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1. ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration

Author:
Liu, Yanhua; Zhu, Zhou; Pei, Xibo; Zhang, Xin; Cheng, Xinting; Hu, Shanshan; Gao, Xiaomeng; Wang, Jian; Chen, Junyu; Wan, Qianbing
Source:
ACS applied materials & interfaces 2020 v.12 no.33 pp. 36978-36995
ISSN:
1944-8252
Subject:
adhesion; adhesives; alkaline phosphatase; angiogenesis; antibacterial properties; biocompatibility; blood; bone formation; bone marrow; bone transplantation; collagen; hydrogels; in vivo studies; mesenchymal stromal cells; nanoparticles; osteocalcin; rats; rheological properties; secretion; strength (mechanics); vascular endothelial growth factors
Abstract:
... Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for bone defect reconstructive treatment, especially for bone graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol–chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the bone graft envi ...
DOI:
10.1021/acsami.0c12090

2. An Ultrashort Peptide-Based Supramolecular Hydrogel Mimicking IGF-1 to Alleviate Glucocorticoid-Induced Sarcopenia

Author:
Shang, Yuna; Kuang, Mingjie; Wang, Zhongyan; Huang, Ying; Liu, Lulu; Zhao, Xige; Zhang, Rui; Zhao, Yanhong; Peng, Rong; Sun, Shenghuan; Yang, Qiang; Yang, Zhimou
Source:
ACS applied materials & interfaces 2020 v.12 no.31 pp. 34678-34688
ISSN:
1944-8252
Subject:
apoptosis; bioactive properties; chronic diseases; collagen; elderly; fibrosis; hydrogels; insulin; insulin-like growth factor I; mortality; muscle tissues; muscles; myoblasts; myotubes; nanofibers; neoplasms; phosphorylation; sarcopenia; sequence analysis; signal transduction; therapeutics
Abstract:
... Sarcopenia is a common disease in older people due to aging, and it can also occur in midlife because of diseases including cancer. Sarcopenia, characterized by rapid loss of muscle mass and accelerated loss of function, can lead to adverse outcomes such as frailty, falls, and even mortality. The development of pharmacological and therapeutic approaches to treat sarcopenia remains challenging. The ...
DOI:
10.1021/acsami.0c09973

3. Superhierarchical Conductive Framework Implanted with Nickel/Graphitic Carbon Nanocages as Sulfur/Lithium Metal Dual-Role Hosts for Li–S Batteries

Author:
Wei, Yunhong; Wang, Yuchen; Zhang, Xuemei; Wang, Boya; Wang, Qian; Wu, Naiteng; Zhang, Yun; Wu, Hao
Source:
ACS applied materials & interfaces 2020 v.12 no.31 pp. 35058-35070
ISSN:
1944-8252
Subject:
active sites; anodes; cathodes; collagen; electrochemistry; graphene; lithium; lithium batteries; nanoparticles; nickel; sulfur; temperature
Abstract:
... High-energy-density Li–S batteries (LSBs) are considered as a promising next-generation energy-storage system. However, the sluggish redox kinetics and severe polysulfide shuttle effect in elemental sulfur cathodes, along with uncontrollable dendrite propagation in lithium metal anodes, inevitably depress the electrochemical performance of LSBs and impede their practical implementation. Motivated ...
DOI:
10.1021/acsami.0c10047

4. Three-Dimensional Electrodeposition of Calcium Phosphates on Porous Nanofibrous Scaffolds and Their Controlled Release of Calcium for Bone Regeneration

Author:
Mi, Xue; Gupte, Melanie J.; Zhang, Zhanpeng; Swanson, W. Benton; McCauley, Laurie K.; Ma, Peter X.
Source:
ACS applied materials & interfaces 2020 v.12 no.29 pp. 32503-32513
ISSN:
1944-8252
Subject:
bone formation; calcium; cell movement; cell proliferation; coatings; collagen; crystal structure; electric potential difference; electroplating; hydroxyapatite; ions; mineral content; mineralization; models; nanofibers; polymers; porous media; stoichiometry; temperature
Abstract:
... To mimic the bone matrix of mineralized collagen and to impart microporous structure to facilitate cell migration and bone regeneration, we developed a nanofibrous (NF) polymer scaffold with highly interconnected pores and three-dimensional calcium phosphate coating utilizing an electrodeposition technique. The mineral content, morphology, crystal structure, and chemical composition could be tailo ...
DOI:
10.1021/acsami.0c11003

5. Adhesion of Epithelial Cells to PNIPAm Treated Surfaces for Temperature-Controlled Cell-Sheet Harvesting

Author:
Kim, Hyejeong; Witt, Hannes; Oswald, Tabea A.; Tarantola, Marco
Source:
ACS applied materials & interfaces 2020 v.12 no.30 pp. 33516-33529
ISSN:
1944-8252
Subject:
adhesion; atomic force microscopy; cell harvesting; coatings; collagen; confocal microscopy; epithelial cells; extracellular matrix; fibronectins; image analysis; microgels; polymers; spectroscopy; temperature
Abstract:
... Stimuli responsive polymer coatings are a common motive for designing surfaces for cell biological applications. In the present study, we have characterized temperature dependent adhesive properties of poly(N-isopropylacrylamide) (PNIPAm) microgel coated surfaces (PMS) using various atomic force microscopy based approaches. We imaged and quantified the material properties of PMS upon a temperature ...
DOI:
10.1021/acsami.0c09166

6. Three-Dimensional Printing Biologically Inspired DNA-Based Gradient Scaffolds for Cartilage Tissue Regeneration

Author:
Zhou, Xuan; Tenaglio, Sara; Esworthy, Timothy; Hann, Sung Yun; Cui, Haitao; Webster, Thomas J.; Fenniri, Hicham; Zhang, Lijie Grace
Source:
ACS applied materials & interfaces 2020 v.12 no.29 pp. 33219-33228
ISSN:
1944-8252
Subject:
allografting; autografting; biomimetics; bioprinting; cartilage; cell adhesion; coatings; collagen; gelatin; gene expression; glycosaminoglycans; inflammation; mesenchymal stromal cells; muscles; nanotubes; pain; polyethylene glycol; printers; three-dimensional printing; tissue engineering; tissue repair
Abstract:
... Cartilage damage caused by aging, repeated overloading, trauma, and diseases can result in chronic pain, inflammation, stiffness, and even disability. Unlike other types of tissues (bone, skin, muscle, etc.), cartilage tissue has an extremely weak regenerative capacity. Currently, the gold standard surgical treatment for repairing cartilage damage includes autografts and allografts. However, these ...
DOI:
10.1021/acsami.0c07918

7. Tremella-Like ZnO@Col-I-Decorated Titanium Surfaces with Dual-Light-Defined Broad-Spectrum Antibacterial and Triple Osteogenic Properties

Author:
Zhao, Siyu; Xu, Yingying; Xu, Wenying; Weng, Zhenzhen; Cao, Fei; Wan, Xinyi; Cui, Tongcan; Yu, Yajun; Liao, Lan; Wang, Xiaolei
Source:
ACS applied materials & interfaces 2020 v.12 no.27 pp. 30044-30051
ISSN:
1944-8252
Subject:
Tremella; antibacterial properties; bone formation; bone marrow; coatings; collagen; gene expression; hydrophilicity; mesenchymal stromal cells; near-infrared spectroscopy; patients; titanium; zinc oxide
Abstract:
... The growing population of peri-implant diseases (PIDs) has become a public obsession, mainly due to the lack of antibacterial ability and osteogenic promotion of titanium (Ti) implants. Herein, inspired by tremella, we reported zinc oxide (ZnO)@collagen type I (Col-I)-decorated Ti for PIDs treatments. Compared with pure Ti implants, ZnO@Col-I-decorated Ti could be activated by a safe visible yello ...
DOI:
10.1021/acsami.0c05413

8. PDA/Cu Bioactive Hydrogel with “Hot Ions Effect” for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing

Author:
Xu, Qing; Chang, Mengling; Zhang, Yu; Wang, Endian; Xing, Min; Gao, Long; Huan, Zhiguang; Guo, Feng; Chang, Jiang
Source:
ACS applied materials & interfaces 2020 v.12 no.28 pp. 31255-31269
ISSN:
1944-8252
Subject:
Escherichia coli; angiogenesis; antibacterial properties; antibiotic resistance; bacteria; calcium silicate; ceramics; collagen; copper; heat; hydrogels; ions; methicillin; methicillin-resistant Staphylococcus aureus; therapeutics; tissue repair
Abstract:
... Quick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the phototh ...
DOI:
10.1021/acsami.0c08890

9. Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing

Author:
Huang, Shaoshan; Liu, Huiling; Liao, Kedan; Hu, Qinqin; Guo, Rui; Deng, Kaixian
Source:
ACS applied materials & interfaces 2020 v.12 no.26 pp. 28952-28964
ISSN:
1944-8252
Subject:
adhesion; angiogenesis; animal models; antibiotics; bacteria; beta-cyclodextrin; collagen; dopamine; drugs; gelatin; graphene oxide; hyaluronic acid; hydrogels; mechanical properties; mice; multiple drug resistance; nanocomposites; nitric oxide; silver; synergism; tissue repair
Abstract:
... Bacteria-infected wounds are attracting increasing attention, as antibiotic misuse and multidrug-resistant bacteria complicate their treatment. Herein, we reported a photothermal activity-based drug consisting of β-cyclodextrin (βCD)-functionalized graphene oxide (GO) near-infrared light-responsive nanovehicles combined with the nitric oxide donor BNN6, in a methacrylate-modified gelatin (GelMA)/h ...
DOI:
10.1021/acsami.0c04080

10. Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing

Author:
Liu, Shuai; Liu, Xin; Ren, Yanhan; Wang, Penghui; Pu, Yajie; Yang, Rong; Wang, Xiaoxue; Tan, Xiaoyan; Ye, Zhiwen; Maurizot, Victor; Chi, Bo
Source:
ACS applied materials & interfaces 2020 v.12 no.25 pp. 27876-27888
ISSN:
1944-8252
Subject:
antibacterial properties; bacteria; bioadhesives; collagen; crosslinking; fibrin; granulation tissue; histology; hyaluronic acid; hydrogels; mixing; models; neonates; peroxidase; rats; schiff bases; tissue repair
Abstract:
... Physicians have long been calling for an inherent antimicrobial wound dressing, which will be a great progress for treating complicated infections. Here, we report a novel bioadhesive hydrogel with inherent antibacterial properties prepared by mixing modified hyaluronic acid (HA) and ε-polylysine (EPL). This hydrogel can effectively kill Gram (+) and (−) bacteria for its high positive charge densi ...
DOI:
10.1021/acsami.0c00782

11. Extracellular Vesicles Enhance the Remodeling of Cell-Free Silk Vascular Scaffolds in Rat Aortae

Author:
Cunnane, Eoghan M.; Lorentz, Katherine L.; Ramaswamy, Aneesh K.; Gupta, Prerak; Mandal, Biman B.; O’Brien, Fergal J.; Weinbaum, Justin S.; Vorp, David A.
Source:
ACS applied materials & interfaces 2020 v.12 no.24 pp. 26955-26965
ISSN:
1944-8252
Subject:
RNA; bioassays; biodegradability; collagen; elastin; endothelium; macrophages; mesenchymal stromal cells; nanomaterials; rats; silk; smooth muscle; staining; stem cells; therapeutics; thrombosis; tissue engineering
Abstract:
... Vascular tissue engineering is aimed at developing regenerative vascular grafts to restore tissue function by bypassing or replacing defective arterial segments with tubular biodegradable scaffolds. Scaffolds are often combined with stem or progenitor cells to prevent acute thrombosis and initiate scaffold remodeling. However, there are limitations to cell-based technologies regarding safety and c ...
DOI:
10.1021/acsami.0c06609

12. One-Step Large-Scale Nanotexturing of Nonplanar PTFE Surfaces to Induce Bactericidal and Anti-inflammatory Properties

Author:
Xu, Jian; Moon, Haesoo; Xu, Jinjia; Lim, Jongcheon; Fischer, Thomas; McNally, Helen A.; Sintim, Herman O.; Lee, Hyowon
Source:
ACS applied materials & interfaces 2020 v.12 no.24 pp. 26893-26904
ISSN:
1944-8252
Subject:
Staphylococcus aureus; anti-inflammatory activity; bacteria; biomimetics; collagen; inflammation; macrophages; medical equipment; mice; oxygen; polytetrafluoroethylene
Abstract:
... Here we demonstrate a simple and scalable nanotexturing method for both planar (films) and nonplanar (tubes) polytetrafluoroethylene (PTFE) surfaces using a commercial desktop oxygen plasma etcher. The simple process can generate semiordered nanopillar structures on both tubular and planar samples with high radial and axial uniformity. We found that the resulting surfaces exhibit good in vitro bac ...
DOI:
10.1021/acsami.0c04729

13. Computational Nanomechanics of Noncollagenous Interfibrillar Interface in Bone

Author:
Wang, Yang; Morsali, Reza; Dai, Zhengwei; Minary-Jolandan, Majid; Qian, Dong
Source:
ACS applied materials & interfaces 2020 v.12 no.22 pp. 25363-25373
ISSN:
1944-8252
Subject:
collagen; mechanical properties; osteocalcin; osteopontin
Abstract:
... The noncollagenous interfibrillar interface in bone provides the critical function of transferring loads among collagen fibrils and their bundles, with adhesive mechanisms at this site thus significantly contributing to the mechanical properties of bone. Motivated by the experimental observations and hypotheses, a computational study is presented to elucidate the critical roles of two major protei ...
DOI:
10.1021/acsami.0c01613

14. Effect of the Buffer on the Buildup and Stability of Tannic Acid/Collagen Multilayer Films Applied as Antibacterial Coatings

Author:
Iqbal, Muhammad Haseeb; Schroder, André; Kerdjoudj, Halima; Njel, Christian; Senger, Bernard; Ball, Vincent; Meyer, Florent; Boulmedais, Fouzia
Source:
ACS applied materials & interfaces 2020 v.12 no.20 pp. 22601-22612
ISSN:
1944-8252
Subject:
Staphylococcus aureus; acetates; antibacterial properties; antibiotics; buffers; citrates; coatings; collagen; cytotoxicity; electrolytes; fibroblasts; humans; pH; polyphenols; tannins
Abstract:
... The deposition of polyelectrolyte multilayers, obtained by the layer-by-layer (LbL) method, is a well-established technology to design biocompatible and antibacterial coatings aimed at preventing implant-associated infections. Several types of LbL films have been reported to exhibit antiadhesive and/or antibacterial (contact-killing or release-killing) properties governed not only by the incorpora ...
DOI:
10.1021/acsami.0c04475

15. Mild Acid-Responsive “Nanoenzyme Capsule” Remodeling of the Tumor Microenvironment to Increase Tumor Penetration

Author:
Yao, Hanchun; Guo, Xiaofang; Zhou, Huijuan; Ren, Jinjin; Li, Ying; Duan, Songchao; Gong, Xiaobao; Du, Bin
Source:
ACS applied materials & interfaces 2020 v.12 no.18 pp. 20214-20227
ISSN:
1944-8252
Subject:
active sites; antineoplastic activity; bromelains; collagen; collagenase; doxorubicin; drug therapy; encapsulation; enzyme activity; extracellular matrix; ferritin; hypoxia; in vitro studies; nanocapsules; nanoparticles; neoplasm cells; neoplasms
Abstract:
... Dense extracellular matrix (ECM) severely impedes the spread of drugs in solid tumors and induces hypoxia, reducing chemotherapy efficiency. Different proteolytic enzymes, such as collagenase (Col) or bromelain, can directly attach to the surface of nanoparticles and improve their diffusion, but the method of ligation may also impair the enzymatic activity due to conformational changes or blockage ...
DOI:
10.1021/acsami.0c03022

16. Copper-Based Metal–Organic Framework as a Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing

Author:
Zhang, Pengju; Li, You; Tang, Yaohui; Shen, Hui; Li, Jiankai; Yi, Zhengfang; Ke, Qinfei; Xu, He
Source:
ACS applied materials & interfaces 2020 v.12 no.16 pp. 18319-18331
ISSN:
1944-8252
Subject:
angiogenesis; anti-inflammatory activity; cell growth; collagen; coordination polymers; copper; diabetes mellitus; endothelial cells; medicine; nanofibers; nitric oxide; therapeutics; tissue repair
Abstract:
... Chronic wounds are one of the most serious complications of diabetes mellitus. Even though utilizing nitric oxide (NO) as a gas medicine to repair diabetic wounds presents a promising strategy, controlling the NO release behavior in the affected area, which is vital for NO-based therapy, still remains a significant challenge. In this work, a copper-based metal–organic framework, namely, HKUST-1, h ...
DOI:
10.1021/acsami.0c01792

17. Micropatterned Biphasic Nanocomposite Platform for Maintaining Chondrocyte Morphology

Author:
Saraswat, Ram; Ratnayake, Ishara; Perez, E. Celeste; Schutz, William M.; Zhu, Zhengtao; Ahrenkiel, S. Phillip; Wood, Scott T.
Source:
ACS applied materials & interfaces 2020 v.12 no.13 pp. 14814-14824
ISSN:
1944-8252
Subject:
adhesion; agarose; analytical methods; cartilage; cell culture; chondrocytes; collagen; films (materials); humans; models; nanocomposites; nanofibers; osteoarthritis; polyvinyl alcohol; transmission electron microscopes; transmission electron microscopy; viability; wells
Abstract:
... One major limitation hindering the translation of in vitro osteoarthritis research into clinical disease-modifying therapies is that chondrocytes rapidly spread and dedifferentiate under standard monolayer conditions. Current strategies to maintain rounded morphologies of chondrocytes in culture either unnaturally restrict adhesion and place chondrocytes in an excessively stiff mechanical environm ...
DOI:
10.1021/acsami.9b22596

18. Zinc Silicate/Nano-Hydroxyapatite/Collagen Scaffolds Promote Angiogenesis and Bone Regeneration via the p38 MAPK Pathway in Activated Monocytes

Author:
Song, Yue; Wu, Hao; Gao, Yi; Li, Junqin; Lin, Kaifeng; Liu, Bin; Lei, Xing; Cheng, Pengzhen; Zhang, Shuaishuai; Wang, Yixiao; Sun, Jinbo; Bi, Long; Pei, Guoxian
Source:
ACS applied materials & interfaces 2020 v.12 no.14 pp. 16058-16075
ISSN:
1944-8252
Subject:
acid phosphatase; angiogenesis; biocompatible materials; bone formation; collagen; cytokines; endothelial cells; genes; immune response; mesenchymal stromal cells; mitogen-activated protein kinase; monocytes; platelet-derived growth factor; secretion; signal transduction; transforming growth factor beta 1; zinc; zinc silicates
Abstract:
... Recent studies show that biomaterials are capable of regulating immune responses to induce a favorable osteogenic microenvironment and promote osteogenesis and angiogenesis. In this study, we investigated the effects of zinc silicate/nanohydroxyapatite/collagen (ZS/HA/Col) scaffolds on bone regeneration and angiogenesis and explored the related mechanism. We demonstrate that 10ZS/HA/Col scaffolds ...
DOI:
10.1021/acsami.0c00470

19. A Synergistic Relationship between Polycaprolactone and Natural Polymers Enhances the Physical Properties and Biological Activity of Scaffolds

Author:
Sawadkar, Prasad; Mohanakrishnan, Jeviya; Rajasekar, Poojitha; Rahmani, Benyamin; Kohli, Nupur; Bozec, Laurent; García-Gareta, Elena
Source:
ACS applied materials & interfaces 2020 v.12 no.12 pp. 13587-13597
ISSN:
1944-8252
Subject:
allantois; angiogenesis; bioactive properties; biocompatible materials; biopolymers; bone formation; chorion; collagen; composite polymers; contact angle; elastin; fibrin; humans; lactones; physical properties; stem cells; tissue engineering; tissue repair; uncertainty
Abstract:
... Biomaterials for tissue engineering include natural and synthetic polymers, but their clinical application is still limited due to various disadvantages associated with the use of these polymers. This uncertainty of the polymeric approach in tissue engineering launches an opportunity to address a key question: can we eliminate the disadvantages of both natural and synthetic polymers by combining t ...
DOI:
10.1021/acsami.9b19715

20. Fibrin Glue/Fibronectin/Heparin-Based Delivery System of BMP2 Induces Osteogenesis in MC3T3-E1 Cells and Bone Formation in Rat Calvarial Critical-Sized Defects

Author:
Ao, Qiang; Wang, Shilin; He, Qing; Ten, Hirotomo; Oyama, Kenichi; Ito, Akihiro; He, Jing; Javed, Rabia; Wang, Aijun; Matsuno, Akira
Source:
ACS applied materials & interfaces 2020 v.12 no.11 pp. 13400-13410
ISSN:
1944-8252
Subject:
alkaline phosphatase; biocompatible materials; bone formation; bone morphogenetic proteins; calcium; collagen; fibrin; fibronectins; heparin; hydrogels; models; osteoblasts; osteocalcin; osteopontin; rats
Abstract:
... Bone morphogenetic proteins (BMPs) have been used to promote bone formation in many clinical scenarios. However, the BMPs are inherently unstable in vivo and therefore need to be combined with carriers for controlled delivery. In this study, an innovative and efficient fibrin glue/fibronectin/heparin (FG/Fn/Hep)-based delivery system was developed for controlled release of BMP2. The incorporation ...
DOI:
10.1021/acsami.0c01371