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- Hanff, Erik, et al. Show all 12 Authors
- Amino acids 2017 v.49 no.6 pp. 1111-1121
- arginine; arteries; atherosclerosis; blood; creatinine; echocardiography; females; gas chromatography-mass spectrometry; males; metabolites; nitrates; nitric oxide; nitric oxide synthase; nitrites; patients; proteins; proteolysis; risk factors; stable isotopes; stroke
- ... Asymmetric dimethylarginine (ADMA) and L-homoarginine (hArg) are L-arginine (Arg) metabolites derived from different pathways. Protein arginine N-methyltransferase (PRMT) and subsequent proteolysis of proteins containing methylarginine residues release ADMA. Arginine:glycine amidinotransferase (AGAT) converts Arg to hArg and guanidinoacetate (GAA). While high concentrations of ADMA and low concent ...
- Hanff, Erik, et al. Show all 10 Authors
- Amino acids 2017 v.49 no.4 pp. 783-794
- adults; arginine; biosynthesis; boys; children; creatinine; dimethylamine; excretion; gas chromatography-mass spectrometry; gestational age; girls; humans; metabolites; neonates; nitrates; nitric oxide; nitrites; premature birth; risk factors; urine
- ... L-Arginine (Arg) and L-homoarginine (hArg) are precursors of nitric oxide (NO), a signalling molecule with multiple important roles in human organism. In the circulation of adults, high concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) and low concentrations of hArg emerged as cardiovascular risk factors. Yet, the importance of the Arg/hArg/NO pathway, espe ...