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- Silva Lucília P. da; Pirraco Rogério P.; Santos Tírcia C.; Novoa-Carballal Ramon; Cerqueira Mariana T.; Reis Rui L.; Correlo Vitor M.; Marques Alexandra P.
- ACS Applied Materials & Interfaces 2016 v.8 no.49 pp. 33464-33474
- angiogenesis; biodegradation; disaccharides; endothelial cells; gellan gum; hindlimbs; humans; hyaluronic acid; hydrogels; medicine; receptors; tissue engineering; tissue repair; umbilical cord
- ... Neovascularization has been a major challenge in many tissue regeneration strategies. Hyaluronic acid (HA) of 3–25 disaccharides is known to be angiogenic due to its interaction with endothelial cell receptors. This effect has been explored with HA-based structures but a transitory response is observed due to HA burst biodegradation. Herein we developed gellan gum (GG)-HA spongy-like hydrogels fro ...
- Wu Yinga; Cai Jia; Han Jingfen; Baigude Huricha
- ACS Applied Materials & Interfaces 2015 v.7 no.38 pp. 21521-21528
- RNA interference; curdlan; cytotoxicity; disaccharides; endocytosis; flow cytometry; fluorescence microscopy; gene expression; human cell lines; motivation; nanoparticles; small interfering RNA
- ... Tissue-specific delivery of therapeutic RNAi has great potential for clinical applications. Receptor-mediated endocytosis plays a crucial role in targeted delivery of biotherapeutics including short interfering RNA (siRNA). Previously we reported a novel Curdlan-based nanoparticle for intracellular delivery of siRNA. Here we designed a nanoparticle based on ligand-functionalized Curdlan. Disacchar ...