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- Ni Guan; Weiwei Gao; Min He; Min Zheng; Xiao Xu; Xiaobo Wang; Ming-Wei Wang
- Analytical biochemistry 2012 v.423 no.1 pp. 61-69
- diagnostic techniques; islets of Langerhans; monitoring; cytotoxicity; free fatty acids; hydrogen peroxide; physiology; cytokines; toxic substances; bioassays; streptozotocin; noninsulin-dependent diabetes mellitus; glucagon-like peptide 1
- ... β-Cell injury plays an important role in the development of type 1 and type 2 diabetes. Most of the β-cell bioassays depend on labeling or endpoint assessments that might not capture the true physiology or pathology of the injury process. In the current study, we dynamically detected a broad range of pathological and pharmacological responses to four toxicants (cytokine mixture, free fatty acid mi ...