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- Bilverstone, T.W.; Kinsmore, N.L.; Minton, N.P.; Kuehne, S.A.
- Anaerobe 2017 v.44 pp. 51-54
- Clostridium difficile; cytotoxicity; loci; toxins; transcription factors; virulence
- ... Assessing the regulation of Clostridium difficile transferase (CDT), is complicated by the presence of a Pathogenicity locus (PaLoc) which encodes Toxins A and B. Here we developed R20291ΔPaLoc model strains and cell-based assays to quantify CDT-mediated virulence. Their application demonstrated that the transcriptional regulator, CdtR, was required for CDT-mediated cytotoxicity. ...
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