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- Paolella, Gaetana; Lepretti, Marilena; Barone, Maria Vittoria; Nanayakkara, Merlin; Di Zenzo, Marina; Sblattero, Daniele; Auricchio, Salvatore; Esposito, Carla; Caputo, Ivana
- Amino acids 2017 v.49 no.3 pp. 541-550
- gliadin, etc ; autoantibodies; autoimmunity; celiac disease; enzyme activity; fibroblasts; grains; immune response; ingestion; innate immunity; intestines; models; mucosa; patients; peptides; phenotype; protective effect; protein-glutamine gamma-glutamyltransferase; Show all 18 Subjects
- ... Type 2 transglutaminase (TG2) has an important pathogenic role in celiac disease (CD), an inflammatory intestinal disease that is caused by the ingestion of gluten-containing cereals. Indeed, TG2 deamidates specific gliadin peptides, thus enhancing their immunogenicity. Moreover, the transamidating activity seems to provoke an autoimmune response, where TG2 is the main autoantigen. Many studies ha ...
- Feriotto, G.; Calza, R.; Bergamini, C. M.; Griffin, M.; Wang, Z.; Beninati, S.; Ferretti, V.; Marzola, E.; Guerrini, R.; Pagnoni, A.; Cavazzini, A.; Casciano, F.; Mischiati, C.
- Amino acids 2017 v.49 no.3 pp. 551-565
- gliadin, etc ; amino acids; antigen-presenting cells; bioinformatics; calcium; celiac disease; gluten; guanosine triphosphate; mechanism of action; models; patients; small intestine; stomach; Show all 13 Subjects
- ... Gluten-induced aggregation of K562 cells represents an in vitro model reproducing the early steps occurring in the small bowel of celiac patients exposed to gliadin. Despite the clear involvement of TG2 in the activation of the antigen-presenting cells, it is not yet clear in which compartment it occurs. Herein we study the calcium-dependent aggregation of these cells, using either cell-permeable ...