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- Meng, Xiangjun; Xu, Haitong; Zhang, Zhi; Fawcett, John Paul; Li, Junru; Yang, Yan; Gu, Jingkai
- Analytical and bioanalytical chemistry 2017 v.409 no.20 pp. 4885-4891
- glucagon-like peptide 1, etc ; anion exchange; dogs; humans; liquid chromatography; monitoring; noninsulin-dependent diabetes mellitus; solid phase extraction; tandem mass spectrometry; Show all 9 Subjects
- ... Liraglutide is a glucagon-like peptide-1 analog for the treatment of type 2 diabetes. Major interference in plasma of human and animals and low fragment signal in tandem mass spectrometry are the main difficulties encountered in the bioanalysis of liraglutide. In this study, by combining differential mobility spectrometry (DMS) with multiple ion monitoring detection (MIM), a liquid chromatography ...