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You searched for: Journal Veterinary immunology and immunopathology Remove constraint Journal: Veterinary immunology and immunopathology
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1. Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells

Author:
Yuri Onizawa; Taiga Katoh; Ryotaro Miura; Kunitoshi Konda; Tatsuo Noguchi; Hisataka Iwata; Takehito Kuwayama; Seizo Hamano; Koumei Shirasuna
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110370
ISSN:
0165-2427
Subject:
acetoacetic acid; blood plasma; caspase-1; estrous cycle; gene expression; immunopathology; inflammasomes; inflammation; ketone bodies; metabolomics; repeat breeder; reproductive disorders; secretion
Abstract:
... Repeat breeding, which is non-pregnancy following three or more breeding attempts, is a serious reproductive disorder in cattle. In the present study, metabolomic profiling was used to identify metabolites in the blood plasma of repeat breeder cows (RBCs) and non-RBCs. Metabolomic analysis showed that acetoacetate (AcAc), a ketone body, was detected in RBCs, but not in non-RBCs. In contrast, β-hyd ...
DOI:
10.1016/j.vetimm.2021.110370

2. Antibodies from healthy or paratuberculosis infected cows have different effects on Mycobacterium avium subspecies paratuberculosis invasion in a calf ileal loop model

Author:
Ana Jolly; Bárbara Fernández; Ana Stempler; Giselle Ingratta; Gabriela Postma; Juan Boviez; Daniel Lombardo; Silvia Hajos; Silvia L. Mundo
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110381
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; calves; histology; histopathology; ileum; immunopathology; microbial load; models; paratuberculosis; protective effect; viability
Abstract:
... In this work, we used a calf ileal loop model to evaluate whether the preincubation of Mycobacterium avium subspecies paratuberculosis (MAP) with antibodies from healthy, MAP-positive or Lipoarabinomannan (LAM) immunized cows could affect the results of infection after 3.5 h. Bacterial load in tissue was assessed by Ziehl-Neelsen and by culture for each loop. MAP was detectable in all infected loo ...
DOI:
10.1016/j.vetimm.2022.110381

3. Assessment of heterologous lumpy skin disease vaccine-induced immunity in pregnant cattle vaccinated at different times of gestation period and their influence on maternally derived antibodies

Author:
Ahmed Gaber; Sherin Rouby; Amera Elsaied; Ahmed El-Sherif
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110380
ISSN:
0165-2427
Subject:
cell-mediated immunity; gestation period; humoral immunity; immunopathology; longevity; lumpy skin disease; maternal immunity; parturition; pregnancy; sheep pox; vaccination; vaccines
Abstract:
... The present study aimed to evaluate the cell-mediated and the humoral immune response to Romanian sheep pox vaccine in pregnant cows (n = 12) vaccinated at different times of gestation period and the duration of maternal immunity in calves born to these cows. Evaluation of cellular immunity revealed an increase in lymphocytic proliferation that peaked at 10th day post vaccination (dpv) then gradua ...
DOI:
10.1016/j.vetimm.2021.110380

4. B cell memory responses induced by foot-and-mouth disease virus-like particles in BALB/c mice

Author:
Jia-huan Liu; Jun-juan Zhang; Wei-jian Han; Chuan Cui; Ming-zhu Li; Zhan-yun Tian; Ruo-man Bai; Li-min Li
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110458
ISSN:
0165-2427
Subject:
antibodies; blood serum; bone marrow; foot-and-mouth disease; immunization; immunoglobulin G; immunopathology; interleukin-6; memory; spleen; vaccine development
Abstract:
... A challenging but critical question is that new foot-and-mouth disease (FMD) vaccines should be to induce B cell memory to provide antibodies for long-term protection. The maintenance of B cell memory is dependent on long-lived plasma cells (LLPCs) and memory B cells. We developed a chimeric FMDV virus-like particles (FMDV-VLPs), fusing VP1-VP4 into HBcAg. In our study, we investigated if or how l ...
DOI:
10.1016/j.vetimm.2022.110458

5. CD4 bovine gene: Differential polymorphisms among cattle breeds and a new tool for rapid identification

Author:
Cintia Hiromi Okino; Wilson Malagó Junior; Cintia Righetti Marcondes; Rodrigo Giglioti; Hélio José Montassier; Henrique Nunes de Oliveira; Márcia Cristina de Sena Oliveira
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110462
ISSN:
0165-2427
Subject:
genes; genotyping; heterozygosity; homozygosity; hybrids; immunopathology; immunophenotyping; taurine; zebu
Abstract:
... Two mutations in the CD4 bovine gene (G>T/Q306H; A>C/K310N) were identified as causative for altered staining with anti-CD4 mAb #CC8. We developed a HRM qPCR for genotyping these mutations and compare with immunophenotyping in different cattle breeds. The assay distinguished five genotypes, B (homozygous, G/A) and C (heterozygous, G/A and T/C), found in taurine, A (homozygous, G/C) and D (heterozy ...
DOI:
10.1016/j.vetimm.2022.110462

6. Canine memory T-cell subsets in health and disease

Author:
Annie B. Bauman; Cambri E. Moeller; Aimee M. Soileau; Christine E. Goodermuth; Victoria R. Costa; Jessica C. Schaumburg; Cherie M. Pucheu-Haston; Nancy D. Welborn; Shannon D. Dehghanpir; Mark A. Mitchell; Sita S. Withers
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110401
ISSN:
0165-2427
Subject:
T-lymphocytes; antigens; atopic dermatitis; dogs; drug therapy; flow cytometry; immunopathology; immunotherapy; inflammation; lymph nodes; lymphoma; memory; prednisone
Abstract:
... A more complete understanding of canine T-lymphocyte immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. The aim of this study was to utilize CD45RA (indicating antigen inexperience) and CD62L (indicating lymph node homing capabi ...
DOI:
10.1016/j.vetimm.2022.110401

7. Changes in rabbit lymphocyte subpopulations and activation following long-term administration of meloxicam

Author:
Pavla Hamouzová; Šárka Stehlíková; Kristína Řeháková; Vladimír Jekl; Jan Chloupek; Jaroslav Doubek
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110496
ISSN:
0165-2427
Subject:
B-lymphocytes; analgesics; flow cytometry; hematology; immunology; immunopathology; meloxicam; rabbits
Abstract:
... Meloxicam is a commonly used analgesic in rabbits. However, its possible impact on lymphocyte subpopulations remained unknown. The aim of the study was to investigate a possible effect of long-term administration of meloxicam on rabbit lymphocyte subpopulations. The study included 8 rabbits given meloxicam orally once daily (1 mg/kg BW) for 14 days and 8 rabbits as a control group. Peripheral bloo ...
DOI:
10.1016/j.vetimm.2022.110496

8. Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression

Author:
Sara Marzo; Mark Gray; Waywen Loh; Lindsey A. Waddell; C. Irene McGuinnes; Jayne C. Hope; Heather A. Mathie
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110363
ISSN:
0165-2427
Subject:
T-lymphocytes; adaptive immunity; cattle; dendritic cells; flow cytometry; immunopathology; lymph; models; phenotype
Abstract:
... The bovine afferent lymphatic cannulation model allows collection of large volumes of afferent lymph and provides an opportunity to study lymphatic cells trafficking from the periphery directly ex-vivo. The technique requires surgical intervention, but influence of the procedure or time post-surgery on cells trafficking in the lymph has not been well documented. Here, we measured the volume of lym ...
DOI:
10.1016/j.vetimm.2021.110363

9. Chitosan-based formulation of hemagglutinin antigens for oculo-nasal booster vaccination of chickens against influenza viruses

Author:
Violetta Sączyńska; Agnieszka Romanik-Chruścielewska; Katarzyna Florys-Jankowska; Violetta Cecuda-Adamczewska; Małgorzata Kęsik-Brodacka
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110406
ISSN:
0165-2427
Subject:
Escherichia coli; aluminum hydroxide; avian influenza; chitosan; glutamic acid; hemagglutination; hemagglutinins; immunopathology; pH; public health; recombinant proteins; secondary immunization; viral antigens
Abstract:
... Avian influenza viruses (AIVs) and especially highly pathogenic (HP) AIVs of the H5 and H7 subtypes are of both veterinary and public health concern worldwide. In response to the demand for effective vaccines against H5N1 HPAIVs, we produced recombinant protein based on hemagglutinin (HA), a protective viral antigen. A fragment of the HA ectodomain, with a multibasic cleavage site deletion, was ex ...
DOI:
10.1016/j.vetimm.2022.110406

10. Controlled release vaccine implants for delivery of booster immunisations

Author:
Freya A. Russell; Logan K. Trim; Flavia Medeiros Savi; Craig Simon; Tim R. Dargaville; Dietmar W. Hutmacher; Kenneth W. Beagley
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110484
ISSN:
0165-2427
Subject:
T-lymphocytes; antibodies; antigens; blood serum; cell proliferation; immune response; immunopathology; livestock; polymers; secondary immunization; subcutaneous injection; tetanus; vaccination; vaccines; weight gain
Abstract:
... Most current animal vaccine regimes involve a primary vaccination followed sometime later by a booster vaccination. This presents challenges when vaccinating difficult to access animals such as livestock. Mustering livestock to deliver a vaccine boost is costly and stressful for animals. Thus, we have produced a platform system that can be administered at the same time as the priming immunisation ...
DOI:
10.1016/j.vetimm.2022.110484

11. Development of low-cost cage-like particles to formulate veterinary vaccines

Author:
Giuliana A. Lupi; Florencia X. Santiago Valtierra; Gabriel Cabrera; Roque Spinelli; Álvaro S. Siano; Verónica González; Antonio Osuna; Gerardo M. Oresti; Iván Marcipar
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110460
ISSN:
0165-2427
Subject:
adjuvants; alum; cholesterol; delayed hypersensitivity; egg yolk; gas chromatography; immunoglobulin G; immunopathology; lysophospholipids; ovalbumin; saponins; thin layer chromatography
Abstract:
... Low-cost adjuvants are urgently needed for the development of veterinary vaccines able to trigger strong immune responses. In this work, we describe a method to obtain a low-cost cage-like particles (ISCOMATRIX-like) adjuvant useful to formulate veterinary vaccines candidates. The main components to form the particles are lipids and saponins, which were obtained from egg yolk by ethanolic extracti ...
DOI:
10.1016/j.vetimm.2022.110460

12. Differential detection of IgM and IgG antibodies to chimeric antigens in bovine tuberculosis

Author:
Archana A. Sridhara; Ashley Johnathan-Lee; Rubyat Elahi; Paul Lambotte; Javan Esfandiari; Maria Laura Boschiroli; Tanya J. Kerr; Michele A. Miller; Thomas Holder; Gareth Jones; H. Martin Vordermeier; Breanne N. Marpe; Tyler C. Thacker; Mitchell V. Palmer; W. Ray Waters; Konstantin P. Lyashchenko
Source:
Veterinary immunology and immunopathology 2022 pp. 110499
ISSN:
0165-2427
Subject:
Mycobacterium bovis; antibodies; blood serum; bovine tuberculosis; cattle; cross reaction; hosts; immunopathology; monitoring; rapid methods; risk; wildlife; France; Great Britain; South Africa
Abstract:
... Recent studies have suggested the potential of innovative serologic tests for accurate and rapid detection of bovine tuberculosis (bTB). Dual Path Platform (DPP) technology has been used to develop rapid animal-side antibody tests for Mycobacterium bovis infection in a range of livestock and wildlife host species. The present study evaluated diagnostic performance of DPP BovidTB IgM/IgG assay desi ...
DOI:
10.1016/j.vetimm.2022.110499

13. Dynamic changes in Holstein heifer circulatory stress biomarkers in response to lipopolysaccharide immune challenge

Author:
T. Sullivan; A. Sharma; K. Lamers; C. White; B.A. Mallard; A. Cánovas; N.A. Karrow
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110426
ISSN:
0165-2427
Subject:
Holstein; acidosis; biomarkers; blood flow; blood serum; body temperature; climate change; cortisol; heat stress; immunopathology; inflammation; interleukin-10; intestinal mucosa; leukopenia; lipopolysaccharides; microRNA; septicemia; stress response; thrombocytopenia
Abstract:
... Dairy cattle routinely face a variety of stressors. For example, climate change has resulted in more frequent heat stress events that increase the incidence of bacterial infections by inducing conditions like leaky gut syndrome, whereby the integrity of the intestinal epithelium is compromised allowing for luminal bacteria and their membrane components to infiltrate the host’s bloodstream resultin ...
DOI:
10.1016/j.vetimm.2022.110426

14. Effect of aging on monocyte phagocytic and inflammatory functions, and on the ex vivo inflammatory responses to lipopolysaccharide, in horses

Author:
A.C. Herbst; S.E. Reedy; A.E. Page; D.W. Horohov; A.A. Adams
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110459
ISSN:
0165-2427
Subject:
Escherichia coli; adiposity; body condition; ex vivo studies; flow cytometry; gene expression; genes; immunopathology; interleukin-18; interleukin-6; interleukin-8; lipopolysaccharides; monocytes; phagocytosis; young adults
Abstract:
... Studies investigating age-related changes in the function of monocytes are currently limited for horses. Thus, the main goal of this study was to determine the effect of aging on monocyte phagocytic capacity and pro-inflammatory cytokine responses to bacterial lipopolysaccharide (LPS). A second goal of this work was to examine the effect of aging on the inflammatory cytokine responses to LPS in a ...
DOI:
10.1016/j.vetimm.2022.110459

15. Effect of major versus minor mastectomy on host immunity in canine mammary cancer

Author:
Maria Karayannopoulou; Tilemachos Anagnostou; Apostolia Margariti; Maria Kritsepi-Konstantinou; Dimitra Psalla; Angelos-Lauris Thomas; Ioannis Savvas
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110403
ISSN:
0165-2427
Subject:
T-lymphocytes; anesthesia; cell-mediated immunity; immunopathology; immunosuppression; innate immunity; mammary neoplasms (animal); metastasis; neutrophils; surgery
Abstract:
... Surgical procedures can affect host immunity proportionally to the extent of surgical trauma. In cancer cases, surgery-induced immunosuppression can potentially promote tumour metastasis. The aim of this study was to investigate, in bitches with malignant mammary tumours, whether major surgery (total unilateral mastectomy or bilateral regional mastectomy) has a more negative effect than minor surg ...
DOI:
10.1016/j.vetimm.2022.110403

16. Effects of immunostimulators of microbial origin on T cells of pigs vaccinated with attenuated vaccine against Aujeszkyʼs disease

Author:
Miroslav Andrišić; Irena Žarković; Ksenija Šandor; Anja Vujnović; Eleonora Perak Junaković; Krešo Bendelja; Ana Savić Mlakar; Nada Oršolić; Lidija Šver; Miroslav Benić; Svjetlana Terzić
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110365
ISSN:
0165-2427
Subject:
Escherichia coli; Parapoxvirus; Propionibacterium granulosum; Suid alphaherpesvirus 1; T-lymphocytes; cell-mediated immunity; immunopathology; live vaccines; vaccination
Abstract:
... Aujeszky’s disease (AD) is a viral infectious disease caused by Suid herpesvirus 1 (SuHV-1). Vaccination and eradication of AD in domestic pigs is possible using marker vaccines with attenuated or inactivated SuHV-1, or subunit vaccines. However, vaccines with attenuated SuHV-1 have shown to be more potent in inducing strong cell-mediated immune response. The studies have shown that Parapoxvirus o ...
DOI:
10.1016/j.vetimm.2021.110365

17. Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints

Author:
Koji Nishi; Yuki Hirano; Ayano Sato; Ayako Eguchi; Kazuya Matsuda; Miyuki Toda; Takafumi Watanabe; Tomohito Iwasaki; Naoki Takahashi; Marina Hosotani; Reina Watanabe; Toshihide Kato; Hiromichi Ohtsuka; Satoshi Gondaira; Hidetoshi Higuchi
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110364
ISSN:
0165-2427
Subject:
Mycoplasma bovis; arthritis; calves; cartilage; fibrin; immunohistochemistry; immunopathology; inflammation; interleukin-12; interleukin-17; interleukin-6; interleukin-8; lameness; messenger RNA; monitoring; phosphates; stifle; synovial fluid; transmission electron microscopy
Abstract:
... Mycoplasma arthritis that caused by Mycoplasma bovis exhibit severe lameness. This disease is difficult to cure with antibiotics, but the detailed pathological mechanisms have not been fully clarified. In this study, we examined the effects of intra-articular inoculation with M. bovis on immunological responses in calf joints. We inoculated three calves each with M. bovis or phosphate buffer salin ...
DOI:
10.1016/j.vetimm.2021.110364

18. Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses

Author:
Constanza Salinas; Gabriel Espinosa; Natalia Morales; Claudio Henríquez; Gabriel Morán; Gonzalo Gajardo; Rafael A. Burgos; Benjamin Uberti
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110455
ISSN:
0165-2427
Subject:
adults; apoptosis; blood; blood glucose; body condition; glucose; hyperglycemia; immunopathology; insulin; insulin resistance; obesity; phagocytosis; reactive oxygen species; statistical models
Abstract:
... Obesity and insulin dysregulation (ID) are increasingly prevalent conditions in equid populations worldwide. Immune impairment is well described in humans with metabolic dysfunction and is reported but still incompletely understood in horses. This study evaluated the effect of acute induced transient hyperglycemia on apoptosis, phagocytosis and oxidative burst activity of peripheral blood polymorp ...
DOI:
10.1016/j.vetimm.2022.110455

19. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis

Author:
Yiğit KAÇAR; Ahmet Tarık BAYKAL; Levent AYDIN; Hasan BATMAZ
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110429
ISSN:
0165-2427
Subject:
Cryptosporidium; Holstein; amyloid; blood serum; calves; cow colostrum; cryptosporidiosis; gamma-glutamyltransferase; immunoglobulin G; immunopathology; oocysts; protein content; proteome; proteomics; sodium bicarbonate; zinc
Abstract:
... This study aimed to investigate the effect of using high-quality colostrum in addition to paromomycin on the treatment outcomes and serum proteomes of calves naturally affected by cryptosporidiosis. Thirty Holstein calves infected with only Cryptosporidium spp. were divided into three equal groups. Calves in the PC group received paromomycin orally at a dose of 100 mg/kg once daily for 5 days. Cal ...
DOI:
10.1016/j.vetimm.2022.110429

20. Evidence for transfer of maternal antigen specific cellular immunity against Mycobacterium avium ssp. paratuberculosis via colostrum in a goat twin model

Author:
L. Robbers; R. van de Mheen; L. Benedictus; R. Jorritsma; M. Nielen; H.J.C. Bijkerk; S.G. van der Grein; L. Ravesloot; A.P. Koets
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110402
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; blood serum; cell-mediated immunity; cow colostrum; epithelium; histology; immune response; immunopathology; injection site; intestines; models; tuberculin; vaccines
Abstract:
... Colostrum intake is one of the most important factors in neonatal health in ruminants, mainly because of its unique immunological properties. Both in practice as well as in research, the attention of lactogenic immunity is focused on the importance of colostral antibodies and less attention is given to the functional role of maternal cells in colostrum. Here we study the transfer of maternal leuko ...
DOI:
10.1016/j.vetimm.2022.110402

21. H3N2 canine influenza virus NS1 protein inhibits canine NLRP3 inflammasome activation

Author:
Pan Tao; Zhangyong Ning; Pei Zhou; Weiqi Xiao; Guiping Wang; Shoujun Li; Guihong Zhang
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110483
ISSN:
0165-2427
Subject:
Influenza A virus; canine influenza; caspase-1; dogs; immunopathology; inflammasomes; inflammation; innate immunity; interleukin-18; oligomerization; transcription (genetics)
Abstract:
... Inflammation is an innate immune response of the body against pathogens and other irritants. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is a major player in the inflammatory response against pathogenic microorganisms. In this study, we analyzed the relationship between the NLRP3 inflammasome and the influenza virus NS1 protein, which is involved in host immune escape. ...
DOI:
10.1016/j.vetimm.2022.110483

22. Immunoproteomic analysis of the secretome of bovine-adapted strains of Staphylococcus aureus demonstrates a strain-specific humoral response

Author:
Shauna D. Drumm; Paul Cormican; Padraig O’Boyle; Rebecca A. Owens; Jennifer Mitchell; Orla M. Keane
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110428
ISSN:
0165-2427
Subject:
Staphylococcus aureus; antigens; blood serum; cows; genes; humoral immunity; immunopathology; mass spectrometry; molecular weight; pathogens; vaccines; virulence
Abstract:
... Staphylococcus aureus is a common pathogen associated with bovine intramammary infection. A number of distinct S. aureus lineages are associated with such infections although there is a dearth of knowledge regarding the major immunogenic antigens associated with each lineage and whether these antigens provide protection against heterologous strains. Identification of the major immunogenic antigens ...
DOI:
10.1016/j.vetimm.2022.110428

23. Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

Author:
J.J. Rosales; M.V. Nieto Farías; M. Burucúa; M.S. Marin; S.E. Pérez
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110391
ISSN:
0165-2427
Subject:
Bovine alphaherpesvirus 1; bioactive properties; brain; epithelium; ganglia; immunopathology; innate immunity; transcription (genetics); virus replication; viruses
Abstract:
... Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to ...
DOI:
10.1016/j.vetimm.2022.110391

24. Influenza A pathway analysis of highly pathogenic avian influenza virus (H5N1) infection in genetically disparate Ri chicken lines

Author:
Jiae Lee; Yeojin Hong; Thi Hao Vu; Sooyeon Lee; Jubi Heo; Anh Duc Truong; Hyun S. Lillehoj; Yeong Ho Hong
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110404
ISSN:
0165-2427
Subject:
Influenza A virus; RNA; chickens; cytokines; gene expression; gene expression regulation; immune system; immunity; immunopathology; influenza; interferons; quantitative polymerase chain reaction; reverse transcription; viruses; Vietnam
Abstract:
... Influenza A/H5N1 virus is a highly pathogenic (HPAIV) and contagious zoonotic virus that can be transmitted to humans. In the present study, infection with this virus and differential gene expression analyses were carried out with genetically resistant and susceptible Ri chicken lines that are native to Vietnam. A total of 20 four-week-old Ri chickens from each line were inoculated with the highly ...
DOI:
10.1016/j.vetimm.2022.110404

25. Insufficiency of CD205-positive cortical thymic epithelial cells in immature Japanese Black cattle with severe thymic abnormalities and poor prognosis

Author:
Shoichi Wakitani; Risako Kawabata; Masahiro Yasuda
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110379
ISSN:
0165-2427
Subject:
Wagyu; cortex; epithelium; histopathology; immunohistochemistry; immunopathology; interleukin-7; prognosis; surveys
Abstract:
... To investigate the involvement of thymic function in the development of diseases with poor prognosis in calves, this study conducted a survey for the assessment of thymus cell composition in immature Japanese Black cattle with poor prognosis. Histopathological evaluation of 47 cattle showed signs of acute thymic involution in most cases. Less than half of the cases had a cortex predominant over th ...
DOI:
10.1016/j.vetimm.2021.110379

26. Interleukin-1Ra (Il-1Ra) and serum cortisol level relationship in horse as dynamic adaptive response during physical exercise

Author:
Francesca Arfuso; Elisabetta Giudice; Michele Panzera; Maria Rizzo; Francesco Fazio; Giuseppe Piccione; Claudia Giannetto
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110368
ISSN:
0165-2427
Subject:
Thoroughbred; antagonists; athletic performance; blood serum; cortisol; erythrocytes; exercise; hematocrit; hemoglobin; horses; immunopathology; interleukin-1; physical health; stress response
Abstract:
... The monitoring of endocrine and immunologic markers during exercise is of paramount importance to assess and/or maintain the physical well-being of athletes as well as to optimize the athletic performance. This study aimed to investigate the linkage between acute stress response and immune status in Thoroughbred horses competing in an official 1300-m race. From 10 horses blood was collected 1 week ...
DOI:
10.1016/j.vetimm.2021.110368

27. Measurement of canine Th17 cells by flow cytometry

Author:
A. Knebel; A. Kämpe; R. Carlson; K. Rohn; A. Tipold
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110366
ISSN:
0165-2427
Subject:
CD4-positive T-lymphocytes; autoimmune diseases; dogs; flow cytometry; immunology; immunopathology; inflammation
Abstract:
... Th17 cells are T helper cells which play an important role during inflammation and autoimmune disease. To investigate the role of these cells in diseases in dogs in a clinical setting, methods for fast identification had to be established. Th17 cells are a rare cell population, for their measurement stimulation is recommended. To examine more samples simultaneously and to receive a relatively high ...
DOI:
10.1016/j.vetimm.2021.110366

28. Oxidative stress in neonatal lambs and its relation to health status and passive colostral immunity

Author:
Erhan Gökçe; Pınar Cihan; Onur Atakişi; Ali Haydar Kirmizigül; Hidayet Metin Erdoğan
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110470
ISSN:
0165-2427
Subject:
antioxidant activity; blood; colostral immunity; colostrum; crossbreds; health status; immunopathology; ingestion; oxidants; oxidative stress; postpartum period
Abstract:
... Oxidative stress (OS) related to birth in ruminants may increase susceptibility to diseases. However, information about the physiological changes related to OS in lambs is limited. This study was designed to evaluate changes in OS parameters [total antioxidant status (TAS, mmol Trolox Equiv./L), total oxidant status (TOS, μmol H₂O₂ Equiv./L)] and calculated oxidative stress index (OSi = TOS/TAS *  ...
DOI:
10.1016/j.vetimm.2022.110470

29. Pharmacological inhibition of the mTOR pathway alters phenotype and cytokine expression in bovine monocyte-derived dendritic cells

Author:
Anja Sipka; Thomas Weichhart; Sabine Mann
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110441
ISSN:
0165-2427
Subject:
Escherichia coli; antigen presentation; cell culture; early lactation; flow cytometry; gene expression; immune response; immunopathology; infectious diseases; inflammation; interleukin-10; lipopolysaccharides; monocytes; nutrient availability; pathogens; phenotype; rapamycin
Abstract:
... Epidemiological studies have long demonstrated the association of nutrient status and immune dysfunction in dairy cows. Postpartum dairy cows experiencing a nutrient deficit show a propensity for increased inflammatory response, decreased pathogen clearance, and increased incidence of infectious disease. Studies in cows and other species show that the nutrient sensing mechanistic target of rapamyc ...
DOI:
10.1016/j.vetimm.2022.110441

30. Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms

Author:
Archana A. Sridhara; Ashley Johnathan-Lee; Rubyat Elahi; Alina Sikar-Gang; Paul Lambotte; Javan Esfandiari; Lucia de Juan; Christian Gortazar; Breanne N. Marpe; Tyler C. Thacker; Mitchell V. Palmer; W. Ray Waters; Konstantin P. Lyashchenko
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110419
ISSN:
0165-2427
Subject:
Mycobacterium bovis; antibodies; biomarkers; blood; bovine tuberculosis; cattle; diagnostic sensitivity; immunopathology; interferon-gamma; tuberculin; Spain
Abstract:
... Bovine tuberculosis (bTB) control programs can be improved by combined use of tests for humoral and cell-mediated immune responses targeting multiple biomarkers of Mycobacterium bovis. To further the diagnostic benefits of this approach, we used Dual Path Platform (DPP) technology to test sera from cattle with naturally acquired bTB in the United States (US) and Spain for the presence of M. bovis ...
DOI:
10.1016/j.vetimm.2022.110419

31. Protective effects of chicoric acid on polyinosinic-polycytidylic acid exposed chicken hepatic cell culture mimicking viral damage and inflammation

Author:
Patrik Tráj; Eva Madeleine Herrmann; Csilla Sebők; Júlia Vörösházi; Máté Mackei; Péter Gálfi; Ágnes Kemény; Zsuzsanna Neogrády; Gábor Mátis
Source:
Veterinary immunology and immunopathology 2022 v.250 pp. 110427
ISSN:
0165-2427
Subject:
Asteraceae; acetylcysteine; biochemical pathways; chickens; coculture; culture media; dose response; double-stranded RNA; free radicals; immunopathology; inflammation; interleukin-6; interleukin-8; lactate dehydrogenase; polyinosinic-polycytidylic acid; poultry industry; viruses
Abstract:
... Virus induced damage triggered by excessive inflammation and free radical production is a major threat in the poultry industry, leading to low productivity even in vaccinated flocks. The purpose of the study was to induce inflammation with the viral double-stranded RNA analog polyinosinic-polycytidylic acid (poly I:C) on chicken primary hepatocyte – non-parenchymal cell co-cultures to investigate ...
DOI:
10.1016/j.vetimm.2022.110427

32. Reduced capability of refrigerated white rhinoceros whole blood to produce interferon-gamma upon mitogen stimulation

Author:
Rebecca Dwyer; Carmel Witte; Peter Buss; Tebogo Manamela; Leana Freese; Guy Hausler; Wynand J. Goosen; Michele Miller
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110485
ISSN:
0165-2427
Subject:
Ceratotherium simum; Mycobacterium bovis; absorbance; blood; immunopathology; interferon-gamma; males; mitogens; monitoring; national parks; refrigeration
Abstract:
... Ante-mortem surveillance for Mycobacterium bovis (M. bovis) infection in the Kruger National Park (KNP) rhinoceros population currently relies on results from the QuantiFERON-TB Gold (In-Tube) Plus (QFT)–interferon gamma (IFN-γ) release assay (IGRA). However, same-day processing of rhinoceros blood samples for this test is a logistical challenge. Therefore, a pilot study was performed to compare m ...
DOI:
10.1016/j.vetimm.2022.110485

33. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens

Author:
Yingwei Liu; Jiangnan Yi; Yuanliang Li; Riaz Hussain; Shanshan Zhu; Yangwei Li; Zhuanxu Ouyang; Khalid Mehmood; Lianmei Hu; Jiaqing Pan; Zhaoxin Tang; Ying Li; Hui Zhang
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110415
ISSN:
0165-2427
Subject:
angiogenesis; apoptosis; autophagy; cell membranes; immunology; immunopathology; immunotoxicity; metabolites; metabolome; necropsy; pollution; public health; sphingolipids; spleen; sulfur; thiram
Abstract:
... Thiram, a well-known sulfur containing organic compound is frequently and extensively used in agriculture because of high biological activity to control different pests. In certain cases, due to long persistence in the environment pesticides and other environmental contaminants induce undesirable toxic impacts to public health and environment. To ascertain the potential mechanisms of toxicity of t ...
DOI:
10.1016/j.vetimm.2022.110415

34. Sheep vaccinated against paratuberculosis have increased levels of B cells infiltrating the intestinal tissue

Author:
Hannah B. Pooley; Richard J. Whittington; Douglas J. Begg; Auriol C. Purdie; Karren M. Plain; Kumudika de Silva
Source:
Veterinary immunology and immunopathology 2022 v.252 pp. 110482
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; enteritis; ileum; immune response; immunohistochemistry; immunopathology; macrophages; paratuberculosis; sheep; vaccination; vaccine development; vaccines
Abstract:
... Systemic immunisation delivered subcutaneously is currently used to control paratuberculosis, a chronic enteritis of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). These vaccines do not provide complete protection and a small cohort of animals still succumb to clinical disease. The aim of this study was to assess mycobacterial infection site-specific variations in immun ...
DOI:
10.1016/j.vetimm.2022.110482

35. Systemic murine cathelicidin CRAMP safely attenuated colonic neutrophil infiltration in pigs

Author:
Cristina C. Fodor; Robert McCorkell; Greg Muench; Eduardo R. Cobo
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110443
ISSN:
0165-2427
Subject:
cathelicidins; colitis; colon; enteropathogens; epithelium; glycosylation; homeostasis; immunology; immunopathology; intraperitoneal injection; mice; mucins; mucus; multiple drug resistance; neutrophils
Abstract:
... Post-weaning diarrheic colitis, often caused by enteropathogens, are severe and potentially lethal diseases in young pigs. Conventional treatment with antibiotics is problematic due to increasing prevalence of multi-drug resistant bacteria. Few alternative treatments exist, so development of antibiotic-free therapies is urgently needed for livestock. Cathelicidin peptides, produced by epithelial c ...
DOI:
10.1016/j.vetimm.2022.110443

36. Thymic changes due to leishmaniasis in dogs: An immunohistochemical study

Author:
Giulia Gonçalves Jussiani; Karen Santos Março; Paulo Henrique Leal Bertolo; Rosemeri de Oliveira Vasconcelos; Gisele Fabrino Machado
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110416
ISSN:
0165-2427
Subject:
Leishmania infantum; apoptosis; atrophy; collagen; death; epithelium; histopathology; immune response; immunohistochemistry; immunopathology; leishmaniasis; macrophages; mitosis; morphometry; parasites; pathophysiology; thymocytes; tissue distribution
Abstract:
... The thymus is necessary for the differentiation of T cells, a process that is regulated by the type of antigens found in thymocytes, the environment of surrounding cells and the thymus architecture. There is evidence that infectious diseases may result in morphological changes in this organ, such as premature atrophy and decreased thymocyte proliferation, that can affect the immune response. We ch ...
DOI:
10.1016/j.vetimm.2022.110416

37. Tracheal cellular immune response in chickens inoculated with Mycoplasma synoviae vaccine, MS-H or its parent strain 86079/7NS

Author:
Oluwadamilola S. Omotainse; Nadeeka K. Wawegama; Sathya N. Kulappu Arachchige; Mauricio J. C. Coppo; Paola K. Vaz; Andrew P. Woodward; Somayeh Kordafshari; Mirjana Bogeski; Mark Stevenson; Amir H. Noormohammadi; Andrew W. Stent
Source:
Veterinary immunology and immunopathology 2022 v.251 pp. 110472
ISSN:
0165-2427
Subject:
Mycoplasma synoviae; cell-mediated immunity; immunopathology; interleukin-17; light microscopy; live vaccines; macrophages; mucosa; respiratory tract diseases; specific pathogen-free animals; vaccination
Abstract:
... Mycoplasma synoviae causes respiratory tract disease in chickens characterised by mild to moderate lymphoplasmacytic infiltration of the tracheal mucosa. MS-H (Vaxsafe1 MS, Bioproperties Pty Ltd.) is an effective live attenuated vaccine for M. synoviae, but the immunological basis for its mechanism of protection has not been investigated, and the phenotypes of lymphocytes and associated cytokines ...
DOI:
10.1016/j.vetimm.2022.110472

38. An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Author:
Anja Ziegler; Judith Olzhausen; Eman Hamza; Ana Stojiljkovic; Michael H. Stoffel; Mattia Garbani; Claudio Rhyner; Eliane Marti
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110351
ISSN:
0165-2427
Subject:
Culicoides; T-lymphocytes; Toll-like receptor 4; adjuvants; agonists; allergens; asthma; cancer therapy; cell proliferation; dendritic cells; dermatitis; horses; humans; immune response; immunogenicity; immunomodulators; immunopathology; immunotherapy; insects; interleukin-10; interleukin-17; interleukin-4; mice; oligodeoxyribonucleotides; ovalbumin
Abstract:
... Allergen-specific immunotherapy (AIT) constitutes the only curative approach for allergy treatment. There is need for improvement of AIT in veterinary medicine, such as in horses suffering from insect bite hypersensitivity, an IgE-mediated dermatitis to Culicoides. Dendritic cell (DC)-targeting represents an efficient method to increase antigen immunogenicity. It is studied primarily for its use i ...
DOI:
10.1016/j.vetimm.2021.110351

39. A clonality assay in canine B cell tumors targeting the immunoglobulin light chain lambda locus

Author:
Masamine Takanosu; Yumiko Kagawa
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110498
ISSN:
0165-2427
Subject:
B-lymphocytes; DNA; antigens; capillary electrophoresis; databases; dogs; genes; immunogenetics; immunoglobulin heavy chains; immunoglobulin light chains; immunopathology; inflammation; loci; lymph; lymphoma; polymerase chain reaction
Abstract:
... Clonality assays for antigen receptor rearrangement have been used as adjunct examinations of lymphoproliferative diseases. These assays have been useful for differentiation between inflammation and clonal expansion of lymphocytes. Whereas the immunoglobulin heavy chain (IGH) and immunoglobulin light chain kappa (IGK) loci have been targeted in canine clonality assays previously, the immunoglobuli ...
DOI:
10.1016/j.vetimm.2022.110498

40. A ferret model of immunosuppression induced with dexamethasone

Author:
Anna Hundakova; Lenka Leva; Miroslav Toman; Zdenek Knotek
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110362
ISSN:
0165-2427
Subject:
Phytolaccaceae; chemiluminescence; concanavalin A; dexamethasone; ferrets; humans; immunopathology; immunosuppression; ingestion; mitogens; monocytes; neutrophils; phagocytosis; phytohemagglutinin; reactive oxygen species
Abstract:
... Ferrets are nowadays frequently used as animal models for biomedical purposes; in many cases, immunosuppression of experimental animals is necessary. The aim of this study was to evaluate the effect of intramuscular dexamethasone administration (2 mg/kg as the initiation dose continued with 1 mg/kg q 12 h applied 5 times) on ferret’s immune system. In comparison with ferrets which received the sal ...
DOI:
10.1016/j.vetimm.2021.110362

41. A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription

Author:
Hao Liu; Changying Wang; Gen Liu; Yanping Li; Li Kang; Yi Sun; Yunliang Jiang
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110202
ISSN:
0165-2427
Subject:
Duroc; Porcine circovirus-2; genes; heart; immune response; immunopathology; kidneys; landraces; large intestine; liver; luciferase; lungs; lymph nodes; mannose; pathogens; promoter regions; small intestine; spleen; swine; transcription (genetics)
Abstract:
... Mannose receptor, C type 1 (MRC1) is a key factor in regulating the body's immune response to resist pathogen invasions. In this study, mRNA expressions of MRC1 gene in nine porcine organs/tissues were compared between Laiwu (LW) and Yorkshire × Landrace crossbred (YL) pigs prior to and post PCV2 infection. We found that, for pigs uninfected with PCV2, MRC1 mRNA expressions in the lung, spleen, la ...
DOI:
10.1016/j.vetimm.2021.110202

42. APB-F1, a long-acting feline granulocyte colony-stimulating factor fusion protein, created by exploiting FL335, a chimeric Fab specific for feline serum albumin

Author:
Hyun-jin Chi; Mihyun Park; Jae-kyu Han; Sun-mi Kim; SeungGoo Kang; Jin-hyuk Yang; Sang-hoon Cha
Source:
Veterinary immunology and immunopathology 2021 v.240 pp. 110322
ISSN:
0165-2427
Subject:
Cricetulus griseus; antibodies; bioactive properties; blood serum; cats; granulocyte colony-stimulating factor; half life; humans; immunopathology; neutropenia; neutrophils; pharmacodynamics; pharmacokinetics; recombinant fusion proteins; serum albumin; therapeutics
Abstract:
... Off-label use of a human granulocyte colony stimulating factor (hG-CSF) has been allowed to treat dogs and cats with neutropenia. However, repeated administration of hG-CSF induces undesirable anti-drug antibody (ADA) responses, implying the necessity of animal-derived G-CSF as a therapeutic reagent, preferably with a long-acting capability. Herein, we generated a recombinant fusion protein by gen ...
DOI:
10.1016/j.vetimm.2021.110322

43. Activation of canine neutrophils by platelet-activating factor

Author:
Ken Okabayashi; Shuichiro Kanai; Fumihiko Katakura; Riku Takeuchi; Takashi Yamauchi; Shunya Nakayama; Rie Kinoshita; Hiroshi Koie; Takanori Narita
Source:
Veterinary immunology and immunopathology 2021 v.241 pp. 110336
ISSN:
0165-2427
Subject:
calcium; dogs; endoplasmic reticulum; immunopathology; inflammation; inositols; neutrophils; phagocytosis; platelet aggregation; platelet-activating factor; respiratory burst; signal transduction; suramin
Abstract:
... Neutrophils are essential for innate immunity as the first line of defence. Neutrophils act as phagocytic white blood cells to kill bacteria and other microorganisms. A strong respiratory burst of neutrophils, dependent on reactive oxygen species, is produced during phagocytosis. Platelet-activating factor (PAF) is a signalling molecule with several prominent roles in tissue injury, inflammation, ...
DOI:
10.1016/j.vetimm.2021.110336

44. Activation of chicken gamma-delta T lymphocytes by a purified ulvan extract

Author:
Nathalie Guriec; Frédérick Bussy; Christelle Gouin; Olivier Mathiaud; Matthieu Le Goff; Jacques Delarue; Pi Nyvall Collén
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110255
ISSN:
0165-2427
Subject:
Avian orthoavulavirus 1; Salmonella; Ulva; chickens; cytotoxicity; flow cytometry; heterophils; immune response; immunopathology; intestines; major histocompatibility complex; monocytes; polysaccharides; spleen; vaccination
Abstract:
... Chicken γδ T lymphocytes are present in a variety of tissues such as blood, spleen and intestine. They constitute a major cytotoxic population. In chicken, Salmonella immunization as well as vaccination against Newcastle disease virus are accompanied by an increase of γδ T lymphocytes in peripheral blood, which may be activated, and thus represent a protective immune response. It has been publishe ...
DOI:
10.1016/j.vetimm.2021.110255

45. Anti-inflammatory activity of citrus pectin on chicken monocytes' immune response

Author:
G. Ávila; D. De Leonardis; G. Grilli; C. Lecchi; F. Ceciliani
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110269
ISSN:
0165-2427
Subject:
Citrus; Escherichia coli; anti-inflammatory activity; apoptosis; biochemical pathways; caspase-3; chemotaxis; dietary fiber; digestibility; dose response; energy; galacturonic acid; immune response; immunopathology; monocytes; pectins; phagocytosis; toxicity testing; viability
Abstract:
... Pectin is a dietary fibre composed of galacturonic acid, primarily found in the citrus fruits' cell walls. Citrus pectin (CP) has demonstrated antioxidative, anticancer, and anti-inflammatory properties in humans and animals. In broilers, CP supplementation improves energy utilization and nutrient digestibility, but limited information on its effects on chicken immunity is available so far. This s ...
DOI:
10.1016/j.vetimm.2021.110269

46. Antibodies that react with bovine T lymphocytes expressing the T cell receptor β chain subgroup BV20 inhibit antigen recognition

Author:
W. Ivan Morrison; Tara Sheldrake; Timothy Connelley
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110392
ISSN:
0165-2427
Subject:
antigens; cattle; cytotoxicity; gene duplication; genes; immunopathology
Abstract:
... In recent years, molecular studies have provided detailed information on the bovine T cell receptor (TCR) variable gene repertoire, both in resting T cells and during T cell responses. However, studies of the biological function of the receptor have been hampered by a lack of reagents that recognise the protein. Herein, we describe the characterisation of two antibodies (IL-A47 and IL-A98) that re ...
DOI:
10.1016/j.vetimm.2022.110392

47. Assessment of three commercial ELISAs for the detection of antibodies against Porcine epidemic diarrhea virus at different stages of the immune response

Author:
I. Díaz; J. Pujols; E. Cano; R. Cuadrado; N. Navarro; E. Mateu; M. Martín
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110206
ISSN:
0165-2427
Subject:
Porcine epidemic diarrhea virus; immune response; immunopathology; nucleocapsid proteins
Abstract:
... Three commercial ELISAs -two based on spike (E1 and E3) and one on nucleocapsid protein (E2)-were used to analyze the development and persistence of antibodies against Porcine epidemic diarrhea virus (PEDV). Seventy-five four-week-old PEDV-negative piglets were inoculated orally with a European G1b PEDV (INOC) and fourteen were kept as controls (CTRL). After the inoculation, E3 detected positive a ...
DOI:
10.1016/j.vetimm.2021.110206

48. Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate

Author:
Matthew J. Cascio; Elizabeth M. Whitley; Bikash Sahay; Galaxia Cortes-Hinojosa; Lung-Ji Chang; Jonathan Cowart; Marc Salute; Elias Sayour; Michael Dark; Zachary Sandoval; Duane A. Mitchell; Rowan J. Milner
Source:
Veterinary immunology and immunopathology 2021 v.232 pp. 110169
ISSN:
0165-2427
Subject:
T-lymphocytes; dogs; humans; immunohistochemistry; immunopathology; ligands; metastasis; osteosarcoma; patients
Abstract:
... Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM, and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring ...
DOI:
10.1016/j.vetimm.2020.110169

49. Characterization of a variant CD4 molecule in Japanese Black cattle

Author:
Yuko Kato-Mori; Taku Okamura; Norihito Kawashita; Katsuro Hagiwara
Source:
Veterinary immunology and immunopathology 2021 v.232 pp. 110167
ISSN:
0165-2427
Subject:
Wagyu; amino acid substitution; amino acids; cytokines; epitopes; farms; flow cytometry; gene expression; genes; glycoproteins; immunopathology; macrophages; mitogens; monocytes
Abstract:
... Monoclonal antibodies (mAbs) that recognize cluster of differentiation (CD) molecules on lymphocytes are useful tools for the study of different lymphocyte subsets in flow cytometry (FCM) analysis. CD4 is a glycoprotein found on the surfaces of helper T cells, monocytes, macrophages, and dendritic cells. In this study, we describe Japanese Black (JB) calves in a farm whose peripheral blood mononuc ...
DOI:
10.1016/j.vetimm.2020.110167

50. Clinical and immunological responses in sheep after inoculation with Himar1-transformed Anaplasma phagocytophilum and subsequent challenge with a virulent strain of the bacterium

Author:
Sveinung Eskeland; Snorre Stuen; Ulrike G. Munderloh; Anthony Barbet; Liliana Crosby; Kari Lybeck; Peter Wilhelmsson; Per-Eric Lindgren; Shokouh Makvandi-Nejad; Stig Tollefsen; Erik G. Granquist
Source:
Veterinary immunology and immunopathology 2021 v.231 pp. 110165
ISSN:
0165-2427
Subject:
Anaplasma phagocytophilum; acaricides; animal welfare; bacteremia; bacteria; cell lines; disease control; genetic transformation; humoral immunity; immunogenicity; immunopathology; nucleotide sequences; tick-borne diseases; ticks; vaccines; virulence; virulent strains; Norway
Abstract:
... In Norway, the tick-transmitted bacterium Anaplasma phagocytophilum is estimated to cause tick-borne fever (TBF) in 300 000 lambs on pastures each year, resulting in economic and animal welfare consequences. Today, prophylactic measures mainly involve the use of acaricides, but a vaccine has been requested by farmers and veterinarians for decades. Several attempts have been made to produce a vacci ...
DOI:
10.1016/j.vetimm.2020.110165