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- Kiss, László; Cselenyák, Attila; Varga, Ágnes; Visegrády, András
- Analytical biochemistry 2016 v.507 pp. 33-39
- G-protein coupled receptors, etc ; calcium; cyclic AMP; fluorescence; fluorometry; genetic engineering; humans; ligands; screening; second messengers; Show all 10 Subjects
- ... Cell-based assays for G-protein-coupled receptor (GPCR) activation applied in high-throughput screening (HTS) monitor various readouts for second messengers or intracellular effectors. Recently, our understanding of diverging signaling pathways downstream of receptor activation and the capability of small molecules to selectively modulate signaling routes has increased substantially, underlining t ...