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- Wu, Ryan T.; Cao, Lei; Mattson, Elliot; Witwer, Kenneth W.; Cao, Jay; Zeng, Huawei; He, Xin; Combs., Gerald F. Jr; Cheng, Wen-Hsing
- Aging Cell 2017 v.16 no.1 pp. 125-135
- DNA damage; alopecia; cataract; cell senescence; diet; gene expression; glucose tolerance; insulin; insulin resistance; knockout mutants; longevity; messenger RNA; mice; microRNA; models; nutrient deficiencies; osteoporosis; pancreas; selenium; sodium selenate; telomerase; telomeres; tissue repair; weanlings
- ... Selenium (Se) is a trace metalloid essential for life, but its nutritional and physiological roles during the aging process remain elusive. While telomere attrition contributes to replicative senescence mainly through persistent DNA damage response, such an aging process is mitigated in mice with inherently long telomeres. Here, weanling third generation telomerase RNA component knockout mice carr ...
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