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You searched for: Journal name Acta tropica Remove constraint Journal name: Acta tropica Publication year rev 7979-2021 Remove constraint Publication year rev: 7979-2021 Source 2021 v.220 Remove constraint Source: 2021 v.220
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1. Antioxidants resveratrol and SkQ1 attenuate praziquantel adverse effects on the liver in Opisthorchis felineus infected hamsters

Author:
Oxana Zaparina; Akbota S Rakhmetova; Nataliya G Kolosova; Guofeng Cheng; Viatcheslav A Mordvinov; Maria Y Pakharukova
Source:
Acta tropica 2021 v.220 pp. 105954
ISSN:
0001-706X
Subject:
Opisthorchis; adults; animal models; bile ducts; blood serum; complications (disease); droplets; fibrosis; gene expression; glycogen; hamsters; histology; hyperplasia; lipid peroxidation; liver; opisthorchiasis; oxidative stress; praziquantel; resveratrol; schistosomiasis
Abstract:
... Anthelmintic praziquantel (PZQ) is the drug of the choice for opisthorchiasis, schistosomiasis and other trematodiases therapy for several decades. Despite its good therapeutic performance and effective control of trematode infections, PZQ has some shortcomings; its inability to counteract disease sequelae necessitates novel therapeutic strategies. Testing of antioxidants that have proven themselv ...
DOI:
10.1016/j.actatropica.2021.105954

2. Application of nanotized formulation in the control of snail intermediate hosts of schistosomes

Author:
Oyetunde T. Oyeyemi
Source:
Acta tropica 2021 v.220 pp. 105945
ISSN:
0001-706X
Subject:
Schistosoma; drugs; freshwater; mice; molluscicides; public health; schistosomiasis; snails; toxicity
Abstract:
... Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant Schistosoma strains. This shortcoming has necessitated the search for other effective methods for the control of schistosomiasis. The breaking of Schistosom ...
DOI:
10.1016/j.actatropica.2021.105945

3. Bioinformatic prediction and identification of immunogenic epitopes of the antigenic 14-3-3 protein of Echinococcus multilocularis

Author:
Wei Wei; Lei Wang; Pei Zhou; Baili Jiang; Haisheng Liu; Lin Feng; Ri-Li Ge; Feng Tang; Runle Li
Source:
Acta tropica 2021 v.220 pp. 105955
ISSN:
0001-706X
Subject:
B-lymphocytes; Canis lupus; Echinococcus multilocularis; Rattus norvegicus; T-lymphocytes; amino acid sequences; amino acids; bioinformatics; echinococcosis; epitopes; larvae; lymphocyte proliferation; models; prediction
Abstract:
... Alveolar echinococcosis is a high-risk parasitic disease caused by the larval stage of Echinococcus multilocularis. The study aimed to predict and identify the dominant Th1/Th2 and B cell epitopes of the antigen protein 14-3-3 beta:alpha from Echinococcus multilocularis.A comparison of the four amino acid sequences of 14-3-3 beta:alpha was respectively derived from Echinococcus multilocularis, Rat ...
DOI:
10.1016/j.actatropica.2021.105955

4. Comparative assessment of interventions for treating cutaneous leishmaniasis: A network meta-analysis of randomized clinical trials.

Author:
Kannan Sridharan; Gowri Sivaramakrishnan
Source:
Acta tropica 2021 v.220 pp. 105944
ISSN:
0001-706X
Subject:
allopurinol; amphotericin B; azithromycin; carbon dioxide; cryosurgery; cutaneous leishmaniasis; dapsone; gentamicin; granulocyte-macrophage colony-stimulating factor; honey; ketoconazole; meta-analysis; placebos; probability; silver; sodium; sodium hypochlorite; thermotherapy; trichloroacetic acid; zinc sulfate
Abstract:
... Various interventions including laser therapy, heat therapy, and several drugs have been trialed in patients with cutaneous leishmaniasis. Due to the lack of an evidence-based comparison of all these interventions, we carried out the present network meta-analysis.Electronic databases were searched for randomized clinical trials evaluating the efficacy and safety of any interventions in patients wi ...
DOI:
10.1016/j.actatropica.2021.105944

5. Evaluation of a urogenital schistosomiasis behavioural intervention among students from rural schools in Unguja and Pemba islands, Zanzibar

Author:
Bobbie Person; David Rollinson; Said M. Ali; Ulfat A. Mohammed; Faiza M. A'kadir; Fatma Kabole; Stefanie Knopp
Source:
Acta tropica 2021 v.220 pp. 105960
ISSN:
0001-706X
Subject:
Schistosoma haematobium; behavior change; disease eradication; drugs; health beliefs; health education; laundry; models; questionnaires; risk; schistosomiasis haematobia; Zanzibar
Abstract:
... Urogenital schistosomiasis is a common experience among children in Zanzibar. There is a paucity of behavioural science-based, health education and behaviour change (HEBC) interventions for school-aged children, those at greatest risk for urogenital schistosomiasis. We assessed the influence of a HEBC intervention, guided by the Health Belief model, among rural schoolchildren on Pemba and Unguja i ...
DOI:
10.1016/j.actatropica.2021.105960

6. First report of novel assemblages and mixed infections of Giardia duodenalis in human isolates from New Zealand

Author:
Juan C. Garcia-R; Paul Ogbuigwe; Anthony B. Pita; Niluka Velathanthiri; Matthew A. Knox; Patrick J. Biggs; Nigel P. French; David T.S. Hayman
Source:
Acta tropica 2021 v.220 pp. 105969
ISSN:
0001-706X
Subject:
Giardia lamblia; epidemiology; genes; genetic variation; giardiasis; humans; parasites; pathogens; New Zealand
Abstract:
... Giardia duodenalis (syn. G. intestinalis and G. lamblia) is a protozoan parasite that cause disease (giardiasis) in humans and other animals. The pathogen is classified into eight assemblages, further divided into sub-assemblages, based on genetic divergence and host specificities. There are two zoonotic subtypes known as assemblages A and B, whilst assemblages from C to H are mainly found in dome ...
DOI:
10.1016/j.actatropica.2021.105969

7. Impact of Toxoplasma gondii infection on TM3 Leydig cells: Alterations in testosterone and cytokines levels

Author:
Larissa Staurengo-Ferrari; Raquel Arruda da Silva Sanfelice; Julia Bagatim de Souza; Joao Paulo Assolini; Dayane Priscila dos Santos; Allan Henrique Depieri Cataneo; Juliano Bordignon; Ivete Conchon-Costa; Idessania Nazareth da Costa; Glaura Scantamburlo Alves Fernandes
Source:
Acta tropica 2021 v.220 pp. 105938
ISSN:
0001-706X
Subject:
Toxoplasma gondii; chemokine CCL2; male fertility; males; parasites; testosterone
Abstract:
... Leydig cells play pivotal roles in eliciting male characteristics by producing testosterone and any damage to these cells can compromise male fertility Toxoplasma gondii (T. gondii) is an intracellular parasite capable to invade any nucleated cell, including cells from male reproductive system. Herein, we evaluated the capacity of RH strain of T. gondii to infect TM3 Leydig cells and the impact of ...
DOI:
10.1016/j.actatropica.2021.105938

8. Molecular detection of Trypanosoma evansi in dogs from India and Southeast Asia

Author:
Viet-Linh Nguyen; Roberta Iatta; Ranju Ravindran Santhakumari Manoj; Vito Colella; Marcos Antônio Bezerra-Santos; Jairo Alfonso Mendoza-Roldan; Domenico Otranto
Source:
Acta tropica 2021 v.220 pp. 105935
ISSN:
0001-706X
Subject:
DNA; Philippines; Trypanosoma evansi; blood; cattle; dogs; etiological agents; genes; genetic variation; nucleotide sequences; sequence analysis; surra; variant surface glycoproteins; India; Indonesia; Malaysia; Thailand; Vietnam
Abstract:
... Trypanosoma evansi, the causative agent of surra, is a hemoflagellate protozoan mechanically transmitted by hematophagous flies, mainly in tropical and subtropical regions. This protozoan affects several mammalian hosts, including dogs, which are highly susceptible to the infection. To investigate the occurrence of T. evansi in dogs, a total of 672 DNA samples from India (n = 228), Indonesia (n =  ...
DOI:
10.1016/j.actatropica.2021.105935

9. Oral immunization with recombinant Lactobacillus plantarum expressing Nudix hydrolase and 43 kDa proteins confers protection against Trichinella spiralis in BALB/c mice

Author:
Dan Wang; Qiong Liu; Yan-Long Jiang; Hai-Bin Huang; Jun-Yi Li; Tian-Xu Pan; Nan Wang; Wen-Tao Yang; Xin Cao; Yan Zeng; Chun-Wei Shi; Jian-Zhong Wang; Gui-Lian Yang; Quan Zhao; Chun-Feng Wang
Source:
Acta tropica 2021 v.220 pp. 105947
ISSN:
0001-706X
Subject:
Lactobacillus acidophilus; Lactobacillus plantarum; Trichinella spiralis; adults; antigens; blood serum; edible vaccines; hydrolases; interleukin-17; interleukin-4; intestines; lymph; mebendazole; muscle larvae; oral vaccination; parasites; recombinant vaccines; tongue; trichinosis
Abstract:
... Trichinellosis is a significant food-borne zoonotic parasitic disease caused by parasite Trichinella. Given the side effects of anti-Trichinella drugs (e.g., Mebendazole) aroused in the course of treatments, an effective vaccine against the parasite is called for. The therapies available to date are in most instances targeting a single stage of Trichinella, resulting in an incomplete protective im ...
DOI:
10.1016/j.actatropica.2021.105947

10. Prevalence and spatial distribution of heterophyidiasis in Southern Philippines

Author:
Kharleezelle J. Moendeg; Lydia R. Leonardo; Trina Galido Isorena; Francine Claire Alexandra S. Hilotina; Imelda S. Pates; Nancy O. Cacayorin
Source:
Acta tropica 2021 v.220 pp. 105940
ISSN:
0001-706X
Subject:
Philippines; fish consumption; freshwater fish; public health; regression analysis; zoonoses
Abstract:
... Heterophyidiasis is a fish-borne zoonotic disease that is considered to be an emerging public health problem in the Philippines. This study was carried out to determine the spatial distribution and risk factors of heterophyidiasis in five selected villages in New Corella, Davao del Norte in Southern Mindanao. Of the 1,101 individuals examined, 26 (2.36% overall prevalence rate, 95% CI 1.46–3.25) w ...
DOI:
10.1016/j.actatropica.2021.105940

11. Surveillance of antimicrobial resistant bacteria in flies (Diptera) in Rio de Janeiro city

Author:
Isabel Nogueira Carramaschi; Jonathan Christian O Lopes; Jéssica Albuquerque Leite; Marcos Tavares Carneiro; Rodrigo Rocha Barbosa; Maria Helena Villas Boas; Karyne Rangel; Thiago Pavoni Gomes Chagas; Margareth MC Queiroz; Viviane Zahner
Source:
Acta tropica 2021 v.220 pp. 105962
ISSN:
0001-706X
Subject:
Diptera; Enterobacteriaceae; analysis of variance; antibiotic resistance; ceftriaxone; cluster analysis; inoculum; maceration; monitoring; multiple drug resistance; pollution; Brazil
Abstract:
... Antimicrobial-resistant bacteria were isolated from muscoid dipterans collected at five different areas of Rio de Janeiro city, in proximity to hospitals. Extracts obtained by maceration of flies were diluted and used as inocula for different culture media, with or without antibiotic (ceftriaxone 1 mg/L) supplementation. Purified isolates were submitted to antimicrobial susceptibility testing (AST ...
DOI:
10.1016/j.actatropica.2021.105962

12. Triatomine and Trypanosoma cruzi discrete typing units distribution in a semi-arid area of northeastern Brazil

Author:
Nathan Ravi Medeiros Honorato; Andressa Noronha Barbosa da Silva; Christiane Carlos Araújo de Negreiros; Lúcia Maria Abrantes Aguiar; Newmar Pinto Marliére; Rita de Cássia Moreira de Souza; Ricardo José de Paula Souza e Guimarães; Lúcia Maria da Cunha Galvão; Antônia Cláudia Jácome da Câmara
Source:
Acta tropica 2021 v.220 pp. 105950
ISSN:
0001-706X
Subject:
Triatoma brasiliensis; Trypanosoma cruzi; blood meal; genes; genotyping; geographical distribution; intergenic DNA; mitochondria; niches; semiarid zones; Brazil
Abstract:
... The occurrence of triatomine species, their bloodmeal sources and the discrete typing units (DTUs) of Trypanosoma cruzi isolated from them were determined in different municipalities of the state of Rio Grande do Norte, Brazil. Triatomine captures were carried out in the rural areas of 23 municipalities. The genotyping of T. cruzi isolates was performed using the mitochondrial cytochrome c oxidase ...
DOI:
10.1016/j.actatropica.2021.105950

13. Axenic amastigotes of Leishmania species as a suitable model for in vitro studies

Author:
Geovane Dias-Lopes; Anabel Zabala-Peñafiel; Barbara Cristina de Albuquerque-Melo; Franklin Souza-Silva; Laura Menaguali do Canto; Léa Cysne-Finkelstein; Carlos Roberto Alves
Source:
Acta tropica 2021 v.220 pp. 105956
ISSN:
0001-706X
Subject:
amastigotes; biomarkers; cell viability; drugs; models; pH; parasites; promastigotes; temperature
Abstract:
... Leishmania spp. are etiological agents of infection diseases, which in some cases can be fatal. The main forms of their biological cycle, promastigotes and amastigotes, can be maintained in vitro. While promastigotes are easier to maintain, amastigotes are more complex and can be obtained through different ways, including infection assays of tissues or in vitro cells, and differentiation from prom ...
DOI:
10.1016/j.actatropica.2021.105956

14. Cryptosporidium infection in humans and animals from Iraq: A review

Author:
Firas Alali; Ibrahim Abbas; Marwa Jawad; Nawal Hijjawi
Source:
Acta tropica 2021 v.220 pp. 105946
ISSN:
0001-706X
Subject:
Cryptosporidium hominis; Cryptosporidium parvum; burden of disease; cattle; cryptosporidiosis; diarrhea; genotyping; monitoring; national surveys; oocysts; parasites; public health; sheep; tap water; Iraq
Abstract:
... The apicomplexan parasite Cryptosporidium causes serious diarrheal disease in humans and animals worldwide. The present review summarizes epidemiological and molecular studies as well as the clinical disease burden of natural Cryptosporidium infections in humans and animals from Iraq. Retrieved reports regarding cryptosporidiosis in Iraq indicated that the disease is highly prevalent in humans and ...
DOI:
10.1016/j.actatropica.2021.105946

15. Development of a PCR-lateral flow assay for rapid detection of Yersinia pestis, the causative agent of plague

Author:
Rita Singh; Vijai Pal; Manoj Kumar; N.K. Tripathi; A.K. Goel
Source:
Acta tropica 2021 v.220 pp. 105958
ISSN:
0001-706X
Subject:
Siphonaptera; Yersinia pestis; agar gel electrophoresis; biotin; blood; chromosomes; cross reaction; detection limit; enteropathogens; genes; humans; molecular biology; mortality; nucleotide sequences; plague; plasmids; rapid methods; zoonoses
Abstract:
... Plague is a zoonotic disease caused by Yersinia pestis, a Gram-negative, rod shaped coccobacillus, which is primarily found in rodents and can be transmitted to humans through flea bite. The disease has three major clinical forms bubonic (by flea bite), pneumonic (by respiratory droplets) and septicemic plague. Y. pestis is classified as a category ‘A’ agent by NIAID, USA due to its high mortality ...
DOI:
10.1016/j.actatropica.2021.105958

16. Development of a novel multiplex PCR assay for the detection and differentiation of Plasmodium caprae from Theileria luwenshuni and Babesia spp. in goats

Author:
Huynh Luu Cam Tu; Yudhi Ratna Nugraheni; Sonthaya Tiawsirisup; Tawee Saiwichai; Anyarat Thiptara; Morakot Kaewthamasorn
Source:
Acta tropica 2021 v.220 pp. 105957
ISSN:
0001-706X
Subject:
Babesia; DNA; Plasmodium; Theileria; computer simulation; detection limit; diagnostic specificity; genes; goats; hemoparasites; microscopy; mixed infection; monitoring; oligodeoxyribonucleotides; parasitemia; polymerase chain reaction; Thailand
Abstract:
... Intraerythrocytic parasites are traditionally identified by the microscopic examination of Giemsa-stained blood smears. However, this method does not always allow for the identification of individual species in goat's RBCs. Moreover, its unreliability in detecting low levels of parasitemia makes it unsuitable for epidemiological investigations and leaves goat farms vulnerable to potential outbreak ...
DOI:
10.1016/j.actatropica.2021.105957

17. Enhanced activation of blood neutrophils and monocytes in patients with Ethiopian localized cutaneous leishmaniasis in response to Leishmania aethiopica Neutrophil activation in Ethiopian cutaneous leishmaniasis

Author:
Menberework Chanyalew; Markos Abebe; Birtukan Endale; Selfu Girma; Geremew Tasew; Kidist Bobosha; Martha Zewide; Rawleigh Howe; Ger van Zandbergen; Uwe Ritter; Endalamaw Gadisa; Abraham Aseffa; Tamás Laskay
Source:
Acta tropica 2021 v.220 pp. 105967
ISSN:
0001-706X
Subject:
Leishmania aethiopica; Phlebotominae; biomarkers; cutaneous leishmaniasis; disease progression; lipopolysaccharides; macrophages; monocytes; neutrophils; parasites; reactive oxygen species; Ethiopia
Abstract:
... Recent studies suggest an essential role of the innate immune effector cells neutrophils and monocytes in protection or disease progression in the early course of Leishmania infection. In areas endemic for cutaneous leishmaniasis in Ethiopia most individuals are exposed to bites of infected sandflies. Still only a minor ratio of the inhabitants develops symptomatic disease. Neutrophils, followed b ...
DOI:
10.1016/j.actatropica.2021.105967

18. Field evaluation of four commercial light traps, trap placement, and effect of carbon dioxide on phlebotomine sand fly collection in northern Thailand

Author:
Puckavadee Somwang; Pathamet Khositharattanakool; Nattaphol Pathawong; Arissara Pongsiri; Silas A. Davidson; Alongkot Ponlawat
Source:
Acta tropica 2021 v.220 pp. 105953
ISSN:
0001-706X
Subject:
Phlebotominae; carbon dioxide; encephalitis; experimental design; light traps; markets; sand; surveys; wind; Thailand
Abstract:
... Several light trap devices have been invented and developed to assess the abundance of sand flies. Traps available in the market have different designs and attractant combinations to catch sand fly vectors. We evaluated the efficacy of four commercial light traps and determined the effect of trap placement and carbon dioxide (CO₂) on sand fly collection in northern Thailand. Trap evaluations were ...
DOI:
10.1016/j.actatropica.2021.105953

19. Identification of a novel calcium activated potassium channel from Leishmania donovani and in silico predictions of its antigenic features

Author:
Anindita Paul; Mubashra; Sushma Singh
Source:
Acta tropica 2021 v.220 pp. 105922
ISSN:
0001-706X
Subject:
B-lymphocytes; Leishmania donovani; T-lymphocytes; Trypanosoma cruzi; calcium; cell viability; computer simulation; drug resistance; drug therapy; drugs; epitopes; heat; histidine; homeostasis; models; plasma membrane; point mutation; potassium; potassium channels; sequence homology; transmembrane proteins; tropical diseases; visceral leishmaniasis
Abstract:
... Visceral Leishmaniasis is a major neglected tropical disease with increasing incidences of drug resistance. This has led to the search for a suitable drug target for chemotherapeutic intervention. Potassium channels are a family of membrane proteins which play a vital role in homeostasis and any perturbation in them alters cell survival which makes them an attractive target. To characterize a calc ...
DOI:
10.1016/j.actatropica.2021.105922

20. Immunoprotective inference of experimental chronic Trichinella spiralis infection on house dust mites induced allergic airway remodeling

Author:
Dalia A. Elmehy; Dina I. Abdelhai; Rasha A. Elkholy; Maram M. Elkelany; Dina M. Tahoon; Reem A. Elkholy; Nema A. Soliman; Marwa A. Hasby Saad; Ahmad A. El-Ebiary; Ghada A. Gamea
Source:
Acta tropica 2021 v.220 pp. 105934
ISSN:
0001-706X
Subject:
Trichinella spiralis; anti-allergic agents; asthma; blood serum; dust; enzymes; eosinophils; flow cytometry; gene expression; histopathology; homeostasis; hygiene; immune response; immunoglobulin E; inflammation; interleukin-10; interleukin-17; interleukin-5; lungs
Abstract:
... Allergic bronchial asthma is characterized by chronic inflammation of the respiratory airways mediated by T-helper 2 (Th2), Th17 and their cytokines. Although most asthmatic patients suffer from allergic airway remodeling (AAR), aggressive anti-allergic treatment failed to reverse it. The hygiene hypothesis illuminated the counter relationship between allergy and helminthic infections. The immune ...
DOI:
10.1016/j.actatropica.2021.105934