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- Nie, Tianqi; He, Zhiyu; Zhou, Yang; Zhu, Jinchang; Chen, Kuntao; Liu, Lixin; Leong, Kam W.; Mao, Hai-Quan; Chen, Yongming
- ACS applied materials & interfaces 2019 v.11 no.33 pp. 29593-29603
- glucagon-like peptide 1, etc ; animal models; blood glucose; coatings; diffusivity; electrostatic interactions; epithelium; hydrophilicity; intestines; liver; lungs; mucus; nanoparticles; noninsulin-dependent diabetes mellitus; patient compliance; permeability; plasmids; polyethylene glycol; therapeutics; transfection; Show all 20 Subjects
- ... Oral delivery of nucleic acid therapy is a promising strategy in treating various diseases because of its higher patient compliance and therapeutic efficiency compared to parenteral routes of administration. However, its success has been limited by the low transfection efficiency resulting from nucleic acid entrapment in the mucus layer and epithelial barrier of the gastrointestinal (GI) tract. He ...