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- Lu, Yifei, et al. Show all 10 Authors
- ACS applied materials 2015 v.7 no.9 pp. 5444-5453
- biodegradability; crosslinking; dehydroascorbic acid; doxorubicin; glucose transporters; glutathione; hepatoma; image analysis; micelles; nanocarriers; neoplasm cells; pharmacokinetics; polymers; prognosis; toxicity
- ... In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as their serious systemic toxicity. In this work, we developed actively tumor-targeting trilayer micelles with microenvironment-sensitive cross-links as a novel nanocarrier for HCC therapy. These micelles comprised biodegradable P ...