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- Zhang, Shao-Wu; Liu, Yan-Fang; Yu, Yong; Zhang, Ting-He; Fan, Xiao-Nan
- Analytical biochemistry 2014 v.449 pp. 164-171
- Internet; amino acid composition; amino acid sequences; amino acids; automation; data collection; gene ontology; genome; humans; prediction; proteins; support vector machines; tissue distribution
- ... Revealing the subcellular location of newly discovered protein sequences can bring insight to their function and guide research at the cellular level. The rapidly increasing number of sequences entering the genome databanks has called for the development of automated analysis methods. Currently, most existing methods used to predict protein subcellular locations cover only one, or a very limited n ...
- Osaki, Fumio; Goto, Takaaki; Lee, Seon Hwa; Oe, Tomoyuki
- Analytical biochemistry 2014 v.449 pp. 59-67
- DNA; Lewis acids; amino acids; benzoquinones; drugs; enzymes; glutathione; human serum albumin; imines; mass spectrometry; models; monitoring; risk; screening
- ... Metabolic activation of drugs frequently generates electrophilic products that may undergo covalent binding to biological macromolecules, such as proteins and DNA. The resulting covalent adducts are of considerable concern in drug discovery and development. Several strategies for assessing the potential risks of candidate drugs have been reported. Of these, glutathione trapping is the most commonl ...