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- Yang, Xuemei, et al. Show all 9 Authors
- ACS applied materials & interfaces 2018 v.11 no.1 pp. 255-268
- apoptosis; blood circulation; doxorubicin; drug therapy; gene expression regulation; glutathione transferase; hyaluronic acid; hyaluronoglucosaminidase; hydrolysis; hydrophobicity; irradiation; materials science; micelles; neoplasm cells; neoplasms; nitric oxide; tumor suppressor genes
- ... Nitric oxide (NO) is an important biological messenger implicated in tumor therapy. However, current NO release systems suffer from some disadvantages, such as hydrolysis during blood circulation, poor specificity, and robust irradiation for stimuli. Accordingly, we constructed an intracellular enzyme-triggered NO-generator to achieve tumor cytoplasm-specific disruption and localized rapid drug re ...