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You searched for: Author "Kim, Hee-Kwon" Remove constraint Author: "Kim, Hee-Kwon" Journal ACS applied materials Remove constraint Journal: ACS applied materials Publication Year 2013 Remove constraint Publication Year: 2013
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1. pH-Responsive Biodegradable Assemblies Containing Tunable Phenyl-Substituted Vinyl Ethers for Use as Efficient Gene Delivery Vehicles

Author:
Kim, Hee-Kwon,   et al.   ; Thompson, David H.; Jang, Ho Seong; Chung, Yong Jin; Van den Bossche, Jeroen;     Show all 5 Authors
Source:
ACS applied materials 2013 v.5 no.12 pp. 5648-5658
ISSN:
1944-8252
Subject:
DNA; biodegradability; cytotoxicity; drugs; ethers; ethylene glycol; hydrolysis; lipids; pH; polyethylene glycol; sulfates; transfection
Abstract:
... Novel pH-responsive assemblies (PEG-lipid:DOPE liposomes) containing tunable and bifunctional phenyl-substituted vinyl ether (PIVE) cross-linkers were prepared. The assemblies consisted of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), acid-cleavable poly(ethylene glycol) (PEG)-conjugated lipids, pDNA, and protamine sulfate (PS). The PIVE linkage was designed to hydrolyze under acidic condi ...
DOI:
10.1021/am400977t