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1. Surface Passivation Improves the Synthesis of Highly Stable and Specific DNA-Functionalized Gold Nanoparticles with Variable DNA Density

Author:
Cacho-Nerin, Fernando,   et al.   ; Deka, Jashmini; Měch, Rostislav; Ianeselli, Luca; Amenitsch, Heinz; Parisse, Pietro; Casalis, Loredana;     Show all 7 Authors
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.12 pp. 7033-7040
ISSN:
1944-8252
Subject:
X-radiation; ethylene glycol; fluorescence; gel electrophoresis; nanogold; nucleic acid hybridization; nucleotide sequences; oligonucleotides; pH; scanning electron microscopy; single-stranded DNA; spectroscopy
Abstract:
... We report a novel and multifaceted approach for the quick synthesis of highly stable single-stranded DNA (ssDNA) functionalized gold nanoparticles (AuNPs). The method is based on the combined effect of surface passivation by (1-mercaptoundec-11-yl)hexa(ethylene glycol) and low pH conditions, does not require any salt pretreatment or high excess of ssDNA, and can be generalized for oligonucleotides ...
DOI:
10.1021/acsami.5b01191