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You searched for: Journal name Amino acids Remove constraint Journal name: Amino acids Subject term adenosine Remove constraint Subject term: adenosine Subject term antagonists Remove constraint Subject term: antagonists
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1. Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia

Author:
Saransaari, Pirjo; Oja, Simo S.
Source:
Amino acids 2010 v.38 no.5 pp. 1387-1393
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; brain stem; ischemia; mice; normoxia; purinergic receptors; taurine; tritium
Abstract:
... The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [³H]taurine release in the brain stem in normoxia and ischemia, using a superfusion system. Under stan ...
DOI:
10.1007/s00726-009-0351-7
PubMed:
19768520

2. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
P. Saransaari; S. S. Oja
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1

3. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry

Author:
Sahún, I.; Gallego, X.; Gratacòs, M.; Murtra, P.; Trullás, R.; Maldonado, R.; Estivill, X.; Dierssen, M.
Source:
Amino acids 2007 v.33 no.4 pp. 677-688
ISSN:
0939-4451
Subject:
adenosine; animal models; antagonists; anxiety; brain stem; caffeine; fearfulness; gene overexpression; immunocytochemistry; mice; patients; sodium; transgenic animals; yohimbine
Abstract:
... Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellularity in brain regions, such as the locus ceruleus, that are important neural subst ...
DOI:
10.1007/s00726-006-0464-1
PubMed:
17111100

4. Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A₂A receptors

Author:
Boeck, C. R.; Kroth, E. H.; Bronzatto, M. J.; Vendite, D.
Source:
Amino acids 2007 v.33 no.3 pp. 439-444
ISSN:
0939-4451
Subject:
adenosine; adenosine monophosphate; antagonists; cell death; glutamic acid; neurons; neurotoxicity; receptors; viability
Abstract:
... Glutamate increases the extracellular adenosine levels, an important endogenous neuromodulator. The neurotoxicity induced by glutamate increases the ecto-5'-nucleotidase activity in neurons, which produces adenosine from AMP. L- and D-aspartate (Asp) mimic most of the actions of glutamate in the N-methyl-D-aspartate (NMDA) receptors. In the present study, both amino acids stimulated the ecto-5'-nu ...
DOI:
10.1007/s00726-006-0455-2