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- Chen, Yi-Ping, et al. Show all 5 Authors
- ACS applied materials & interfaces 2019 v.11 no.5 pp. 4790-4798
- bioactive compounds; blood flow; confocal microscopy; drugs; electrostatic interactions; encapsulation; enzymes; erythrocytes; flow cytometry; fluorescence; hemolysis; humans; hydrodynamics; membrane proteins; moieties; monocytes; nanoparticles; peptides; porous media; scanning electron microscopy; silica
- ... Mesoporous silica nanoparticles (MSNs) hold great potential as a versatile platform for biomedical applications, especially drug delivery. However, evidence shows that MSNs even when PEGylated are rapidly cleared from the bloodstream by the monocyte phagocytic system. Erythrocytes, also called red blood cells (RBCs), can serve as biocompatible carriers of various bioactive substances, including dr ...
- Chen, Yi-Ping, et al. Show all 6 Authors
- ACS applied materials & interfaces 2019 v.11 no.17 pp. 15322-15331
- amyotrophic lateral sclerosis; curcumin; drugs; electrostatic interactions; gene expression; gene therapy; genes; human diseases; inflammation; microfilaments; nanocarriers; nanoparticles; neurites; oxidative stress; pathogenesis; peptides; plasmids; porous media; pseudopodia; reactive oxygen species; silica; synergism
- ... Reactive oxygen species (ROS)-induced oxidative stress leads to neuron damage and is involved in the pathogenesis of chronic inflammation in neurodegenerative diseases (NDs), such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. Researchers, therefore, are looking for antiinflammatory drugs and gene therapy approaches to slow down or even prevent neurological disorders. Combining th ...