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- Li, Jiale, et al. Show all 6 Authors
- Analytical and bioanalytical chemistry 2016 v.408 no.13 pp. 3485-3493
- amino acids; biomarkers; blood serum; cell culture; chromatography; digestion; enzyme-linked immunosorbent assay; humans; ions; isotope dilution technique; isotope labeling; matrix-assisted laser desorption-ionization mass spectrometry; mixing; peptides; stable isotopes; traceability; transferrin; uncertainty
- ... Isotope dilution mass spectrometry (IDMS), an important metrological method, is widely used for absolute quantification of peptides and proteins. IDMS employs an isotope-labeled peptide or protein as an internal standard although the use of a protein provides improved accuracy. Generally, the isotope-labeled protein is obtained by stable isotope labeling by amino acids in cell culture (SILAC) tech ...