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- Zhang, Chengyuan; Long, Ling; Xiong, Yao; Wang, Chenping; Peng, Cuiping; Yuan, Yuchuan; Liu, Zhirui; Lin, Yongyao; Jia, Yi; Zhou, Xing; Li, Xiaohui
- ACS applied materials & interfaces 2019 v.11 no.10 pp. 9872-9883
- indomethacin, etc ; active ingredients; antineoplastic activity; blood serum; chemical interactions; drug therapy; engineering; immunotherapy; nanocrystals; nanomedicine; nanoparticles; neoplasms; paclitaxel; polymers; surfactants; Show all 15 Subjects
- ... Carrier-free nanomedicines mainly composed of drug nanocrystals are considered as promising candidates for next-generation nanodrug formulations. However, such nanomedicines still need to be stabilized by additive surfactants, synthetic polymers, or biologically based macromolecules. Based on the strong intermolecular interactions between indomethacin (IDM, a COX-2 inhibitor) and paclitaxel (PTX, ...