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Amino acids
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7990-2010
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2010 v.38 no.5
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- Author:
- Saransaari, Pirjo; Oja, Simo S.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1387-1393
- ISSN:
- 0939-4451
- Subject:
- adenosine; adults; agonists; antagonists; brain stem; ischemia; mice; normoxia; purinergic receptors; taurine; tritium
- Abstract:
- ... The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [³H]taurine release in the brain stem in normoxia and ischemia, using a superfusion system. Under stan ...
- DOI:
- 10.1007/s00726-009-0351-7
- PubMed:
- 19768520
- https://doi.org/10.1007/s00726-009-0351-7
- Author:
- Florini, Nicola; Faglioni, Francesco; Zucchi, Claudia; Caglioti, Luciano; Pályi, Gyula
- Source:
- Amino acids 2010 v.38 no.5 pp. 1343-1350
- ISSN:
- 0939-4451
- Subject:
- amino acids; enantiomers; neodymium; nuclear magnetic resonance spectroscopy; quantitative analysis
- Abstract:
- ... A neodymium-(S)-PDTA (PDTA = N,N,N′,N′-tetrakis[(hydroxycarbonyl)methyl]-1,2-diaminopropane) complex was found exceptionally useful in the quantitative determination of enantiomer ratios of water-soluble natural amino acids by ¹³C-NMR. The method is demonstrated on mixtures of l- and d-enantiomers of various amino acids. The interactions of the chiral shift reagent with the amino acid molecules we ...
- DOI:
- 10.1007/s00726-009-0341-9
- https://doi.org/10.1007/s00726-009-0341-9
- Author:
- Millington, Keith R.; Ishii, Hiroshi; Maurdev, George
- Source:
- Amino acids 2010 v.38 no.5 pp. 1395-1405
- ISSN:
- 0939-4451
- Subject:
- advanced glycation end products; air; arginine; asparagine; chemiluminescence; fluorescence; heat; lysine; milk proteins; nitrogen; oxidation; polyamides; schiff bases; singlet oxygen; threonine; tryptophan
- Abstract:
- ... Chemiluminescence (CL) with maximum emission in the range 550-650 nm is observed when proteins and certain amino acids are heated in air, and CL intensity is significantly reduced in nitrogen. Of the 20 common amino acids, lysine (Lys) has the highest thermal CL intensity by a factor of ~30 over arginine, threonine and asparagine. This finding differs from previous studies on amino acids and prote ...
- DOI:
- 10.1007/s00726-009-0352-6
- PubMed:
- 19763784
- https://doi.org/10.1007/s00726-009-0352-6
- Author:
- Celotto, Andréa Carla; Fukada, Sandra Y.; Laurindo, Francisco R. M.; Haddad, Renato; Eberlin, Marcos N.; de Oliveira, Ana Maria
- Source:
- Amino acids 2010 v.38 no.5 pp. 1515-1522
- ISSN:
- 0939-4451
- Subject:
- acetylcholine; adrenergic agonists; body weight; carotid arteries; coronary disease; endothelial nitric oxide synthase; females; homocysteine; inducible nitric oxide synthase; nitric oxide; nitroprusside; ovariectomy; rats; risk factors; vasoconstriction
- Abstract:
- ... Homocysteine is an independent risk factor for coronary heart disease, as well as for cerebrovascular and peripheral vascular diseases. The purpose of this study was to investigate the effects of hyperhomocysteinemia (HHcy) on vascular reactivity within carotid artery segments isolated from ovariectomized female rats. Treatment with dl-Hcy thiolactone (1 g/kg body weight per day) reduced the pheny ...
- DOI:
- 10.1007/s00726-009-0368-y
- PubMed:
- 19876715
- https://doi.org/10.1007/s00726-009-0368-y
- Author:
- Janssens, Michiel Etienne; Geysen, Dirk; Broos, Katleen; De Goeyse, Ine; Robbens, Johan; Van Petegem, Filip; Timmermans, Jean-Pierre; Guisez, Yves
- Source:
- Amino acids 2010 v.38 no.5 pp. 1617-1626
- ISSN:
- 0939-4451
- Subject:
- capsid; chimerism; disulfide bonds; glycine (amino acid); hepatitis B; peptides; prediction; recombinant fusion proteins; vaccination
- Abstract:
- ... The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting successful capsid formation. In contrast to previous work, we show that common in silico ...
- DOI:
- 10.1007/s00726-009-0365-1
- PubMed:
- 19957000
- https://doi.org/10.1007/s00726-009-0365-1
- Author:
- Chen, Min-Feng; Qi, Lin; Li, Yuan; Zu, Xiong-Bing; Dai, Yuan-Qin; Zhang, Peng
- Source:
- Amino acids 2010 v.38 no.5 pp. 1505-1513
- ISSN:
- 0939-4451
- Subject:
- Western blotting; antagonists; apoptosis; cell growth; cyclins; estrogen receptors; estrogens; growth retardation; humans; hyperplasia; mitogen-activated protein kinase; myocytes; phosphorylation; signal transduction; smooth muscle
- Abstract:
- ... Icaritin has selective estrogen receptor (ER) modulating activity. ERs are expressed in the prostate stroma, and estrogens have an important role in the pathology of benign prostatic hyperplasia (BPH). However, the impact of icaritin on BPH was not studied. Human prostatic smooth muscle cells (PSMCs) were treated with 0-100 μM icaritin, also using 10 μM ICI182780 as a specific ER antagonist. The e ...
- DOI:
- 10.1007/s00726-009-0366-0
- PubMed:
- 19876716
- https://doi.org/10.1007/s00726-009-0366-0
- Author:
- Austin, Jeffrey; Kimura, Richard H.; Woo, Youn-Hi; Camarero, Julio A.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1313-1322
- ISSN:
- 0939-4451
- Subject:
- Escherichia coli; Helianthus annuus; biosynthesis; directed evolution; disulfide bonds; mutants; peptide libraries; polypeptides; screening; trypsin inhibitors
- Abstract:
- ... We present the in vivo biosynthesis of wild-type sunflower trypsin inhibitor 1 (SFTI-1) inside E. coli cells using an intramolecular native chemical ligation in combination with a modified protein splicing unit. SFTI-1 is a small backbone cyclized polypeptide with a single disulfide bridge. A small library containing multiple Ala mutants was also biosynthesized and its activity was assayed using a ...
- DOI:
- 10.1007/s00726-009-0338-4
- PubMed:
- 19685144
- PubMed Central:
- PMC2936557
- https://doi.org/10.1007/s00726-009-0338-4
- Author:
- Baum, Alina; García-Sastre, Adolfo
- Source:
- Amino acids 2010 v.38 no.5 pp. 1283-1299
- ISSN:
- 0939-4451
- Subject:
- RNA; RNA viruses; Toll-like receptors; adaptive immunity; genes; innate immunity; interferons; melanoma; retinoic acid; virus replication; viruses
- Abstract:
- ... Virus recognition and induction of interferon (IFN) are critical components of the innate immune system. The Toll-like receptor (TLR) and RIG-I-like receptor families have been characterized as key players in RNA virus detection. Signaling cascades initiated by these receptors are crucial for establishment of an IFN signaling mediated antiviral state in infected and neighboring cells and containme ...
- DOI:
- 10.1007/s00726-009-0374-0
- PubMed:
- 19882216
- PubMed Central:
- PMC2860555
- https://doi.org/10.1007/s00726-009-0374-0
9. Isoform-specific determinants in the HP1 binding to histone 3: insights from molecular simulations
- Author:
- Machado, Matias R.; Dans, Pablo D.; Pantano, Sergio
- Source:
- Amino acids 2010 v.38 no.5 pp. 1571-1581
- ISSN:
- 0939-4451
- Subject:
- Human immunodeficiency virus 1; electrostatic interactions; epigenetics; genome; heterochromatin; histones; methylation; phosphorylation
- Abstract:
- ... Despite the significant improvements in anti HIV-1 treatment, AIDS remains a lifelong disease due to the impossibility to eradicate the viral reservoir established upon integration of the viral genome. Controlling the epigenetic block imposed by the host cell machinery to the viral transcription may represent a therapeutic alternative to purge the viral reservoir, offering a way to eradicate the i ...
- DOI:
- 10.1007/s00726-009-0371-3
- PubMed:
- 19888549
- https://doi.org/10.1007/s00726-009-0371-3
- Author:
- Liao, Sha; Qie, Jian-Kun; Xue, Ming; Zhang, Zhen-Qing; Liu, Ke-Liang; Ruan, Jin-Xiu
- Source:
- Amino acids 2010 v.38 no.5 pp. 1595-1605
- ISSN:
- 0939-4451
- Subject:
- electrospray ionization mass spectrometry; half life; humans; kidneys; liquid chromatography; liver; matrix-assisted laser desorption-ionization mass spectrometry; metabolism; metalloproteinases; parathyroid hormone; proteinase inhibitors; proteolysis; rats; serine
- Abstract:
- ... The present study aim to investigate the metabolic stability and degradation of cleavage sites of human parathyroid hormone peptide, hPTH (1-34), in rat tissue homogenate, and to identify the types of proteases involved in hPTH (1-34) processing degradation. The stability of hPTH (1-34) in rat kidney, lung and liver homogenates was evaluated by LC-ESI-MS, and the structures of the major degradatio ...
- DOI:
- 10.1007/s00726-009-0376-y
- PubMed:
- 19894098
- https://doi.org/10.1007/s00726-009-0376-y
- Author:
- Yanni, Amalia E.; Agrogiannis, George; Nomikos, Tzortzis; Fragopoulou, Elisabeth; Pantopoulou, Alkisti; Antonopoulou, Smaragdi; Perrea, Despoina
- Source:
- Amino acids 2010 v.38 no.5 pp. 1323-1331
- ISSN:
- 0939-4451
- Subject:
- alanine transaminase; animal disease models; aspartate transaminase; aspartic acid; atherogenesis; blood serum; brain; cholesterol; dietary supplements; drinking water; fatty liver; gamma-glutamyltransferase; glutamic acid; high density lipoprotein; liver; nutritional intervention; rabbits; staining; triacylglycerols
- Abstract:
- ... Previous studies have shown that dietary supplementation with l-aspartate and l-glutamate inhibits fatty streak initiation in cholesterol-fed rabbit. The present study investigates the role of dicarboxylic amino acids on the progression of fatty streaks and the development of fatty liver disease, which were caused in New Zealand White rabbits after a 0.5% w/w cholesterol diet for 7 weeks. A group ...
- DOI:
- 10.1007/s00726-009-0340-x
- PubMed:
- 19701712
- https://doi.org/10.1007/s00726-009-0340-x
- Author:
- Peters, Verena; Kebbewar, Moustafa; Jansen, Erwin W.; Jakobs, Cornelis; Riedl, Eva; Koeppel, Hannes; Frey, Dirk; Adelmann, Katja; Klingbeil, Kristina; Mack, Matthias; Hoffmann, Georg F.; Janssen, Bart; Zschocke, Johannes; Yard, Benito A.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1607-1615
- ISSN:
- 0939-4451
- Subject:
- adults; blood serum; cerebrospinal fluid; children; diabetic nephropathy; dipeptidases; enzyme-linked immunosorbent assay; homocarnosine; patients; risk; substrate specificity
- Abstract:
- ... Activity of carnosinase (CN1), the only dipeptidase with substrate specificity for carnosine or homocarnosine, varies greatly between individuals but increases clearly and significantly with age. Surprisingly, the lower CN1 activity in children is not reflected by differences in CN1 protein concentrations. CN1 is present in different allosteric conformations in children and adults since all sera o ...
- DOI:
- 10.1007/s00726-009-0367-z
- PubMed:
- 19915793
- https://doi.org/10.1007/s00726-009-0367-z
- Author:
- Roviello, Giovanni N.; Gaetano, Sonia Di; Capasso, Domenica; Cesarani, Annalisa; Bucci, Enrico M.; Pedone, Carlo
- Source:
- Amino acids 2010 v.38 no.5 pp. 1489-1496
- ISSN:
- 0939-4451
- Subject:
- Murine leukemia virus; RNA-directed DNA polymerase; bioactive properties; electrospray ionization mass spectrometry; in vitro studies; lysine; messenger RNA; reverse transcription; reversed-phase high performance liquid chromatography; spectral analysis
- Abstract:
- ... In this work, we report the synthesis of an alternate nucleo-alpha,epsilon-peptide based on l-lysine moieties, an in vitro study of its biological activity, and spectroscopical binding studies between the novel nucleopeptide and Moloney murine leukemia virus reverse transcriptase as well as RNA. An alternate homothymine hexamer was synthesized by a straightforward solid phase route starting from c ...
- DOI:
- 10.1007/s00726-009-0361-5
- PubMed:
- 19813074
- https://doi.org/10.1007/s00726-009-0361-5
14. Changes in plasma amino acid concentrations with increasing age in patients with propionic acidemia
- Author:
- Scholl-Bürgi, Sabine; Sass, Jörn Oliver; Heinz-Erian, Peter; Amann, Edda; Haberlandt, Edda; Albrecht, Ursula; Ertl, Claudia; Sigl, Sara Baumgartner; Lagler, Florian; Rostasy, Kevin; Karall, Daniela
- Source:
- Amino acids 2010 v.38 no.5 pp. 1473-1481
- ISSN:
- 0939-4451
- Subject:
- alanine; arginine; asparagine; aspartic acid; correlation; glutamic acid; glutamine; histidine; isoleucine; leucine; lysine; methionine; normal values; ornithine; patients; phenylalanine; proline; propionyl-CoA carboxylase; serine; threonine; valine
- Abstract:
- ... The objective of the study is to analyze plasma amino acid concentrations in propionic acidemia (PA) for the purpose of elucidating possible correlations between propionyl-CoA carboxylase deficiency and distinct amino acid behavior. Plasma concentrations of 19 amino acids were measured in 240 random samples from 11 patients (6 families) with enzymatically and/or genetically proven propionic acidem ...
- DOI:
- 10.1007/s00726-009-0356-2
- https://doi.org/10.1007/s00726-009-0356-2
- Author:
- Taylor, Lee; Midgley, Adrian W.; Chrismas, Bryna; Madden, Leigh A.; Vince, Rebecca V.; McNaughton, Lars R.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1483-1488
- ISSN:
- 0939-4451
- Subject:
- blood serum; circadian rhythm; diurnal variation; heat shock proteins; humans; males; monocytes; temperature
- Abstract:
- ... The inducible human stress protein heat shock protein 72 (HSP72) performs vital roles within the body at rest and during periods of stress. Recently it was shown over a 24 h period that basal HSP72 followed a diurnal variation. However, these results and previous literature demonstrate noticeable inter-subject variation in basal HSP72 expression. The notion of intra/inter-day variation in basal HS ...
- DOI:
- 10.1007/s00726-009-0360-6
- PubMed:
- 19816654
- https://doi.org/10.1007/s00726-009-0360-6
- Author:
- Miyamoto, Tetsuya; Sekine, Masae; Ogawa, Tetsuhiro; Hidaka, Makoto; Homma, Hiroshi; Masaki, Haruhiko
- Source:
- Amino acids 2010 v.38 no.5 pp. 1377-1385
- ISSN:
- 0939-4451
- Subject:
- Escherichia coli; acid hydrolysis; amino acids; beta-galactosidase; humans; hydrolysates; linear models; molecular weight; protein synthesis; proteins; tissues
- Abstract:
- ... It has long been believed that amino acids comprising proteins of all living organisms are only of the l-configuration, except for Gly. However, peptidyl d-amino acids were observed in hydrolysates of soluble high molecular weight fractions extracted from cells or tissues of various organisms. This strongly suggests that significant amounts of d-amino acids are naturally present in usual proteins. ...
- DOI:
- 10.1007/s00726-009-0348-2
- PubMed:
- 19768521
- https://doi.org/10.1007/s00726-009-0348-2
- Author:
- Atherton, Philip J.; Smith, Ken; Etheridge, Timothy; Rankin, Debbie; Rennie, Michael J.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1533-1539
- ISSN:
- 0939-4451
- Subject:
- blood serum; chemical structure; essential amino acids; immunoblotting; isoleucine; leucine; mammals; myotubes; non-specific serine/threonine protein kinase; phosphorylation; protein synthesis; signal transduction; skeletal muscle; valine
- Abstract:
- ... The essential amino acids (EAA) activate anabolic signalling through mechanisms, which are unclear in detail but include increased signalling through the mammalian target of rapamycin complex 1 (mTORC1). Of all the EAA, the branched chain amino acid (BCAA) leucine has been suggested as the most potent in stimulating protein synthesis, although there have been no studies investigating the effects o ...
- DOI:
- 10.1007/s00726-009-0377-x
- PubMed:
- 19882215
- https://doi.org/10.1007/s00726-009-0377-x
18. Effects of zinc ex vivo and intracellular zinc chelator in vivo on taurine uptake in goldfish retina
- Author:
- Nusetti, S.; Urbina, M.; Obregón, F.; Quintal, M.; Benzo, Z.; Lima, L.
- Source:
- Amino acids 2010 v.38 no.5 pp. 1429-1437
- ISSN:
- 0939-4451
- Subject:
- chelating agents; goldfish; high performance liquid chromatography; nutrient deficiencies; retina; spectroscopy; taurine; transporters; tritium; zinc; zinc sulfate
- Abstract:
- ... Taurine and zinc exert neurotrophic effects. Zinc modulates Na⁺/Cl⁻-dependent transporters. This study examined the effect of zinc (ZnSO₄) ex vivo and zinc chelator N,N,N′,N′-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN) in vivo on [³H]taurine transport in goldfish retina. The effect of TPEN in vivo on taurine and zinc levels was determined. Isolated cells were incubated in Ringer with zinc (0 ...
- DOI:
- 10.1007/s00726-009-0357-1
- PubMed:
- 19784807
- https://doi.org/10.1007/s00726-009-0357-1
- Author:
- Carducci, Martina; Licata, Luana; Peluso, Daniele; Castagnoli, Luisa; Cesareni, Gianni
- Source:
- Amino acids 2010 v.38 no.5 pp. 1541-1547
- ISSN:
- 0939-4451
- Subject:
- protein binding; Human papillomavirus type 16; proteome; oncogenic viruses; humans; peptides; Human mastadenovirus B; protein-protein interactions; databases
- Abstract:
- ... Protein-protein interactions play an essential role in the regulation of most cellular processes. The process of viral infection is no exception and many viral pathogenic strategies involve targeting and perturbing host-protein interactions. The characterization of the host protein subnetworks disturbed by invading viruses is a major goal of viral research and may contribute to reveal fundamental ...
- DOI:
- 10.1007/s00726-009-0375-z
- https://doi.org/10.1007/s00726-009-0375-z
- Author:
- Topo, Enza; Soricelli, Andrea; Di Maio, Angela; D'Aniello, Enrico; Di Fiore, Maria Maddalena; D'Aniello, Antimo
- Source:
- Amino acids 2010 v.38 no.5 pp. 1561-1569
- ISSN:
- 0939-4451
- Subject:
- amino acids; analysis of variance; cognition; correlation; hippocampus; memory; oral administration; rats; sodium
- Abstract:
- ... d-Aspartic acid (d-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that d-Asp in the rat is involved in learning and memory processes. Oral administration of sodium d-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the Morris water maze system. Two sessions per day for three consecutive days were per ...
- DOI:
- 10.1007/s00726-009-0369-x
- PubMed:
- 19890700
- https://doi.org/10.1007/s00726-009-0369-x