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- Hashii, Noritaka, et al. Show all 4 Authors
- Analytical biochemistry 2012 v.420 no.1 pp. 61-67
- blood serum; deuterium; drugs; humans; insulin; mass spectrometry; pharmacokinetics; rapid methods; subcutaneous injection
- ... Insulin analog products for subcutaneous injection are prepared as solutions in which insulin analog molecules exist in several oligomeric states. Oligomeric stability can affect their onset and duration of action and has been exploited in designing them. To investigate the oligomeric stability of insulin analog products having different pharmacokinetics, we performed hydrogen/deuterium exchange m ...