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- Hanff, Erik, et al. Show all 7 Authors
- Analytical biochemistry 2019 v.577 pp. 59-66
- amidinotransferases; analysis of variance; arginase; arginine; catalytic activity; cattle; creatine; enzyme activity; enzyme inhibitors; gas chromatography-mass spectrometry; homeostasis; humans; liver; lysine; metabolism; metabolites; methyltransferases; mortality; nitric oxide synthase; oral administration; stable isotopes
- ... l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine (N-methyl guanidinoacetate) by guanidinoacetate N-methyl-transferase (GAMT). Low circulating and excretory concentrations of hArg are associated with worse ...