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- Hossain, Mohammed Akhter; Samuel, Chrishan S.; Binder, Claudia; Hewitson, Tim D.; Tregear, Geoffrey W.; Wade, John D.; Bathgate, Ross A. D.
- Amino acids 2010 v.39 no.2 pp. 409-416
- G-protein coupled receptors, etc ; matrix-assisted laser desorption-ionization mass spectrometry; bioactive properties; humans; antagonists; drugs; high performance liquid chromatography; metastasis; neoplasm cells; amino acid composition; prostatic neoplasms; rats; relaxin; agonists; synthetic peptides; Show all 15 Subjects
- ... Relaxin is a pleiotropic hormone which exerts its biological functions through its G-protein coupled receptor, RXFP1. While relaxin is well known for its reproductive and antifibrotic roles, recent studies suggest that it is produced by cancer cells and acts on RXFP1 to induce growth and metastasis. Furthermore, more recently Silvertown et al. demonstrated that lentiviral production of a human gen ...
- Patil, Nitin A.; Bathgate, Ross A. D.; Kocan, Martina; Ang, Sheng Yu; Tailhades, Julien; Separovic, Frances; Summers, Roger; Grosse, Johannes; Hughes, Richard A.; Wade, John D.; Hossain, Mohammed Akhter
- Amino acids 2016 v.48 no.4 pp. 987-992
- G-protein coupled receptors, etc ; acids; amides; anorexia; colon; disulfide bonds; drugs; electrostatic interactions; food intake; humans; obesity; peptides; relaxin; Show all 13 Subjects
- ... Insulin-like peptide 5 (INSL5) is an orexigenic peptide hormone belonging to the relaxin family of peptides. It is expressed primarily in the L-cells of the colon and has a postulated key role in regulating food intake. Its G protein-coupled receptor, RXFP4, is a potential drug target for treating obesity and anorexia. We studied the effect of modification of the C-terminus of the A and B-chains o ...