas (CMT), as the most frequently diagnosed tumor in intact dogs, is becoming a crucial issue. Although many studies have been carried out concerning the clinical application of mammary tumor biomarkers, no ideal biomarker has yet been identified in CMT. Therefore, in this work, we ...
DOI:
10.1016/j.vetimm.2022.110432

37. Immunoproteomic analysis of the secretome of bovine-adapted strains of Staphylococcus aureus demonstrates a strain-specific humoral response

Author:
Shauna D. Drumm; Paul Cormican; Padraig O’Boyle; Rebecca A. Owens; Jennifer Mitchell; Orla M. Keane
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110428
ISSN:
0165-2427
Subject:
Staphylococcus aureus; antigens; blood serum; cows; genes; humoral immunity; immunopathology; mass spectrometry; molecular weight; pathogens; vaccines; virulence
Abstract:
... Staphylococcus aureus is a common pathogen associated with bovine intramammary infection. A number of distinct S. aureus lineages are associated with such infections although there is a dearth of knowledge regarding the major immunogenic antigens associated with each lineage and whether these antigens provide protection against heterologous strains. Identification of the major immunogenic antigens ...
DOI:
10.1016/j.vetimm.2022.110428

38. Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

Author:
J.J. Rosales; M.V. Nieto Farías; M. Burucúa; M.S. Marin; S.E. Pérez
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110391
ISSN:
0165-2427
Subject:
Bovine alphaherpesvirus 1; bioactive properties; brain; epithelium; ganglia; immunopathology; innate immunity; transcription (genetics); virus replication; viruses
Abstract:
... Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to ...
DOI:
10.1016/j.vetimm.2022.110391

39. Influenza A pathway analysis of highly pathogenic avian influenza virus (H5N1) infection in genetically disparate Ri chicken lines

Author:
Jiae Lee; Yeojin Hong; Thi Hao Vu; Sooyeon Lee; Jubi Heo; Anh Duc Truong; Hyun S. Lillehoj; Yeong Ho Hong
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110404
ISSN:
0165-2427
Subject:
Influenza A virus; RNA; chickens; cytokines; gene expression; gene expression regulation; immune system; immunity; immunopathology; influenza; interferons; quantitative polymerase chain reaction; reverse transcription; viruses; Vietnam
Abstract:
... Influenza A/H5N1 virus is a highly pathogenic (HPAIV) and contagious zoonotic virus that can be transmitted to humans. In the present study, infection with this virus and differential gene expression analyses were carried out with genetically resistant and susceptible Ri chicken lines that are native to Vietnam. A total of 20 four-week-old Ri chickens from each line were inoculated with the highly ...
DOI:
10.1016/j.vetimm.2022.110404

40. Insufficiency of CD205-positive cortical thymic epithelial cells in immature Japanese Black cattle with severe thymic abnormalities and poor prognosis

Author:
Shoichi Wakitani; Risako Kawabata; Masahiro Yasuda
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110379
ISSN:
0165-2427
Subject:
Wagyu; cortex; epithelium; histopathology; immunohistochemistry; immunopathology; interleukin-7; prognosis; surveys
Abstract:
... To investigate the involvement of thymic function in the development of diseases with poor prognosis in calves, this study conducted a survey for the assessment of thymus cell composition in immature Japanese Black cattle with poor prognosis. Histopathological evaluation of 47 cattle showed signs of acute thymic involution in most cases. Less than half of the cases had a cortex predominant over th ...
DOI:
10.1016/j.vetimm.2021.110379

41. Interferon gamma, lipopolysaccharide, and modified-live viral vaccines stimulation alter the mRNA expression of tumor necrosis factor α, inducible nitric oxide synthase, and interferon β in bovine alveolar macrophages

Author:
Shingo Ishikawa; Masataka Miyazawa; Chiho Tanaka; Ryoma Uesawa; Juri Nishizawa; Ryoko Uemura; Ikuo Kobayashi; Seiji Hobo
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110378
ISSN:
0165-2427
Subject:
bovine respiratory disease; cattle; gene expression; immunopathology; inducible nitric oxide synthase; interferon-gamma; lipopolysaccharides; macrophages; pathogenesis; polyinosinic-polycytidylic acid; sodium; therapeutics; tumor necrosis factor-alpha
Abstract:
... To understand the pathogenesis of bovine respiratory disease (BRD), it is necessary to elucidate the mechanisms of alveolar macrophage regulation by cytokines and pathogen-associated molecular patterns (PAMPs). Moreover, "non-specific effects (NSEs)” an innate immune regulatory mechanism in response to vaccines containing PAMPs, has recently attracted attention. It may be applied to BRD control, b ...
DOI:
10.1016/j.vetimm.2021.110378

42. Interleukin-1Ra (Il-1Ra) and serum cortisol level relationship in horse as dynamic adaptive response during physical exercise

Author:
Francesca Arfuso; Elisabetta Giudice; Michele Panzera; Maria Rizzo; Francesco Fazio; Giuseppe Piccione; Claudia Giannetto
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110368
ISSN:
0165-2427
Subject:
Thoroughbred; antagonists; athletic performance; blood serum; cortisol; erythrocytes; exercise; hematocrit; hemoglobin; horses; immunopathology; interleukin-1; physical health; stress response
Abstract:
... The monitoring of endocrine and immunologic markers during exercise is of paramount importance to assess and/or maintain the physical well-being of athletes as well as to optimize the athletic performance. This study aimed to investigate the linkage between acute stress response and immune status in Thoroughbred horses competing in an official 1300-m race. From 10 horses blood was collected 1 week ...
DOI:
10.1016/j.vetimm.2021.110368

43. Low molecular weight heparin reduces acute phase response and multiple organ dysfunction following Ovine experimental endotoxemia model

Author:
Rouhollah Esmaeili Seraji; Aliasghar Chalmeh; Mehrdad Pourjafar
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110361
ISSN:
0165-2427
Subject:
Escherichia coli; amyloid; anti-inflammatory agents; aspartate transaminase; bilirubin; biomarkers; blood serum; creatine kinase; creatinine; death; dose response; endotoxemia; glutathione peroxidase; heparin; homocysteine; immunopathology; intravenous injection; lipopolysaccharides; models; oxidative stress; serotypes; superoxide dismutase; tumor necrosis factor-alpha
Abstract:
... Endotoxemia is one of the most common inflammatory situations leading to death of ruminants. Owing to the importance of this condition, several therapeutic regimens have been proposed, evaluated and implemented to treat endotoxemia. It has recently been suggested that low molecular weight heparin may be effective in treating endotoxemia. Thus, the present experimental study was conducted to evalua ...
DOI:
10.1016/j.vetimm.2021.110361

44. Measurement of canine Th17 cells by flow cytometry

Author:
A. Knebel; A. Kämpe; R. Carlson; K. Rohn; A. Tipold
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110366
ISSN:
0165-2427
Subject:
CD4-positive T-lymphocytes; autoimmune diseases; dogs; flow cytometry; immunology; immunopathology; inflammation
Abstract:
... Th17 cells are T helper cells which play an important role during inflammation and autoimmune disease. To investigate the role of these cells in diseases in dogs in a clinical setting, methods for fast identification had to be established. Th17 cells are a rare cell population, for their measurement stimulation is recommended. To examine more samples simultaneously and to receive a relatively high ...
DOI:
10.1016/j.vetimm.2021.110366

45. Oxidative stress in neonatal lambs and its relation to health status and passive colostral immunity

Author:
Erhan Gökçe; Pınar Cihan; Onur Atakişi; Ali Haydar Kirmizigül; Hidayet Metin Erdoğan
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110470
ISSN:
0165-2427
Subject:
antioxidant activity; blood; colostral immunity; colostrum; crossbreds; health status; immunopathology; ingestion; oxidants; oxidative stress; postpartum period
Abstract:
... Oxidative stress (OS) related to birth in ruminants may increase susceptibility to diseases. However, information about the physiological changes related to OS in lambs is limited. This study was designed to evaluate changes in OS parameters [total antioxidant status (TAS, mmol Trolox Equiv./L), total oxidant status (TOS, μmol H₂O₂ Equiv./L)] and calculated oxidative stress index (OSi = TOS/TAS *  ...
DOI:
10.1016/j.vetimm.2022.110470

46. Pharmacological inhibition of the mTOR pathway alters phenotype and cytokine expression in bovine monocyte-derived dendritic cells

Author:
Anja Sipka; Thomas Weichhart; Sabine Mann
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110441
ISSN:
0165-2427
Subject:
Escherichia coli; antigen presentation; cell culture; early lactation; flow cytometry; gene expression; immune response; immunopathology; infectious diseases; inflammation; interleukin-10; lipopolysaccharides; monocytes; nutrient availability; pathogens; phenotype; rapamycin
Abstract:
... Epidemiological studies have long demonstrated the association of nutrient status and immune dysfunction in dairy cows. Postpartum dairy cows experiencing a nutrient deficit show a propensity for increased inflammatory response, decreased pathogen clearance, and increased incidence of infectious disease. Studies in cows and other species show that the nutrient sensing mechanistic target of rapamyc ...
DOI:
10.1016/j.vetimm.2022.110441

47. Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms

Author:
Archana A. Sridhara; Ashley Johnathan-Lee; Rubyat Elahi; Alina Sikar-Gang; Paul Lambotte; Javan Esfandiari; Lucia de Juan; Christian Gortazar; Breanne N. Marpe; Tyler C. Thacker; Mitchell V. Palmer; W. Ray Waters; Konstantin P. Lyashchenko
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110419
ISSN:
0165-2427
Subject:
Mycobacterium bovis; antibodies; biomarkers; blood; bovine tuberculosis; cattle; diagnostic sensitivity; immunopathology; interferon-gamma; tuberculin; Spain
Abstract:
... Bovine tuberculosis (bTB) control programs can be improved by combined use of tests for humoral and cell-mediated immune responses targeting multiple biomarkers of Mycobacterium bovis. To further the diagnostic benefits of this approach, we used Dual Path Platform (DPP) technology to test sera from cattle with naturally acquired bTB in the United States (US) and Spain for the presence of M. bovis ...
DOI:
10.1016/j.vetimm.2022.110419

48. Protective effects of chicoric acid on polyinosinic-polycytidylic acid exposed chicken hepatic cell culture mimicking viral damage and inflammation

Author:
Patrik Tráj; Eva Madeleine Herrmann; Csilla Sebők; Júlia Vörösházi; Máté Mackei; Péter Gálfi; Ágnes Kemény; Zsuzsanna Neogrády; Gábor Mátis
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110427
ISSN:
0165-2427
Subject:
Asteraceae; acetylcysteine; biochemical pathways; chickens; coculture; culture media; dose response; double-stranded RNA; free radicals; immunopathology; inflammation; interleukin-6; interleukin-8; lactate dehydrogenase; polyinosinic-polycytidylic acid; poultry industry; viruses
Abstract:
... Virus induced damage triggered by excessive inflammation and free radical production is a major threat in the poultry industry, leading to low productivity even in vaccinated flocks. The purpose of the study was to induce inflammation with the viral double-stranded RNA analog polyinosinic-polycytidylic acid (poly I:C) on chicken primary hepatocyte – non-parenchymal cell co-cultures to investigate ...
DOI:
10.1016/j.vetimm.2022.110427

49. Reduced capability of refrigerated white rhinoceros whole blood to produce interferon-gamma upon mitogen stimulation

Author:
Rebecca Dwyer; Carmel Witte; Peter Buss; Tebogo Manamela; Leana Freese; Guy Hausler; Wynand J. Goosen; Michele Miller
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110485
ISSN:
0165-2427
Subject:
Ceratotherium simum; Mycobacterium bovis; absorbance; blood; immunopathology; interferon-gamma; males; mitogens; monitoring; national parks; refrigeration
Abstract:
... Ante-mortem surveillance for Mycobacterium bovis (M. bovis) infection in the Kruger National Park (KNP) rhinoceros population currently relies on results from the QuantiFERON-TB Gold (In-Tube) Plus (QFT)–interferon gamma (IFN-γ) release assay (IGRA). However, same-day processing of rhinoceros blood samples for this test is a logistical challenge. Therefore, a pilot study was performed to compare m ...
DOI:
10.1016/j.vetimm.2022.110485

50. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens

Author:
Yingwei Liu; Jiangnan Yi; Yuanliang Li; Riaz Hussain; Shanshan Zhu; Yangwei Li; Zhuanxu Ouyang; Khalid Mehmood; Lianmei Hu; Jiaqing Pan; Zhaoxin Tang; Ying Li; Hui Zhang
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110415
ISSN:
0165-2427
Subject:
angiogenesis; apoptosis; autophagy; cell membranes; immunology; immunopathology; immunotoxicity; metabolites; metabolome; necropsy; pollution; public health; sphingolipids; spleen; sulfur; thiram
Abstract:
... Thiram, a well-known sulfur containing organic compound is frequently and extensively used in agriculture because of high biological activity to control different pests. In certain cases, due to long persistence in the environment pesticides and other environmental contaminants induce undesirable toxic impacts to public health and environment. To ascertain the potential mechanisms of toxicity of t ...
DOI:
10.1016/j.vetimm.2022.110415