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1. Modulation of GABA-A receptors of astrocytes and STC-1 cells by taurine structural analogs

Author:
Reyes-Haro, Daniel; Cabrera-Ruíz, Elizabeth; Estrada-Mondragón, Argel; Miledi, Ricardo; Martínez-Torres, Ataúlfo
Source:
Amino acids 2014 v.46 no.11 pp. 2587-2593
ISSN:
0939-4451
Subject:
agonists; astrocytes; chloride channels; chlorides; electrophysiology; gamma-aminobutyric acid; receptors; taurine
Abstract:
... Taurine activates and modulates GABA receptors in vivo as well as those expressed in heterologous systems. This study aimed to determine whether the structural analogs of taurine: homotaurine and hypotaurine, have the ability to activate GABA-A receptors that include GABAρ subunits. The expression of GABA-A receptors containing GABAρ has been reported in the STC-1 cells and astrocytes. In both cel ...
DOI:
10.1007/s00726-014-1813-0

2. Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia

Author:
Komm, Barbara; Beyreis, Marlena; Kittl, Michael; Jakab, Martin; Ritter, Markus; Kerschbaum, Hubert H.
Source:
Amino acids 2014 v.46 no.8 pp. 1907-1917
ISSN:
0939-4451
Subject:
agonists; amino acid transporters; antagonists; choline; glycine (amino acid); isobutyric acid; membrane potential; mice; neuroglia; phagocytes; phagocytosis; polystyrenes; pseudopodia; reverse transcriptase polymerase chain reaction; scanning electron microscopy; strychnine; taurine
Abstract:
... Phagocytes form engulfment pseudopodia at the contact area with their target particle by a process resembling cell volume (CV) regulatory mechanisms. We evaluated whether the osmoregulatory active neutral amino acid glycine, which contributes to CV regulation via activation of sodium-dependent neutral amino acid transporters (SNATs) improves phagocytosis in isotonic and hypertonic conditions in th ...
DOI:
10.1007/s00726-014-1745-8

3. Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia

Author:
Saransaari, Pirjo; Oja, Simo S.
Source:
Amino acids 2010 v.38 no.5 pp. 1387-1393
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; brain stem; ischemia; mice; normoxia; purinergic receptors; taurine; tritium
Abstract:
... The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [³H]taurine release in the brain stem in normoxia and ischemia, using a superfusion system. Under stan ...
DOI:
10.1007/s00726-009-0351-7
PubMed:
19768520

4. Modulation of taurine release in ischemia by glutamate receptors in mouse brain stem slices

Author:
Saransaari, Pirjo; Oja, Simo S.
Source:
Amino acids 2010 v.38 no.3 pp. 739-746
ISSN:
0939-4451
Subject:
agonists; antagonists; brain stem; glutamic acid; ischemia; mice; neurons; receptors; taurine; tritium; young adults
Abstract:
... Glutamate is the main excitatory transmitter in the brain stem, regulating many vital sensory and visceral processes. Taurine is inhibitory and functions as a neuromodulator and regulator of cell volumes in the brain, being especially important in the developing brain. Taurine release is markedly enhanced under ischemic conditions in many brain areas, providing protection against excitotoxicity. T ...
DOI:
10.1007/s00726-009-0278-z

5. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
Saransaari, P.; Oja, S. S.
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1