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You searched for: Journal name ACS Applied Materials & Interfaces Remove constraint Journal name: ACS Applied Materials & Interfaces Subject medicine Remove constraint Subject: medicine Subject humans Remove constraint Subject: humans Subject term medicine Remove constraint Subject term: medicine Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Microfluidic Encapsulation of Human Mesenchymal Stem Cells for Articular Cartilage Tissue Regeneration

Author:
Li Fanyi; Truong Vinh X.; Thissen Helmut; Frith Jessica E.; Forsythe John S.
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.10 pp. 8589-8601
ISSN:
1944-8252
Subject:
apoptosis; cartilage; chondrogenesis; collagen; gelatin; humans; hydrogels; medicine; microencapsulation; polyethylene glycol; stem cells; tissue repair
Abstract:
... Stem cell injections for the treatment of articular cartilage damage are a promising approach to achieve tissue regeneration. However, this method is encumbered by high cell apoptosis rates, low retention in the cartilage lesion, and inefficient chondrogenesis. Here, we have used a facile, very low cost-based microfluidic technique to create visible light-cured microgels composed of gelatin norbor ...
DOI:
10.1021/acsami.7b00728

2. Development of Laser-Structured Liquid-Infused Titanium with Strong Biofilm-Repellent Properties

Author:
Doll Katharina; Fadeeva Elena; Schaeske Joern; Ehmke Tobias; Winkel Andreas; Heisterkamp Alexander; Chichkov Boris N.; Stiesch Meike; Stumpp Nico S.
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.11 pp. 9359-9368
ISSN:
1944-8252
Subject:
Streptococcus oralis; antibiotics; bacterial adhesion; bacterial colonization; biofilm; biomedical materials; biomimetics; contact angle; fibroblasts; gravity; humans; hysteresis; lubricants; medicine; osteoblasts; pathogens; risk; titanium; toxicity testing; viscosity
Abstract:
... Medical implants are commonly used in modern medicine but still harbor the risk of microbial infections caused by bacterial biofilms. As their retrospective treatment is difficult, there is a need for biomedical materials that inhibit bacterial colonization from the start without using antibacterial agents, as these can promote resistance development. The promising concept of slippery liquid-infus ...
DOI:
10.1021/acsami.6b16159

3. Neovascularization Induced by the Hyaluronic Acid-Based Spongy-Like Hydrogels Degradation Products

Author:
Silva Lucília P. da; Pirraco Rogério P.; Santos Tírcia C.; Novoa-Carballal Ramon; Cerqueira Mariana T.; Reis Rui L.; Correlo Vitor M.; Marques Alexandra P.
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.49 pp. 33464-33474
ISSN:
1944-8252
Subject:
angiogenesis; biodegradation; disaccharides; endothelial cells; gellan gum; hindlimbs; humans; hyaluronic acid; hydrogels; medicine; receptors; tissue engineering; tissue repair; umbilical cord
Abstract:
... Neovascularization has been a major challenge in many tissue regeneration strategies. Hyaluronic acid (HA) of 3–25 disaccharides is known to be angiogenic due to its interaction with endothelial cell receptors. This effect has been explored with HA-based structures but a transitory response is observed due to HA burst biodegradation. Herein we developed gellan gum (GG)-HA spongy-like hydrogels fro ...
DOI:
10.1021/acsami.6b11684

4. Stimulation of Early Osteochondral Differentiation of Human Mesenchymal Stem Cells Using Binary Colloidal Crystals (BCCs)

Author:
Wang Peng-Yuan; Thissen Helmut; Kingshott Peter
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.7 pp. 4477-4488
ISSN:
1944-8252
Subject:
biocompatible materials; cell culture; colloids; crystals; humans; medicine; nanomaterials; polymethylmethacrylate; polystyrenes; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; silica; silicon; stem cells; tissue culture
Abstract:
... A new surface based on self-assembly of two colloids into well-defined nanostructures, so-called binary colloidal crystals (BCCs), was fabricated for stem cell culture. The facile fabrication process are able to cover large surface areas (>3 cm-diameter, i.e. > 7 cm²) with ordered surface nanotopographies that is often a challenge particularly in biomaterials science. From our library, four differ ...
DOI:
10.1021/acsami.5b12660

5. miR-29b-Loaded Gold Nanoparticles Targeting to the Endoplasmic Reticulum for Synergistic Promotion of Osteogenic Differentiation

Author:
Pan Ting; Song Wenjing; Gao Huichang; Li Tianjie; Cao Xiaodong; Zhong Shizhen; Wang Yingjun
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.30 pp. 19217-19227
ISSN:
1944-8252
Subject:
bone formation; cell proliferation; cytotoxicity; endoplasmic reticulum; genes; humans; medicine; microRNA; mineralization; nanogold; osteoblasts; stem cells; tissue engineering; transfection
Abstract:
... Precise control of stem cells, such as human bone marrow-derived mesenchymal stem cells (hMSCs), is critical for the development of effective cellular therapies for tissue engineering and regeneration medicine. Emerging evidence suggests that several miRNAs act as key regulators of diverse biological processes, including differentiation of various stem cells. In this study, we have described a del ...
DOI:
10.1021/acsami.6b02969

6. Gd@C82-(ethylenediamine)8 Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger

Author:
Li Jie; Guan Mirong; Wang Taishan; Zhen Mingming; Zhao Fuwen; Shu Chunying; Wang Chunru
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.39 pp. 25770-25776
ISSN:
1944-8252
Subject:
biocompatibility; cosmetics; humans; hydroxyl radicals; medicine; nanoparticles; protective effect
Abstract:
... It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C₈₂ to obtain water-soluble Gd@C₈₂-(EDA)₈ nanoparticles (NPs) through a facile solid–liquid reaction. Gd ...
DOI:
10.1021/acsami.6b08659

7. Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine

Author:
Xu Shicai; Man Baoyuan; Jiang Shouzhen; Wang Jihua; Wei Jie; Xu Shida; Liu Hanping; Gao Shoubao; Liu Huilan; Li Zhenhua; Li Hongsheng; Qiu Hengwei
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.20 pp. 10977-10987
ISSN:
1944-8252
Subject:
Raman spectroscopy; adenosine; biotechnology; blood serum; copper; graphene; humans; hydrogen; medicine; methane; nanoparticles; quartz; urine; vapors
Abstract:
... We present a graphene/Cu nanoparticle hybrids (G/CuNPs) system as a surface-enhanced Raman scattering (SERS) substrate for adenosine detection. The Cu nanoparticles wrapped by a monolayer graphene shell were directly synthesized on flat quartz by chemical vapor deposition in a mixture of methane and hydrogen. The G/CuNPs showed an excellent SERS enhancement activity for adenosine. The minimum dete ...
DOI:
10.1021/acsami.5b02303

8. In Vitro Culture and Directed Osteogenic Differentiation of Human Pluripotent Stem Cells on Peptides-Decorated Two-Dimensional Microenvironment

Author:
Wang Mengke; Deng Yi; Zhou Ping; Luo Zuyuan; Li Qiuhong; Xie Bingwu; Zhang Xiaohong; Chen Tong; Pei Duanqing; Tang Zhihui; Wei Shicheng
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.8 pp. 4560-4572
ISSN:
1944-8252
Subject:
biocompatible materials; bone formation; bones; calcium; cell differentiation; chemistry; chitosan; coatings; embryonic stem cells; gene expression; humans; induced pluripotent stem cells; medicine; phosphates; somatic cells; tissue engineering; translation (genetics)
Abstract:
... Human pluripotent stem cells (hPSCs) are a promising cell source with pluripotency and capacity to differentiate into all human somatic cell types. Designing simple and safe biomaterials with an innate ability to induce osteoblastic lineage from hPSCs is desirable to realize their clinical adoption in bone regenerative medicine. To address the issue, here we developed a fully defined synthetic pep ...
DOI:
10.1021/acsami.5b00188

9. Micropatterning Extracellular Matrix Proteins on Electrospun Fibrous Substrate Promote Human Mesenchymal Stem Cell Differentiation Toward Neurogenic Lineage

Author:
Li Huaqiong; Wen Feng; Chen Huizhi; Pal Mintu; Lai Yuekun; Zhao Allan Zijian; Tan Lay Poh
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.1 pp. 563-573
ISSN:
1944-8252
Subject:
cell differentiation; engineering; extracellular matrix; gene expression; humans; medicine; messenger RNA; microtubules; neurogenesis; phenotype; pseudopodia; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; stem cells; topography; tubulin
Abstract:
... In this study, hybrid micropatterned grafts constructed via a combination of microcontact printing and electrospinning techniques process were utilized to investigate the influencing of patterning directions on human mesenchymal stem cells (hMSCs) differentiation to desired phenotypes. We found that the stem cells could align and elongate along the direction of the micropattern, where they randoml ...
DOI:
10.1021/acsami.5b09588

10. Adhesion and Proliferation of Human Mesenchymal Stem Cells from Dental Pulp on Porous Silicon Scaffolds

Author:
Collart-Dutilleul Pierre-Yves; Secret Emilie; Panayotov Ivan; Deville de Périère Dominique; Martín-Palma Raúl J.; Torres-Costa Vicente; Martin Marta; Gergely Csilla; Durand Jean-Olivier; Cunin Frédérique; Cuisinier Frédéric J.
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.3 pp. 1719-1728
ISSN:
1944-8252
Subject:
adhesion; cell adhesion; cell proliferation; chemical treatment; culture media; enzyme activity; fluorescence microscopy; growth factors; humans; medicine; mitosis; oxidation; physicochemical properties; porosity; scanning electron microscopy; silicon; stem cells; therapeutics; tissue engineering; tooth pulp
Abstract:
... In regenerative medicine, stem-cell-based therapy often requires a scaffold to deliver cells and/or growth factors to the injured site. Porous silicon (pSi) is a promising biomaterial for tissue engineering as it is both nontoxic and bioresorbable. Moreover, surface modification can offer control over the degradation rate of pSi and can also promote cell adhesion. Dental pulp stem cells (DPSC) are ...
DOI:
10.1021/am4046316

11. Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel

Author:
Xu Zhiyuan; Wang Song; Li Yongjun; Wang Mingwei; Shi Ping; Huang Xiaoyu
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.19 pp. 17268-17276
ISSN:
1944-8252
Subject:
biocompatibility; breast neoplasms; cell viability; cytotoxicity; drug delivery systems; drug therapy; drugs; ethylene glycol; fluorescein; fluorescence microscopy; graphene; graphene oxide; humans; hydrophobic bonding; isothiocyanates; lung neoplasms; medicine; nanomaterials; oxidation; paclitaxel; polyethylene glycol
Abstract:
... Graphene oxide (GO), a novel 2D nanomaterial prepared by the oxidation of natural graphite, has been paid much attention in the area of drug delivery due to good biocompatibility and low toxicity. In the present work, 6-armed poly(ethylene glycol) was covalently introduced into the surface of GO sheets via a facile amidation process under mild conditions, making the modified GO, GO-PEG (PEG: 65 wt ...
DOI:
10.1021/am505308f

12. Impact of Shape and Pore Size of Mesoporous Silica Nanoparticles on Serum Protein Adsorption and RBCs Hemolysis

Author:
Ma Zhifang; Bai Jing; Wang Yichen; Jiang Xiue
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.4 pp. 2431-2438
ISSN:
1944-8252
Subject:
Fourier transform infrared spectroscopy; adsorption; albumins; biocompatibility; erythrocytes; fibrinogen; globulins; guidelines; hemolysis; humans; kinetics; medicine; nanoparticles; porosity; porous media; silica
Abstract:
... With the rapid development of nanotechnology, mesoporous silica nanoparticles (MSNs) with numerous forms and structures have been synthesized and extensively applied in biomedicine in the past decades. However, our knowledge about the biocompatibility of the developed MSNs has not matched their development. Therefore, in this work, we have synthesized sphere-shaped MSNs with different pore scales ...
DOI:
10.1021/am404860q

13. MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection

Author:
Deng Wenwen; Cao Xia; Chen Jingjing; Zhang Zhijian; Yu Qingtong; Wang Yan; Shao Genbao; Zhou Jie; Gao Xiangdong; Yu Jiangnan; Xu Ximing
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.34 pp. 18957-18966
ISSN:
1944-8252
Subject:
Pleurotus eryngii; genetic engineering; humans; induced pluripotent stem cells; medicine; microRNA; nanoparticles; particle size; physicochemical properties; plasmids; polysaccharides; transcription factors; umbilical cord
Abstract:
... Induced pluripotent stem cells (iPSCs), resulting from the forced expression of cocktails out of transcription factors, such as Oct4, Sox2, Klf4, and c-Myc (OSKM), has shown tremendous potential in regenerative medicine. Although rapid progress has been made recently in the generation of iPSCs, the safety and efficiency remain key issues for further application. In this work, microRNA 302-367 was ...
DOI:
10.1021/acsami.5b06768

14. Rationally Separating the Corona and Membrane Functions of Polymer Vesicles for Enhanced T2 MRI and Drug Delivery

Author:
Qin Jingya; Liu Qiuming; Zhang Junxue; Chen Jing; Chen Shuai; Zhao Yao; Du Jianzhong
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.25 pp. 14043-14052
ISSN:
1944-8252
Subject:
Pseudomonas; acrylic acid; biodegradability; carboxylic ester hydrolases; composite polymers; cytotoxicity; doxorubicin; energy; ethylene oxide; hepatocytes; humans; hydrochloric acid; iron oxides; light scattering; magnetic resonance imaging; medicine; metastasis; mice; nanocarriers; nanoparticles; polyethylene glycol; spectroscopy; transmission electron microscopy
Abstract:
... It is an important challenge to in situ grow ultrafine super-paramagnetic iron oxide nanoparticles (SPIONs) in drug carriers such as polymer vesicles (also called polymersomes) while keeping their biodegradability for enhanced T₂-weighted magnetic resonance imaging (MRI) and drug delivery. Herein, we present a new strategy by rationally separating the corona and membrane functions of polymer vesic ...
DOI:
10.1021/acsami.5b03222

15. Simultaneous Detection of Circulating OncomiRs from Body Fluids for Prostate Cancer Staging Using Nanographene Oxide

Author:
Hizir Mustafa Salih; Balcioglu Mustafa; Rana Muhit; Robertson Neil M.; Yigit Mehmet V.
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.17 pp. 14772-14778
ISSN:
1944-8252
Subject:
biomarkers; blood; fluorescence; humans; medicine; microRNA; patients; prognosis; prostatic neoplasms; saliva; therapeutics; urine; wavelengths
Abstract:
... Circulating oncomiRs are highly stable diagnostic, prognostic, and therapeutic tumor biomarkers, which can reflect the status of the disease and response to cancer therapy. miR-141 is an oncomiR, which is overexpressed in advanced prostate cancer patients, whereas its expression is at the normal levels in the early stages of the disease. On the other hand, miR-21 is significantly elevated in the e ...
DOI:
10.1021/am504190a

16. Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions

Author:
Tan Xiaofang; Feng Liangzhu; Zhang Jing; Yang Kai; Zhang Shuai; Liu Zhuang; Peng Rui
Source:
ACS Applied Materials & Interfaces 2013 v.5 no.4 pp. 1370-1377
ISSN:
1944-8252
Subject:
Western blotting; binding capacity; binding proteins; blood proteins; blood serum; chemical bonding; complement; graphene oxide; humans; hypersensitivity; immune response; inflammation; mass spectrometry; medicine; nanosheets; risk; toxicity
Abstract:
... Potential toxicity and risk of inducing allergy and inflammation have always been a great concern of using nanomaterials in biomedicine. In this work, we investigate the serum behaviors of graphene oxide (GO) and how such behaviors are affected by its surface modification such as PEGylation. The results show that, when incubated with human sera, unfunctionalized GO adsorbs a significant amount of ...
DOI:
10.1021/am302706g