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1. Activatable Multifunctional Persistent Luminescence Nanoparticle/Copper Sulfide Nanoprobe for in Vivo Luminescence Imaging-Guided Photothermal Therapy

Author:
Chen, Li-Jian; Sun, Shao-Kai; Wang, Yong; Yang, Cheng-Xiong; Wu, Shu-Qi; Yan, Xiu-Ping
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.48 pp. 32667-32674
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; chemical bonding; copper; image analysis; luminescence; medicine; metalloproteinases; nanoparticles; sulfides; therapeutics;     Show all 10 Subjects
Abstract:
... Multifunctional nanoprobes that provide diagnosis and treatment features have attracted great interest in precision medicine. Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) are optimal materials due to no in situ excitation needed, deep tissue penetration, and high signal-to-noise ratio, while activatable optical probes can further enhance signal-to-noise ratio for the signal tu ...
DOI:
10.1021/acsami.6b10702

2. Albumin-Mediated Biomineralization of Shape-Controllable and Biocompatible Ceria Nanomaterials

Author:
Yang, Zhangyou; Luo, Shenglin; Zeng, Yiping; Shi, Chunmeng; Li, Rong
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.8 pp. 6839-6848
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; bioactive properties; biomineralization; bovine serum albumin; disulfide bonds; nanoparticles; superoxide dismutase; temperature;     Show all 8 Subjects
Abstract:
... Although ceria-based nanostructures have emerged as fascinating materials with diverse biological activities, developing a facile, rapid, and biocompatible method of their preparation remains a major challenge. Herein we describe bovine serum albumin (BSA) protein-directed synthesis of ceria-based nanostructures, including ceria nanoclusters (CNLs), nanoparticles (CNPs), and nanochains (CNHs). The ...
DOI:
10.1021/acsami.6b15442

3. A Neutralized Noncharged Polyethylenimine-Based System for Efficient Delivery of siRNA into Heart without Toxicity

Author:
Wang, Fang; Gao, Lu; Meng, Liu-Yi; Xie, Jing-Ming; Xiong, Jing-Wei; Luo, Ying
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.49 pp. 33529-33538
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; DNA; Danio rerio; cardiovascular diseases; crosslinking; cytotoxicity; electrostatic interactions; gene silencing; heart; ligands; models; nanoparticles; neutralization; polymers; small interfering RNA; therapeutics;     Show all 16 Subjects
Abstract:
... Cationic polymers constitute an important class of materials in development of delivery vehicles for nucleic acid-based therapeutics. Among them, polyethylenimine (PEI) has been a classical cationic carrier intensively studied for therapeutic delivery of DNA, RNA, and short RNA molecules to treat diseases. However, the development of PEI for in vivo applications has been hampered by the inherent p ...
DOI:
10.1021/acsami.6b13295

4. Bifunctional Magnetic-Fluorescent Nanoparticles: Synthesis, Characterization, and Cell Imaging

Author:
Lu, Yanjiao; Zheng, Yang; You, Shusen; Wang, Feng; Gao, Zhuo; Shen, Jie; Yang, Wantai; Yin, Meizhen
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.9 pp. 5226-5232
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; ambient temperature; cell viability; coatings; fluorescence; image analysis; nanoparticles; polymers; spectroscopy; transmission electron microscopy;     Show all 10 Subjects
Abstract:
... A new type of bifunctional magnetic-fluorescent Fe₃O₄@SiO₂–PDI–PAA/Ca²⁺ nanoparticles has been prepared by coating PDI-cored star polymers (PDI–PAA) onto the surface of Fe₃O₄@SiO₂ core–shell nanostructures. The morphology and properties of the composite nanoparticles are investigated by transmission electron microscopy, ultraviolet–visible spectrometry, fluorescence spectrometry, and vibrating sam ...
DOI:
10.1021/am508266p

5. Biocompatible Chitosan–Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal–Chemo Therapy

Author:
Wang, Hui; Mukherjee, Sumit; Yi, Jinhui; Banerjee, Probal; Chen, Qianwang; Zhou, Shuiqin
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.22 pp. 18639-18649
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; EDTA (chelating agent); adverse effects; animal models; chemical elements; chitosan; crosslinking; doxorubicin; drug therapy; fluorescence; image analysis; in vitro studies; in vivo studies; irradiation; mice; nanocarriers; nanoparticles; neoplasms; pH; tissues; wavelengths;     Show all 21 Subjects
Abstract:
... Multifunctional nanocarriers with good biocompatibility, good imaging function, and smart drug delivery ability are crucial for realizing highly efficient imaging-guided chemotherapy in vivo. This paper reports a type of chitosan–carbon dot (CD) hybrid nanogels (CCHNs, ∼65 nm) by integrating pH-sensitive chitosan and fluorescent CDs into a single nanostructure for simultaneous near-infrared (NIR) ...
DOI:
10.1021/acsami.7b06062

6. Biocompatible Fe–Si Nanoparticles with Adjustable Self-Regulation of Temperature for Medical Applications

Author:
Jing, Ying; Liu, Jinming; Ji, Wei-Hang; Wang, Wei; He, Shi-Hai; Jiang, Xiao-Ze; Wiedmann, Timothy; Wang, Chun; Wang, Jian-Ping
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.23 pp. 12649-12654
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; drugs; energy; heat; iron; iron oxides; magnetic fields; nanoparticles; polymers; silicon; temperature;     Show all 11 Subjects
Abstract:
... Because of the noninvasive, locally selective potential of thermal energy, considerable effort has been focused on the use of an external, alternating magnetic field for conversion of magnetic work to heat with iron oxide nanoparticles. However, proper regulation of thermal energy remains a challenge because of the lack of feedback from the local temperature change to the external power supply. He ...
DOI:
10.1021/acsami.5b01680

7. Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo

Author:
Tan, Longfei; Tang, Wenting; Liu, Tianlong; Ren, Xiangling; Fu, Changhui; Liu, Bo; Ren, Jun; Meng, Xianwei
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.18 pp. 11237-11245
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; nanogold; microwave radiation; acute toxicity; intravenous injection; neoplasms; cytotoxicity; antineoplastic activity; nanocomposites; mice; irradiation; ionic liquids; blood; nanoparticles;     Show all 14 Subjects
Abstract:
... Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as microwave susceptible agent is introduced for enhancing the selectivity and targeting of MWTT. ILs/PDA nanocomposites have an excellent microwave heating ...
DOI:
10.1021/acsami.5b12329

8. Biocompatible Magnetite/Gold Nanohybrid Contrast Agents via Green Chemistry for MRI and CT Bioimaging

Author:
Narayanan, Sreeja; Sathy, Binulal N.; Mony, Ullas; Koyakutty, Manzoor; Nair, Shantikumar V.; Menon, Deepthy
Source:
ACS Applied Materials & Interfaces 2012 v.4 no.1 pp. 251-260
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; X-radiation; ambient temperature; apoptosis; cell viability; confocal microscopy; ferric chloride; gold; grape seeds; green chemistry; humans; image analysis; iron; magnetic resonance imaging; magnetite; nanogold; nanoparticles; phytopharmaceuticals; proanthocyanidins; reactive oxygen species; reducing agents; staining; stem cells; tomography;     Show all 24 Subjects
Abstract:
... Magnetite/gold (Fe₃O₄/Au) hybrid nanoparticles were synthesized from a single iron precursor (ferric chloride) through a green chemistry route using grape seed proanthocyanidin as the reducing agent. Structural and physicochemical characterization proved the nanohybrid to be crystalline, with spherical morphology and size ∼35 nm. Magnetic resonance imaging and magnetization studies revealed that t ...
DOI:
10.1021/am201311c

9. Casein-Coated Iron Oxide Nanoparticles for High MRI Contrast Enhancement and Efficient Cell Targeting

Author:
Huang, Jing; Wang, Liya; Lin, Run; Wang, Andrew Y.; Yang, Lily; Kuang, Min; Qian, Weiping; Mao, Hui
Source:
ACS Applied Materials & Interfaces 2013 v.5 no.11 pp. 4632-4639
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; antibodies; biomarkers; breast neoplasms; casein; coatings; epidermal growth factor receptors; hydrodynamics; intravenous injection; iron oxides; ligands; liver; magnetic resonance imaging; mice; milk; nanoparticles; neoplasm cells; pH; polymers; spleen; water solubility;     Show all 21 Subjects
Abstract:
... Surface properties, as well as inherent physicochemical properties, of the engineered nanomaterials play important roles in their interactions with the biological systems, which eventually affect their efficiency in diagnostic and therapeutic applications. Here we report a new class of MRI contrast agent based on milk casein protein-coated iron oxide nanoparticles (CNIOs) with a core size of 15 nm ...
DOI:
10.1021/am400713j

10. Cell Selective Apoptosis Induced by Polymorphic Alteration of Self-Assembled Silica Nanowebs

Author:
Keshavarz, Meysam; Tan, Bo; Venkatakrishnan, Krishnan
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.7 pp. 6292-6305
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; apoptosis; biomarkers; cell adhesion; crystal structure; drug carriers; endocytosis; energy; engineering; extracellular matrix; fibroblasts; ionization; mammals; nanoparticles; neoplasms; silica; silicon;     Show all 17 Subjects
Abstract:
... The biocompatibility of silicon-based nanomaterials makes them suitable for biophysical and biomedical applications. However, the application of silicon-based nanomaterials has been mainly restricted to nanoparticles (NPs) as a potential drug carrier and the extracellular matrix (ECM) as a platform for cell adhesion and proliferation. Here, we introduce silica NPs self-assembled into a 3D nanoweb ...
DOI:
10.1021/acsami.6b14836

11. Composite Magnetite and Protein Containing CaCO3 Crystals. External Manipulation and Vaterite → Calcite Recrystallization-Mediated Release Performance

Author:
Sergeeva, Alena; Sergeev, Roman; Lengert, Ekaterina; Zakharevich, Andrey; Parakhonskiy, Bogdan; Gorin, Dmitry; Sergeev, Sergey; Volodkin, Dmitry
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.38 pp. 21315-21325
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; applied research; calcite; calcium carbonate; citric acid; coatings; crystal structure; crystallization; crystals; electrolytes; ion exchange; lysozyme; magnetite; microstructure; models; nanoparticles; pH; porous media; vaterite;     Show all 19 Subjects
Abstract:
... Biocompatibility and high loading capacity of mesoporous CaCO₃ vaterite crystals give an option to utilize the polycrystals for a wide range of (bio)applications. Formation and transformations of calcium carbonate polymorphs have been studied for decades, aimed at both basic and applied research interests. Here, composite multilayer-coated calcium carbonate polycrystals containing Fe₃O₄ magnetite ...
DOI:
10.1021/acsami.5b05848

12. Composite of Functional Mesoporous Silica and DNA: An Enzyme-Responsive Controlled Release Drug Carrier System

Author:
Zhang, Guilong; Yang, Minglei; Cai, Dongqing; Zheng, Kang; Zhang, Xin; Wu, Lifang; Wu, Zhengyan
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.11 pp. 8042-8047
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; chlorides; drug carriers; drug toxicity; drugs; hydrolysates; hydrolysis; nanoparticles; porous media; silica; single-stranded DNA;     Show all 11 Subjects
Abstract:
... An efficient enzyme-responsive controlled release carrier system was successfully fabricated using single-stranded DNA encapsulated functional mesoporous silica nanoparticles. Mesoporous silica nanoparticles were initially fabricated through hydrolysis of tetraethyl orthosilicate (TEOS) in cetyltrimethylammonium chloride (CTAC) solution, and the surface of nanoparticles could be encapsulated with ...
DOI:
10.1021/am502154w

13. Composite Photothermal Platform of Polypyrrole-Enveloped Fe3O4 Nanoparticle Self-Assembled Superstructures

Author:
Zhang, Xue; Xu, Xiaowei; Li, Tingting; Lin, Min; Lin, Xiaoying; Zhang, Hao; Sun, Hongchen; Yang, Bai
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.16 pp. 14552-14561
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; biodegradability; diameter; electrons; ions; iron; iron oxides; irradiation; nanoparticles; toxicity;     Show all 10 Subjects
Abstract:
... Photothermal nanoplatforms with small size, low cost, multifunctionality, good biocompatibility and in particular biodegradability are greatly desired in the exploration of novel diagnostic and therapeutic methodologies. Despite Fe₃O₄ nanoparticles (NPs) have been approved as safe clinical agents, the low molar extinction coefficient and subsequent poor photothermal performance shed the doubt as e ...
DOI:
10.1021/am503831m

14. Construction of Fe3O4/Vancomycin/PEG Magnetic Nanocarrier for Highly Efficient Pathogen Enrichment and Gene Sensing

Author:
Zhu, Minjun; Liu, Weipeng; Liu, Hongxing; Liao, Yuhui; Wei, Jitao; Zhou, Xiaoming; Xing, Da
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.23 pp. 12873-12881
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; Listeria monocytogenes; amines; bacteria; bacterial infections; detection limit; genes; iron oxides; nanocarriers; nanoparticles; nucleic acids; pathogens; polyethylene glycol; public health; vancomycin; water solubility;     Show all 16 Subjects
Abstract:
... Infectious diseases, especially pathogenic bacterial infections, pose a growing threat to public health worldwide. As pathogenic bacteria usually exist in complex experimental matrixes at very low concentrations, developing a technology for rapid and biocompatible sample enrichment is essential for sensitive diagnosis. In this study, an Fe₃O₄/Vancomycin/PEG magnetic nanocarrier was constructed for ...
DOI:
10.1021/acsami.5b02374

15. Cosynthesis of Cargo-Loaded Hydroxyapatite/Alginate Core–Shell Nanoparticles (HAP@Alg) as pH-Responsive Nanovehicles by a Pre-gel Method

Author:
Liang, Yung-He; Liu, Chia-Hung; Liao, Shih-Hsiang; Lin, Yuan-Yun; Tang, Hao-Wei; Liu, Shin-Yun; Lai, I-Rue; Wu, Kevin C.-W.
Source:
ACS Applied Materials & Interfaces 2012 v.4 no.12 pp. 6720-6727
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; alginates; calcium chloride; chemical elements; confocal laser scanning microscopy; cytotoxicity; drug delivery systems; drugs; hydroxyapatite; liver neoplasms; models; nanoparticles; neoplasm cells; pH; particle size; transmission electron microscopy;     Show all 16 Subjects
Abstract:
... A new core–shell nanostructure consisting of inorganic hydroxyapatite (HAP) nanoparticles as the core and organic alginate as the shell (denoted as HAP@Alg) was successfully synthesized by a pre-gel method and applied to pH-responsive drug delivery systems (DDS). HAP@Alg nanoparticles have the advantages of hydroxyapatite and alginate, where hydroxyapatite provides pH-responsive degradability, and ...
DOI:
10.1021/am301895u

16. Defect-Related Luminescent Mesoporous Silica Nanoparticles Employed for Novel Detectable Nanocarrier

Author:
Ge, Kun; Zhang, Cuimiao; Jia, Guang; Ren, Huihui; Wang, Jianyuan; Tan, Aaron; Liang, Xing-Jie; Zang, Aimin; Zhang, Jinchao
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.20 pp. 10905-10914
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; annealing; antineoplastic activity; diameter; drugs; light intensity; luminescence; monitoring; nanocarriers; nanoparticles; neoplasm cells; neoplasms; porous media; silica; surface area; walnuts;     Show all 16 Subjects
Abstract:
... Uniform and well-dispersed walnut kernel-like mesoporous silica nanoparticles (MSNs) with diameters about 100 nm have been synthesized by a templating sol–gel route. After an annealing process, the as-obtained sample (DLMSNs) inherits the well-defined morphology and good dispersion of MSNs, and exhibits bright white-blue luminescence, higher specific surface area and pore volume, and better biocom ...
DOI:
10.1021/acsami.5b02146

17. Design and Fabrication of Multifunctional Sericin Nanoparticles for Tumor Targeting and pH-Responsive Subcellular Delivery of Cancer Chemotherapy Drugs

Author:
Huang, Lei; Tao, Kaixiong; Liu, Jia; Qi, Chao; Xu, Luming; Chang, Panpan; Gao, Jinbo; Shuai, Xiaoming; Wang, Guobin; Wang, Zheng; Wang, Lin
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.10 pp. 6577-6585
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; adverse effects; chemical bonding; cytotoxicity; doxorubicin; drug therapy; folate receptors; folic acid; hydrophilicity; hydrophobicity; immune response; lysosomes; nanoparticles; neoplasm cells; neoplasms; pH; sericin; silk;     Show all 18 Subjects
Abstract:
... The severe cytotoxicity of cancer chemotherapy drugs limits their clinical applications. Various protein-based nanoparticles with good biocompatibility have been developed for chemotherapy drug delivery in hope of reducing drugs’ side effects. Sericin, a natural protein from silk, has no immunogenicity and possesses diverse bioactivities that have prompted sericin’s application studies. However, t ...
DOI:
10.1021/acsami.5b11617

18. Effect of pH-Responsive Alginate/Chitosan Multilayers Coating on Delivery Efficiency, Cellular Uptake and Biodistribution of Mesoporous Silica Nanoparticles Based Nanocarriers

Author:
Feng, Wei; Nie, Wei; He, Chuanglong; Zhou, Xiaojun; Chen, Liang; Qiu, Kexin; Wang, Weizhong; Yin, Zhiqi
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.11 pp. 8447-8460
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; adverse effects; alginates; chitosan; coatings; cytotoxicity; doxorubicin; electrolytes; erythrocytes; histology; humans; in vitro studies; nanocarriers; nanoparticles; pH; pharmacokinetics; porous media; rats; silica;     Show all 19 Subjects
Abstract:
... Surface fuctionalization plays a crucial role in developing efficient nanoparticulate drug-delivery systems by improving their therapeutic efficacy and minimizing adverse effects. Here we propose a simple layer-by-layer self-assembly technique capable of constructing mesoporous silica nanoparticles (MSNs) into a pH-responsive drug delivery system with enhanced efficacy and biocompatibility. In thi ...
DOI:
10.1021/am501337s

19. Encapsulating Gold Nanoparticles or Nanorods in Graphene Oxide Shells as a Novel Gene Vector

Author:
Xu, Cheng; Yang, Darong; Mei, Lin; Lu, Bingan; Chen, Libao; Li, Qiuhong; Zhu, Haizhen; Wang, Taihong
Source:
ACS Applied Materials & Interfaces 2013 v.5 no.7 pp. 2715-2724
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; DNA; cetyltrimethylammonium bromide; commercialization; cytotoxicity; encapsulation; genes; gold; graphene oxide; hydrophilicity; ligands; nanogold; nanoparticles; nanorods; nanosheets; polyethyleneimine; surfactants; transfection; viability;     Show all 19 Subjects
Abstract:
... Surface modification of inorganic nanoparticles (NPs) is extremely necessary for biomedical applications. However, the processes of conjugating ligands to NPs surface are complicated with low yield. In this study, a hydrophilic shell with excellent biocompatibility was successfully constructed on individual gold NPs or gold nanorods (NRs) by encapsulating NPs or NRs in graphene oxide (GO) nanoshee ...
DOI:
10.1021/am400212j

20. Encapsulation of Gadolinium Oxide Nanoparticle (Gd2O3) Contrasting Agents in PAMAM Dendrimer Templates for Enhanced Magnetic Resonance Imaging in Vivo

Author:
Mekuria, Shewaye Lakew; Debele, Tilahun Ayane; Tsai, Hsieh-Chih
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.8 pp. 6782-6795
ISSN:
1944-8252
Subject:
biocompatibility,   etc   ; bladder; encapsulation; gadolinium; intestines; kidneys; liver; macrophages; magnetic resonance imaging; nanoparticles; polyethylene glycol; spleen;     Show all 12 Subjects
Abstract:
... There has been growing interest in the research of nanomaterials for biomedical applications in recent decades. Herein, a simple approach to synthesize the G4.5-Gd₂O₃-poly(ethylene glycol) (G4.5-Gd₂O₃-PEG) nanoparticles (NPs) that demonstrate potential as dual (T₁ and T₂) contrasting agents in magnetic resonance imaging (MRI) has been reported in this study. Compared to the clinically popular Gd-D ...
DOI:
10.1021/acsami.6b14075