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- Author:
- Guan, Ni; Gao, Weiwei; He, Min; Zheng, Min; Xu, Xiao; Wang, Xiaobo; Wang, Ming-Wei
- Source:
- Analytical biochemistry 2012 v.423 no.1 pp. 61-69
- ISSN:
- 0003-2697
- Subject:
- glucagon-like peptide 1, etc ; diagnostic techniques; islets of Langerhans; monitoring; cytotoxicity; free fatty acids; hydrogen peroxide; physiology; cytokines; toxic substances; bioassays; streptozotocin; noninsulin-dependent diabetes mellitus; Show all 13 Subjects
- Abstract:
- ... β-Cell injury plays an important role in the development of type 1 and type 2 diabetes. Most of the β-cell bioassays depend on labeling or endpoint assessments that might not capture the true physiology or pathology of the injury process. In the current study, we dynamically detected a broad range of pathological and pharmacological responses to four toxicants (cytokine mixture, free fatty acid mi ...
- DOI:
- 10.1016/j.ab.2012.01.014
-
http://dx.doi.org/10.1016/j.ab.2012.01.014